陈永湘 - 清华大学

个人简介

教育背景 2002 - 2007 清华大学化学系，博士 1998 - 2002 湖南大学化学化工学院，学士工作履历 2011 至今清华大学化学系，副教授 2007 - 2011 德国马普分子生理所，博士后（洪堡学者）奖励与荣誉 2022 第四届全国高校混合式教学设计创新大赛“设计之星”奖 2020 清华大学第九届青年教师教学大赛一等奖 2019 “中国青年化学家元素周期表”磷元素代言人 2019 国际蛋白质化学合成会议“Rising Star” 2018 中国国际多肽学术会议青年论文奖 2015 Asian Core Program/Advanced Research Network Lectureship Awards 学术兼职 2019.11至今 Bioorganic Chemistry (Elsevier) 编委 2022.04至今 Journal of Peptide Science (Wiley) 编委 2019.08至今中国生化制药工业协会多肽分会专业委员会委员 2023.02至今 International Chemical Biology Society Scientific Program Committee 委员

研究领域

Protein is the key player of tremendous life activities, which are achieved through the interaction network of protein with different biomolecules. Our research group have great interests in natural or artificial modifications on protein sequence composed of canonical amino acids, which endow it with largely expanded properties and function. Both mechanistic elucidation of natural modifications’ regulation and modulation of protein-biomolecules interaction for biomedical purpose urgently require structure-defined homogeneous modified proteins and peptides. We mainly focus on three research topics describes as follows.

近期论文

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Liu, D.; Liu, Y.; Duan, H.-Z.; Chen, X.; Wang, Y.; Wang, T.; Yu, Q.; Chen, Y.-X.*; Lu, Y.*, Customized synthesis of phosphoprotein bearing phosphoserine or its nonhydrolyzable analog. Synthetic and Systems Biotechnology 2023, 8 (1), 69-78. Duan, H.-Z.; Hu, C.; Li, Y.-L.; Wang, S.-H.; Xia, Y.; Liu, X.*; Wang, J.*; Chen, Y.-X.*, Genetically Encoded Phosphine Ligand for Metalloprotein Design. Journal of the American Chemical Society 2022, 14 (50), 22831-22837. Chang, R.; Chen, J.-L.; Zhang, G.-Y.; Li, Y.; Duan, H.-Z.; Luo, S.-Z.; Chen, Y.-X.*, Intrinsically Disordered Protein Condensate-Modified Surface for Mitigation of Biofouling and Foreign Body Response. Journal of the American Chemical Society 2022, 144 (27), 12147-12157. Chang, R.; Liu, Y.-J.; Zhang, Y.-L.; Zhang, S.-Y.; Han, B.-B.; Chen, F.*; Chen, Y.-X.*, Phosphorylated and Phosphonated Low-Complexity Protein Segments for Biomimetic Mineralization and Repair of Tooth Enamel. Advanced Science 2022, 9(6), 2103829. Wu, J.-J.; Chen, F.-Y.; Han, B.-B.; Zhang, H.-Q.; Zhao, L.; Zhang, Z.-R.; Li, J.-J.; Zhang, B.-D.; Zhang, Y.-N.; Yue, Y.-X.; Hu, H.-G.; Li, W.-H.; Zhang, B.*; Chen, Y.-X.*; Guo, D.-S.*; Li, Y.-M.*, CASTING: A Potent Supramolecular Strategy to Cytosolically Deliver STING Agonist for Cancer Immunotherapy and SARS-CoV-2 Vaccination. CCS Chemistry 2022, DOI: 10.31635/ccschem.022.202201859. Li, Y.; Chang, R.; Chen, Y.-X.*, Recent Advances in Post-polymerization Modifications on Polypeptides: Synthesis and Applications. Chemistry-an Asian Journal 2022, 17(14), e202200318. Hu, J.; Sun, X.-M.; Su, J.-Y.; Zhao, Y.-F.; Chen, Y.-X.*, Different phosphorylation and farnesylation patterns tune Rnd3-14-3-3 interaction in distinct mechanisms. Chemical Science 2021, 12 (12), 4432-4442. Zhu, P.-C.; Chen, Y.-X.*, Facile Synthesis of Boc-Protected Selenocystine and its Compatibility with Late-Stage Farnesylation at Cysteine Site. Protein and Peptide Letters 2021, 28 (6), 603-611. Li, F.-Y.; Zhang, Z.-F.; Voss, S.; Wu, Y.-W.; Zhao, Y.-F.; Li, Y.-M.; Chen, Y.-X.*, Inhibition of K-Ras4B-plasma membrane association with a membrane microdomain-targeting peptide. Chemical Science 2020, 11 (3), 826-832. Duan, H.-Z.; Nie, Z.-K.; Li, Y.; Chen, Y.-X.*, Unremitting progresses for phosphoprotein synthesis. Current Opinion in Chemical Biology 2020, 58, 96-111. Hackenberger, C. P. R.*; Dawson, P. E.*; Chen, Y.-X.*; Hojo, H.*, Modern Peptide and Protein Chemistry: Reaching New Heights. Journal of Organic Chemistry 2020, 85 (3), 1328-1330. Han, B.-B.; Pan, Y.-C.; Li, Y.-M.; Guo, D.-S.*; Chen, Y.-X.*, A host-guest ATP responsive strategy for intracellular delivery of phosphopeptides. Chemical Communications 2020, 56 (41), 5512-5515. Zhang, Y.-L.; Chang, R.; Duan, H.-Z.; Chen, Y.-X.*, Metal ion and light sequentially induced sol-gel-sol transition of a responsive peptide-hydrogel. Soft Matter 2020, 16 (33), 7652-7658. Duan, H.-Z.; Chen, H.-X.; Yu, Q.; Hu, J.; Li, Y.-M.; Chen, Y.-X.*, Stereoselective synthesis of a phosphonate pThr mimetic via palladium-catalyzed gamma-C(sp(3))-H activation for peptide preparation. Organic & Biomolecular Chemistry 2019, 17 (8), 2099-2102. Gao, N.; Huang, Y.-P.; Chu, T.-T.; Li, Q.-Q.; Zhou, B.; Chen, Y.-X.*; Zhao, Y.-F.; Li, Y.-M.*, TDP-43 specific reduction induced by Di-hydrophobic tags conjugated peptides. Bioorganic Chemistry 2019, 84, 254-259. Chen, H.-X.; Kang, J.; Chang, R.; Zhang, Y.-L.; Duan, H.-Z.; Li, Y.-M.; Chen, Y.-X.*, Synthesis of alpha,alpha-Difluorinated Phosphonate pSer/pThr Mimetics via Rhodium-Catalyzed Asymmetric Hydrogenation of beta-Difluorophosphonomethyl alpha-(Acylamino)acrylates. Organic Letters 2018, 20 (11), 3278-3281. Huang, S.-Q.; Han, B.-B.; Li, Y.-M.; Chen, Y.-X.*, A site-specific branching poly-glutamate tag mediates intracellular protein delivery by cationic lipids. Biochemical and Biophysical Research Communications 2018, 503 (2), 671-676. Hu, J.; Zhu, P.; Li, Y.; Chen, Y.-X.*, Synthesis of Ras proteins and their application in biofunctional studies. Chinese Chemical Letters 2018, 29 (7), 1043-1050. Yu, Q.; Sun, J.; Huang, S.; Chang, H.; Bai, Q.; Chen, Y.-X.*; Liang, D.*, Inward Budding and Endocytosis of Membranes Regulated by de Novo Designed Peptides. Langmuir 2018, 34 (21), 6183-6193. Zhang, S.-Y.; Sperlich, B.; Li, F.-Y.; Al-Ayoubi, S.; Chen, H.-X.; Zhao, Y.-F.; Li, Y.-M.; Weise, K.; Winter, R.*; Chen, Y.-X.*, Phosphorylation Weakens but Does Not Inhibit Membrane Binding and Clustering of K-Ras4B. ACS Chemical Biology 2017, 12 (6), 1703-1710. Kang, J.; Chen, H.-X.; Huang, S.-Q.; Zhang, Y.-L.; Li, F.-Y.; Li, Y.-M.; Chen, Y.-X.*, Facile synthesis of Fmoc-protected phosphonate pSer mimetic and its application in assembling a substrate peptide of 14-3-3 zeta. Tetrahedron Letters 2017, 58 (26), 2551-2553. Gao, N.; Chu, T. T.; Li, Q. Q.; Lim, Y. J.; Qiu, T.; Ma, M. R.; Hu, Z. W.; Yang, X. F.; Chen, Y.-X.*; Zhao, Y. F.; Li, Y. M.*, Hydrophobic tagging-mediated degradation of Alzheimer's disease related Tau. RSC Advances 2017, 7 (64), 40362-40366. Shi, L.; Chen, H.; Zhang, S. Y.; Chu, T. T.; Zhao, Y. F.; Chen, Y.-X.*; Li, Y. M.*, Semi-synthesis of murine prion protein by native chemical ligation and chemical activation for preparation of polypeptide--thioester. Journal of Peptide Science 2017, 23 (6), 438-444. Chu, T.-T.; Gao, N.; Li, Q.-Q.; Chen, P.-G.; Yang, X.-F.; Chen, Y.-X.*; Zhao, Y.-F.; Li, Y.-M.*, Specific Knockdown of Endogenous Tau Protein by Peptide-Directed Ubiquitin-Proteasome Degradation. Cell Chemical Biology 2016, 23 (4), 453-461. Li, L.; Zhang, S.-Y.; Li, Y.-M.; Chen, Y.-X.*, Dual-labeling of ubiquitin proteins by chemoselective reactions for sensing UCH-L3. Molecular Biosystems 2016, 12 (6), 1764-1767. He, Y.-H.; Li, Y.-M.; Chen, Y.-X.*, Phosphorylation regulates proteolytic efficiency of TEV protease detected by a 5(6)-carboxyfluorescein-pyrene based fluorescent sensor. Talanta 2016, 150, 340-345.