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个人简介

教育背景 1986-1990 年 陕西师范大学化学系 (学士) 1993-1996 年 陕西师范大学化学系 (硕士) 1997-2000 年 西北大学分析科学研究所(博士) 工作履历 2000-2002 年 南京大学化学化工学院,博士后 2002-2004 年 清华大学化学系,博士后 2004-2011 年 清华大学化学系,高级工程师 2011-2014年 清华大学化学系,副教授 2015-至今 清华大学化学系,教授

研究领域

主要从事光谱/质谱分析的方法、仪器和应用研究。近年来的研究工作聚焦于单细胞代谢物质谱分析。

近期论文

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2022年 Shen, Z., Zhao, H., Yao, H., Pan, X., Yang, J., Zhang, S., Han, G., Zhang, X. Dynamic metabolic change of cancer cells induced by natural killer cells at the single-cell level studied by label-free mass cytometry. Chem. Sci. doi:10.1039/d1sc06366a (2022). Full Text Wu, T., Ma, M., Sun, G., Zhang, S., Zhang, X. The simultaneous quantitative detection of multiple hormones based on PS-MS: affinity capture by a single antibody. Analyst. doi:10.1039/d2an00029f (2022). Full Text Ma, M., Wu, T., Sun, G., Zhang, S. Determination of testosterone in serum by magnetic molecularly imprinted polymer-coupled nano-ESI-MS. Anal. Biochem. doi:10.1016/j.ab.2022.114719 (2022). Full Text Liu, J., Mao, J., Hou, M., Hu, Z., Sun, G., Zhang, S. A rapid SARS-CoV-2 nucleocapsid protein profiling assay with high sensitivity comparable to nucleic acid detection. Anal. Chem. doi:10.1021/acs.analchem.2c02670 (2022). Full Text Shen, Z., Yao, H., Yang, J., Pan, X., Zhao, H., Han, G., Zhang, S., Zhang, X. The heterogeneity of oxidized lipids in individual tumor cells reveals NK cell-mediated cytotoxicity by label-free mass cytometry. Analyst. doi:10.1039/d2an01416e (2022). Full Text Pan, X., Yao, H., Zhang, S., Zhang, X. Recent progress in mass spectrometry for single-cell metabolomics. Curr. Opin. Chem. Biol. doi:10.1016/j.cbpa.2022.102226 (2022). Full Text 2021年 Yan, Z., Xue, J., Zhou, M., Wang, J., Zhang, Y., Wang, Y., Qiao, J., He, Y., Li, P., Zhang, S., Zhang, X. Dynamic monitoring of phase-separated biomolecular condensates by photoluminescence lifetime imaging. Anal. Chem. doi:10.1021/acs.analchem.0c05011 (2021). Full Text Yang, Y., Li, R., Zhang, S., Zhang, X. A fluorescent nanoprobe based on cell-penetrating peptides and quantum dots for ratiometric monitoring of pH fluctuation in lysosomes. Talanta. doi:10.1016/j.talanta.2021.122208 (2021). Full Text Feng, J., Zhao, H., Gong, X., Xia, M., Cai, L., Yao, H., Zhao, X., Yan, Z., Li, Z., Nie, H., Ma, X., Zhang, S. In situ identification and spatial mapping of microplastic standards in paramecia by secondary-Ion mass spectrometry imaging. Anal. Chem. doi:10.1021/acs.analchem.0c05383 (2021). Full Text Zhao, H., Ge, F., Zhang, Y., Huang, Z., Shi, X., Xiong, B., Liao, X., Zhang, S., He, Y. Uncover single nanoparticle dynamics on live cell membrane with data-driven historical experience analysis. Anal. Chem. doi:10.1021/acs.analchem.1c01666 (2021). Full Text Liu, G., Yang, H., Zhao, H., Zhang, Y., Zhang, S., Zhang, X., Jin, G. Combination of structured illumination microscopy with hyperspectral imaging for cell analysis. Anal. Chem. doi:10.1021/acs.analchem.1c00660 (2021). Full Text Yao, H., Zhao, H., Pan, X., Zhao, X., Feng, J., Yang, C., Zhang, S., Zhang, X. Discriminating leukemia cellular heterogeneity and screening metabolite biomarker candidates using label-free mass cytometry. Anal. Chem. doi:10.1021/acs.analchem.1c01746 (2021). Full Text Hu, Z., Yang, J., Xu, F., Sun, G., Pan, X., Xia, M., Zhang, S., Zhang, X. Site-specific scissors based on myeloperoxidase for phosphorothioate DNA. J. Am. Chem. Soc. doi:10.1021/jacs.1c06370 (2021). Full Text Wu, T., Sun, G., Ma, M., Pan, X., Zhang, S., Zhang, X. Rapid quantitative analysis of hormones in serum by multilayer paper spray MS: Free MS from HPLC. Talanta doi:10.1016/j.talanta.2021.122900 (2021). Full Text Yuan, Z., Zhou, Q., Cai, L., Pan, L., Sun, W., Qumu, S., Yu, S., Feng, J., Zhao, H., Zheng, Y., Shi, M., Li, S., Chen, Y., Zhang, X., Zhang, M Q. SEAM is a spatial single nuclear metabolomics method for dissecting tissue microenvironment. Nat. Methods doi:10.1038/s41592-021-01276-3 (2021). Full Text Ma, M., Wu, T., Hu, Z., Sun, G., Zhang, S. Fe3O4@UiO-66 as solid-phase extraction sorbent coupled with Nano-ESI-MS for the analysis of androgens in serum. Microchem. J. doi:10.1016/j.microc.2021.106916 (2021). Full Text Zhao, H., Zhang, S., Ma, Q., Zhang, X., Ma, X. Rapid disulfide mapping in peptides and proteins by meta-chloroperoxybenzoic acid (mCPBA) oxidation and tandem mass spectrometry. Anal. Chem. doi:10.1021/acs.analchem.1c02379 (2021). Full Text 2020年 Yang, Y., Xia, M., Zhang, S., Zhang, X. Cell-penetrating peptide-modified quantum dots as a ratiometric nanobiosensor for the simultaneous sensing and imaging of lysosomes and extracellular pH. Chem. Commun. doi:10.1039/c9cc07596h (2020). Full Text Zhu, X., He, Q., Xu, F., Ma, X., Xing, Z., Zhang, S., Zhang, X. The screening of intermediates in a ruthenium and iridium ion-catalyzed gas-phase reaction of ethanol converting to butanol by ICP-MS/MS. J. Anal. Atom. Spectrom. doi:10.1039/d0ja00021c (2020). Full Text Hu, Z., Xu, F., Sun, G., Zhang, S., Zhang, X. Homogeneous multiplexed digital detection of microRNA with ligation-rolling circle amplification. Chem. Commun. doi:10.1039/d0cc01530j (2020). Full Text Zhu, X., Xu, F., Xing, Z., Zhang, S., Zhang, X. Intermediates detection in the conversion of ethanol to butanol catalyzed by zirconium, cerium, titanium monoxide cations by inductively coupled plasma tandem mass spectrometry. Microchem. J. doi:10.1016/j.microc.2020.104926 (2020). Full Text Qiao, H., Bai, J., Zhu, M., Gao, J., Anna, Zhang, S., Li, C. Rhodium (II)-Catalyzed Synthesis of Tetracyclic 3,4-Fused Indoles and Dihydroindoles. Catalysts doi:10.3390/catal10080920 (2020). Full Text Qiao, H., Bai, J., Zhang, S., Li, C. A guanosine-based 2-formylphenylborate ester hydrogel with high selectivity to K(+)ions RSC Adv. doi:10.1039/d0ra05254j (2020). Full Text Wu, T., Lu, Y., Liu, J., Zhang, S., Zhang, X. In situ monitoring of catalytic reaction on single nanoporous gold nanowire with tuneable SERS and catalytic activity. Talanta doi:10.1016/j.talanta.2020.121181 (2020). Full Text Song, Z., Wang, Z., Zhao, H., Cai, L., Li, Z., Zhang, S., Zhang, X. Metabolic fingerprinting of cell types in mouse skeletal muscle by combining TOF-SIMS with immunofluorescence staining. Analyst doi:10.1039/d0an00738b (2020). Full Text Zhang, Y., Sun, G., Hu, Z., Xing, Z., Zhang, S., Zhang, X. A multiplex bacterial assay using an element-labeled strategy for 16S rRNA detection. Analyst doi:10.1039/d0an01272f (2020). Full Text Zhao, H., Ge, F., Zhang, S., Zhang, X., He, Y. Reveal heterogeneous motion states in single nanoparticle trajectory using its own history. Sci. China Chem. doi:10.1007/s11426-020-9896-8 (2020). Full Text Zhu, X., Xu, F., He, Q., Xing, Z., Zhang, S., Zhang, X. Detection of intermediates for diatomic [TaO](+) catalyzed gas-phase reaction of methane coupling to ethane and ethylene by ICP-MS/MS. Microchem. J. doi:10.1016/j.microc.2020.105762 (2020). Full Text 2019年 Yao, H.,Zhao, H., Zhao, X., Pan, X., Feng, J., Xu, F., Zhang, S., Zhang, X. Label-free Mass Cytometry for Unveiling Cellular Metabolic Heterogeneity. Anal. Chem. doi:10.1021/acs.analchem.9b01419 (2019). Full Text Zhao, X.,Chen, J., Zhang, W., Yang, C., Ma, X., Zhang, S., Zhang, X. Lipid Alterations during Zebrafish Embryogenesis Revealed by Dynamic Mass Spectrometry Profiling with C=C Specificity. J. Am. Soc. Mass Spectrom doi:10.1007/s13361-019-02334-z (2019). Full Text Xia, M., Cai, L., Yang, Y., Zhang, S., Zhang, X. Tuning the pK(a) of Carboxyfluorescein with Arginine-Rich Cell-Penetrating Peptides for Intracellular pH Imaging. Anal. Chem. doi:10.1021/acs.analchem.9b01864 (2019). Full Text Feng, J., Zhang, X., Huang, L., Yao, H., Yang, C., Ma, X., Zhang, S., Zhang, X. Quantitation of Glucose-phosphate in Single Cells by Microwell-Based Nanoliter Droplet Microextraction and Mass Spectrometry. Anal. Chem. doi:10.1021/acs.analchem.8b05226 (2019). Full Text Hu, Z., Sun, G., Jiang, W., Xu, F., Zhang, Y., Xia, M., Pan, X., Xing, Z., Zhang, S., Zhang, X. Chemical-Modified Nucleotide-Based Elemental Tags for High-Sensitive Immunoassay. Anal. Chem. doi:10.1021/acs.analchem.9b00405 (2019). Full Text Sun, J., Hu, Z., Wang, R., Zhang, S., Zhang, X. A Highly Sensitive Chemiluminescent Probe for Detecting Nitroreductase and Imaging in Living Animals. Anal. Chem. doi:10.1021/acs.analchem.8b03955 (2019). Full Text Sun, J., Hu, Z., Zhang, S., Zhang, X. A Novel Chemiluminescent Probe Based on 1,2-Dioxetane Scaffold for Imaging Cysteine in Living Mice. ACS Sensors doi:10.1021/acssensors.8b00936 (2019). Full Text Zhang, L., Zhao, X., Zhao, Y., Xu, F., Kong, J., Hu, Z., Ma, M., Zhang, S., Zhang, X. Rapid analysis of chemical warfare agents by metal needle-enhanced low-temperature plasma mass spectrometry. Anal. Methods doi:10.1039/c9ay00886a (2019). Full Text 2018年 Shen, L., Wang, H., Liu, S., Bai, Z., Zhang, S., Zhang, X., Zhang, C. Assembling of Sulfur Quantum Dots in Fission of Sublimed Sulfur. J. Am. Chem. Soc. doi:10.1021/jacs.8b02792 (2018). Full Text Zhao, H., Zhou, Q., Xia, M., Feng, J., Chen, Y., Zhang, S., Zhang, X. Characterize Collective Lysosome Heterogeneous Dynamics in Live Cell with a Space- and Time-Resolved Method. Anal. Chem. doi:10.1021/acs.analchem.8b01563 (2018). Full Text Yan, Z., Wang, J., Zhang, Y., Zhang, S., Qiao, J., Zhang, X. An iridium complex-based probe for photoluminescence lifetime imaging of human carboxylesterase 2 in living cells. Chem. Commun. doi:10.1039/C8CC04481C (2018). Full Text Zhao, X., Zhao, Y., Zhang, L., Ma, X., Zhang, S., Zhang, X. Rapid Analysis of Unsaturated Fatty Acids on Paper-Based Analytical Devices via Online Epoxidation and Ambient Mass Spectrometry. Anal. Chem. doi:10.1021/acs.analchem.7b04312 (2018). Full Text Zhang, Y., Sun, G., Zhang, Y., Huang, B., Xing, Z., Zhang, S., Zhang, X. Simultaneous competitive and sandwich formats multiplexed immunoassays based on ICP-MS detection. Talanta doi:10.1016/j.talanta.2018.03.032 (2018). Full Text Zhang, X., Zang, Q., Zhao, H., Ma, X., Pan, X., Feng, J., Zhang, S., Zhang, R., Abliz, Z., Zhang, X., Combination of Droplet Extraction and Pico-ESI-MS Allows the Identification of Metabolites from Single Cancer Cells. Anal. Chem. doi:10.1021/acs.analchem.8b02098 (2018). Full Text Wang, J., Wang, Z., Liu, F., Cai, L., Pan, J., Li, Z., Zhang, S., Chen, H., Zhang, X., Mo, Y. Vacuum Ultraviolet Laser Desorption/Ionization Mass Spectrometry Imaging of Single Cells with Submicron Craters. Anal. Chem. doi:10.1021/acs.analchem.8b02478 (2018). Full Text Wang, J., Wang, Z., Liu, F.; Mo, Y., Cai, L., Sun, C., Zhang, S., Zhang, R., Abliz, Z., Zhang, X. Mass spectrometry imaging of intact cholesterol in a mouse esophagus tissue section and mouse zygotes using VUV laser desorption/ionization method. Int. J. Mass. Spectrom. doi:10.1016/j.ijms.2018.06.008 (2018). Full Text Wei, Z., Zhang, X., Wang, J., Zhang, S., Zhang, X., Cooks, G. High yield accelerated reactions in nonvolatile microthin films: chemical derivatization for analysis of single-cell intracellular fluid. Chemical Science doi:10.1039/C8SC03382J (2018). Full Text Xia, M., Cai, L., Zhang, S., Zhang, X. A cell-penetrating ratiometric probe for simultaneous measurement of lysosomal and cytosolic pH change. Talanta doi:10.1016/j.talanta.2017.09.044 (2018). Full Text Yang, Y., Xia, M., Zhao, H., Zhang, S., Zhang, X. A Cell-Surface-Specific Ratiometric Fluorescent Probe for Extracellular pH Sensing with Solid-State Fluorophore. ACS Sensors doi:10.1021/acssensors.8b00514(2018). Full Text Zhang, L., Zhao, X., Cheng, H., Kong, J., Zhao, Y., Zhu, X., Zhang, S., Zhang, X. Gold nanoparticles-enhanced ion-transmission mass spectrometry for highly sensitive detection of chemical warfare agent simulants. Talanta doi:10.1016/j.talanta.2018.08.021(2018). Full Text He, Q., Wu, J., Zhang, S., Fang, X., Xing, Z., Wei, C., Zhang, X. Rapid screening of gaseous catalysts in methane activation using ICP-QQQ-MS. J. Anal. Atom. Spectrom. doi:10.1039/C7JA00345E (2018). Full Text 2017年 Wang, J., Xue, J., Yan, Z., Zhang, S.& Zhang, X. Photoluminescence Lifetime Imaging of Newly Synthesized Proteins in Living Cells with Iridium-alkyne Probe. Angew. Chem.-Int. Edit. doi:10.1002/anie.201708566 (2017). Full Text Zhao, Y., Zhao, H., Zhao, X., Jia, J., Ma, Q., Zhang, S., Zhang, X., Chiba,H., Hui, S.-P.& Ma, X. Identification and Quantitation of C═C Location Isomers of Unsaturated Fatty Acids by Epoxidation Reaction and Tandem Mass Spectrometry. Anal. Chem. doi:10.1021/acs.analchem.7b01870 (2017). Full Text Wang, S., Xia, M.-C., Liu, J., Zhang, S. & Zhang, X. Simultaneous Imaging of Three Tumor-Related mRNAs in Living Cells with a DNA Tetrahedron-Based Multicolor Nanoprobe. ACS Sens. 2, 735–739 doi:10.1021/acssensors.7b00290 (2017). Full Text Cai. L., Xia, M.-C., Wang, Z., Zhao, Y.-B., Li, Z., Zhang, S. & Zhang, X. Chemical Visualization of Sweat Pores in Fingerprints Using GO-Enhanced TOF-SIMS. Anal. Chem. 89, 8372−8376, doi: 10.1021/acs.analchem.7b01629 (2017). Full Text Cai, L., Sheng, L., Xia, M., Li, Z., Zhang, S., Zhang, X. & Chen, H. Graphene Oxide as a Novel Evenly Continuous Phase Matrix for TOF-SIMS. J. Am. Soc. Mass Spectrom. 28,399-408, doi:10.1007/s13361-016-1557-z (2017). Full Text Si, X., Xiong, X., Zhang, S., Fang, X. & Zhang, X. Detecting Low-abundance Molecules at Single-cell Level by Repeated Ion Accumulation in Ion Trap Mass Spectrometer. Anal. Chem. 89, 2275–2281, doi:10.1021/acs.analchem.6b03390 (2017). Full Text Xia, M.-C., Cai, L., Zhang, S. & Zhang, X. Cell-Penetrating Peptide Spirolactam Derivative as a Reversible Fluorescent pH Probe for Live Cell Imaging. Anal. Chem. 89, 1238-1243, doi:10.1021/acs.analchem.6b03813 (2017). Full Text He, Q., Wang, J., Mo, Y., Wei, C., Fang, X., Xing, Z., Zhang, S. & Zhang, X. A rapid screening platform for catalyst discovery in azide–alkyne cycloaddition by ICP-MS/MS. Talanta 165, 39-43, doi:http://dx.doi.org/10.1016/j.talanta.2016.12.014 (2017). Full Text Wang, J., Sheng, L., Zhao, H., Zhang, X. & Zhang, S. Spatiotemporal fluorescence imaging of newly synthesized proteins in normal and cancerous cells with anticarcinogen modulation. Talanta 162, 641-647, doi:10.1016/j.talanta.2016.10.017 (2017). Full Text 2016年 Cai, L., Sheng, L., Xia, M., Li, Z., Zhang, S., Zhang, X. & Chen, H. Graphene Oxide as a Novel Evenly Continuous Phase Matrix for TOF-SIMS. J. Am. Soc. Mass Spectrom. 1-10, doi:10.1007/s13361-016-1557-z (2016). Full Text Zhao, Y., Wei, Z., Zhao, H., Jia, J., Chen, Z., Zhang, S., Ouyang, Z., Ma, X. & Zhang, X. In Situ Ion-Transmission Mass Spectrometry for Paper-Based Analytical Devices. Anal. Chem. 88, 10805-10810, doi:10.1021/acs.analchem.6b03272 (2016). Full Text He, Q., Xing, Z., Wei, C., Fang, X., Zhang, S. & Zhang, X. Rapid screening of copper intermediates in Cu(i)-catalyzed azide-alkyne cycloaddition using a modified ICP-MS/MS platform. Chem. Commun. 52, 10501-10504, doi:10.1039/C6CC04793A (2016). Full Text Zhang, X.-C., Wei, Z.-W., Gong, X.-Y., Si, X.-Y., Zhao, Y.-Y., Yang, C.-D., Zhang, S.-C. & Zhang, X.-R. Integrated Droplet-Based Microextraction with ESI-MS for Removal of Matrix Interference in Single-Cell Analysis. Sci. Rep. 6, 24730, doi:10.1038/srep24730 (2016). Full Text Yang, Y., Lei, Y., Zhang, X. & Zhang, S. A ratiometric strategy to detect hydrogen sulfide with a gold nanoclusters based fluorescent probe. Talanta 154, 190-196, doi:10.1016/j.talanta.2016.03.066 (2016). Full Text Liu, R., Zhang, S., Wei, C., Xing, Z., Zhang, S. & Zhang, X. Metal Stable Isotope Tagging: Renaissance of Radioimmunoassay for Multiplex and Absolute Quantification of Biomolecules. Acc. Chem. Res. 49, 775-783, doi:10.1021/acs.accounts.5b00509 (2016). Full Text 2015年 Wei, Z., Xiong, X., Guo, C., Si, X., Zhao, Y., He, M., Yang, C., Xu, W., Tang, F., Fang, X., Zhang, S. & Zhang, X. Pulsed Direct Current Electrospray: Enabling Systematic Analysis of Small Volume Sample by Boosting Sample Economy. Anal. Chem. 87, 11242-11248, doi:10.1021/acs.analchem.5b02115 (2015). Gong, X., Xiong, X., Wang, S., Li, Y., Zhang, S., Fang, X. & Zhang, X. Desalting by Crystallization: Detection of Attomole Biomolecules in Picoliter Buffers by Mass Spectrometry. Anal. Chem. 87, 9745-9751, doi:10.1021/acs.analchem.5b01877 (2015). Si, X., Zhao, Y., Yang, C., Zhang, S. & Zhang, X. DNA methylation as a potential diagnosis indicator for rapid discrimination of rare cancer cells and normal cells. Sci. Rep. 5, 11882, doi:10.1038/srep11882 (2015). Zhao, Y., Gong, X., Si, X., Wei, Z., Yang, C., Zhang, S. & Zhang, X. Coupling a solid phase microextraction (SPME) probe with ambient MS for rapid enrichment and detection of phosphopeptides in biological samples. Analyst 140, 2599-2602, doi:10.1039/c4an02156h (2015). Xue, C., Lei, Y., Zhang, S. & Sha, Y. A cyanine-derived “turn-on” fluorescent probe for imaging nitroreductase in hypoxic tumor cells. Anal. Methods 7, 10125-10128, doi:10.1039/c5ay02312b (2015). Feng, L., Liu, J., Zhang, S. C. & Zhang, X. R. Label-free DNA detection based on a DNA-silver nanocluster pair. Anal. Methods 7, 5689-5694, doi:10.1039/C5AY01194A (2015). Li, Y., Ma, X., Wei, Z., Gong, X., Yang, C., Zhang, S. & Zhang, X. Pyroelectricity Assisted Infrared-Laser Desorption Ionization (PAI-LDI) for Atmospheric Pressure Mass Spectrometry. J. Am. Soc. Mass. Spectrom. 26, 1266-1273, doi:10.1007/s13361-015-1154-6 (2015). He, Q., Xing, Z., Zhang, S. & Zhang, X. ICP-MS/MS as a tool to study abiotic methylation of inorganic mercury reacting with VOCs. J. Anal. At. Spectrom. 30, 1997-2002, doi:10.1039/c5ja00245a (2015). 2014年 Zhang, S. X., Han, G. J., Xing, Z., Zhang, S. C. & Zhang, X. R. Multiplex DNA Assay Based on Nanoparticle Probes by Single Particle Inductively Coupled Plasma Mass Spectrometry. Anal. Chem. 86, 3541-3547, doi:10.1021/ac404245z (2014). Gong, X. Y., Zhao, Y. Y., Cai, S. Q., Fu, S. J., Yang, C. D., Zhang, S. C. & Zhang, X. R. Single Cell Analysis with Probe ESI-Mass Spectrometry: Detection of Metabolites at Cellular and Subcellular Levels. Anal. Chem. 86, 3809-3816, doi:10.1021/ac500882e (2014). Kong, H., Ma, Z. R., Wang, S., Gong, X. Y., Zhang, S. C. & Zhang, X. R. Hydrogen Sulfide Detection Based on Reflection: From a Poison Test Approach of Ancient China to Single-Cell Accurate Localization. Anal. Chem. 86, 7734-7739, doi:10.1021/ac5016672 (2014). Wang, S., Kong, H., Gong, X. Y., Zhang, S. C. & Zhang, X. R. Multicolor Imaging of Cancer Cells with Fluorophore-Tagged Aptamers for Single Cell Typing. Anal. Chem. 86, 8261-8266, doi:10.1021/ac501657g (2014). Zhang, S. & Zhang, X. Teaching analytical chemistry in China: past, present, and future perspectives. Anal. Bioanal. Chem. 406, 4005-4008, doi:10.1007/s00216-014-7869-6 (2014). 2013年 Zhang, Z. P., Gong, X. Y., Zhang, S. C., Yang, H. J., Shi, Y. M., Yang, C. D., . . . Ouyang, Z. Observation of Replacement of Carbon in Benzene with Nitrogen in a Low-Temperature Plasma. Sci. Rep. 3, 5, doi:10.1038/srep03481 (2013). Wei, Z. W., Han, S., Gong, X. Y., Zhao, Y. Y., Yang, C. D., Zhang, S. C. & Zhang, X. R. Rapid Removal of Matrices from Small-Volume Samples by Step-Voltage Nanoelectrospray. Angew. Chem.-Int. Edit. 52, 11025-11028, doi:10.1002/anie.201302870 (2013). Han, G. J., Zhang, S. C., Xing, Z. & Zhang, X. R. Absolute and Relative Quantification of Multiplex DNA Assays Based on an Elemental Labeling Strategy. Angew. Chem.-Int. Edit. 52, 1466-1471, doi:10.1002/anie.201206903 (2013). 2012年 Wu, L. Y., Zhang, Y. T., Zhang, S. C. & Zhang, X. R. Development of a cataluminescence-based method for rapid screening of de-NOx catalysts. Anal. Methods 4, 2218-2220, doi:10.1039/c2ay25323b (2012). Peng, Y. E., Zhang, S. C., Wen, F., Ma, X. X., Yang, C. D. & Zhang, X. R. In Vivo Nanoelectrospray for the Localization of Bioactive Molecules in Plants by Mass Spectrometry. Anal. Chem. 84, 3058-3062, doi:10.1021/ac300748h (2012). 2011年 Han, G., Xing, Z., Dong, Y., Zhang, S. & Zhang, X. One-Step Homogeneous DNA Assay with Single-Nanoparticle Detection. Angew. Chem. Int. Ed. 50, 3462-3465, doi:10.1002/anie.201006838 (2011). Peng, Y. E., Zhang, S. C., Gong, X. Y., Ma, X. X., Yang, C. D. & Zhang, X. R. Controlling Charge States of Peptides through Inductive Electrospray Ionization Mass Spectrometry. Anal. Chem. 83, 8863-8866, doi:10.1021/ac2024969 (2011). Gong, X. Y., Xiong, X. C., Peng, Y. E., Yang, C. D., Zhang, S. C., Fang, X. & Zhang, X. R. Low-temperature plasma ionization source for the online detection of indoor volatile organic compounds. Talanta 85, 2458-2462, doi:10.1016/j.talanta.2011.07.097 (2011). 2010年 Liu, Y. Y., Ma, X. X., Lin, Z. Q., He, M. J., Han, G. J., Yang, C. D., . . . Zhang, X. R. Imaging Mass Spectrometry with a Low-Temperature Plasma Probe for the Analysis of Works of Art. Angew. Chem.-Int. Edit. 49, 4435-4437, doi:10.1002/anie.200906975 (2010). Liu, R., Xing, Z., Lv, Y., Zhang, S. C. & Zhang, X. R. Sensitive sandwich immunoassay based on single particle mode inductively coupled plasma mass spectrometry detection. Talanta 83, 48-54, doi:10.1016/j.talanta.2010.08.037 (2010). Liu, D., Liu, M. Y., Liu, G. H., Zhang, S. C., Wu, Y. Y. & Zhang, X. R. Dual-Channel Sensing of Volatile Organic Compounds with Semiconducting Nanoparticles. Anal. Chem. 82, 66-68, doi:10.1021/ac902422s (2010). Lin, Z. Q., Zhao, M. X., Zhang, S. C., Yang, C. D. & Zhang, X. R. In situ arsenic speciation on solid surfaces by desorption electrospray ionization tandem mass spectrometry. Analyst 135, 1268-1275, doi:10.1039/b919972a (2010). Almasian, M. R., Yang, C. D., Xing, Z., Zhang, S. C. & Zhang, X. R. Development of a graphite low-temperature plasma source with dual-mode in-source fragmentation for ambient mass spectrometry. Rapid Commun. Mass Spectrom. 24, 742-748, doi:10.1002/rcm.4444 (2010). Almasian, M. R., Na, N., Wen, F., Zhang, S. C. & Zhang, X. R. Development of a Plasma-Assisted Cataluminescence System for Benzene, Toluene, Ethylbenzene, and Xylenes Analysis. Anal. Chem. 82, 3457-3459, doi:10.1021/ac1006975 (2010). 2009年 Zhang, Y., Ma, X. X., Zhang, S. C., Yang, C. D., Ouyang, Z. & Zhang, X. R. Direct detection of explosives on solid surfaces by low temperature plasma desorption mass spectrometry. Analyst 134, 176-181, doi:10.1039/b816230a (2009). Xue, J. H., Zhu, Z. L., Zhang, S. C. & Zhang, X. R. A simple and fast detection technique for arsenic speciation based on high-efficiency photooxidation and gas-phase chemiluminescence detection. Luminescence 24, 290-294, doi:10.1002/bio.1099 (2009). Wu, Y. Y., Na, N., Zhang, S., Wang, X., Liu, D. & Zhang, X. R. Discrimination and Identification of Flavors with Catalytic Nanomaterial-Based Optical Chemosensor Array. Anal. Chem. 81, 961-966, doi:10.1021/ac801733k (2009). Wen, F., Zhang, S. C., Na, N., Wu, Y. Y. & Zhang, X. R. Development of a sensitive gas sensor by trapping the analytes on nanomaterials and in situ cataluminescence detection. Sens. Actuator B-Chem. 141, 168-173, doi:10.1016/j.snb.2009.06.014 (2009). Wang, W. J., Zhang, S. C., Liu, C. H., Lu, L. Z., Wang, S. D. & Zhang, X. R. CE immunoassay with enhanced chemiluminescence detection of erythropoietin using silica dioxide nanoparticles as pseudostationary phase. Electrophoresis 30, 3092-3098, doi:10.1002/elps.200800616 (2009). Na, N., Zhang, S. C., Wang, X. & Zhang, X. R. 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