张新荣 - 清华大学

个人简介

教育经历 1956年7月生于陕西省西安市 1978-1982 年就读于陕西师大化学系（学士） 1982-1985 年就读于陕西师大化学系（硕士） 1993-1997 年就读于比利时根特大学（博士）工作经历 1985-1993年陕西师范大学化学系（任教） 1998- 至今任清华大学化学系教授、博士生导师学术兼职 2013-至今 Analytical Chemistry（ACS）执行主编 2008-至今 Talanta（Elsevier）编委 2008-2013年 Analyst（RSC）副主编 2006-2022年 Luminescence （Wiley）主编中国分析测试协会副理事长北京质谱学会理事长英国皇家化学会会士荣誉与获奖 2014年教育部自然科学一等奖排名1 2010年国家科技进步二等奖排名2 2009年中国化学会分析化学基础研究梁树权奖 2008年教育部自然科学二等奖排名1 2008年北京市教学名师 2001年宝钢教育基金会优秀教师奖

研究领域

1. 单细胞质谱分析虽然荧光显微成像技术适于研究单细胞，但难以进行“组学”分析，因此，单细胞分析，特别是基于质谱的单细胞分析，可能会成为未来一段时间分析化学研究的一个颇具挑战性的课题。我们课题组最近在单细胞质谱分析研究方面开展了一些初步探索，发展了固相微萃取-针尖电喷雾检测单细胞中多种代谢组分的方法，还发展了脉冲-直流电喷雾单细胞代谢组学分析方法，用于单细胞代谢组分析。 2. 荧光探针与细胞分析本课题组对花菁类近红外染料进行了研究，设计合成的NTR 类荧光分子在烟酰胺腺嘌呤二核苷酸存在下，对硝基还原酶具有“开/关”类型的荧光响应，在近红外区域荧光发射强度产生较大的增强；而基于半花菁-萘酚杂化的活性氧类荧光分子，以苯硼酸频哪醇酯为识别基团，对于过氧化氢具有良好的比率型荧光响应。对细胞器的定位分析进行了初步的探索, CyMito 荧光分子能够定向聚集线粒体，CyLyo 荧光分子能够定向聚集溶酶体，实现了细胞器的选择性定位成像。 3. 金属探针与DNA分析金属元素的稳定同位素作为探针结合ICP-MS检测能够实现多组分生物分子的同时分析，还能够进行精准定量研究。基于这一设想，我们设计了系列稀土同位素探针，并对样品中15种DNA进行同时分析，由于我们所设计的探针具有同位素稀释功能，因此，不仅能够实现多种DNA的同时分析，亦可进行DNA的定量研究，为重要生物分子的准确定量提供了一个新的思路。

近期论文

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Shen, Z., Zhao, H., Yao, H., Pan, X., Yang, J., Zhang, S., Han, G., Zhang, X. Dynamic metabolic change of cancer cells induced by natural killer cells at the single-cell level studied by label-free mass cytometry. Chem. Sci. doi:10.1039/d1sc06366a (2022). Wu, T., Ma, M., Sun, G., Zhang, S., Zhang, X. The simultaneous quantitative detection of multiple hormones based on PS-MS: affinity capture by a single antibody. Analyst. doi:10.1039/d2an00029f (2022). Ma, M., Wu, T., Sun, G., Zhang, S. Determination of testosterone in serum by magnetic molecularly imprinted polymer-coupled nano-ESI-MS. Anal. Biochem. doi:10.1016/j.ab.2022.114719 (2022). Liu, J., Mao, J., Hou, M., Hu, Z., Sun, G., Zhang, S. A rapid SARS-CoV-2 nucleocapsid protein profiling assay with high sensitivity comparable to nucleic acid detection. Anal. Chem. doi:10.1021/acs.analchem.2c02670 (2022). Shen, Z., Yao, H., Yang, J., Pan, X., Zhao, H., Han, G., Zhang, S., Zhang, X. The heterogeneity of oxidized lipids in individual tumor cells reveals NK cell-mediated cytotoxicity by label-free mass cytometry. Analyst. doi:10.1039/d2an01416e (2022). Pan, X., Yao, H., Zhang, S., Zhang, X. Recent progress in mass spectrometry for single-cell metabolomics. Curr. Opin. Chem. Biol. doi:10.1016/j.cbpa.2022.102226 (2022). Yan, Z., Xue, J., Zhou, M., Wang, J., Zhang, Y., Wang, Y., Qiao, J., He, Y., Li, P., Zhang, S., Zhang, X. Dynamic monitoring of phase-separated biomolecular condensates by photoluminescence lifetime imaging. Anal. Chem. doi:10.1021/acs.analchem.0c05011 (2021). Yang, Y., Li, R., Zhang, S., Zhang, X. A fluorescent nanoprobe based on cell-penetrating peptides and quantum dots for ratiometric monitoring of pH fluctuation in lysosomes. Talanta. doi:10.1016/j.talanta.2021.122208 (2021). Feng, J., Zhao, H., Gong, X., Xia, M., Cai, L., Yao, H., Zhao, X., Yan, Z., Li, Z., Nie, H., Ma, X., Zhang, S. In situ identification and spatial mapping of microplastic standards in paramecia by secondary-Ion mass spectrometry imaging. Anal. Chem. doi:10.1021/acs.analchem.0c05383 (2021). Zhao, H., Ge, F., Zhang, Y., Huang, Z., Shi, X., Xiong, B., Liao, X., Zhang, S., He, Y. Uncover single nanoparticle dynamics on live cell membrane with data-driven historical experience analysis. Anal. Chem. doi:10.1021/acs.analchem.1c01666 (2021). Liu, G., Yang, H., Zhao, H., Zhang, Y., Zhang, S., Zhang, X., Jin, G. Combination of structured illumination microscopy with hyperspectral imaging for cell analysis. Anal. Chem. doi:10.1021/acs.analchem.1c00660 (2021). Yao, H., Zhao, H., Pan, X., Zhao, X., Feng, J., Yang, C., Zhang, S., Zhang, X. Discriminating leukemia cellular heterogeneity and screening metabolite biomarker candidates using label-free mass cytometry. Anal. Chem. doi:10.1021/acs.analchem.1c01746 (2021). Hu, Z., Yang, J., Xu, F., Sun, G., Pan, X., Xia, M., Zhang, S., Zhang, X. Site-specific scissors based on myeloperoxidase for phosphorothioate DNA. J. Am. Chem. Soc. doi:10.1021/jacs.1c06370 (2021). Wu, T., Sun, G., Ma, M., Pan, X., Zhang, S., Zhang, X. Rapid quantitative analysis of hormones in serum by multilayer paper spray MS: Free MS from HPLC. Talanta doi:10.1016/j.talanta.2021.122900 (2021). Yuan, Z., Zhou, Q., Cai, L., Pan, L., Sun, W., Qumu, S., Yu, S., Feng, J., Zhao, H., Zheng, Y., Shi, M., Li, S., Chen, Y., Zhang, X., Zhang, M Q. SEAM is a spatial single nuclear metabolomics method for dissecting tissue microenvironment. Nat. Methods doi:10.1038/s41592-021-01276-3 (2021). Ma, M., Wu, T., Hu, Z., Sun, G., Zhang, S. Fe3O4@UiO-66 as solid-phase extraction sorbent coupled with Nano-ESI-MS for the analysis of androgens in serum. Microchem. J. doi:10.1016/j.microc.2021.106916 (2021). Zhao, H., Zhang, S., Ma, Q., Zhang, X., Ma, X. Rapid disulfide mapping in peptides and proteins by meta-chloroperoxybenzoic acid (mCPBA) oxidation and tandem mass spectrometry. Anal. Chem. doi:10.1021/acs.analchem.1c02379 (2021). Yang, Y., Xia, M., Zhang, S., Zhang, X. Cell-penetrating peptide-modified quantum dots as a ratiometric nanobiosensor for the simultaneous sensing and imaging of lysosomes and extracellular pH. Chem. Commun. doi:10.1039/c9cc07596h (2020). Zhu, X., He, Q., Xu, F., Ma, X., Xing, Z., Zhang, S., Zhang, X. The screening of intermediates in a ruthenium and iridium ion-catalyzed gas-phase reaction of ethanol converting to butanol by ICP-MS/MS. J. Anal. Atom. Spectrom. doi:10.1039/d0ja00021c (2020). Hu, Z., Xu, F., Sun, G., Zhang, S., Zhang, X. Homogeneous multiplexed digital detection of microRNA with ligation-rolling circle amplification. Chem. Commun. doi:10.1039/d0cc01530j (2020). Zhu, X., Xu, F., Xing, Z., Zhang, S., Zhang, X. Intermediates detection in the conversion of ethanol to butanol catalyzed by zirconium, cerium, titanium monoxide cations by inductively coupled plasma tandem mass spectrometry. Microchem. J. doi:10.1016/j.microc.2020.104926 (2020). Qiao, H., Bai, J., Zhu, M., Gao, J., Anna, Zhang, S., Li, C. Rhodium (II)-Catalyzed Synthesis of Tetracyclic 3,4-Fused Indoles and Dihydroindoles. Catalysts doi:10.3390/catal10080920 (2020). Qiao, H., Bai, J., Zhang, S., Li, C. A guanosine-based 2-formylphenylborate ester hydrogel with high selectivity to K(+)ions RSC Adv. doi:10.1039/d0ra05254j (2020). Wu, T., Lu, Y., Liu, J., Zhang, S., Zhang, X. In situ monitoring of catalytic reaction on single nanoporous gold nanowire with tuneable SERS and catalytic activity. Talanta doi:10.1016/j.talanta.2020.121181 (2020). Song, Z., Wang, Z., Zhao, H., Cai, L., Li, Z., Zhang, S., Zhang, X. Metabolic fingerprinting of cell types in mouse skeletal muscle by combining TOF-SIMS with immunofluorescence staining. Analyst doi:10.1039/d0an00738b (2020). Zhang, Y., Sun, G., Hu, Z., Xing, Z., Zhang, S., Zhang, X. A multiplex bacterial assay using an element-labeled strategy for 16S rRNA detection. Analyst doi:10.1039/d0an01272f (2020). Zhao, H., Ge, F., Zhang, S., Zhang, X., He, Y. Reveal heterogeneous motion states in single nanoparticle trajectory using its own history. Sci. China Chem. doi:10.1007/s11426-020-9896-8 (2020). Zhu, X., Xu, F., He, Q., Xing, Z., Zhang, S., Zhang, X. Detection of intermediates for diatomic [TaO](+) catalyzed gas-phase reaction of methane coupling to ethane and ethylene by ICP-MS/MS. Microchem. J. doi:10.1016/j.microc.2020.105762 (2020). Yao, H.,Zhao, H., Zhao, X., Pan, X., Feng, J., Xu, F., Zhang, S., Zhang, X. Label-free Mass Cytometry for Unveiling Cellular Metabolic Heterogeneity. Anal. Chem. doi:10.1021/acs.analchem.9b01419 (2019). Zhao, X.,Chen, J., Zhang, W., Yang, C., Ma, X., Zhang, S., Zhang, X. Lipid Alterations during Zebrafish Embryogenesis Revealed by Dynamic Mass Spectrometry Profiling with C=C Specificity. J. Am. Soc. Mass Spectrom doi:10.1007/s13361-019-02334-z (2019). Xia, M., Cai, L., Yang, Y., Zhang, S., Zhang, X. Tuning the pK(a) of Carboxyfluorescein with Arginine-Rich Cell-Penetrating Peptides for Intracellular pH Imaging. Anal. Chem. doi:10.1021/acs.analchem.9b01864 (2019). Feng, J., Zhang, X., Huang, L., Yao, H., Yang, C., Ma, X., Zhang, S., Zhang, X. Quantitation of Glucose-phosphate in Single Cells by Microwell-Based Nanoliter Droplet Microextraction and Mass Spectrometry. Anal. Chem. doi:10.1021/acs.analchem.8b05226 (2019). Hu, Z., Sun, G., Jiang, W., Xu, F., Zhang, Y., Xia, M., Pan, X., Xing, Z., Zhang, S., Zhang, X. Chemical-Modified Nucleotide-Based Elemental Tags for High-Sensitive Immunoassay. Anal. Chem. doi:10.1021/acs.analchem.9b00405 (2019). Sun, J., Hu, Z., Wang, R., Zhang, S., Zhang, X. A Highly Sensitive Chemiluminescent Probe for Detecting Nitroreductase and Imaging in Living Animals. Anal. Chem. doi:10.1021/acs.analchem.8b03955 (2019). Sun, J., Hu, Z., Zhang, S., Zhang, X. A Novel Chemiluminescent Probe Based on 1,2-Dioxetane Scaffold for Imaging Cysteine in Living Mice. ACS Sensors doi:10.1021/acssensors.8b00936 (2019). Zhang, L., Zhao, X., Zhao, Y., Xu, F., Kong, J., Hu, Z., Ma, M., Zhang, S., Zhang, X. Rapid analysis of chemical warfare agents by metal needle-enhanced low-temperature plasma mass spectrometry. Anal. Methods doi:10.1039/c9ay00886a (2019). Shen, L., Wang, H., Liu, S., Bai, Z., Zhang, S., Zhang, X., Zhang, C. Assembling of Sulfur Quantum Dots in Fission of Sublimed Sulfur. J. Am. Chem. Soc. doi:10.1021/jacs.8b02792 (2018). Zhao, H., Zhou, Q., Xia, M., Feng, J., Chen, Y., Zhang, S., Zhang, X. Characterize Collective Lysosome Heterogeneous Dynamics in Live Cell with a Space- and Time-Resolved Method. Anal. Chem. doi:10.1021/acs.analchem.8b01563 (2018). Yan, Z., Wang, J., Zhang, Y., Zhang, S., Qiao, J., Zhang, X. An iridium complex-based probe for photoluminescence lifetime imaging of human carboxylesterase 2 in living cells. Chem. Commun. doi:10.1039/C8CC04481C (2018). Zhao, X., Zhao, Y., Zhang, L., Ma, X., Zhang, S., Zhang, X. Rapid Analysis of Unsaturated Fatty Acids on Paper-Based Analytical Devices via Online Epoxidation and Ambient Mass Spectrometry. Anal. Chem. doi:10.1021/acs.analchem.7b04312 (2018). Zhang, Y., Sun, G., Zhang, Y., Huang, B., Xing, Z., Zhang, S., Zhang, X. Simultaneous competitive and sandwich formats multiplexed immunoassays based on ICP-MS detection. Talanta doi:10.1016/j.talanta.2018.03.032 (2018). Zhang, X., Zang, Q., Zhao, H., Ma, X., Pan, X., Feng, J., Zhang, S., Zhang, R., Abliz, Z., Zhang, X., Combination of Droplet Extraction and Pico-ESI-MS Allows the Identification of Metabolites from Single Cancer Cells. Anal. Chem. doi:10.1021/acs.analchem.8b02098 (2018). Wang, J., Wang, Z., Liu, F., Cai, L., Pan, J., Li, Z., Zhang, S., Chen, H., Zhang, X., Mo, Y. Vacuum Ultraviolet Laser Desorption/Ionization Mass Spectrometry Imaging of Single Cells with Submicron Craters. Anal. Chem. doi:10.1021/acs.analchem.8b02478 (2018). Wang, J., Wang, Z., Liu, F.; Mo, Y., Cai, L., Sun, C., Zhang, S., Zhang, R., Abliz, Z., Zhang, X. Mass spectrometry imaging of intact cholesterol in a mouse esophagus tissue section and mouse zygotes using VUV laser desorption/ionization method. Int. J. Mass. Spectrom. doi:10.1016/j.ijms.2018.06.008 (2018). Wei, Z., Zhang, X., Wang, J., Zhang, S., Zhang, X., Cooks, G. High yield accelerated reactions in nonvolatile microthin films: chemical derivatization for analysis of single-cell intracellular fluid. Chemical Science doi:10.1039/C8SC03382J (2018). Xia, M., Cai, L., Zhang, S., Zhang, X. A cell-penetrating ratiometric probe for simultaneous measurement of lysosomal and cytosolic pH change. Talanta doi:10.1016/j.talanta.2017.09.044 (2018). Yang, Y., Xia, M., Zhao, H., Zhang, S., Zhang, X. A Cell-Surface-Specific Ratiometric Fluorescent Probe for Extracellular pH Sensing with Solid-State Fluorophore. ACS Sensors doi:10.1021/acssensors.8b00514(2018). Zhang, L., Zhao, X., Cheng, H., Kong, J., Zhao, Y., Zhu, X., Zhang, S., Zhang, X. Gold nanoparticles-enhanced ion-transmission mass spectrometry for highly sensitive detection of chemical warfare agent simulants. Talanta doi:10.1016/j.talanta.2018.08.021(2018). He, Q., Wu, J., Zhang, S., Fang, X., Xing, Z., Wei, C., Zhang, X. Rapid screening of gaseous catalysts in methane activation using ICP-QQQ-MS. J. Anal. Atom. Spectrom. doi:10.1039/C7JA00345E (2018).