个人简介
1971年毕业于台湾新竹清华大学,1975年在美国纽约州立大学石溪分校化学系获得博士学位。1975-1979年分别在美国纽约州立大学石溪分校和美国纽约大学化学系从事博士后研究。1979年回国,在中国科学院化学研究所工作。现为清华大学化学系教授,任清华大学生命科学与工程研究院副院长和清华大学生命有机磷化学教育部重点实验室主任。
研究领域
生命有机磷化学、生物有机化学、有机合成化学,生命起源
近期论文
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Xin Chen, Nan-Jiang Zhang and Yu-Fen Zhao, Bioorganic Chemistry, 1997, 25, 23-31, “Reaction Kinetics of Oxyphosphoranes with Model Compounds of Nucleosides”
Yan-Mei Li, Ming Wei, Yu-Fen Zhao, Jian-Yuan Yu, Qun Zhou, Spectroscopy Letters, 1999, 32(2), 197-203, “Investigations on the Effects of cAMP on Membrane Phospholipid of Human Erythrocytes by Laser Raman Spectroscopy”
Yu-Fen Zhao, Yong Ju, Yan-Mei Li Qian Wang, Yin-Wu Yin, Bo Tan, Int. J. Of Peptide and Protein Res., 1995, 1-5, 514-518, “Self-Activation of N-Phosphoamino Acids and N-Phosphodipeptides in Oligopeptide Formation”
Yu-Fen Zhao, Qing-Jin Yan, Qian Wang, Int. J. Of Peptide and Protein Res., 1996, 46, 276-281. “Phosphoryl Transfer Reaction Regulated by Amino Acid Side Chains: A Model for Phosphorproteins”
Yong-Fang Li, Yao-Wu Sha, Yuan Ma, Yu-Fen Zhao, Biochemical Biophysical Research Communication, 1995, 213(3), 875-880, “Cleavage of DNA by N-Phosphoryl Histidine”
Yu-Fen Zhao and Pei-Sheng Cao, J. Chela-Flores and F. Raulin (eds.), Chemical Evolution: Physics of the Origin and Life, 1996, 279-285, Kluwer Academic Publishers, Printed in the Netherland, “Basic Models of Chemical Evolution of Life: The Minimum Evolving System”
Wei-Hua Zhou, Yong Ju, Yu-Fen Zhao, Qing-Gang Wang and Guo-an Luo, Origins of Life and Evolution of the Biosphere, 1996, 26, 547-560, “Simultaneous Fomation of Peptides and Nucleotides from N-Phosphothreonine”
Hua Fu, Zhao-Long Li, Yu-Fen Zhao, Guang-Zhong Tu, J. Am. Chem. Soc., 1999, 121, 291-295, “Oligomerization of N,O-Bis(trimethylsilyl)-a-amino Acids into Peptides Mediated by o-Phenylene Phosphorochloridate”
Nan-Jing Zhang, Hai-Yan Lu, Xin Chen, Yu-Fen Zhao, Synthesis, 1998, 376-378, “A Facile Synthesis of Acylaminotetraoxyspirophosphoranes”
Hua Fu, Guang-Zhong Tu, Zhao-Long Li, Yu-Fen Zhao, Synthesis, 1998, 855-858, “Synthesis of 2-Phenoxy-2,75-spirol[1,3,2-benzodioxaphosphole-2,2’-1,3,2-oxazophospholan]-5’-ones”