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个人简介

·2018/07-至今,安徽师范大学,生命科学学院生物制药系,讲师; ·2014/09-2018/06,南京理工大学,化学工程与技术,工学博士; ·2011/09-2014/06,中国药科大学,中药化学,理学硕士; ·2007/09-2011/06,山东农业大学,中药资源与开发系,理学学士。 ◆主要研究课题 ·安徽师范大学博士科研启动金项目,基于小胶质细胞极化研究二苯乙烯苷对大鼠脑缺血再灌注损伤的保护机制,2019/01-2021/12,10万元,在研,主持。

研究领域

基于代谢组学的中药药理机制研究

近期论文

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· Li, M.-H.#; Feng, X.#; Chen, C.; Ruan, L.-Y.; Xing, Y.-X.; Chen, L.-Y.; Zhong, G.-J.*; Wang, J.-S.*, Hepatoprotection of Herpetospermum caudigerum Wall. against CCl4-induced liver fibrosis on rats. J. Ethnopharmacol. 2019, 229, 1-14. · Ruan, L.-Y.#; Li, M.-H.#; Xing, Y.-X.; Hong, W.; Chen, C.; Chen, J.-F.; Xu, H.; Zhao, W.-L.; Wang, J.-S.*, Hepatotoxicity and hepatoprotection of Polygonum multiflorum Thund as two sides of the same biological coin. J. Ethnopharmacol. 2019, 230, 81-94. · Li, M.-H.; Ruan, L.-Y.; Chen, C.; Xing, Y.-X.; Hong, W.; Du, R.-H.; Wang, J.-S.*, Protective effects of Polygonum multiflorum on ischemic stroke rat model analysed by 1H NMR metabolic profiling. J. Pharm. Biomed. Anal. 2018, 155, 91-103. · Xing, Y.-X.#; Li, M.-H.#; Tao, L.; Ruan, L.-Y.; Hong, W.; Chen, C.; Zhao, W.-L.; Xu, H.; Chen, J.-F.; Wang, J.-S.*, Anti-Cancer Effects of Emodin on HepG2 Cells as Revealed by 1H NMR Based Metabolic Profiling. J. Proteome Res. 2018, 17 (5), 1943-1952. · Feng, X.#; Li, M.-H.#; Xia, J.; Ba, D. J. D.; Ruan, L.-Y.; Xing, Y.-X.; Chen, C.; Wang, J.-S.*; Zhong, G.-J.*, Tibetan Medical Formula Shi-Wei-Gan-Ning-Pill Protects Against Carbon Tetrachloride-Induced Liver Fibrosis–An NMR-Based Metabolic Profiling. Front. Pharmacol. 2018, 9. · Li, M.-H.#; Du, H.-Z.#; Kong, G.-J.; Liu, L.-B.; Li, X.-X.; Lin, S.-S.; Jia, A.-Q.; Yuan, S.-T.*; Sun, L.*; Wang, J.-S.*, Nuclear Magnetic Resonance-Based Metabolomics Approach to Evaluate the Prevention Effect of Camellia nitidissima Chi on Colitis-Associated Carcinogenesis. Front. Pharmacol. 2017, 8, 447. · Li, M.-H.; Ruan, L.-Y.; Zhou, J.-W.; Fu, Y.-H.; Jiang, L.; Zhao, H.; Wang, J.-S.*, Metabolic profiling of goldfish (Carassius auratis) after long-term glyphosate-based herbicide exposure. Aquat. Toxicol. 2017, (188), 159-169. · Li, M.-H.; Xu, H.-D.; Liu, Y.; Chen, T.; Jiang, L.; Fu, Y.-H.; Wang, J.-S.*, Multi-tissue metabolic responses of goldfish (Carassius auratus) exposed to glyphosate-based herbicide. Toxicol. Res. 2016, 5 (4), 1039-1052. · Li, M.-H.#; Ruan, L.-Y.#; Liu, Y.; Xu, H.-D.; Chen, T.; Fu, Y.-H.; Jiang, L.; Wang, J.-S.*, Insight into biological system responses in goldfish (Carassius auratus) to multiple doses of avermectin exposure by integrated 1H NMR-based metabolomics. Toxicol. Res. 2015, 4 (5), 1374-1388. · Li, M.; Wang, J.*; Lu, Z.; Wei, D.; Yang, M.; Kong, L.*, NMR-based metabolomics approach to study the toxicity of lambda-cyhalothrin to goldfish (Carassius auratus). Aquat. Toxicol. 2014, 146, 82-92. · Lu, Z.-G.#; Li, M.-H.#; Wang, J.-S.*; Wei, D.-D.; Liu, Q.-W.; Kong, L.-Y.*, Developmental toxicity and neurotoxicity of two matrine-type alkaloids, matrine and sophocarpine, in zebrafish (Danio rerio) embryos/larvae. Reprod. Toxicol. 2014, 47, 33-41. · Sun, Q.; Li, M.; Yang, X.; Xu, X.; Wang, J.; Zhang, J.*, Dietary salecan reverts partially the metabolic gene expressions and NMR-based metabolomic profiles from high-fat-diet-induced obese rats. J. Nutr. Biochem. 2017, 47, 53-62. · Chen, C.; Fu, Y.-H.; Li, M.-H.; Ruan, L.-Y.; Xu, H.; Chen, J.-F.; Zhao, W.-L.; Meng, H.-H.; Xing, Y.-X.; Hong, W.; Wang, J.-S.*, Nuclear magnetic resonance-based metabolomics approach to evaluate preventive and therapeutic effects of Gastrodia elata Blume on chronic atrophic gastritis. J. Pharm. Biomed. Anal. 2019, 164, 231-240. · Wei, D.-D.; Wang, J.-S.*; Li, M.-H.; Guo, P.-P.; Dong, G.; Yang, M.-H.; Kong, L.-Y.*, A pilot study of the onset of hepatic encephalopathy (OHE) in mice induced by thioacetamide and the protective effect of taurine by holistic metabolic characterization. Metabolomics 2015, 11 (3), 559-570. · Lu, Z.; Wang, J.*; Li, M.; Liu, Q.; Wei, D.; Yang, M.; Kong, L.*, 1H NMR-based metabolomics study on a goldfish model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Chem. Biol. Interact. 2014, 223, 18-26. · Chen, T.; Sheng, J.; Fu, Y.; Li, M.; Wang, J.*; Jia, A. Q.*, 1H NMR-Based Global Metabolic Studies of Pseudomonas aeruginosa upon Exposure of the Quorum Sensing Inhibitor Resveratrol. J. Proteome Res. 2017, 16 (2), 824-830. · Wei, D. D.; Wang, J. S.*; Wang, P. R.; Li, M. H.; Yang, M. H.; Kong, L. Y.*, Toxic effects of chronic low-dose exposure of thioacetamide on rats based on NMR metabolic profiling. J. Pharm. Biomed. Anal. 2014, 98, 334-8. · Sun, Q.; Zhao, Y.; Yang, Y.; Yang, X.; Li, M.; Xu, X.; Wen, D.; Wang, J.; Zhang, J.*, Loss of the clock protein PER2 shortens the erythrocyte life span in mice. J. Biol. Chem. 2017, 292 (30), 12679-12690. · Zhou, J.; Bi, S.; Chen, H.; Chen, T.; Yang, R.; Li, M.; Fu, Y.; Jia, A. Q.*, Anti-Biofilm and Antivirulence Activities of Metabolites from Plectosphaerella cucumerina against Pseudomonas aeruginosa. Front. Microbiol. 2017, 8, 769.

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