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个人简介

段亚君教授是国家自然科学基金优秀青年科学基金获得者,黄山青年学者。2004年毕业于南开大学生物科学专业,获得学士学位;2009年毕业于南开大学生物化学与分子生物学专业,获得博士学位。 近五年发表通讯或共同通讯作者论文20余篇,共同第一作者论文2篇,其中包括:在动脉粥样硬化领域权威期刊之一ATVB发表2篇论文;在经典期刊JournalofBiologicalChemistry(JBC)发表论文6篇;在IntJCancer发表论文1篇、BiochemJ发表论文2篇、BBA-MolBasisDis发表论文1篇、BBA-MolCellBiolLipid发表论文2篇、授权发明专利1项。代表性研究成果 发现巨噬细胞泡沫化调控的新机制,防治动脉粥样硬化的新靶点,发表SCI论文三十余篇。 目前承担科研项目 主持国家自然科学基金优秀青年科学基金:巨噬细胞在动脉粥样硬化中的作用和机制研究,2018.1-2020.12,直接经费130万元。 主持国家自然科学基金面上项目:MEK1/2抑制剂协同肝X受体激动剂促进动脉粥样硬化斑块稳定与消退,2016.1-2019.12,直接经费65万元。 另承担国际合作项目子课题、黄山青年学者、合肥工业大学应用科技成果培育计划重点项目、优秀青年人才培育B计划等,经费约200万元。 获奖情况 中国脂质与脂蛋白专业委员会青年委员,多次获得会议论文奖励、博士在读期间获得国家留学基金委建设高水平大学项目资助;2017年获教育部高等学校科学研究优秀成果奖(科学技术)自然科学二等奖(排名第三)。

研究领域

重大慢病防治研究:硕士招生方向为药学、生物学、食品科学、生物工程、制药工程等;博士招生方向为食品科学;欢迎推免和报考!

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

通讯作者或第一作者论文: 1.LiuY,WeiZ,ZhangY,MaX,ChenY,YuM,MaC,LiX,CaoY,LiuJ,HanJ,YangX*,DuanY*.ActivationofliverXreceptorplaysacentralroleinantiviralactionsof25-hydroxycholesterol.JLipidRes.2018Dec;59(12):2287-2296.(封面论文) 2.LiuY,WeiZ,MaX,YangX,ChenY,SunL,MaC,MiaoQR,HajjarDP,HanJ*,DuanY*.25-Hydroxycholesterolactivatestheexpressionofcholesterol25-hydroxylaseinanLXR-dependentmechanism.JLipidRes.2018Mar;59(3):439-451. 3.MaC,ZhangW,YangX,LiuY,LiuL,FengK,ZhangX,YangS,SunL,YuM,YangJ,LiX,HuW,MiaoRQ,ZhuY,LiLY,HanJ*,ChenY*,DuanY*.FunctionalinterplaybetweenLXRandAMPKinhibitsatherosclerosisinapoEdeficientmice-Anewanti-atherogenicstrategy.BrJPharmacol.2018May;175(9):1486-1503. 4.ZhangW,YangX,ChenY,HuW,LiuL,ZhangX,LiuM,SunL,LiuY,YuM,LiX,LiLY,ZhuY,MiaoQR*,HanJ*,DuanY*.ActivationofhepaticNogo-Breceptorexpression—Anewanti-liversteatosismechanismofstatins.BiochimBiophysActa.2018;1863(2):177-190. 5.SunL,YangX,LiQ,ZengP,LiuY,LiuL,ChenY,YuM,MaC,LiX,LiY,ZhangR,ZhuY,MiaoQR,HanJ*,DuanY*.ActivationofAdiponectinReceptorRegulatesProproteinConvertaseSubtilisin/KexinType9ExpressionandInhibitsLesionsinApoE-DeficientMice.ArteriosclerThrombVascBiol.2017Jul;37(7):1290-1300. 6.ZhangL,ChenY,YangX,YangJ,CaoX,LiX,LiL,MiaoQR,HajjarDP,DuanY*,HanJ*.MEK1/2inhibitorsactivatemacrophageABCG1expressionandreversecholesteroltransport-Ananti-atherogenicfunctionofERK1/2inhibition.BiochimBiophysActa.2016Sep;1861(9PtA):1180-91. 7.YuM,JiangM,ChenY,ZhangS,ZhangW,YangX,LiX,LiY,DuanS,HanJ*,DuanY*.InhibitionofMacrophageCD36ExpressionandCellularOxidizedLowDensityLipoprotein(oxLDL)AccumulationbyTamoxifen:APEROXISOMEPROLIFERATOR-ACTIVATEDRECEPTOR(PPAR)γ-DEPENDENTMECHANISM.JBiolChem.2016Aug12;291(33):16977-89.(封面论文) 8.WangQ,SunL,YangX,MaX,LiQ,ChenY,LiuY,ZhangD,LiX,XiangR,WeiY,HanJ*,DuanY*.ActivationofliverXreceptorinhibitsthedevelopmentofpulmonarycarcinomasinducedby3-methylcholanthreneandbutylatedhydroxytolueneinBALB/cmice.SciRep.2016Jun2;6:27295. 9.YangX,ZhangW,ChenY,LiY,SunL,LiuY,LiuM,YuM,LiX,HanJ*,DuanY*.ActivationofPeroxisomeProliferator-activatedReceptorγ(PPARγ)andCD36ProteinExpression:THEDUALPATHOPHYSIOLOGICALROLESOFPROGESTERONE.JBiolChem.2016Jul15;291(29):15108-18. 10.LiX,CaoX,ZhangX,KangY,ZhangW,YuM,MaC,HanJ,DuanY*,ChenY*.MEK1/2inhibitorsinduceinterleukin-5expressioninmousemacrophagesandlymphocytes.BiochemBiophysResCommun.2016May13;473(4):939-946. 11.LiuM,ZhangW,LiX,HanJ,ChenY*,DuanY*.ImpactofageandsexonthedevelopmentofatherosclerosisandexpressionoftherelatedgenesinapoEdeficientmice.BiochemBiophysResCommun.2016Jan15;469(3):456-62. 12.YangX,YaoH,ChenY,SunL,LiY,MaX,DuanS,LiX,XiangR,HanJ*,DuanY*.InhibitionofGlutathioneProductionInducesMacrophageCD36ExpressionandEnhancesCellular-oxidizedLowDensityLipoprotein(oxLDL)Uptake.JBiolChem.2015Sep4;290(36):21788-99. 13.LiuM,PanQ,ChenY,YangX,ZhaoB,JiaL,ZhuY,ZhangB,GaoX,LiX,HanJ*,DuanY*.AdministrationofDanhongInjectiontodiabeticdb/dbmiceinhibitsthedevelopmentofdiabeticretinopathyandnephropathy.SciRep.2015Jun10;5:11219. 14.LiuM,ChenY,ZhangL,WangQ,MaX,LiX,XiangR,ZhuY,QinS,YuY,JiangXC,DuanY*,HanJ*.RegulationofHepaticCholesterylEsterTransferProteinExpressionandReverseCholesterolTransportbyInhibitionofDNATopoisomeraseII.JBiolChem.2015Jun5;290(23):14418-29. 15.ZhangW,WangX,HuW,LiuL,LiX,HanJ,ChenY*,DuanY*.Co-treatmentofPitavastatinandDexamethasoneExacerbatestheHigh-fatDiet-inducedAtherosclerosisinapoE-deficientMice.JCardiovascPharmacol.2015Aug;66(2):189-95. 16.LiuM,PanQ,ChenY,YangX,ZhaoB,JiaL,ZhuY,HanJ,LiX*,DuanY*.NaoXinTongInhibitstheDevelopmentofDiabeticRetinopathyindb/dbMice.EvidBasedComplementAlternatMed.2015;2015:242517. 17.ChenY#,DuanY#,YangX,SunL,LiuM,WangQ,MaX,ZhangW,LiX,HuW,MiaoRQ,XiangR,HajjarDP,HanJ.InhibitionofERK1/2andactivationofLXRsynergisticallyreduceatheroscleroticlesionsinApoE-deficientmice.ArteriosclerThrombVascBiol.2015Apr;35(4):948-59. 18.MaX,LiuY,WangQ,ChenY,LiuM,LiX,XiangR,WeiY,DuanY*,HanJ*.TamoxifeninducesthedevelopmentofherniainmicebyactivatingMMP-2andMMP-13expression.BiochimBiophysActa.2015May;1852(5):1038-48. 19.MaX,WangQ,LiuY,ChenY,ZhangL,JiangM,LiX,XiangR,MiaoRQ,DuanY*,HanJ*.InhibitionoftumorgrowthbyU0126isassociatedwithinductionofinterferon-γproduction.IntJCancer.2015Feb15;136(4):771-83.(封面论文) 20.ChenY,LiuM,ZhaoT,ZhaoB,JiaL,ZhuY,ZhangB,GaoX,LiG,LiX,XiangR,HanJ,DuanY*.DanhonginjectioninhibitsthedevelopmentofatherosclerosisinbothApoe-/-andLdlr-/-mice.JCardiovascPharmacol.2014May;63(5):441-52. 21.LiuM,ChenY,YangX,ZhangL,ZhaoT,ZhaoB,JiaL,ZhuY,GaoX,ZhangB,LiX,HanJ,DuanY*.DanhongInjectioninhibitsthedevelopmentofprimaryabdominalaorticaneurysmsinapoEknockoutmice.ChineseSciBull.2014;59:1366-1373. 22.WangQ,MaX,ChenY,ZhangL,JiangM,LiX,XiangR,MiaoR,HajjarDP,DuanY*,HanJ*.Identificationofinterferon-γasanewmoleculartargetofliverXreceptor.BiochemJ.2014Apr15;459(2):345-54.(Commentary:BiochemicalJournal.2014;459:e1-e3,专评论文) 23.JiangM,ZhangL,MaX,HuW,ChenY,YuM,WangQ,LiX,YinZ,ZhuY,GaoX,HajjarDP,DuanY*,HanJ*.TamoxifeninhibitsmacrophageFABP4expressionthroughthecombinedeffectsoftheGRandPPARγpathways.BiochemJ.2013Sep15;454(3):467-77. 24.ZhangL,JiangM,ShuiY,ChenY,WangQ,HuW,MaX,LiX,LiuX,CaoX,LiuM,DuanY*,HanJ*.DNAtopoisomeraseIIinhibitorsinducemacrophageABCA1expressionandcholesterolefflux-anLXR-dependentmechanism.BiochimBiophysActa.2013Jun;1831(6):1134-45. 25.ChenY,DuanY*,KangY,YangX,JiangM,ZhangL,LiG,YinZ,HuW,DongP,LiX,HajjarDP,HanJ*.ActivationofliverXreceptorinducesmacrophageinterleukin-5expression.JBiolChem.2012Dec21;287(52):43340-50.26.DuanY#,ChenY#,HuW,LiX,YangX,ZhouX,YinZ,KongD,YaoZ,HajjarDP,LiuL,LiuQ,HanJ.PeroxisomeProliferator-activatedreceptorγactivationbyligandsanddephosphorylationinducesproproteinconvertasesubtilisinkexintype9andlowdensitylipoproteinreceptorexpression.JBiolChem.2012Jul6;287(28):23667-77.

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