Greenberg, Marc - The Johns Hopkins University

个人简介

Marc Greenberg is the Vernon K. Krieble Professor of Chemistry and has been a member of the Johns Hopkins University faculty since 2002. Greenberg received his training as an American Cancer Society Postdoctoral Fellow at Caltech in the laboratory of Professor Peter Dervan and earned his Ph.D. at Yale University under the guidance of Professor Jerome Berson. He has undergraduate degrees in Chemistry and Chemical Engineering from New York University and the Cooper Union School of Engineering, respectively. Greenberg is a Fellow of the American Association for the Advancement of Science. He was the recipient of an Arthur C. Cope Scholar Award from the American Chemical Society (2016) for his research on nucleic acids, and was an Alfred P. Sloan Foundation fellow (1996-2000). Greenberg was the Founding Director of the Chemistry-Biology Interface program (2005-2013) at Johns Hopkins University. Education: New York University, B. S. Chemistry, June 1982 The Cooper Union School of Engineering, B. E. Chemical Engineering, June 1982 Yale University, Ph.D. in Chemistry, May 1988 Thesis Title: Studies on Heterocyclic Derivatives of Tetramethyleneethane Thesis Advisor: Professor Jerome A. Berson California Institute of Technology 1988-1990 American Cancer Society Postdoctoral Fellow Advisor: Professor Peter B. Dervan Professional Experience: Assistant Professor, Department of Chemistry 1990-1996 Colorado State University Associate Professor, Department of Chemistry 1996-1999 Colorado State University Professor, Department of Chemistry 1999-2002 Colorado State University Professor, Department of Chemistry 2002-2015 The Johns Hopkins University Vernon K. Krieble Professor of Chemistry 2016-present The Johns Hopkins University Professor, Department of Biology (secondary appointment) 2015-present The Johns Hopkins University Professor, Department of Oncology (secondary appointment) 2015-present The Johns Hopkins University School of Medicine Member, Sidney Kimmel Comprehensive Cancer Center 2015-present Cancer Chemical and Structural Biology Program The Johns Hopkins University School of Medicine

研究领域

DNA Damage is Only the Beginning: Histone Protein Catalyzed Chemistry of Damaged DNA in Nucleosomes The Effects of DNA Lesions on Repair Enzymes How are DNA and RNA Oxidatively Damaged? Inhibitors of DNA Repair Enzymes Photochemical Control of Nucleic Acid Structure Radiosenistizing Agents

近期论文

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Facile Synthesis of 5-Methylene-2-pyrrolones.Jacinto, M. P.; Pichling, P.; Greenberg, M. M. Org. Lett. 2018, 20, 4885-4887. (PMC:6132240) Expanded Substrate Scope of DNA Polymerase Theta and DNA Polymerase Beta: Lyase Activity on 5'-Overhangs and Clustered Lesions.Laverty, D. J.; Greenberg, M. M. Biochemistry 2018, 57, 6119-6127. (PMC: 6200648) Oxidation of 8-Oxo-7,8-dihydro-2'-deoxyguanosine Leads to Substantial DNA-Histone Cross-links Within Nucleosome Core Particles.Bai, J.; Zhang, Y.; Xi, Z.; Greenberg, M. M.; Zhou, C. Chem. Res. Toxicol. 2018, 31, 1364-1372. (PMC: 6425731) Histone Tail Sequences Balance Their Role in Genetic Regulation and the Need to Protect DNA Against Destruction in Nucleosome Core Particles Containing Abasic Sites.Yang, K.; Greenberg, M. M. ChemBioChem 2019, 20, 78-82. (PMC: 6317330) A Guardian Residue Hinders Insertion of a Fapy•dGTP Analog by Modulating the OpenClosed DNA Polymerase Transition.Smith, M. R.; Shock, D. D.; Beard, W. A.; Greenberg, M. M.; Freudenthal, B. D.; Wilson, S.H. Nucleic Acids Res. 2019, 47, 3197-3207. (PMC: 6451102) Reactivity of the Major C5'-Oxidative DNA Damage Product in Nucleosome CoreParticles.Rana, A.; Yang, K.; Greenberg, M. M. ChemBioChem 2019, 20, 672-676. Designated as a Very Important Paper (VIP) by the Editor. (PMC: 6397081) Effect of Histone Lysine Methylation on DNA Lesion Reactivity in Nucleosome Core Particles.Yang, K.; Prasse, C.; Greenberg, M. M. Chem. Res. Toxicol. 2019, 32, 910-916. Invited article for special issue: Epigenetics in Toxicology. (PMC: 6533150) Positional Dependence of DNA Hole Transfer Efficiency in Nucleosome Core Particles.Sun, H.; Zheng, L.; Yang, K.; Greenberg, M. M. J. Am. Chem. Soc. 2019, 141, 10154-10158. (PMC: 6610759) Reactivity of 3-Methyl-2'-Deoxyadenosine in Nucleosome Core Particles.Yang, K.; Sun, H.; Lowder, L.; Varadarajan, S.; Greenberg, M. M. Chem. Res. Toxicol.2019, 32, 2118-2124. Selected to be Editor’s Choice by the American Chemical Society;September 30, 2019. (PMC: 6803048) DNA-Protein Cross-link Formation in Nucleosome Core Particles Treated with Methyl Methanesulfonate.Yang, K.; Greenberg, M. M. Chem. Res. Toxicol. 2019, 32, 2144-2151. (PMC: 6803050) Mutagenic Effects of a 2-Deoxyribonolactone – Thymine Glycol Tandem Lesion in Human Cells.Naldiga, S.; Huang, H.; Greenberg, M. M.; Basu, A. K. Biochemistry 2020, 59, 417-424.(PMC: 7003646) Solid-Phase Synthesis of Oligonucleotides Containing the N6-(2-Deoxy-α, β-Derythropentofuranosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidine (Fapy•dG)Oxidative Damage Product Derived from 2'-Deoxyguanosine.Yang, H.; Tang, J. A.; Greenberg, M. M. Chem. – Eur. J. 2020, 26, 5441 – 5448. Designated by the editor as a Hot Paper. (PMC: 7309192) Light-Controlled Twister Ribozyme With Single Molecule Detection Resolves RNA Function in Time and Space.Korman, A.; Sun, H.; Hua, B.; Yang, H.; Capilato, J. N.; Paul, R.; Panja, S.; Ha, T.;Greenberg, M. M.; Woodson, S. A. Proc. Natl. Acad. Sci. USA 2020, 117, 12080-12086.(PMC: 7275738) Independent Generation and Time-Resolved Detection of 2'-Deoxyguanosin-N2-yl Radicals.Zheng, L.; Dai, X.; Su, H.; Greenberg, M. M. Angew. Chem. Int. Ed. 2020, 59, 13406-13413. Designated by the editor as a Hot Paper. (PMC: 7395871) Independent Generation and Reactivity of 2’-Deoxyguanosin-N1-yl Radical.Zheng, L.; Greenberg, M. M. J. Org. Chem. 2020, 85, 8665-8672. (PMC: 7334105) Identifying Poly(ADP-ribose)-Binding Proteins With Photoaffinity-Based Proteomics.Dasovich, M.; Beckett, M. Q.; Bailey, S.; Ong, S.; Greenberg, M. M.; Leung, A. K. L. J.Am. Chem. Soc. 2021, 143, 3037-3042. (PMC: 8109396) Selective Inhibition of DNA Polymerase β by a Covalent Inhibitor.Yuhas, S. C.; Laverty, D. J.; Lee, H.; Greenberg, M. M. J. Am. Chem. Soc. 2021, 143, 8099-8107. Correction: J. Am. Chem. Soc. 2022, 144, 2825. (PMC: 8284926) Sequence Context Effects of Replication of Fapy•dG in Three Mutational Hot Spot Sequences of the p53 Gene in Human Cells.Bacurio, J. H.; Yang, H.; Naldiga, S.; Powell, B. V.; Ryan, B. J.; Freudenthal, B. D.;Greenberg, M. M. Basu, A. K. DNA Repair 2021, 108, 103213. (PMC: 8616820) Protein Domain Specific Covalent Inhibition of Human DNA Polymerase β.Yuhas, S. C.; Majumdar, A.; Greenberg, M. M. ChemBioChem 2021, 22, 2619-2623.Designated by the editor as a Very Important Paper. (PMC: 8373715) Suppression of DNA Polymerase β Activity is Synthetically Lethal in BRCA1-Deficient Cells.Yuhas, S. C.; Mishra, A.; DeWeese, T. L.; Greenberg, M. M. ACS Chem. Biol. 2021, 16,1339-1343. Correction: ACS Chem. Biol. 2022, 17, 492. (PMC: 8380700) Reactivity and DNA Damage by Independently Generated 2'-Deoxycytidin-N4-yl Radical.Peng, H.; Jialong, J.; Mortimer, I. P.; Zehan, M.; Su, H.; Greenberg, M. M. J. Am. Chem.Soc. 2021, 143, 14738-14747. (PMC: 8728764) Intracellular Formation of A DNA Damage-Induced, Histone Post-Translational Modification Following Bleomycin Treatment.Jacinto, M. P.; Fried, S. D.; Greenberg, M. M. J. Am. Chem. Soc. 2022, 144, 7600-7605.(PMC: 9121625) Structural Dynamics of a Common Mutagenic Oxidative DNA Lesion in Duplex DNA and During DNA Replication.Ryan, B. J.; Yang, H.; Bacurio, J.H.; Smith, M. R.; Basu, A. K.; Greenberg, M. M.;Freudenthal, B. D. J. Am. Chem. Soc. 2022, 144, 8054-8065. (PMC:9097547) Local Alteration of Ionic Strength in a Nucleosome Core Particle and its Effect on N7-Methyl-2’-deoxyguanosine Depurination.Wen, T.; Yang, K.; Greenberg, M. M. Biochemistry 2022, 61, 2221-2228. (PMC: 9670023) Covalent Modification of Bromodomain Proteins by Peptides Containing a DNA DamageInduced, Histone Post-Translational Modification.Jacinto, M. P.; Heidenreich, D.; Müller, S.; Greenberg, M. M. ChemBioChem 2022, 23,e202200373. (PMC: 9675715) Histone Deacetylase 1 Inhibition by Peptides Containing a DNA Damage-Induced, Nonenzymatic, Histone Covalent Modification.Jacinto, M. P.; Greenberg, M. M. Biochemistry 2023, 62, 1388-1393. (PMC: 10124317) 8-Oxo-2’-deoxyguanosine Replication in Mutational Hot Spot Sequences of the p53 Gene in Human Cells is Less Mutagenic Than That of the Corresponding Formamidopyrimidine.Stanio, S.; Bacurio, J. H.; Yang, H.; Greenberg, M. M.; Basu, A. K. Chem. Res. Toxicol.2023, 36, 782-789. (PMC: 10192040) Photochemical and Single Electron Transfer Generation of 2′-Deoxycytidin-N4-yl Radical From Oxime Esters.Peng, H.; Vu, S.; Retes, P.; Ward, S.; Kumar, A.; Sevilla, M. D.; Adhikary, A.; Greenberg,M. M. J. Org. Chem. 2023, 88, 7381-7390. (PMC: 10308854) Deoxyguanosine-Linked Bifunctional Inhibitor of SAMHD1 dNTPase Activity and Nucleic Acid Binding.Egleston, M.; Dong, L; Howlader, A. H.; Bhat, S.; Orris, B.; Bianchet, M.; Greenberg, M.M.; Stivers, J. T. ACS Chem. Biol. doi.org/10.1021/acschembio.3c00118. Synergistic Effects on the Mutagenicity of Tandem Lesions Containing 8-Oxo-7,8-dihydro2ʹ-deoxyguanosine or Fapy•dG Flanked by a 3ʹ 5-Formyl-2ʹ-deoxyuridine in Human Cells. Bacurio, J. H.; Gao, S.; Yang, H.; Basu, A. K.; Greenberg, M. M. DNA Repair 2023, 129,103527