个人简介
2017- Academician of the Chinese Academy of Sciences
1999-present Professor, Nanjing University
2001-2005 Cheung Kong Professor, Ministry of Education
1996-1999 Research Associate, University of Edinburgh, UK
1996-1996 Visiting Scientist, University of British Columbia, Canada
1994-1996 Post-doctoral Research Fellow, University of London, Birkbeck College, UK
1989-1994 PhD Student, University of Padua, Italy
郭子建，博士生导师，中国科学院院士，英国皇家化学会会士。现任南京大学化学和生物医药创新研究院院长，南京大学新生学院院长，南京大学学术委员会副主任，配位化学国家重点实验室（南京大学）学委会副主任，国务院学位委员会学科评议组（化学）成员，教育部科技委员会委员化学化工学部委员，中国化学会常务理事。担任爱思唯尔CoordChem Rev副主编，中国化学会《无机化学学报》主编，以及NatSci Rev, Dalton Trans等国内外多家学术期刊编委或顾问编委等。曾主持多项国家自然科学基金重点项目，科技部973计划重大科学前沿领域项目（首席科学家），国家自然科学基金委创新群体（学术带头人），得到国家基金委化学生物学领域首个重大研究计划培育、集成及择优项目的连续资助以及多项国家自然科学基金重点项目。曾获教育部2015年度自然科学一等奖，意大利化学会2016年度Luigi Sacconi奖章，2020年度“亚洲生物无机化学学会杰出成就奖”等奖项。团队长期从事化学生物学交叉领域研究，在生物无机传感与成像示踪、金属抗肿瘤药物的分子作用机制与靶向输运及金属人工核酸酶等方面取得了系列创新性研究成果，已发表SCI论文300余篇，被引用1.9万次,H指数70。
研究领域
Metal-based Antitumor Agents and Artificial Nucleases
Platinum-based anticancer drugs play critical role in the treatment of many different malignancies. However, there is a huge scope in further rational design of these complexes to overcome the side effects, resistance and toxicities which often accompanying the chemotherapy. Metal-based artificial nucleases provide much diverse DNA cleavage abilities and activities, and can be applied in modern biotechnology and medicine. In this context, our research work focuses on the design of metal complexes with novel structural features and reactivities. Transitional metals such as platinum, palladium, nickel, copper and zinc are employed in these studies.
Targeting and delivery (DTD) strategies can be used to prevent the above mentioned shortcomings of platinum-based chemotherapy. Our approaches include conjugation of platinum drugs with selective targeting moieties or encapsulation of platinum drugs in host molecules or particles to achieve enhanced permeability and retention effect in tumour tissues. For example, bis-phosphonates, peptides, proteins and nanoparticles are commonly used in targeting and delivery studies.
Metal-Biomolecule Interactions
Metal complexes exert their biological effects and activities by interacting biomolecules such as DNA and proteins. For example, the anticancer efficacy of platinum anticancer drugs was achieved by their interaction with DNA without being deactivated by cellular proteins. Metal induced b-amyloid aggregations are potentially associated with Alzheimer’s disease, and this why metal chelators can have a role in the therapy of the disease by eliminate excessive causative metals. In these aspects, we have been investigating the role of metals and metal complexes in their DNA and protein interactions and recognitions. These studies are important for the understanding of the mechanism of action of metal-based biological and medicinal agents.
Fluorescent Imaging and Phototherapy
Coordination chemistry plays an essential role in the design of photoluminescent probes for biological inorganic species. Metal coordination-induced alteration or nucleophilic addition of small molecule is essential for the development of fluorescent sensors for these species. Related applications in photoluminescent sensing and detection. We have been recently developed a variety of fluorescent sensors which can be used for the detection of biologically essential metal ions, environmentally toxic heavy metals, inorganic drug species, DNA nucleases, and small signaling inorganic molecules.Photophysical and photochemical processes could also be adopted for photobased therapy such as PDT, PTT.
近期论文
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Hao Yuan; Zhong Han; Yuncong Chen*; Fen Qi; Hongbao Fang; ZijianGuo*; Shuren Zhang; Weijiang He*; FerroptosisPhotoinduced by New Cyclometalated Iridium (III) Complexes and Its Synergism with Apoptosis in Tumor Cell Inhibition, Angew. Chem. Int. Ed., 2021, 60, 8174;
Yuming Zhang, Wenxuan Zhao, Yuncong Chen,* Hao Yuan, Hongbao Fang, Shankun Yao, Changli Zhang, Hongxia Xu, Nan Li, Zhipeng Liu, ZijianGuo,* Qingshun Zhao,* Yong Liang, and Weijiang He*，Rational Construction of a Reversible Arylazo-based NIR Probe for Cycling Hypoxia Imaging in vivo，Nat. Commun., 2021, 12，2772;
SuxingJin; Nafees Muhammad; Yuewen Sun; Yehong Tan; Hao Yuan; Dongfan Song; ZijianGuo*; Xiaoyong Wang*; Multispecific Platinum(IV) Complex Deters Breast Cancer via Interposing Inflammation and Immunosuppression as an Inhibitor of COX-2 and PD-L1, Angew. Chem. Int. Ed., 2020, 59, 23313;
Shuren Zhang; XuanmengZhong; Hao Yuan; Yan Guo; Dongfan Song; Fen Qi; Zhenzhu Zhu; Xiaoyong Wang*; ZijianGuo*; Interfering in apoptosis and DNA repair of cancer cells to conquer cisplatin resistance by platinum(iv) prodrugs, Chem. Sci., 2020, 11, 3829;
Qixin Chen; Hongbao Fang; Xintian Shao; Zhiqi Tian; ShanshanGeng; Yuming Zhang; Huaxun Fan; Pan Xiang; Jie Zhang; Xiaohe Tian; Kai Zhang*; Weijiang He*; ZijianGuo*; JiajieDiao*; A dual-labeling probe to track functional mitochondria–lysosome interactions in live cells, Nat. Commun., 2020, 11, 6290;
XulingXue;Chenggen Qian; Qin Tao;Yuanxin Dai;MengdiLv;Jingwen Dong;Zhi Su; Yong Qian; Jing Zhao*;Hongke Liu*;ZijianGuo*; Using bioorthogonally catalyzed lethality strategy to generate mitochondria-targeting antitumor metallodrugs in vitro and in vivo,Nat. Sci. Rev., doi.org/10.1093/nsr/nwaa286;
Zhongyan Chen, Xueling Mu, Zhong Han, Shiping Yang*, Changli Zhang, ZijianGuo*, Yang Bai, Weijiang He* An Optical/Photoacoustic Dual-Modality Probe: Ratiometric in/ex Vivo Imaging for Stimulated H2S Upregulation in Mice. J. Am. Chem. Soc., 2019, 141, 17973;
XulingXue; Chenggen Qian; Hongbao Fang; Hong-Ke Liu*; Hao Yuan; ZijianGuo*; Yang Bai; Weijiang He*;Photoactivated Lysosomal Escape of a Monofunctional Pt-II Complex Pt-BDPA for Nucleus Access, Angew. Chem. Int. Ed.,2019, 58, 12661;
Kun Wang; Chengcheng Zhu; Yafeng He; Zhenqin Zhang; Wen Zhou; Nafees Muhammad; Yan Guo; Xiaoyong Wang*; ZijianGuo*; Restraining Cancer Cells by Dual Metabolic Inhibition with a Mitochondrion-Targeted Platinum(II) Complex, Angew. Chem. Int. Ed., 2019, 58, 4638;
Zhenzhu Zhu; Zenghui Wang; Changli Zhang; Yanjun Wang; Hongmei Zhang; ZhenjiGan; ZijianGuo*; Xiaoyong Wang*;Mitochondrion-targeted platinum complexes suppressing lung cancer through multiple pathways involving energy metabolism, Chem. Sci., 2019, 10, 3089.
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