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个人简介

受教育经历 2002/04-2005/03,日本广岛大学,医齿药学综合研究科药学系药理学专业,博士; 2000/04-2002/03,日本广岛大学,医齿药学综合研究科药学系药理学专业,硕士; 1998/10-2000/03,日本广岛大学,医学研究科生命科学系药理学专业,研究生; 1991/09-1996/06,湖南中医学院,中医医疗一系五官科学专业,学士 研究工作经历 2009/04-至今,中南民族大学,药学院药理学研究室,教授 2005/04-2009/03,日本广岛大学,药学院药理学研究室,助理教授; 1996/07-1998/09,湖南省株洲市中医伤科医院,五官科,医师 1996年毕业于湖南中医学院(现更名湖南中医药大学),获医学学士学位;同年任湖南株洲市中医伤科医院五官科医师;1998年9月赴日本国立广岛大学医学部留学,于2005年3月,获博士(药学)学位;2005年4月至2009年3月任广岛大学药学部助理教授;在日本广岛大学任教期间,主持日本国家自然科学基金项目2项,并与NipponChemiphar、大鹏药品工业和协和发酵工业等几家主要药业公司合作开展扎托洛芬、紫杉醇等4项新药的研发工作。回国后主持完成包括国家自然科学基金项目在内的各级研究项目17项。多年来主要从事中西医结合科学领域的研究工作,自主开发了生肤油和降糖剂等多个产品,相关成果已获中国发明专利授权,并先后与上海新生源、广州无限极等公司合作开展了“OAGel注射液”及功能性油脂等产品的开发;在NanomedicineNBM、JournalofAgriculturalandFoodChemistry、InternationalJournalofNanomedicine、Neuropharmacology、ToxicologyResearch等期刊上发表论文60余篇,申报发明专利11项,其中7项已授权。 近年主持或参与的国家自然科学基金项目 1.平卧菊三七干预“β-catenin/COX-2”炎性环路的防治肝癌机制研究.2016年国家自然科学基金面上项目; 2.傣药帕崩板激活肠肝轴AMPK治疗酒精性肝病的机制研究.2014年国家自然科学基金青年项目; 3.生肤油促进Ⅲ度烫伤皮肤无瘢痕修复的机制研究。2013年国家自然科学基金面上项目; 4.Wnt/β-catenin信号通路调控原发性肝癌发生的机制研究.2011年国家自然科学基金青年项目; 5.非神经细胞对背根神经节神经细胞内P物质释放的调控机制。2010年国家自然科学基金面上项目;

研究领域

肝损伤机制及民族药物干预;皮肤创伤修复的民族药物药理学机制研究;慢性疼痛机制研究及民族药物干预等。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1.HuangXL,LiXJ,QinQF,LiYS,ZhangWK,TangHB*.Anti-inflammatoryandantinociceptiveeffectsofactiveingredientsintheessentialoilsfromGynuraprocumbens,atraditionalmedicineandanewandpopularfoodmaterial.JournalofEthnopharmacology.2019,239:111916.DOI:10.1016/j.jep.2019.111916 2.ChenMT,ZhangWK,LiangWL,LiYS,LiXJ,ZhuLH,TangHB*.Controllableandextra-fastsynthesisofbio-applicablesilvernanoparticleswithLyciumBarbarumL.MaterialsTechnology.2019,DOI:10.1080/10667857.2019.1603656 3.LiangWL,XiaoL,GuHW,LiXJ,LiYS,ZhangWK,TangHB*.Solidlipidnanoparticleinducedapoptosisofmacrophagesviaamitochondrial-dependentpathwayinvitroandinvivo.InternationalJournalofNanomedicine.2019,14:3283-3295. 4.LiXJ,HuangFZ,WanY,LiYS,ZhangWK,XiY,TianGH,TangHB*.LipopolysaccharideStimulatedtheMigrationofNIH3T3CellsThroughaPositiveFeedbackBetweenβ-CateninandCOX-2.FrontiersinPharmacology.2018,9:1487. 5.ChenXZ,ZhangWK,TangHB,LiXJ,TianGH,ShangHC,LiYS*.TheEthanolSupernatantExtractsofLiushenwanCouldAlleviateNanodiethylnitrosamine-InducedLiverCancerinMice.CanadianJournalofGastroenterologyandHepatology.2018,2018:6934809. 6.ZhangMT,YeXX,LanW,YangYL,WuT,LiYS*,TangHB.StrategicCombinationofIsocraticandGradientElutionforSimultaneousSeparationofPolarCompoundsinTraditionalChineseMedicinesbyHPLC.JournalofAnalyticalMethodsinChemistry.2018,2018:7569283. 7.LiXJ,MuYM,QinQF,ZengZX,LiYS,ZhangWK,TangHB*,TianGH,ShangHC.Chronichigh-dosagefishoilexacerbatesgut–liveraxisinjuryinalcoholicsteatohepatitisinmice:therolesofendotoxinandIL-4inKupffercellpolarizationimbalance.ToxicologyResearch.2017,6:611–620. 8.RazzaqueS,CaiC,LuQW,HuangFZ,LiYS,TangHB*,HussaindI,TanBE.Developmentoffunctionalizedhollowmicroporousorganiccapsulesencapsulatingmorphine–aninvitroandinvivostudy.JournalofMaterialsChemistryB.2017,5,742-749 9.ChenMT,YangYJ,LiYS,LiXJ,ZhangWK,WangJP,WangX,TianGH,TangHB*,ShangHC.ShengfuOilEnhancestheHealingofFull-ThicknessScaldedSkinAccompanyingtheDifferentialRegulationofβ-Catenin,Dlk1,andCOX-2.FrontiersinPharmacology.2017,8(801):1-10. 10.NingD,ZhangWK,TianH,LiXJ,LiuM,LiYS,TangHB.TheInvolvementofβ-Catenin/COX-2/VEGFAxisinNMDA-CausedRetinopathy.JournalofOphthalmology.2017,2017(9760501):1-12. 11.ZhangWK,GuHW,LiXJ,LiYS,TangHB*,TianGH,ShangHC.Thedarksideoftheforce-lipidnanoparticlesenhancetheoncogenesisofdiethylnitrosamineandresultinlivercancerinmice.Nanomedicine:Nanotechnology,Biology,andMedicine.2017,13(2):701-711. 12.RazzaqueS,CaiC,LuQW,HuangFZ,LiYS,TangHB*,HussaindI,TanB.Developmentoffunctionalizedhollowmicroporousorganiccapsulesencapsulatingmorphine–aninvitroandinvivostudy.JournalofMaterialsChemistryB.2017,5:742-749 13.TianGH,TaoSS,ChenMT,LiYS,LiYP,ShangHC,TangXY,ChenJX,TangHB*.Electroacupuncturetreatmentalleviatescentralpoststrokepainbyinhibitingbrainneuronalapoptosisandaberrantastrocyteactivation.NeuralPlasticity.2016,2016:1437148 14.ZhangWK,TaoSS,LiTT,LiYS,LiXJ,TangHB*,CongRH,MaFL,WanCJ.NutmegoilalleviateschronicinflammatorypainthroughinhibitionofCOX-2expressionandsubstancePreleaseinvivo.Food&NutritionResearch.2016,60:30849. 15.LiYS,LengCL,ChenMT,ZhangWK,LiXJ,TangHB*,ShangHC,ZhuLH.Mousehepaticneoplasmformationinducedbytracelevelandlowfrequencyexposuretodiethylnitrosaminethroughβ-cateninsignalingpathway.ToxicologyResearch.2016,5:210-223. 16.WanY,YangYJ,LiYS,LiXJ,ZhangW,LiuM,TangHB*.EffectsofSan-huang-sheng-fuoilonperipheralcirculatorydisordersandfootulcersindiabeticratsandthemechanisms.ZhonghuaShaoShangZaZhi.2016,32(3):168-75. 17.LiXJ,YangYJ,LiTT,LiYS,ZhangWK,TangHB*,α-Pinene,linalool,and1-octanolcontributetothetopicalanti-inflammatoryandanalgesicactivitiesoffrankincensebyinhibitingCOX-2.JournalofEthnopharmacology.2016,179:22-26. 18.LiXJ,MuYM,LiTT,YangYL,ZhangMT,LiYS,ZhangWK,TangHB*,ShangHC.Gynuraprocumbensreversesacuteandchronicethanol-inducedliversteatosisthroughMAPK/SREBP-1c-dependentand-independentpathways.JournalofAgriculturalandFoodChemistry.2015,63(38):8460-8471. 19.LiYS,XiY,LiXJ,LengCL,JiaMM,ZhangWK,TangHB*.Up-regulationofthebiosynthesisandreleaseofsubstancePthroughWnt/β-cateninsignalingpathwayinratdorsalrootganglioncells.PLoSOne.2015,10(6):e0129701. 20.ZhaoXJ,ChenQ,LiYS,TangHB,LiuW,YangXL.Doxorubicinandcurcuminco-deliverybylipidnanoparticlesforenhancedtreatmentofdiethylnitrosamine-inducedhepatocellularcarcinomainmice.EuropeanJournalofPharmaceuticsandBiopharmaceutics.2015,93:27-36. 21.ZhaoXJ,ChenQ,LiuW,LiYS,TangHB,LiuXHandYangXL.Co-deliveryofdoxorubicinandcurcuminwithlipidnanoparticlesresultsinimprovedefficacyofchemotherapyinlivercancer.InternationalJournalofNanomedicine.2015,10:257–270. 22.LiYS,ChenBF,LiXJ,ZhangWK,TangHB*.Cytotoxicityofpolyanilinenanomaterialonratceliacmacrophagesinvitro.PLoSOne.2014,9(9):e107361. 23.LiXJ,JiaMM,LiYS,YangYL,MaoXQ,TangHB.Involvementofsubstancep/neurokinin-1receptorintheanalgesicandanticanceractivitiesofminimallytoxicfractionfromthetraditionalChinesemedicineLiu-Shen-Waninvitro.BiolPharmBull.2014,37(3):431-438. 24.LiL,GuoQL,LiJ,YanW,LengCL,TangHB*,LuQW,TangBE.Designofapolymerligandfortheone-steppreparationofhighlystablefluorescentAg5clustersfortissuelabeling.JournalofMaterialsChemistryB.2013,1,3999-4004. 25.JiaMM,LiYS,PeiLJ,LiuM,LiXJ,TangHB*.EffectofSan-huang-sheng-fuoilonwoundsoffull-thicknessscaldinrabbits.ZhonghuaShaoShangZaZhi.2013,29(1):50-54. 26.LiYS,WangJX,JiaMM,LiuM,LiXJ,TangHB*.Dragon'sBloodInhibitsChronicInflammatoryandNeuropathicPainResponsesbyBlockingtheSynthesisandReleaseofSubstancePinRats.JournalofPharmacologicalSciences.2012,118:43-54. 27.LiYS,LiuM,NakataY,TangHB*.β-Cateninaccumulationinnucleiofhepatocellularcarcinomacellsup-regulatesglutathione-s-transferaseM3mRNA.WorldJournalofGastroenterology.2011,17:1772-1778.

学术兼职

2009年4月回国,任中南民族大学教授,兼职中国中医药信息研究会临床研究分会常务理事、湖北省药理学会理事、中国中药实验药理学学会委员、日本药理学会会员等。

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