杨小龙 - 中南民族大学

个人简介

教育及工作经历 2019.3-至今中南民族大学药学院，教授/博士生导师 2019.9-至今广西科学院客座研究员 2018.9-至今中国科学院西北高原生物所客座研究员 2018.5-至今中国科学院藏药研究重点实验室客座研究员 2016.2-2019.2 重庆大学药学院，入选重庆大学“百人计划”学者，研究员/博士生导师 2014.5-2015.5 德国莱布尼茨汉诺威大学，博士后，合作导师:Prof.RussellJ.Cox 2012.4-2014.4 日本东京大学药学院，日本学术振兴会特别研究员，合作导师:Prof.IkuroAbe 2009.9-2012.4 河北大学药学院任职，副教授/硕士生导师 2004.9-2009.7 中科院昆明植物研究所，理学博士，导师：刘吉开教授 2000.9-2004.7 西北农林科技大学，理学学士教学工作参与编写“十三五”规划教材《天然产物结构解析》1部。共承担多门课程教学工作，本科生课程包括：《天然药物化学》、《天然药物化学实验》、《药理学实验》、《生理解剖学实验》和《药剂学实验》；研究生课程包括：《高等天然药物化学》和《高等有机化学》。已指导多名本科生完成国家级等大学生创新训练项目和荣获校级优秀毕业论文。已指导多名研究生荣获多种奖励和荣誉。研究领域 1、民族特色药物的药效物质基础及作用机制研究 2、药用植物内生真菌化学与功能研究 3、真菌天然产物生物合成途径和机制研究科研项目主持包括国家自然科学基金(面上和青年)、省部级和横向等10余项课题，其中国家级项目为： [1]表观遗传修饰策略驱动的11株植物内生真菌中新型抗耐药菌活性分子合成潜能的挖掘(81872755)，国家自然科学基金面上项目，直接经费57万元，2019.01-2022.12，主持，在研。 [2]拟盘多毛孢内生真菌中抗肿瘤活性先导化合物的发现及活性评价(21202033)，国家自然科学青年基金，25万元，2013.01-2015.12，主持，已结题。获奖及荣誉 2015:获得重庆大学“百人计划”学者 2012:获得日本振兴学会外国特别研究员 2008:获得中国科学院朱李月华优秀博士奖学金 2006:获得中国科学院西部学子一等奖学金

研究领域

真菌化学与合成生物学

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

[1]Xiao-LongYang,SteffenFriedrich,SenYin,OliverPiech,KatherineWilliams,ThomasJ.Simpson,RussellJ.Cox*.Molecularbasisofmethylationandchain-lengthprogramminginafungaliterativehighlyreducingpolyketidesynthase.ChemicalScience,2019,10:8478–8489.（Nature指数收录） [2]Lu-LinXu#,Hai-LiChen#,PingHai,YuanGao,Chuan-DongXie,Xiao-LongYang*,IkuroAbe*.(+)-and(−)-PreuisolactoneA:Apairofcagednorsesquiterpenoidalenantiomerswithatricyclo[4.4.01,6.02,8]decanecarbonskeletonfromtheendophyticfungusPreussiaisomera.OrganicLetters,2019,21:1078−1081.（Nature指数收录） [3]Lu-LinXu,PingHai,Shuai-BingZhang,Jing-FangXiao,YuanGao,Bing-JiMa,Hai-YanFu*,Ye-MiaoChen*,Xiao-LongYang*.PrenylatedIndoleDiterpeneAlkaloidsfromaMineSoil-derivedTolypocladiumsp.JournalofNaturalProducts,2019,82:221-231. [4]Heng-YeChen#,Ting-KaiLiu#,JianYang*,Xiao-LongYang*.EmeronesA-C:ThreenovelmerosesquiterpenoidswithunprecedentedskeletonsfromEmericellasp.XL029.Organic&BiomolecularChemistry,2019,17:8450-8455. [5]Heng-YeChen,Ting-KaiLiu,QiongShi,Xiao-LongYang*.SesquiterpenoidsandditerpeneswithantimicrobialactivityfromLeptosphaeriasp.XL026,anendophyticfungusinPanaxnotoginseng.Fitoterapia,2019,137:104243. [6]WeiZhao,Hai-LiChen,LiuHong,XiaZhang,Xian-JunJiang,Dong-LaiZhu*,FeiWang*,Xiao-LongYang*.FivenewpolyphenolicderivativeswithantimicrobialactivitiesfromtherootbarksofPeriplocasepium.Fitoterapia,2019,137:104254. [7]XiaZhang,Hai-LiChen,LiuHong,Lu-LinXu,Xiao-WeiGong,Dong-LaiZhu,Xiao-HuaXu,WeiZhao*,FeiWang*,Xiao-LongYang*.Threenewhopane-typetriterpenoidsfromtheaerialpartofAdiantumcapillus-venerisandtheirantimicrobialactivities.Fitoterapia,2019,133:146-149. [8]DanXu,XiaZhang,XiongShi,Peng-JieXian,LiuHong,Yan-DuoTao*,Xiao-LongYang*.Twonewcytochalasansfromthemarinesediment-derivedfungusWesterdykelladispersaandtheirantibacterialactivities.PhytochemistryLetters,2019,32:52-55. [9]Lu-LinXu#,Xue-JiaoPang#,XiongShi,Peng-JieXian,Hai-LiChen,Deng-FengYang*,Xiao-LongYang*.TwonewprenylatedindolediterpenoidsfromTolypocladiumsp.XL115andtheirantimicrobialactivities.Chemistry&Biodiversity,2019,16:e1900116. [10]Wen-TingZhao#,XiongShi#,Peng-JieXian,ZhangFeng*,JianYang*,Xiao-LongYang*.AnewfusicoccanediterpeneandanewpolyenefromtheplantendophyticfungusTalaromycespinophilusandtheirantimicrobialactivities.NaturalProductResearch,2019,doi:10.1080/14786419.2019.1616727. [11]Sheng-XiangYang#,Wen-TingZhao#,Heng-YeChen,LeiZhang,Ting-KaiLiu,He-PingChen*,JianYang*,Xiao-LongYang*.TwonewC13-polyketidesfromChaetomiumglobosum,anendophyticfungusinSalviamiltiorrhiza.Chemistry&Biodiversity,2019,16:e1900364. [12]TingZhao,Lu-LinXu,YanZhang,Zheng-HongLin,TaoXia,Deng-FengYang*,Ye-MiaoChen*,Xiao-LongYang*.Threenewα-pyronederivativesfromtheplantendophyticfungusPenicilliumochrochlorontheandtheirantibacterial,antifungalandcytotoxicactivities.JournalofAsianNaturalProductsResearch,2019,21:851-858. [13]WeiZhao,Xiao-WeiGong,Yuan-XingDuan,JiYang,XiaWu,Xian-JunJiang,Xiao-HuaXu,Yong-KuanChen,LiuYang*,FeiWang*,Xiao-LongYang*.TwonewtriterpenoidswithantimicrobialactivityfromtheleavesandtwigsofOropheayunnanensis.NaturalProductResearch,2019,33:3472-3477. [14]LeYu,LingDong,YangWang,LiuLiu,HuaLong,HuiLi,Jin-PingLi,Xiao-LongYang,Zhao-JianLiu,Guang-JieDuan,Xiao-TianDai,Zheng-HongLin∗.ReversibleregulationofSATB1ubiquitinationbyUSP47andSMURF2mediatescoloncancercellproliferationandtumorprogression.CancerLetters,2019,448:40-51. [15]Xue-JiaoPang,Shuai-BingZhang,Peng-JieXian,XiaWu,Deng-FengYang*,Hai-YanFu*,Xiao-LongYang*.EmericellinsAandB:Twosesquiterpenoidswithanunprecedentedtricyclo[4,4,2,1]hendecanescaffoldfromtheliquidculturesofendophyticfungusEmericellasp.XL029.Fitoterapia,2018,131:55-58. [16]WeiZhao,Lu-LinXu,XiaZhang,Xiao-WeiGong,Dong-LaiZhu,Xiao-HuaXu,FeiWang*,Xiao-LongYang*.ThreenewphenanthreneswithantimicrobialactivitiesfromtheaerialpartsofJuncuseffuses.Fitoterapia,2018,130:247-250. [17]XiaWu,Xue-JiaoPang,Lu-LinXu,Qiong-YinZhang,Xin-YuLong,Hai-LiQin,Deng-FengYang*,Xiao-LongYang*.TwonewalkylatedfuranderivativeswithantifungalandantibacterialactivitiesfromtheplantendophyticfungusEmericellasp.XL029.NaturalProductResearch,2018,32:2625-2631. [18]Xue-JiaoPang#,Shuai-BingZhang#,Hai-LiChen,Wen-TingZhao,Deng-FengYang,Peng-JieXian,Lu-LinXu,Yan-DuoTao*,Hai-YanFu*,Xiao-LongYang*.EmericelactonesA-D:FournovelpolyketidesproducedbyEmericellasp.XL029,afungusassociatedtheleavesofPanaxnotoginseng.TetrahedronLetters,2018,59:4566-4570. [19]LiuLiu,HuaLong,YanWu,HuiLi,LingDong,Ju-Lia,LiZhong,Zhao-JianLiu,Xiao-LongYang,LeiShi,Mao-ZhiRen,Zheng-HongLin.HRD1-mediatedPTENdegradationpromotescellproliferationandhepatocellularcarcinomaprogression.CellularSignalling,2018,50:90-99. [20]DanXu,Ming-HeLuo,Feng-LouLiu,DongWang,Xue-JiaoPang,TingZhao,Lu-LinXu,XiaWu,Ming-YuXia*,Xiao-LongYang*.Cytochalasanandtyrosine-derivedalkaloidsfromthemarinesediment-derivedfungusWesterdykelladispersaandtheirbioactivities.ScientificReports,2017,7:11956-11964. [21]XiaWu,Li-ZhenFang,Feng-LouLiu,Xue-JiaoPang,Hai-LiQin,TingZhao,Lu-LinXu,Deng-FengYang,Xiao-LongYang*.Newprenylxanthones,polyketidehemiterpenoidpigmentsfromtheendophyticfungusEmericellasp.XL029andtheiranti-agriculturalpathogenicfungalandantibacterialactivities.RSCAdvances,2017,7,31115-31122. [22]DanXu,Xue-JiaoPang,TingZhao,Lu-Lin,Xiao-LongYang*.Newalkenylatedtetrahydropyranderivativesfromthemarinesediment-derivedfungusWesterdykelladispersaandtheirbioactivities.Fitoterapia,2017,122:45-51. [23]Feng-LouLiu,andXiao-LongYang*.IndolederivativesproducedbythemetagenomegenesoftheEscherichiacoli-harboringmarinespongeDiscodermiacalyx.Molecules,2017,22:681.

学术兼职

兼任广西科学院客座研究员（2019.9-至今）兼任中国科学院藏药研究重点实验室客座研究员（2018.5-至今）兼任中国科学院西北高原生物所客座研究员（2018.9-至今）担任中国菌物学会菌物化学专业委员会委员（2018.7-至今）担任中国抗癌协会肿瘤代谢专业委员会委员（2019.1-至今）担任广西海洋天然产物与组合生物合成化学重点实验室学术委员会委员（2018.10-至今）担任河北省自然科学奖励评审专家（2018.4-至今）担任国际期刊DrugDiscoveries&Therapeutics编委（2018.1-至今）兼任重庆市紫杉烷类药物工程技术研究中心专家委员会副主任（2016.10-至今）曾担任重庆大学药学院党委委员和教工党支部书记（2016.12-2019.3）曾担任重庆大学药学院药物分析、药物设计与天然药物学系副主任（2018.10-2019.3）