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个人简介

张炼辉,男,博士,教授,世界微生物群体感应主要研究者,被认为是该研究领域的奠基者之一(oneofthecofounders),首次用转基因植物证明利用淬灭群体感应信号防治病害的可能性,并首次提出群体淬灭(QuorumQuenching)防治病害的新概念,对病原细菌的QS系统、TCS系统中的信号反应、信号传导和致病性调控机理等方面,进行了深入系统的研究,发表SCI论文85篇,影响因子(impactfactor)大于9的论文13篇,其中,Nature2篇(1篇为第一作者,1篇为通讯作者),NatureBiotechnology(第一作者)及NatureChemicalBiology(通讯作者)各一篇,PNAS6篇。被SCI学术论文它引(citedtimes)3500次以上。

研究领域

世界微生物群体感应

近期论文

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Wang C, Ye F, Kumar V, Gao YG, Zhang LH* (2014) BswR controls bacterial motility and biofilm formation in Pseudomonas aeruginosa through modulation of the small RNA rsmZ. Nucleic Acids Research 42, 4563-4576 (IF = 8.278). Lee J, Wu J, Deng Y, Wang J, Wang C, Wang JH, Chang CQ, Dong Y, Williams P, Zhang LH* (2013) A cell-cell communication signal integrates quorum sensing and stress response. Nature Chem Biol 9, 339-343 (IF = 12.948). Fan H, Dong Y, Wu D, Bowler MW, Zhang LH*, Song H* (2013) QslA disrupts LasR dimerization in antiactivation of bacterial quorum sensing. PNAS 110, 20765-20770 (IF = 9.737). Deng YY, Wu J, Tao F, Zhang LH* (2011) Listening to a New Language: DSF-Based Quorum Sensing in Gram-Negative Bacteria. Chem Rev 111, 160-73 (IF = 41.298). Deng Y, Schmid N, Wang C, Wang J, Pessi G, Wu D, Lee J, Aguilar C, Ahrens CH, Chang C, Song H, Eberl L*, Zhang LH* (2012) Cis-2-dodecenoic acid receptor RpfR links quorum sensing signal perception with regulation of virulence through cyclic dimeric quanosine monophosphate turnover. PNAS 109, 15479-15484 (IF = 9.737).

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