陈元利 - 合肥工业大学 - 食品与生物工程学院

个人简介

2005-2009：南开大学，生物科学专业，学士； 2009-2014：南开大学，生物化学与分子生物学专业，博士。 2014-2015：南开大学，医学院，讲师 2015-至今：合肥工业大学，副教授； 2016年6月-9月：美国威斯康辛医学院，访问学者。代表性研究成果发现组合药物疗法防治动脉粥样硬化的新策略；获得国家自然科学基金青年基金和面上项目的支持，近五年发表一作/通讯作者论文14篇、授权发明专利1项。目前承担科研项目 1.国家自然科学基金面上项目：LXR调控25HC与25HC3S合成代谢平衡与抗病毒功能，项目编号：31770863，2018年1月-2021年12月，60万元。在研，主持。 2.步长制药集团：龙生蛭胶囊改善糖尿病下肢血管病变的作用与机制研究，2017.5-2018.5，20万，在研，主持。 3.合肥工业大学优秀青年培育计划（A）：MEK1/2抑制剂拮抗血管钙化的作用与机制研究，项目编号：JZ2018HGPA0270，2018年5月-2020年12月，40万，在研，主持。 4.另参与国际合作项目子课题、政府间国际科技创新合作重点专项等国家重大项目。获奖情况中国生物化学与分子生物学会脂质与脂蛋白专业委员会青年委员；教育部高等学校科学研究优秀成果奖（科学技术），自然科学奖二等奖，第4获奖人；多次获得会议论文奖励。

研究领域

动脉粥样硬化、血管钙化病理机制研究；肝脏糖脂代谢调控与相关疾病防治；脂代谢与肿瘤。硕士招生方向：生物化学与分子生物学、制药工程

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

第一作者与通讯作者论文（#：共同第一作者；*：通讯作者）： 1.LiuL,ZengP,YangX,DuanY,ZhangW,MaC,ZhangX,YangS,LiX,YangJ,LiangY,HanH,ZhuY,HanJ*,ChenY*.Inhibitionofvascularcalcification—Anewanti-atherogenicmechanismofDNAtopoisomeraseIIinhibitors.ArteriosclerosisThrombosisandVascularBiology2018;38:00-00.DOI:10.1161/ATVBAHA.118.311546. 2.MaC,ZhangW,YangX,LiuY,LiuL,FengK,ZhangX,YangS,SunL,YuM,YangJ,LiX,HuW,MiaoRQ,ZhuY,LiL,HanJ*,ChenY*,DuanY*.FunctionalinterplaybetweenLXRandAMPKinhibitsatherosclerosisinapoEdeficientmice-Anewanti-atherogenicstrategy.BritishJournalofPharmacology.2018;175(9):1486-1503. 3.ZhangW#,YangX#,ChenY#,HuW,LiuL,ZhangX,LiuM,SunL,LiuY,YuM,LiX,LiL,ZhuY,MiaoRQ*,HanJ*,DuanY*.ActivationofhepaticNogo-Breceptorexpression—Anewanti-liversteatosismechanismofstatins.BBA-MolecularandCellBiologyofLipids.2018;1863(2):177-190. 4.ZhangL#,ChenY#,YangX,YangJ,CaoX,LiX,LiL,MiaoQR,HajjarDP,DuanY,HanJ.MEK1/2inhibitorsactivatemacrophageABCG1expressionandreversecholesteroltransport—ananti-atherogenicfunctionofERK1/2inhibition.BBA-MolecularandCellBiologyofLipids.2016;1861:1180-1191. 5.YangX#,ZhangW#,ChenY#,LiY,SunL,LiuY,LiuM,YuM,LiX,HanJ,DuanY.ActivationofPPARandCD36expression--thedualpathophysiologicalrolesofprogesterone.TheJournalofBiologicalChemistry.2016;291:15108-18. 6.LiX,CaoX,ZhangX,KangY,ZhangW,YuM,MaC,HanJ,DuanY*,ChenY*.MEK1/2inhibitorsinduceinterleukin-5expressioninmousemacrophagesandlymphocytes.BiochemicalandBiophysicalResearchCommunications.2016;473:939-46. 7.LiuM,ZhangW,LiX,HanJ,ChenY*,DuanY*.ImpactofageandsexonthedevelopmentofatherosclerosisandexpressionoftherelatedgenesinapoEdeficientmice.BiochemicalandBiophysicalResearchCommunications.2016;469:456-462. 8.YangX,SunL,LiY,MaC,YangJ,ZhangW,ZhaoB,JiaL,DuanY,HanJ,LiX*,ChenY*.NaoXinTonginhibitstheadvancedatherosclerosisandenhancestheplaquestabilityinapoEdeficientmice.JournalofCardiovascularPharmacology,2016;67:203-211. 9.ZhangW,WangX,HuW,LiuL,LiX,HanJ,ChenY*,DuanY*.Co-treatmentofpitavastatinanddexamethasoneexacerbatesthehighfatdiet-inducedatherosclerosisinapoE-/-mice.JournalofCardiovascularPharmacology2015;66:189-95. 10.ChenY#,DuanY#,YangX,SunL,LiuM,WangQ,MaX,ZhangW,LiX,HuW,MiaoQR,XiangR,HajjarDP,HanJ.InhibitionofERK1/2andactivationofLXRsynergisticallyreduceatheroscleroticlesionsinapoEdeficientmice.ArteriosclerosisThrombosisandVascularBiology2015;35:948-959. 11.ChenY#,LiuM#,ZhaoT,ZhaoB,JiaL,ZhuY,ZhangB,GaoX,LiG,LiX,XiangR,HanJ,DuanY.DanhongInjectioninhibitsthedevelopmentofatherosclerosisinbothApoe-/-andLdlr-/-mice.JournalofcardiovascularPharmacology2014;63:441–452. 12.LiuM#,ChenY#,YangX,ZhangL,ZhaoT,ZhaoB,JiaL,ZhuY,GaoX,ZhangB,LiX,HanJ,DuanY.DanhonginjectioninhibitsthedevelopmentofprimaryabdominalaorticaneurysmsinapoEknockoutmice.ChineseScienceBulletin2014;59:1366-1373. 13.ChenY,DuanY,KangY,YangX,JiangM,ZhangL,LiG,YinZ,HuW,DongP,LiX,HajjarDP,HanJ.ActivationofliverXreceptorinducesmacrophageinterleukin-5expression.TheJournalofBiologicalChemistry2012;287:43340-50. 14.DuanY#,ChenY#,HuW,LiX,YangX,ZhouX,YinZ,KongD,YaoZ,HajjarDP,LiuL,LiuQ,HanJ.PeroxisomeProliferator-activatedreceptoractivationbyligandsanddephosphorylationinducesproproteinconvertasesubtilisinkexintype9andlowdensitylipoproteinreceptorexpression.TheJournalofBiologicalChemistry2012;287:23667-77. 15.杨潇潇，刘力沛，孙蕾，李小菊，段亚君，陈元利*.过氧化物酶体增殖物激活受体gamma激动剂和促分裂原活化蛋白激酶1/2抑制剂药物组合对Apoe-/-小鼠动脉粥样硬化发展的抑制作用.中国动脉硬化杂志.2015;23:763-768. 其他作者论文： 1.YangS,LiuM,ChenY,MaC,LiuL,ZhaoB,WangY,LiX,ZhuY,GaoX,KongD,DuanY,HanJ*,YangX*.NaoXinTongCapsulesinhibitthedevelopmentofdiabeticnephropathyindb/dbmice.ScientificReports2018;8(1):9158. 2.LiQ,ChenY,ZhaoD,WeiZ,ZhangS,ChenY,WangY,QianK,ZhaoB,ZhuY,GaoX,DongP,LiX,DuanY,HanJ,YangX.NaoXinTongcapsuleinhibitscarrageenan-inducedthrombosisinmice.JournalofCardiovascularPharmacology.2018;72(1):49-59. 3.LiuY,WeiZ,MaX,YangX,ChenY,SunL,YuM,MaC,MiaoRQ,HajjarDP,HanJ*,DuanY*.25-Hydroxycholesterolinducesitsownproductionbyactivatingcholesterol25-hydroxylaseexpressioninanLXRdependentmechanism.JournalofLipidResearch,2018;59(3):439-451. 4.SunL,YangX,LiQ,ZengP,LiuY,LiuL,ChenY,YuM,MaC,LiX,LiY,ZhangR,ZhuY,MiaoQR,HanJ,DuanY.Activationofadiponectinreceptorregulatesproproteinconvertasesubtilisin/kexintype9expressionandinhibitslesionsinapoEdeficientmice.ArteriosclerosisThrombosisandVascularBiology.2017;37(7):1290-1300. 5.YangX,LiY,SunL,LiuY,MaC,ChenY,TanH,LiQ,LiX,WangY,DuanY,ZhaoB,HanJ.NaoXinTongenhancesatorvastatin-inducedplaquestabilitywhileamelioratingatorvastatin-inducedhepaticinflammation.JournalofCardiovascularPharmacology,2017;69:55-64. 6.HuW,ZhangW,ChenY,RanaU,TengRJ,DuanY,LiuZ,ZhaoB,FoecklerJ,WeilerH,KallingerRE,ThomasMJ,ZhangK,HanJ,MiaoQR.Nogo-BreceptordeficiencyincreasesLXRnucleartranslocationandhepaticlipogenesisviaAMPK-dependentpathway.Hepatology,2016;64:1559-1576. 7.YuM,JiangM,ChenY,ZhangS,ZhangW,YangX,LiX,LiY,DuanS,HanJ,DuanY.InhibitionofmacrophageCD36expressionandcellularoxLDLaccumulationbytamoxifen—APPARdependentmechanism.TheJournalofBiologicalChemistry.2016;291(33):16977-89. 8.WangQ,SunL,YangX,MaX,LiQ,ChenY,LiuY,ZhangD,LiX,XiangR,WeiY,HanJ,DuanY.ActivationofliverXreceptorinhibitsthedevelopmentofpulmonarycarcinomasinducedby3-methylcholanthreneandbutylatedhydroxytolueneinBABL/cmice.ScientificReports.2016;6:27295. 9.YangX,YaoH,ChenY,SunL,LiY,MaX,DuanS,LiX,XiangR,HanJ,DuanY.2015.InhibitionofglutathioneproductioninducesmacrophageCD36expressionandenhancescellularoxLDLuptake.TheJournalofBiologicalChemistry.2015;290:21788-99.10.LiuM,PanQ,ChenY,YangX,ZhaoB,JiaL,ZhuY,ZhangB,GaoX,LiX,HanJ,DuanY.AdministrationofDanhongInjectiontodiabeticdb/dbmiceinhibitsthedevelopmentofdiabeticretinopathyandnephropathy.ScientificReports.2015;5:11219. 11.LiuM,ChenY,ZhangL,WangQ,MaX,LiX,XiangR,ZhuY,QinS,YuY,JiangX,DuanY,HanJ.RegulationofhepaticcholesterylestertransferproteinexpressionandreversecholesteroltransportbyinhibitionofDNAtopoisomeraseII.TheJournalofBiologicalChemistry2015;290:14418-29. 12.MaX,LiuY,WangQ,ChenY,LiuM,LiX,XiangR,WeiY,DuanY,HanJ.TamoxifeninducesthedevelopmentofherniainmicebyactivatingMMP-2andMMP-13expression.BiochimicaetBiophysicaActa-MolecularBasisofDisease2015;1852:1038-1048. 13.LiuM,PanQ,ChenY,YangX,ZhaoB,JiaL,ZhuY,HanJ,LiX,DuanY.NaoXinTonginhibitsthedevelopmentofdiabeticretinopathyindb/dbmice.Evidence-BasedComplementaryandAlternativeMedicine2015;2015:242517. 14.MaX,WangQ,LiuY,ChenY,ZhangL,JiangM,LiX,XiangR,MiaoRQ,DuanY,HanJ.InhibitionoftumorgrowthbyU0126isassociatedwithinductionofinterferon-production.InternationalJournalofCancer2015;136:771-83. 15.WangQ,MaX,ChenY,ZhangL,JiangM,LiX,XiangR,MiaoR,HajjarDP,DuanY,HanJ.Identificationofinterferon-asanewmoleculartargetofliverXreceptor.BiochemicalJournal2014;459:345-354.