刘冬生 - 清华大学

个人简介

Education 5/1999~5/2002 Graduate student (Ph. D. degree awarded in July, 2002) Chemical Biology, Nucleic acid chemistry and bioorganic chemistry Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University Supervisor: Professor Albert S. C. Chan 9/1997~5/1999 Graduate student (M. S. degree awarded in April, 1999) Polymer Chemistry Institute of Chemistry, Chinese Academy of Sciences, P. R. China Supervisor: Professor Rongben Zhang 9/1988~7/1993 Undergraduate student (B. S. degree, first honor, awarded in July, 1993) Polymer Chemistry University of Science and Technology of China, P. R. China Research Experience 6/2009~ Professor Biopolymers and Chemical Biology Department of Chemistry, Tsinghua University 1/2005~5/2009 Principle Investigator, Professor Chemical Biology and Bio-Nanotechnology National Centre for NanoScience & Technology, China 2/2003~1/2005 NanoIRC Postdoc Research Associate Chemical Biology and Bio-Nanotechnology Department of Chemistry, University Chemical Laboratory University of Cambridge 5/2002~1/2003 Postdoc Research Associate Chemical Biology, Organic, Bioorganic and Nucleic acid chemistry Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic University 7/1997~5/1999 Assistant professor Polymer Chemistry and Physics Institute of Chemistry, Chinese Academy of Sciences, P. R. China 7/1993~7/1997 Research Associate Polymer Chemistry and Physics Institute of Chemistry, Chinese Academy of Sciences, P. R. China

研究领域

We are interesting in using biomolecules and their specific interaction in nanostructure fabrication and nanodevice design, which include: DNA molecular machines and related nanodevices based on DNA tetrads; 2D and 3D nanostructures self-assembly by DNA/protein/nanoparticle; molecular devices' application in diagnosis; bio-inspired smart materials; DNA sequence and secondary structure relationship.

近期论文

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Rui Xu, Yujie Li, Chenyou Zhu, Dongsheng Liu*, and Yuhe R. Yang Cellular Ingestible DNA Nanostructures for Biomedical Applications.Advanced NanoBiomed Research, 2023, 3, 2370011 Xiancheng Tian, Yawei Sun, Yuanchen Dong*, and Dongsheng Liu*Enhancing Stability of Liposome by Synergistic Effect of Polymer Multiple-Units Acta. Polym. Sin., 2023, DOI: 10.11777/j.issn1000-3304.2022.22305 Ruofan Chen, Yujie Li, Yu Jin, Yawei Sun, Zhiyong Zhao*, Yun Xu, Jiang-Fei Xu, Yuanchen Dong*, and Dongsheng Liu*Reinforcing supramolecular hyaluronan hydrogels via kinetically interlocking multiple-units strategy Carbohydrate Polymers, 2023, 310, 120703. Yufan Pan†, Yuqiao Ding†, Yuanchen Dong*, and Dongsheng Liu* Construction, Functionalization and Biomedical Application of DNA Supramolecular Hydrogels Acta. Polym. Sin., 2023, DOI: 10.11777/j.issn1000-3304.2022.22380 Bo Yang†, Bini Zhou†, Cuifeng Li†, Xiaowei Li, Ziwei Shi, Yuxin Li, Chenyou Zhu, Xin Li, Yi Hua, Yufan Pan, Jian He, Tianyang Cao, Yawei Sun, Wanli Liu, Min Ge, Yuhe R. Yang, Yuanchen Dong*, and Dongsheng Liu* A Biostable L-DNA Hydrogel with Improved Stability for Biomedical Applications Angew. Chem. Int. Ed., 2022, 61, e20220250. Xin Li, Xiaobin Dai, Yufan Pan, Yawei Sun, Bo Yang, Kun Chen, You Wang, Jiang-Fei Xu, Yuanchen Dong, Yuhe Renee Yang*, Li-Tang Yan, and Dongsheng Liu*Studies on the Synergistic Effect of Tandem Semi-Stable Complementary Domains on Sequence-Defined DNA Block Copolymers J. Am. Chem. Soc., 2022, 144, 46, 21267-21277. Yuanchen Dong, Yang Yang, Chenxiang Lin*, and Dongsheng Liu*Frame-Guided Assembly of Amphiphiles Acc. Chem. Res., 2022, 55,14, 1938–1948. Yufan Pan, Bo Yang, Rui Xu, Xin Li, Yuanchen Dong*, and Dongsheng Liu*Rigidity-dependent Formation Process of DNA Supramolecular Hydrogels NPG Asia Mater., 2022, 14, 92. Yujie Li, Yuqiao Ding, Bo Yang, Tianyang Cao, Jiang-Fei Xu, Yuanchen Dong, Quan Chen, Lijin Xu, and Dongsheng Liu*Reinforcing DNA Supramolecular Hydrogel with Polymeric Multiple-Unit Linker CCS Chem., 2022, 5, 2, 434-444 Yu Jin†, Yujie Li†, Sijia Song, Yuqiao Ding, Yuanchen Dong, Yao Lu*, Dongsheng Liu* and Chun Zhang DNA Supramolecular Hydrogel as a Biocompatible Artificial Vitreous Substitute Adv. Mater. Interfaces, 2022, 2101321. Xiaobin Dai†, Zhichao Zhu†, Yujie Li†, Bo Yang, Jiang-Fei Xu, Yuanchen Dong*, Xin Zhou, Li-Tang Yan*, and Dongsheng Liu* “Shutter” Effects Enhance Protein Diffusion in Dynamic and Rigid Molecular Networks J. Am. Chem. Soc., 2022, 144, 41, 19017-19025. Tanxi Bai, Jiayi Zhang, Kai Huang, Wen Wang, Bowen Chen, Yujie Li, Mengyao Zhao, Suoyu Zhang, Chenyou Zhu, Dongsheng Liu*, and Bryan Wei*Reconfiguration of DNA nanostructures induced by enzymatic ligation treatment Nucleic Acids Research, 2022, 50, 14, 8392–8398 Taoyang Yuan†, Yu Shao†, Xu Zhou, Qian Liu, Zhichao Zhu, Bini Zhou, Yuanchen Dong, Nicholas Stephanopoulos, Songbai Gui*, Hao Yan*, and Dongsheng Liu*Highly Permeable DNA Supramolecular Hydrogel Promotes Neurogenesis and Functional Recovery after Completely Transected Spinal Cord Injury Adv. Mater., 2021, 2102428. Xin Yan†, Bo Yang†, Yourong Chen†，Yifan Song, Jing Ye, Yufan Pan, Bini Zhou, Yuqing Wang, Fengbiao Mao, Yuanchen Dong, Dongsheng Liu*, Jiakuo Yu* Anti-Friction MSCs Delivery System Improves the Therapy for Severe Osteoarthritis Adv. Mater., 2021, 2104758. Bo Yang, Zhihan Zhao, Yufan Pan, Jiayin Xie, Bini Zhou, Yujie Li, Yuanchen Dong, and Dongsheng Liu*Shear-Thinning and Designable Responsive Supramolecular DNA Hydrogels Based on Chemically Branched DNA ACS Appl. Mater. Interfaces, 2021, 13, 41, 48414–48422. Bini Zhou, Yuanchen Dong, and Dongsheng Liu*Recent Progress in DNA Motor-Based Functional Systems ACS Appl. Bio Mater., 2021, 4, 3, 2251–2261. Jiezhong Shi, Chenyou Zhu, Qian Li, Yujie Li, Liangxiao Chen, Bo Yang, Jiang-Fei Xu, Yuanchen Dong*, Chengde Mao*, Dongsheng Liu*Kinetically Interlocking Multiple-Units Polymerization of DNA Double Crossover and Its Application in Hydrogel Formation Macromol. Rapid Commun., 2021, 42, 2100182. Bo Yang, Limei Sun, Yufan Pan, Yuanchen Dong, Yawei Sun*, Dongsheng Liu*Photo-responsive DNA Hydrogel Based on Photoactive Thymine Phosphoramidite Monomer Acta. Polym. Sin., 2021, 52, 996-1005. Chao Wang, Jiafang Piao, Yujie Li, Xiancheng Tian, Yuanchen Dong*, and Dongsheng Liu*Construction of Liposomes Mimicking Cell Membrane Structure through Frame‐Guided Assembly Angew. Chem. Int. Ed., 2020, 59, 15176–15180. Chao Wang, Yiyang Zhang, Yu Shao, Xiancheng Tian, Jiafang Piao, Yuanchen Dong*, and Dongsheng Liu*pH-responsive Frame-Guided Assembly with hydrophobicity controllable peptide as leading hydrophobic groups Giant, 2020, 1, 100006. Yawei Sun†, Bo Yang†, Yi Hua, Yuanchen Dong, JianhanYe, Jiqian Wang, Lijin Xu, and Dongsheng Liu* Construction and Characterization of aMirror-Image L-DNA i-Motif Chembiochem, 2020, 21,94–97. Iliya D. Stoev†, Tianyang Cao†, Alessio Caciagli, Jiaming Yu, Christopher Ness, Ren Liu, Rini Ghosh, Thomas O’Neill, Dongsheng Liu* and Erika Eiser* On the role of flexibility in linker-mediated DNA hydrogels Soft Matter, 2020, 16, 990-1001. Tianyang Cao, Haoyang Jia, Yuanchen Dong, Songbai Gui* and Dongsheng Liu*In Situ Formation of Covalent Second Network in a DNA Supramolecular Hydrogel and Its Application for 3D Cell Imaging ACS Appl. Mater. Interfaces, 2020, 12, 4, 4185–4192. Jiezhong Shi, Ziwei Shi, Yuanchen Dong, Fen Wu*, and Dongsheng Liu*Responsive DNA-Based Supramolecular Hydrogels ACS Appl. Bio Mater., 2020, 3, 5, 2827–2837. Yujie Li†, Chenyou Zhu†, Yuanchen Dong, and Dongsheng Liu*Supramolecular hydrogels: Mechanical strengthening with dynamicPolymer, 2020, 210, 122993. Li Yujie, Chen Jie, Dong Yuanchen, Huajie Liu* and Dongsheng Liu*Construction of pH-Triggered DNA Hydrogels Based on Hybridization Chain Reactions Chem. Res. Chinese Universities, 2020, 36(2), 243―246. Yiyang Zhang#, Chao Wang#, Yuanchen Dong*, Dianming Wang, Tianyang Cao, Shuo Wang and Dongsheng Liu*Fold 2D Woven DNA Origami to Origami+ Structures Adv. Funct. Mater., 2019, 29(22), 1809097. HaoyangJia, Jiezhong Shi, Weibin Ren, Jiang Zhao, Yuanchen Dong and Dongsheng Liu*Controllable supramolecular “ring opening” polymerization based on DNA duplex Polymer, 2019, 171, 121-126. Shuo Wang, Yiyang Zhang, Yuanchen Dong* and Dongsheng Liu*Redox triggered disassembly of frame-guided assemblies Polymer, 2019, 175, 146-151. Jiezhong Shi†, Haoyang Jia†, Hao Chen, Xi Wang, Jiang-Fei Xu, Weibin Ren, Jiang Zhao, Xin Zhou, Yuanchen Dong and Dongsheng Liu* Concentration Insensitive Supramolecular Polymerization Enabled by Kinetically Interlocking Multiple-Units Strategy CCS Chem., 2019, 1, 296-303. Yiyang Zhang, Dandan Bao, Shuo Wang, Yuancheng Dong, Fen Wu, Haitao Li,* and Dongsheng Liu* A Modularly Designable Vesicle for Sequentially Multiple Loading Small, 2018, 14(8), 1703259. Zhongyang Xing,* Alessio Caciagli#, Tianyang Cao#, Iliya Stoev, Mykolas Zupkauskas, Thomas O’Neill, Tobias Wenzel, Robin Lamboll, Dongsheng Liu and Erika Eiser* Microrheology of DNA hydrogel Proc. Natl. Acad. Sci. U. S. A., 2018, 115(32), 8137-8142. Fen Wu, Zhiyong Zhao, Chun Chen, Tianyang Cao, Chuang Li, Yu Shao, Yiyang Zhang, Dong Qiu, Qian Shi, Qing-Hua Fan,* and Dongsheng Liu*Self-Collapsing of Single Molecular Poly-Propylene Oxide (PPO) in a 3D DNA Network Small, 2018, 14(10), 1703426. Yawei Sun, Yanyun Ji, Dong Wang, Jiqian Wang,* and Dongsheng Liu Stabilization of an intermolecular i-motif by lipid modification of cytosine-oligodeoxynucleotides Org. Biomol. Chem., 2018, 16(26), 4857-4863. Yu Shao, Zhan-Yi Sun, Yijie Wang, Bo-Dou Zhang, Dongsheng Liu* and Yan-Mei Li*Designable Immune Therapeutical Vaccine System Based on DNA Supramolecular Hydrogels ACS Appl. Mater. Interfaces, 2018, 10 (11), 9310-9314. Hengyuan Liu#, Tianyang Cao#, Yun Xu, Yuanchen Dong, and Dongsheng Liu* Tuning the Mechanical Properties of a DNA Hydrogel in Three Phases Based on ATP Aptamer Int. J. Mol. Sci., 2018, 19 (6), 1633. Yuanchen Dong, Shuobing Chen, Shijian Zhang, Joseph Sodroski, Zhongqiang Yang, Dongsheng Liu, and Youdong Mao*Folding DNA into a Lipid-Conjugated Nanobarrel for Controlled Reconstitution of Membrane Proteins Angew. Chem. Int. Ed., 2018, 57 (8), 2072-2076. Quanmei Sun, Xiaoli Shi, Jiantao Feng, Qiang Zhang, Zhuo Ao, Yinglu Ji, Xiaochun Wu, Dongsheng Liu* and Dong Han*Cytotoxicity and Cellular Responses of Gold Nanorods to Smooth Muscle Cells Dependent on Surface Chemistry Coupled Action Small, 2018, 14(52), 1803715. Bo Bian, Yi-Yang Zhang, Yuan-Chen Dong*, Fen Wu, Chao Wang, Shuo Wang, Yun Xu and Dong-Sheng Liu*The investigation of the stability of DNA-b-PPO vesicles formed through frame guided assembly Sci. China Chem., 2018, 61(12), 1568-1571. Ian Holland, Jack Logan, Jiezhong Shi, Christopher McCormick, Dong-Sheng Liu* and Wenmiao Shu*3D biofabrication for tubular tissue engineering Bio-Design and Manufacturing, 2018, 1, 89-100.