个人简介
·2012年获安徽师范大学博士学位
·2012年至今在安徽师范大学生命科学学院工作,历任讲师、副教授
·2014年至2017年在国外从事博士后研究工作
◆主要研究课题
·国家自然科学基金(31400003),2015-2017,主持。
·安徽省高校自然科学研究重点项目(KJ2018A0319),2018-2019,主持。
·安徽省留学人员创新项目择优资助计划重点项目,2018-2019,主持。
·安徽省高校优秀青年人才支持计划重点项目(gxyqZD2018013),2018-2020,主持。
·安徽省自然科学基金(1308085QC67),2013-2015,主持。
·安徽省高校自然科学研究重点项目(KJ2013A128),2013-2015,主持。
·安徽师范大学人才培育基金(2012rcpy047),2013-2014,主持。
·安徽省高等院校科研平台创新团队,2016-2018,参与。
·安徽省高等学校自然科学研究重大项目,2017-2019,参与。
·人工合成酵母基因组(2012AA02A708),863计划,2012-2015,参与。
·国家自然科学基金(31170005),2012-2015,参与。
·国家自然科学基金(31040003),2011-2012,参与。
研究领域
病原微生物关键代谢酶的结构、功能、进化及其与致病性的关系
近期论文
查看导师新发文章
(温馨提示:请注意重名现象,建议点开原文通过作者单位确认)
1、代表性论文(20篇以内,*号为通讯作者):
· Wang P, Chen X, Yang J, Pei Y, Bian M, Zhu G. (2019) Characterization of the nicotinamide adenine dinucleotides (NAD and NADP) binding sites of the monomeric isocitrate dehydrogenases from Campylobacter species. Biochimie. 160, 148-155.
· Wang P, Liu T, Zhou X, Zhu G. (2019) Evaluation of the potential phosphorylation effect on isocitrate dehydrogenases from Saccharomyces cerevisiae and Yarrowia lipolytica. Applied Biochemistry and Biotechnology. 187: 1131-1142.
· Zhu Y#, Wang P#, Zhang L, Bai G, Yang C, Wang Y, He J, Zhang Z, Zhu G, Zou D (2019) Superhero Rictor promotes cellular differentiation of mouse embryonic stem cells. Cell Death and Differentiation. 26(5): 958-968. (#co-first author)
· Wang P, Li J, Tao J, Sha B (2018) The luminal domain of the ER stress sensor protein PERK binds misfolded proteins and thereby triggers PERK oligomerization. Journal of Biological Chemistry 293(11): 4110-4121.
· Wang P, Wu Y, Liu J, Song P, Li S, Zhou X, Zhu G (2018) Crystal structure of the isocitrate dehydrogenase 2 from Acinetobacter baumannii (AbIDH2) reveals a novel dimeric structure with two monomeric-IDH like subunits. International Journal of Molecular Science. 19: 1131.
· Lv P, Tang W, Wang P, Cao Z, Zhu G (2018) Enzymatic characterization and functional implication of two structurally different isocitrate dehydrogenases from Xylella fastidiosa. Biotechnology and Applied Biochemistry DOI:10.1002/bab.1560
· Wang P, Li J, Sha B (2017) Preliminary X-Ray crystallographic studies of the N-terminal domains of Hsp104 from yeast Candida albicans and Saccharomyces cerevisiae. Crystallography Reports. 62 (7): 1171-1176.
· Wang P, Li J, Weaver C, Lucius A, Sha B (2017) Crystal structures of Hsp104 N-terminal domains from Saccharomyces cerevisiae and Candida albicans suggest the mechanism for Hsp104 functions to dissolve prions. Acta Crystallographica Section D. 73, 365–372.
· Wang P, Li J, Sha B (2016) The ER stress sensor PERK luminal domain functions as a molecular chaperone to interact with misfolded proteins. Acta Crystallographica Section D. 72, 1290–1297.
· Song P, Li S, Wu Y, Lv C, Wang P*, Zhu G* (2016) Point mutation (R153H or R153C) in Escherichia coli isocitrate dehydrogenase: Biochemical characterization and functional implication. Journal of Basic Microbiology. 56: 1-9. (co-correspondence author)
· Lv C#, Wang P#, Wang W, Su R, Ge Y, Zhu Y, Zhu G (2016) Two isocitrate dehydrogenases from a plant pathogen Xanthomonas campestris pv. campestris 8004. Bioinformatic analysis, enzymatic characterization, and implication in virulence. Journal of Basic Microbiology. 56(9):975-985. (co-first author)
· Huang SP, Cheng HM, Wang P, Zhu GP (2016) Biochemical characterization and complete conversion of coenzyme specificity of isocitrate dehydrogenase from Bifidobacterium longum. International Journal of Molecular Science. 17(3): E296.
· Wang P, Lv CQ, Zhu GP (2015) Novel type II and monomeric NAD+ specific isocitrate dehydrogenases: Phylogenetic affinity, enzymatic characterization, and evolutionary implication. Scientific Reports, 5:9150.
· Wu MC, Tian CQ, Cheng HM, Xu L, Wang P*, Zhu GP* (2015). A novel type II NAD+-specific isocitrate dehydrogenase from the marine bacterium Congregibacter litoralis KT71. PLoS ONE, 10(5): e0125229 (co-correspondence author)
· Tang WG, Song P, Cao ZY, Wang P, Zhu GP (2015). A unique homodimeric NAD+-linked isocitrate dehydrogenase from the smallest autotrophic eukaryote Ostreococcus tauri. The FASEB Journal, 29(6):2462-2472.
· Song P. Wei HH, Cao ZY, Wang P*, Zhu GP* (2014) Single arginine mutation in two yeast isocitrate dehydrogenases: Biochemical characterization and functional implication. PLoS ONE, 9(12): e115025. (co-correspondence author)
· Wang P, Song P, Jin M, Zhu G (2013) Isocitrate dehydrogenase from Streptococcus mutans: Biochemical properties and evaluation of a putative phosphorylation site at Ser102. PLoS ONE 8(3): e58918.
· Wang P, Jin M, Zhu G (2012) Biochemical and molecular characterization of NAD+-dependent isocitrate dehydrogenase from the ethanologenic bacterium Zymomonas mobilis. FEMS Microbiology Letters 327: 134-141.
· Wang P, Song P, Li X, Su RR, Wang H, Zhu GP. (2012) Study on soluble expression of glutamate dehydrogenase from tea plant in Escherichia coli using fusion tags. African Journal Biotechnology 11(23): 6241-6250.
· Wang P, Jin M, Su R, Song P, Wang M, Zhu G (2011) Enzymatic characterization of isocitrate dehydrogenase from an emerging zoonotic pathogen Streptococcus suis. Biochimie 93:1470-1475.
2、专利:
· 徐蕾,文斌,王鹏,朱国萍,吕培培,曹正宇,黄士平。一种大肠杆菌DNA光修复酶及其构建方法。2017. 6,中国,ZL201510511413.0。
· 文斌,徐蕾,王鹏,朱国萍,田常青,曹正宇,黄士平。一种定点突变的大肠杆菌DNA光修复酶及其构建方法。2017. 6,中国,ZL201510511411.0。
· 朱国萍,王宝娟,李全发,姚贺帮,晏蓉,马文杰,靳明明,曹正宇,王鹏,葛亚东。一种脂肪酶高产菌株、其筛选方法及用该菌株发酵生产脂肪酶的方法。2013. 9,中国,CN201310204900.3。
· 朱国萍,徐蕾,凌烈锋,王鹏,曹正宇,宋平,吕俊,靳明明,徐雷雷,裴云云。不含基因组DNA的总RNA制备方法。2012. 10,中国,201110146840.5。