张艳 - 南京大学 - 化学化工学院

个人简介

1993-1997 B.S. Jilin University 1997-2002 Ph.D. Nanjing University 2002-2004 Postdoc in HongKong University of Science and Technology 2004-2006 Postdoc in Stanford University, Molecular Imaging Programm of Stanford 2006-present Professor of chemistry in Nanjing University

研究领域

Optochemical biology, with focus on the development of photo-induced bioorthogonal reactions and the exploration on the chemical and biological applications of biocompatible photo-reactions.

近期论文

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Angew.Chem.Int.Ed.2022 Ziwei Xi+, Hao Kong+, Yu Chen, Jiafang Deng, Wenyuan Xu, Yong Liang,* and Yan Zhang* Metal- and Strain-Free Bioorthogonal Cycloaddition of o-Diones with Furan-2(3H)-one as Anionic Cycloaddend.Angew.Chem.Int.Ed.2022,61,e202200239 Angew.Chem.Int.Ed.2022 Yuqi Wang, He Bai, Yinxing Miao, Jianhui Weng, Zheng Huang, Jiayu Fu, Yan Zhang,*Jianguo Lin,* and Deju Ye* Tailoring a Near-Infrared Macrocyclization Scaffold Allows the Control of In Situ Self-Assembly for Photoacoustic/PET Bimodal Imaging.Angew.Chem.Int.Ed.2022,61,e202200369 Chem.Sci.2022 Xingxing Wang,‡ Xiao Xiao,‡ Yi Feng, Jinbo Li * and Yan Zhang * A photoresponsive antibody–siRNA conjugate for activatable immunogene therapy of cancer† Chem.Sci.2022,13,5345 Nano Res.2022 Dongdong Wu, Hai Lei,, Xian Xie, Liang Zhou, Peng Zheng, Yi Cao *， and Yan Zhang * Self-sorting double network hydrogels with photo-definable biochemical cues as artificial synthetic extracelular matrix Nano Res.2022,15,4294 ACS Nano 2021 Lei Chen, Gaigai Li, Xingxing Wang, Jinbo Li,* and Yan Zhang* Spherical Nucleic Acids for Near-Infrared Light-Responsive Self-Delivery of SmallInterfering RNA and Antisense Oligonucleotide ACS Nano 2021,15,11929 J. Am. Chem. Soc. 2020 Yuqi Wang, Jianhui Weng, Jianguo Lin, Deju Ye, and Yan Zhang*，NIR Scaffold Bearing Three Handles for Biocompatible Sequential Click Installation of Multiple Functional Arms. J. Am. Chem. Soc. 2020, 142, 2787-2794. Chem. Commun. 2020 Lei Chen, Yu Sun, Jinbo Li*and Yan Zhang*, A photoactivatable microRNA probe for identification of microRNA targets and light-controlled suppression of microRNA target expression. Chem. Commun, 2020, 56, 627-630. ExRNA 2019 Jinbo Li and Yan Zhang*, Current experimental strategies for intracellular target identification of microRNA. ExRNA 2019, 1, 6. Chem. Commun. 2019 Xingxing Wang, Xiao Xiao, Bingsen Zhang, Jinbo Li* and Yan Zhang*, A self-assembled peptide nucleic acid-microRNA nanocomplex for dual-modulation of cancer-related microRNAs. Chem. Commun. 2019, 55, 2106-2109. Angew. Chem. Int. Ed. 2019 Yuqi Wang, Xiaoming Hu, Jianhui Weng, Jinbo Li, Quli Fan, Yan Zhang, and Deju Ye*, A Photoacoustic Probe for the Imaging of Tumor Apoptosis by Caspase-Mediated Macrocyclization and Self-Assembly. Angew. Chem. Int. Ed. 2019, 58, 4886-4890 Chem. Asian J. 2018 Xiao Xiao, Xingxing Wang, Haidong Gao, Xi Chen, Jinbo Li* and Yan Zhang*, Cell-Selective Delivery of MicroRNA with a MicroRNA-Peptide Conjugate Nanocomplex. Chem. Asian J. 2018, 13, 3845-3849. J. Am. Chem. Soc. 2018 Jinbo Li, Hao Kong, Lei Huang, Bo Cheng, Ke Qin, Mengmeng Zheng, Zheng Yan and Yan Zhang* Visible Light-Initiated Bioorthogonal Photoclick Cycloaddition. J. Am. Chem. Soc. 2018, 140, 14542-14546. Chem. Eur. J. 2018 Xiao Xiao, Xingxing Wang, Yuqi Wang, Tianren Yu, Lei Huang, Lei Chen, Jinbo Li,* Chenyu Zhang* and Yan Zhang* Multi-functional peptide-microRNA nanocomplex for targeted microRNA delivery and function imaging. Chem. Eur. J. 2018, 24, 2277-2285. Org. Biomol. Chem. 2017 Zhengquan Zhou, Xian Xie, Qikun Yi, Wencui Yin, Adnan A. Kadi, Jinbo Li* and Yan Zhang* Enzyme-instructed self-assembly with photo-responses for the photo-regulation of cancer cells. Org. Biomol. Chem. 2017, 15, 6892-6895. Chem. Commun. 2017 Lei Huang, Yingjie Chen, Lei Chen, Xiao Xiao, Xingxing Wang, Jinbo Li* and Yan Zhang* Photo-clickable microRNA for in-situ fluorescence labeling and imaging of microRNA in living cells. Chem. Commun. 2017, 53, 6452-6455. Org. Biomol. Chem. 2017 Zhengquan Zhou, Qikun Yi, Tingting Xia, Wencui Yin, Adnan A. Kadi, Jinbo Li* and Yan Zhang* A photo-degradable supramolecular hydrogel for selective delivery of microRNA into 3D-cultured cells. Org. Biomol. Chem. 2017, 15, 2191-2198.