李玉桑 - 中南民族大学

个人简介

1997年毕业于湖南中医学院（现更名湖南中医药大学）临床医疗专业；1999年3月赴日本国立广岛大学医学部留学，于2006年3月，获人体病理学专业博士（医学）学位；2006年4月至2009年3月日本国立广岛大学大学院医学部任博士研究员；2009年4月任中南民族大学副教授；2016年6月任中南民族大学教授。多年来主要从事肿瘤发生、发展的病理学机制及抗肿瘤药物的药理学基础理论研究及镇痛新药的研究开发工作。回国后主要开展原发性肝癌发生、发展的病理学机制探讨及抗肝癌药物的药理学研究，主持或参与包括国家自然科学基金在内项目等十余项，并在NanomedicineNBM、ToxicologyResearch、JournalofAgriculturalandFoodChemistry、InternationalJournalofNanomedicine、Neuropharmacology等国际或国内学术刊物上发表了40余篇研究论文，获国家发明专利6项。奖励一等奖，论文题名“浸潤性微小乳頭癌的淋巴行性转移及血管新生因子的表达”；第13届日本乳腺癌学术总会，2005；一等奖，论文题名“ThereversedapicalpatternofMUC1expressionischaracteristicsofinvasivemicropapillarycarcinomaofthebreast”；第8届日本乳腺癌学会优秀论文奖，2007 近年主持或参与的国家自然科学基金项目 1.平卧菊三七干预“β-catenin/COX-2”炎性环路的防治肝癌机制研究.2016年国家自然科学基金面上项目； 2.电针对CPSP大鼠星形胶质细胞介导的Wnt/β-catenin信号通路调控作用.2016年国家自然科学基金面上项目 3.六神丸干预“β-catenin与COX-2环路”的镇癌痛机制研究.2015年国家自然科学基金面上项目； 4.基于Wnt/β-catenin靶点的益气活血方抗糖尿病视网膜病变作用机制研究。2012年国家自然科学基金青年项目； 5.Wnt/β-catenin信号通路调控原发性肝癌发生的机制研究.2011年国家自然科学基金青年项目； 6.非神经细胞对背根神经节神经细胞内P物质释放的调控机制。2010年国家自然科学基金面上项目；

研究领域

肿瘤形成的病理学机制及抗肿瘤药物的干预研究；肝损伤机制及民族药物干预

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.HuangXL,LiXJ,QinQF,LiYS*,ZhangWK,TangHB.Anti-inflammatoryandantinociceptiveeffectsofactiveingredientsintheessentialoilsfromGynuraprocumbens,atraditionalmedicineandanewandpopularfoodmaterial.JournalofEthnopharmacology.2019,239:111916.DOI:10.1016/j.jep.2019.111916 2.ChenMT,ZhangWK,LiangWL,LiYS,LiXJ,ZhuLH,TangHB.Controllableandextra-fastsynthesisofbio-applicablesilvernanoparticleswithLyciumBarbarumL.MaterialsTechnology.2019,DOI:10.1080/10667857.2019.1603656 3.LiangWL,XiaoL,GuHW,LiXJ,LiYS,ZhangWK,TangHB.Solidlipidnanoparticleinducedapoptosisofmacrophagesviaamitochondrial-dependentpathwayinvitroandinvivo.InternationalJournalofNanomedicine.2019,14:3283-3295. 4.LiXJ,HuangFZ,WanY,LiYS,ZhangWK,XiY,TianGH,TangHB.LipopolysaccharidestimulatedthemigrationofNIH3T3Cellsthroughapositivefeedbackbetweenβ-cateninandCOX-2.FrontiersinPharmacology.2018,9:1487. 5.QinQF,LiuM,TianGH,ChenJ,LiYS*.Extractofthebloodcirculation-promotingrecipe-84canprotectratretinasbyinhibitingthebeta-cateninsignalingpathway.InternationalJournalofMolecularSciences.2018,19:2712. 6.ChenXZ,ZhangWK,TangHB,LiXJ,TianGH,ShangHC,LiYS*.TheethanolsupernatantextractsofLiushenwancouldalleviatenanodiethylnitrosamine-inducedlivercancerinmice.CanadianJournalofGastroenterologyandHepatology.2018,2018:6934809. 7.ZhangMT,YeXX,LanW,YangYL,WuT,LiYS*,TangHB.StrategiccombinationofisocraticandgradientelutionforsimultaneousseparationofpolarcompoundsintraditionalChinesemedicinesbyHPLC.JournalofAnalyticalMethodsinChemistry.2018,2018:7569283. 8.LiXJ,MuYM,QinQF,ZengZX,LiYS,ZhangWK,TangHB*,TianGH,ShangHC.Chronichigh-dosagefishoilexacerbatesgut–liveraxisinjuryinalcoholicsteatohepatitisinmice:therolesofendotoxinandIL-4inKupffercellpolarizationimbalance.ToxicologyResearch.2017,6:611–620. 9.RazzaqueS,CaiC,LuQW,HuangFZ,LiYS,TangHB*,HussaindI,TanBE.Developmentoffunctionalizedhollowmicroporousorganiccapsulesencapsulatingmorphine–aninvitroandinvivostudy.JournalofMaterialsChemistryB.2017,5,742-749 10.ChenMT,YangYJ,LiYS,LiXJ,ZhangWK,WangJP,WangX,TianGH,TangHB*,ShangHC.ShengfuOilEnhancestheHealingofFull-ThicknessScaldedSkinAccompanyingtheDifferentialRegulationofβ-Catenin,Dlk1,andCOX-2.FrontiersinPharmacology.2017,8(801):1-10. 11.NingD,ZhangWK,TianH,LiXJ,LiuM,LiYS*,TangHB.TheInvolvementofβ-Catenin/COX-2/VEGFAxisinNMDA-CausedRetinopathy.JournalofOphthalmology.2017,2017(9760501):1-12. 12.ZhangWK,GuHW,LiXJ,LiYS*,TangHB,TianGH,ShangHC.Thedarksideoftheforce-lipidnanoparticlesenhancetheoncogenesisofdiethylnitrosamineandresultinlivercancerinmice.Nanomedicine:Nanotechnology,Biology,andMedicine.2017,13(2):701-711. 13.ZhangWK,TaoSS,LiTT,LiYS,LiXJ,TangHB,CongRH,MaFL,WanCJ.NutmegoilalleviateschronicinflammatorypainthroughinhibitionofCOX-2expressionandsubstancePreleaseinvivo.Food&nutritionresearch.2016,60:30849. 14.LiYS,LengCL,ChenMT,ZhangWK,LiXJ,TangHB,ShangHC,ZhuLH.Mousehepaticneoplasmformationinducedbytracelevelandlowfrequencyexposuretodiethylnitrosaminethroughβ-cateninsignalingpathway.ToxicologyResearch.2016,5:210-223. 15.WanY,YangYJ,LiYS,LiXJ,ZhangW,LiuM,TangHB.EffectsofSan-huang-sheng-fuoilonperipheralcirculatorydisordersandfootulcersindiabeticratsandthemechanisms.ZhonghuaShaoShangZaZhi.2016,32(3):168-75. 16.LiXJ,YangYJ,LiTT,LiYS,ZhangWK,TangHB,α-Pinene,linalool,and1-octanolcontributetothetopicalanti-inflammatoryandanalgesicactivitiesoffrankincensebyinhibitingCOX-2.JournalofEthnopharmacology.2016,179:22-26. 17.YangYL,YeXX,LiYS*,JiangJZ.Determinationofmorphineinpharmaceuticalproductsbyon-linesolid-phaseextractionandhigh-performanceliquidchromatography.AnalyticalLetters.2016,49(9):1303-1309. 18.LiXJ,MuYM,LiTT,YangYL,ZhangMT,LiYS,ZhangWK,TangHB,ShangHC.Gynuraprocumbensreversesacuteandchronicethanol-inducedliversteatosisthroughMAPK/SREBP-1c-dependentand-independentpathways.JournalofAgriculturalandFoodChemistry.2015,63(38):8460-8471. 19.LiYS,XiY,LiXJ,LengCL,JiaMM,ZhangWK,TangHB.Up-regulationofthebiosynthesisandreleaseofsubstancePthroughWnt/β-cateninsignalingpathwayinratdorsalrootganglioncells.PLoSOne.2015,10(6):e0129701. 20.ZhaoXJ,ChenQ,LiYS*,TangHB,LiuW,YangXL.Doxorubicinandcurcuminco-deliverybylipidnanoparticlesforenhancedtreatmentofdiethylnitrosamine-inducedhepatocellularcarcinomainmice.EuropeanJournalofPharmaceuticsandBiopharmaceutics.2015,93:27-36. 21.ZhaoXJ,ChenQ,LiuW,LiYS*,TangHB,LiuXHandYangXL.Co-deliveryofdoxorubicinandcurcuminwithlipidnanoparticlesresultsinimprovedefficacyofchemotherapyinlivercancer.InternationalJournalofNanomedicine.2015,10:257–270. 22.LiYS,ChenBF,LiXJ,ZhangWK,TangHB.Cytotoxicityofpolyanilinenanomaterialonratceliacmacrophagesinvitro.PLoSOne.2014,9(9):e107361. 23.LiXJ,JiaMM,LiYS*,YangYL,MaoXQ,TangHB.Involvementofsubstancep/neurokinin-1receptorintheanalgesicandanticanceractivitiesofminimallytoxicfractionfromthetraditionalChinesemedicineLiu-Shen-Waninvitro.BiolPharmBull.2014,37(3):431-438. 24.XiY,LiYS*,TangHB.HighmobilitygroupA1proteinactsasanewtargetofNotch1signalingandregulatescellproliferationinTleukemiacells.MolCellBiochem.2013,374:173-180. 25.JiaMM,LiYS,PeiLJ,LiuM,LiXJ,TangHB.EffectofSan-huang-sheng-fuoilonwoundsoffull-thicknessscaldinrabbits.ZhonghuaShaoShangZaZhi.2013,29(1):50-54. 26.LiYS,WangJX,JiaMM,LiuM,LiXJ,TangHB.Dragon'sBloodInhibitsChronicInflammatoryandNeuropathicPainResponsesbyBlockingtheSynthesisandReleaseofSubstancePinRats.JournalofPharmacologicalSciences.2012,118:43-54. 27.LiYS,LiuM,NakataY,TangHB.β-Cateninaccumulationinnucleiofhepatocellularcarcinomacellsup-regulatesglutathione-s-transferaseM3mRNA.WorldJournalofGastroenterology.2011,17:1772-1778.