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个人简介

学历 1982.09-1987.07 清华大学化学系 学士 1987.09-1989.12 清华大学化学系 硕士 1989.12-1992.07 清华大学化学系 博士 1996.10-1997.10 德国卡尔斯鲁厄大学有机化学所 博士后 工作经历 1992.07-1993.12 清华大学化学系 讲师 1993.12-1998.08 清华大学化学系 副教授 1998.08-今 清华大学化学系 教授 1999.04-今 清华大学化学系 博导 所获主要奖励 教育部科技进步二等奖(1995年,“磷酰化氨基酸、小肽的合成及机理研究与波谱应用”,第三完成人) 清华大学基础性研究成果奖(1995年,第三完成人) 北京市爱国立功标兵(1995年) 茅以升北京青年科技奖提名奖(1996年) 第五届中国国际多肽学术会议青年优秀论文奖(1998年) 国家教育部优秀年轻教师基金(1999年) 教育部首届“青年教师奖”(2000年) 教育部提名国家科学技术奖自然科学二等奖(“氨基酸、核苷和糖的五配位磷化合物研究”,2003年,第三完成人) 清华大学教学成果一等奖(“突出创新、强化实践―研究型有机化学教学改革探索”,2004年,第一完成人) 清华大学教学成果一等奖(“研究性教学模式下的本科精品课程建设”,2004年,第四完成人) 清华大学教学成果二等奖(“抓住科学前沿,提高综合素质-?化学与社会?教学实践”,2006年,第四完成人) 北京市教学成果一等奖(“突出创新、强化实践―研究型有机化学教学改革探索”,2004年,第一完成人) 国家级教学成果二等奖(“突出创新、强化实践―研究型有机化学教学改革探索”,2005年,第一完成人) 宝钢教育奖优秀教师奖(2004年) 北京市教学名师奖(2006年) 国家自然科学基金委国家杰出青年科学基金(2008年) 教育部高等学校教学名师奖(2009年) Bayer Investigator Award (2009年) 中国国际多肽学术会议“华夏奖”(Cathay Award)(2010年) 政府特殊津贴(2011年)

研究领域

淀粉样蛋白错误折叠机制研究 糖肽合成及免疫性质研究 淀粉样蛋白降解及抑制研究 修饰蛋白合成 理论计算 HIV膜融合抑制剂的设计合成及相关性质的研究

近期论文

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Zhang S#, Liu Y Q#, Jia C#, Lim Y J#, Feng G#, Xu E, Long H, Kimura Y, Tao Y, Zhao C, Wang C, Liu Z, Hu J J, Ma M R, Liu Z, Jiang L, Li D, Wang R, Dawson V L, Dawson T M*, Li Y M*, Mao X*, Liu C*.“Mechanistic basis for receptor-mediated pathological alpha-synuclein fibril cell-to-cell transmission in Parkinson's disease.”Proc Natl Acad Sci U S A 2021, 118 (26). Li W H, Wu J J, Wu L, Zhang B D, Hu H G, Zhao L, Li Z B, Yu X F*, Li Y M*.“Black phosphorous nanosheet: A novel immune-potentiating nanoadjuvant for near-infrared-improved immunotherapy.”Biomaterials 2021, 273, 120788. Liang C Q, Wang L, Luo Y Y, Li Q Q, Li Y M*.“Capturing protein droplets: label-free visualization and detection of protein liquid-liquid phase separation with an aggregation-induced emission fluorogen.” Chem Commun (Camb) 2021, 57 (31), 3805-3808. Wu J J, Zhao L, Han B B, Hu H G, Zhang B D, Li W H, Chen Y X, Li Y M*.“A novel STING agonist for cancer immunotherapy and a SARS-CoV-2 vaccine adjuvant.” Chem Commun (Camb) 2021, 57 (4), 504-507. Liu Y Q#, Mao Y Y#, Xu E Q, Jia H M, Zhang S, Dawson V L, Dawson T M, Li Y M*, Zheng Z*, He W W*, Mao X B*.“Nanozyme scavenging ROS for prevention of pathologic α-synuclein transmission in Parkinson’s disease.” Nano Today 2021, 36, 101027. Liang C Q, Li Y M*.“Peptides for disrupting and degrading amyloids.”Curr Opin Chem Biol. 2021, 64, 124-130. Zhang M Q, He P Y, Li Y M*.“Contemporary Approaches to α,β-Dehydroamino Acid Chemical Modifications.” Chem. Res. Chinese Universities 2021, 37(5), 1044-1054 Luo Y Y, Wu J J, Li Y M*.“Regulation of Liquid-Liquid Phase Separation with Focus on Post-Translational Modifications.” Chem Commun (Camb) 2021, 57, 13275-13287. Zhao L, Wu, JJ and Li Y M*.“Poly(ADP-ribose): the structure and the synthesis.”Arkivoc 2021, iv, 65-88. Li,Wen-Hao; Li, Yan-Mei*“Chemical Strategies to Boost Cancer Vaccines.” Chem. Rev. 2020, 120, 11420-11478. Zhao, Kun#; Lim, Yeh-Jun#; Liu, Zhenying#; Long, Houfang; Sun, Yunpeng; Hu, Jin-Jian; Zhao, Chunyu; Tao, Youqi; Zhang, Xing; Li, Dan; Li, Yan-Mei*; Liu, Cong*“Parkinson’s disease-related phosphorylation at Tyr39 rearranges α-synuclein amyloid fibril structure revealed by cryo-EM.”Proc. Natl. Acad. Sci. USA 2020, 117, 20305–20315. He, Pei-Yang; Chen, Huai; Hu, Hong-Guo; Hu, Jin-Jian, Lim, Yeh-Jun; Li, Yan-Mei*“Late-stage peptide and protein modifications through phospha-Michael addition reaction.” Chem. Commun. 2020, 56, 12632-12635. Han, Bei-Bei#; Pan, Yu-Chen#; Li, Yan-Mei; Guo, Dong-Sheng*; Chen, Yong-Xiang*“A host-guest ATP responsive strategy for intracellular delivery of phosphopeptides.” Chem.Commun. 2020,56,5512-5515. Li, Qian-Qian; Liu, Yu-Qing; Luo, Yun-Yi; Chu, Ting-Ting; Gao, Na; Chen, Pu-Guang; Chen, Yong-Xiang; Li, Yan-Mei*“Uncovering the pathological functions of Ser404 phosphorylation by semisynthesis of a phosphorylated TDP-43 prion-like domain.” Chem.Commun. 2020,56,5370-5373. Li, Gao; Yang, Wu-Yue; Li, Wen-Hao; Luo, Yun-Yi; Lim, Yeh-Jun; Li, Yang; Paul, Ashim; Segal, Daniel; Hong, Liu; Li, Yan-Mei*“Rational Design of a Cocktail of Inhibitors against A beta Aggregation.” Chem. Eur. J, 2020, 26, 3499-3503. Chen, Pu-Guang; Hu, Hong-Guo; Sun, Zhan-Yi; Li, Qian-Qian; Zhang, Bo-Dou; Wu, Jun-Jun; Li, Wen-Hao; Zhao, Yu-Fen; Chen, Yong-Xiang; Li, Yan-Mei*“Fully Synthetic Invariant NKT Cell-Dependent Self-Adjuvanting Antitumor Vaccines Eliciting Potent Immune Response in Mice.”Mol. Pharm. 2020, 17, 2, 417-425 Wu, Jun-Jun; Zhao, Lang; Hu, Hong-Guo; Li, Wen-Hao; Li, Yan-Mei*“Agonists and inhibitors of the STING pathway: Potential agents for immunotherapy.”Med. Res. Rev. 2020, 40, 1117-1141. Liu, Chengcheng; Zhang, Wanlin; Zhao, Yang; Lin, Changxu; Zhou, Kang; Li, Yanmei; Li, Guangtao*“Urea-Functionalized Poly(ionic liquid) Photonic Spheres for Visual Identification of Explosives with a Smartphone.” ACS Appl. Mater. Inter. 2019, 11, 21078-21085. Paul, Ashim; Li, Wen-Hao; Viswanathan, Guru KrishnaKumar; Arad, Elad; Mohapatra, Satabdee; Li, Gao; Jelinek, Raz; Gazit, Ehud; Li, Yan-Mei; Segal, Daniel*“Tryptophan-glucosamine conjugates modulate tau-derived PHF6 aggregation at low concentrations.” Chem. Commun. 2019, 55, 14621-14624 Paul, Ashim; Zhang, Bo-Dou; Mohapatra, Satabdee; Li, Gao; Li, Yan-Mei; Gazit, Ehud; Segal, Daniel*“Novel Mannitol-Based Small Molecules for Inhibiting Aggregation of alpha-Synuclein Amyloids in Parkinson's Disease.”Front. Mol. Biosci. 2019, 6, 16. Gao, Na; Huang, Yun-Peng; Chu, Ting-Ting; Li, Qian-Qian; Zhou, Bing; Chen, Yong-Xiang*; Zhao, Yu-Fen; Li, Yan-Mei*“TDP-43 specific reduction induced by Di-hydrophobic tags conjugated peptides.”Bioorg. Chem, 2019, 84, 254-259. Duan, Hua-Zhen; Chen, Hong-Xue; Yu, Qing; Hu, Jun; Li, Yan-Mei; Chen, Yong-Xiang*“Stereoselective synthesis of a phosphonate pThr mimetic via palladium-catalyzed gamma-C(sp(3))-H activation for peptide preparation.” Org. Biomol. Chem. 2019, 17, 2099-2102. Chen, Huai; Zhao, Yu-Fen; Chen, Yong-Xiang; Li, Yan-Mei*“Exploring the Roles of Post-Translational Modifications in the Pathogenesis of Parkinson's Disease Using Synthetic and Semisynthetic Modified alpha-Synuclein.” ACS. Chem. Neurosci., 2019, 10, 910-921. Wu J.J, Li W.H, Chen P. G, Zhang B.D, Hu H.G, Li Q.Q, Zhao L, Chen Y.X, Zhao Y.F, Li Y.M. *"Targeting STING with cyclic di-GMP greatly augmented immune responses of glycopeptide cancer vaccines" Chem.Commun, 2018,54,9655-9658. Li G, Yang W.Y, Zhao Y.F, Chen Y.X, Hong L*, Li Y.M.*"Differential Modulation of the Aggregation of N-Terminal Truncated A? using Cucurbiturils" Chem. Eur. J.2018, 24, 13647-13653. Chen H, Zhang Y, Li Q.Q, Zhao Y.F, Chen Y.X, Li Y.M*"De Novo Design To Synthesize Lanthipeptides Involving Cascade Cysteine Reactions: SapB Synthesis as an Example." J. Org. Chem. 2018,83,7528-7533. Gao N, Huang YP, Chu TT, Li QQ, Zhou B, Chen YX, Zhao YF, Li YM.* "TDP-43 specific reduction induced by Di-hydrophobic tags conjugated peptides."Bioorg Chem. 2018 Nov 27;84:254-259. doi: 10.1016/j.bioorg.2018.11.042. Chen H.X, Kang J, Chang R, Zhang Y.L, Duan H.Z, Li Y.M, Chen Y.X.* "Synthesis of α,α-Difluorinated Phosphonate pSer/pThr Mimetics via Rhodium-Catalyzed Asymmetric Hydrogenation of -Difluorophosphonomethyl α-(Acylamino)acrylates." Org. Lett. 2018,20,3278-3281. Hu J, Zhu P.C, Li Y.M, Chen Y.X.*"Synthesis of Ras proteins and their application in biofunctional studies."Chinese Chemical Letters.2018,29,1043-1050

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