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个人简介

1985年7月在安徽医科大学获医学学士学位,1987年7月在安徽师范大学获文学学士学位。毕业后在安徽医科大学及安徽省医学遗传中心工作。1998年6月赴澳大利亚做访问学者,2004年4月在墨尔本大学获哲学博士学位。在澳先后从事博士后、研究官员及研究员工作。现为安徽师范大学特聘教授。◆主要研究课题 ·国家自然科学基金重大研究计划项目、血管组织DC的区域免疫特性及抑炎机制、91742101、国家基金委、主持。 ·安徽省对外科学技术合作项目、炎症条件下树突状细胞发育和功能的分子机制研究、1604b0602017、安徽省科技厅、主持。 ·安徽省自然基金面上项目、胱抑素C调控在血管内膜损伤机制中的研究、1608085MH160、安徽省自然科学基金委员会、主持。 ·澳大利亚国立卫生医学研究委员会项目基金、RegulationofCardiovascularDisease-AssociatedProteaseInhibitorCystatinCforTherapeuticApplication、1006428、主持。 ·澳大利亚国立卫生医学研究委员会PeterDoherty基金、ImprovingAnti-TumorTherapybyGeneticallyModifyingCD4+Tcells、400426、主持。 ·美国SusanKomen基金、GeneticModificationofMultipleImmuneSystemCellsforBreastCancerTherapy、PDF39606、主持。

研究领域

免疫细胞的信号传导,炎性树突状细胞的发育和功能,免疫生化

近期论文

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·SunL,RautelaJ,DelconteRB,Souza-Fonseca-GuimaraesF,CarringtonEM,SchenkRL,HeroldMJ,HuntingtonND,LewAM,XuY*,ZhanY.GM-CSFQuantityHasaSelectiveEffectonGranulocyticvs.MonocyticMyeloidDevelopmentandFunction.FrontImmunol.2018Aug28;9:1922.doi:10.3389/fimmu.2018.01922.eCollection2018. ·W.Zhang,YDing,L.Sun,Q.Hong,Y.Sun,L.Han,M.Zi,Y.Xu*,Bonemarrow-derivedinflammatoryandsteadystateDCsaredifferentinbothfunctionsandsurvival.CellImmunol,331,100-109(2018). ·S.Chen,X.Li,W.Zhang,M.Zi,Y.Xu*,InflammatorycompoundlipopolysaccharidepromotesthesurvivalofGM-CSFcultureddendriticcellviaPI3kinase-dependentupregulationofBcl-x.ImmunolCellBiol,doi:10.1111/imcb.12051.[Epubaheadofprint](2018). ·ZiM,Xu,Y*.InvolvementofcystatinCinimmunityandapoptosis.ImmunolLett.196:80-90,2018 ·XLi,YDing,MZi,LSun,WZhang,SChen,YXu*:CD19,frombenchtobedside.ImmunolLett,183:86-95.2017 ·Xu,Y*,Ding,Y.,Li,X.,andWu,X.CystatinCisadisease-associatedproteinsubjecttomultipleregulation.ImmunolCellBiol.93(5):442-51.2015 ·XuY*,LindemannP,Vega-RamosJ,ZhangJG,VilladangosJA.DevelopmentalRegulationofSynthesisandDimerizationoftheAmyloidogenicProteaseinhibitorCystatinCintheHematopoieticSystem.JBiolChem.289(14):9730-40.2014. ·XuY*,FairfaxK,LightA,HuntingtonND,TarlintonDM.CD19DifferentiallyRegulatesBCRSignallingthroughtheRecruitmentofPI3K.Autoimmunity.2014Jun23:1-8.[Epubaheadofprint]. ·XuW,PanH,XuY*,andYeD.InterferonRegulatoryFactor5andAutoimmuneLupus.ExpertRevMolMed.10.1017/erm2013.7.2013.(*seniorauthor) ·LiB,YeQ,XuW,LiJ,YeDandXuY*.GM-CSFaltersdendriticcellsinautoimmunediseases.Autoimmunity.46:409.2013. ·ZhanY,Vega-RamosJ,CarringtonEM,VilladangosJA,LewAMandXuY*.Theinflammatorycytokine,GM-CSF,altersthedevelopmentaloutcomeofmurinedendriticcells.EurJImmunol.42:2889.2012. ·XuWD.PanHF,YeDQ,andXuY*.TargetingIRF4inautoimmunediseases.Autoimmun.Rev.11:918.2012. ·XuY,HuntingtonND,HarderK,NandurkarH,HibbsMLandTarlinton.Phosphatidylinositol-3kinaseactivityinBcellsisnegativelyregulatedbyLyntyrosinekinase.ImmunolCellBiol.90:903.2012 ·XuY*,SchnorrerP,ProiettoA,KowalskiG,FebbraioMA,Acha-OrbeaH,DickinsRAandVilladangosJA.Interleukin-10ControlsCystatinCSynthesisandBloodConcentrationinResponsetoInflammationthroughRegulationofIRF-8Expression.J.Immunol.186:3666(2011). ·XuY*,ZhanY,LewAM,NaikSHandKershawMH.DifferentialdevelopmentofmurinedendriticcellsbyGM-CSFversusFlt3ligandhasimplicationsforinflammationandtrafficking.J.Immunol179(11):7577-84(2007). ·HuntingtonND,XuY,PuthalakathH,LightA,WillisSN,StrasserA,TarlintonDM.CD45linkstheBcellreceptorwithcellsurvivalandisrequiredforthepersistenceofgerminalcenters.Nat.Immunol.7(2):190-8.(2006). ·XuY,HarderKW,HuntingtonND,HibbsML,andTarlintonDM.Lyntyrosinekinase:accentuatingthepositiveandthenegative.Immunity.22:9-18(2005). ·HuntingtonND,XuY,NuttS,TarlintonDM.ArequirementforCD45distinguishesLy49D-mediatedcytokineandchemokineproductionfromkillinginprimaryNKcells.J.Exp.Med.201:1421-33(2005). ·XuY,DaviesJ,RamslandP,HolmdahlR,KumarN,ScealyM,RowleyM.TwomonoclonalantibodiestopreciselythesameepitopeoftypeIIcollagenselectnon-crossreactivephageclonesbyphagedisplay:implicationsforautoimmunityandmolecularmimicry.Mol.Immunol.41:411-9(2004). ·XuY,BeavittSJ,HarderKW,HibbsML,TarlintonDM.TheactivationandsubsequentregulatoryrolesofLynandCD19afterBcellreceptorligationareindependent.J.Immunol.169:6910-8(2002).

学术兼职

·澳亚免疫协会会员 ·安徽省细胞生物学学会常务理事 ·安徽省免疫学会理事

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