焦雷 - 清华大学

个人简介

Lei Jiao was born in Beijing, China in January 1983. He obtained his BSc in chemistry in 2005 at Peking University, and continued to study synthetic and computational organic chemistry there in the lab of Prof. Zhi-Xiang Yu. In 2010, after receiving his PhD, he performed postdoctoral research in the Thorsten Bach group at the Department of Chemistry, Technical University Munich with the support of the Humboldt Fellowship. After a 3-year research stay in Germany, he started his independent career as a principle investigator at the Center of Basic Molecular Science (CBMS), Department of Chemistry at Tsinghua University in 2014, and he has been an associate professor with tenure since 2022.

研究领域

He is interested in mechanistic study on organic reactions, mechanism-based design and development of new reactions and catalytic systems, and their application in natural product synthesis. The research group is devoted to studying basic scientific problems in molecular transformation and solving challenging synthetic problems by rational design. At present, the major research areas include N-boryl pyridyl anion chemistry, novel ligand design, and synthesis of indole alkaloids.

近期论文

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Direct Observation of All Open-Shell Intermediates in a Photocatalytic Cycle.Jian-Qing Qi, Weiqun Suo, Jing Liu, Songtao Sun, Lei Jiao*, Xingwei Guo*March 2024 J. Am. Chem. Soc. 2024, doi:10.1021/jacs.3c14471. Direct Observation of All Open-Shell Intermediates in a Photocatalytic Cycle.Thio-Cyclopentene Ligands for Catellani-Type Reactions.Feng-Yuan Wang, Lei Jiao*January 2024 Encyclopedia of Reagents for Organic Synthesis (EROS), doi:10.1002/047084289X.rn02570. Thio-Cyclopentene Ligands for Catellani-Type Reactions.Unveiling the Mechanistic Role of Chiral Palladacycles in Pd(II)-Catalyzed Enantioselective C(sp3)-H Functionalization.Chen-Hui Yuan, Xiao-Xia Wang, Keyun Huang, Lei Jiao*January 2024 ChemRxiv 2024, doi:10.26434/chemrxiv-2024-1rw6m. Unveiling the Mechanistic Role of Chiral Palladacycles in Pd(II)-Catalyzed Enantioselective C(sp³)-H Functionalization.Direct Observation of Enamine-Derived Radicals with Time-Resolved Electron Paramagnetic Resonance.Shixue Zhang, Liang Cheng, Jian-Qing Qi, Zongbin Jia, Long Zhang, Lei Jiao*, Xingwei Guo*, Sanzhong Luo*January 2024 ChemRxiv 2024, doi:10.26434/chemrxiv-2024-r7hxq. Direct Observation of Enamine-Derived Radicals with Time-Resolved Electron Paramagnetic Resonance.Ligand-Enabled Palladium(II)-Catalyzed γ-C(sp3)−H Arylation of Primary Aliphatic Amines.Chen-Hui Yuan, Lei Jiao*January 2024 Org. Lett. 2024, 26, 29-34. Ligand-Enabled Palladium(II)-Catalyzed γ-C(sp³)−H Arylation of Primary Aliphatic Amines.4-Pyridyl Perfluoroalkyl Sulfide as a Practical Nucleophilic Perfluoroalkylation Reagent.Fei-Yu Zhou, Lei Jiao*December 2023 ChemRxiv 2023, doi:10.26434/chemrxiv-2023-l3lhp. 4-Pyridyl Perfluoroalkyl Sulfide as a Practical Nucleophilic Perfluoroalkylation Reagent.Time-Resolved Electron Paramagnetic Resonance Spectrometer Based on Ultrawide Single-Sideband Phase-Sensitive Detection.Shixue Zhang, Shengqi Zhou, Jian-Qing Qi, Lei Jiao, Xingwei Guo*August 2023 Rev. Sci. Instrum. 2023, 94, 084101. Time-Resolved Electron Paramagnetic Resonance Spectrometer Based on Ultrawide Single-Sideband Phase-Sensitive Detection.Modular Photoredox System with Extreme Reduction Potentials Based on Pyridine Catalysis.Lutao Bai, Lei Jiao*July 2023 Chem 2023, 9, 3245-3267. Xinyu Xu, Lei Jiao* "The Stereochemistry of the Reactions between Palladacycle Complexes and Primary Alkyl Iodides." Organometallics, 2023, DOI:10.1021/acs.organomet.3c00042. Chen-Hui Yuan, Xiao-Xia Wang, Lei Jiao* "Ligand-Enabled Pd(II)-Catalyzed Enantioselective β-C(sp3)-H Arylation of Aliphatic Tertiary Amides." Angew. Chem. Int. Ed. 2023, 62, e202300854. Feng-Yuan Wang, Yu-Xiu Li, Lei Jiao* "Functionalized Cycloolefin Ligand as a Solution to Ortho-Constraint in the Catellani-Type Reaction." J. Am. Chem. Soc. 2023, 145, 4871-4881. Fei-Yu Zhou, Lei Jiao* "Asymmetric Defluoroallylation of 4-Trifluoromethylpyridines Enabled by Umpolung C-F Bond Activation." Angew. Chem. Int. Ed. 2022, 61, e202201102. Ya-Xin Zheng, Lei Jiao* "Hybrid Cycloolefin Ligands for Palladium/Olefin Cooperative Catalysis." Nature Synthesis 2022, 1, 180-187. Dong Gao, Lei Jiao* "Divergent Synthesis of Indolenine and Indoline Ring Systems by Palladium-Catalyzed Asymmetric Dearomatization of Indoles." Angew. Chem. Int. Ed. 2022, 61, e202116024. Dong Gao, Lei Jiao* "Construction of Indoline/Indolenine Ring Systems by a Palladium-Catalyzed Intramolecular Dearomative Heck Reaction and the Subsequent Aza-Semipinacol Rearrangement." J. Org. Chem. 2021, 86, 5727-5743. Feng-Yuan Wang, Lei Jiao* "Total Synthesis of (-)-Arborisidine." Angew. Chem. Int. Ed. 2021, 60, 12732-12736. Fei-Yu Zhou, Lei Jiao* "Recent Developments in Transition-Metal-Free Functionalization and Derivatization Reactions of Pyridines." Synlett 2021, 32, 159-178. Tan-Hao Shi, Shuo Tong, Lei Jiao*, Mei-Xiang Wang* "A Theoretical Study on the Macrocyclic Strain of Zigzag Molecular Belts." Organic Materials 2020, 2, 300-305. Jian-Qing Qi, Lei Jiao* "DFT Study on the Mechanism of 4,4′-Bipyridine-Catalyzed Nitrobenzene Reduction by Diboron(4) Compounds." J. Org. Chem. 2020, 85, 13877-13885. Yu-Jie Wang, Chen-Hui Yuan, De-Zhao Chu, Lei Jiao* "Regiocontrol in the Oxidative Heck Reaction of Indole by Ligand-Enabled Switch of the Regioselectivity-Determining Step." Chem. Sci. 2020, 11, 11042-11054. Huan Yang, Li Zhang, Fei-Yu Zhou, Lei Jiao* "An Umpolung Approach to the Hydroboration of Pyridines: A Novel and Efficient Synthesis of N-H 1,4-Dihydropyridines." Chem. Sci. 2020, 11, 742-747. Li Zhang, Zhong-Qian Wu, Lei Jiao* "Photoinduced Radical Borylation of Alkyl Bromides Catalyzed by 4-Phenylpyridine." Angew. Chem. Int. Ed. 2020, 59, 2095-2099. Zongyang Li, Shiyang Xu, Baoliang Huang, Chenhui Yuan, Wenxu Chang, Bin Fu, Lei Jiao*, Peng Wang, Zhenhua Zhang* "Pd-Catalyzed Carbonylation of Acyl Azides." J. Org. Chem. 2019, 84, 9497-9508. Li Zhang, Lei Jiao* "Visible-Light-Induced Organocatalytic Borylation of Aryl Chlorides." J. Am. Chem. Soc. 2019, 141, 9124-9128. Xufang Liu, Wei Zhang, Yujie Wang, Ze-Xin Zhang, Lei Jiao*, Qiang Liu* "Cobalt-Catalyzed Regioselective Olefin Isomerization Under Kinetic Control." J. Am. Chem. Soc. 2018, 140, 6873-6882. Huan Yang, De-Zhao Chu, Lei Jiao* "Aromatization Modulates the Activity of Small Organic Molecules as Promoters for Carbon– Halogen Bond Activation." Chem. Sci. 2018, 9, 1534-1539. Yu-Jie Wang, Wei-Tang Li, Lei Jiao* "A Convenient Method for the Direct Acquisition of Kinetic Rate Data for Catalytic Organic Reactions by Gas Uptake Measurements." Asian J. Org. Chem. 2018, 7, 570-578. Hao-Yi Du, Si-Cong Chen, Xiao-Jun Su, Lei Jiao*, Ming-Tian Zhang* "Redox-Active Ligand Assisted Multielectron Catalysis: A Case of CoIII Complex as Water Oxidation Catalyst." J. Am. Chem. Soc. 2018, 140, 1557-1565. Li Zhang, Lei Jiao* "Super Electron Donors Derived from Diboron." Chem. Sci. 2018, 9, 2711-2722. Ze-Xin Zhang, Si-Cong Chen, Lei Jiao* "Asymmetric Total Synthesis of (+)-Minfiensine by an Asymmetric Cascade Cyclization Strategy." Synlett 2017, 28, 2199-2204. Huan Yang, Li Zhang, Lei Jiao* "N-Methylanilines as Simple and Efficient Promoters for Radical-Type Cross-Coupling Reactions of Aryl Iodides." Chem. – Eur. J. 2017, 23, 65-69. Li Zhang, Lei Jiao* "Pyridine-Catalyzed Radical Borylation of Aryl Halides." J. Am. Chem. Soc. 2017, 139, 607-610. Lei Jiao*, Kathrin Lang* "The 6th Sino–German Frontiers of Chemistry Symposium (Community Report)." Chem. - Asian. J. 2016, 11, 3292-3296. Li Zhang, Huan Yang, Lei Jiao* "Revisiting the Radical Initiation Mechanism of the Diamine-Promoted Transition-Metal-Free Cross-Coupling Reaction." J. Am. Chem. Soc. 2016, 138, 7151-7160. Ze-Xin Zhang, Si-Cong Chen, Lei Jiao* "Total Synthesis of (+)-Minfiensine: Construction of the Tetracyclic Core Structure by an Asymmetric Cascade Cyclization." Angew. Chem. Int. Ed. 2016, 55, 8090-8094. Lei Jiao, Thorsten Bach* "Regioselective Direct C-H Alkylation of NH Indoles and Pyrroles by a Palladium/Norbornene-Cocatalyzed Process" Synthesis 2014, 46, 35-41. Lei Jiao, Zhi-Xiang Yu* "Vinylcyclopropane Derivatives in Transition-Metal-Catalyzed Cycloadditions for the Synthesis of Carbocyclic Compounds." J. Org. Chem. 2013, 78, 6842-6848. Lei Jiao, Thorsten Bach* "Palladium-Catalyzed Direct C-H Alkylation of Electron-Deficient Pyrrole Derivatives" Angew. Chem. Int. Ed. 2013, 52, 6080-6083.