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韩际宏博士,长江学者特聘教授、973计划首席科学家,合肥工业大学食品与生物工程学院教授、博士生导师,国家自然科学基金会评专家,科技部、卫计委国家重点研发计划评审专家,科技部国际合作项目、国家重大研究计划评审专家,国家科技奖励评审专家,中国生物化学与分子生物学会脂质与脂蛋白专业委员会常务委员。 韩际宏教授1987年毕业于南开大学化学系、理学学士,1989年毕业于南开大学高分子研究所、理学硕士,1995年毕业于美国康奈尔大学医学院(CornellUniversityMedicalCollege)、理学博士。分别于1999年、2004年被康奈尔大学医学院血管生物学中心(VascularCenterofCornellUniversityMedicalCollege)聘为助理教授、副教授。2007年全职回国,2009年入选“长江学者奖励计划”特聘教授。主要从事重大慢病防治研究,特别是脂质代谢异常所引起的动脉粥样硬化、糖尿病、脂肪肝等疾病发生发展过程中的分子生物学机制研究;结合胆固醇和脂代谢研究寻找预防、减少重大慢病发病的新机理和途径。近年来主持973计划、国家自然科学基金等项目十余项。目前已在国际一流刊物上以通讯作者等身份发表八十多篇论文并多次在国际学术大会作报告,总科学影响因子高于350点,被引用次数总计3000次以上,研究成果先后获中华中医药学会科学技术奖一等奖、教育部高等学校科学研究优秀成果自然科学二等奖、中华医学会科技奖三等奖等。中药大品种丹红注射液药效物质基础、作用机制、质量控制及产业化”中华中医药学会科学技术奖一等奖,2015年,第四完成人 “动脉粥样硬化干预靶点与机制研究”,教育部高等学校科学研究优秀成果自然科学二等奖,2017年,第一完成人 “动脉粥样硬化干预靶点与机制研究”,中华医学会科技奖三等奖,2018年,第一完成人 ActaPharmacologicaSinicaOutstandingReviewerAwardin2016 近三年主持科研项目 政府间国际科技创新合作重点专项:Nogo-B表达在胆汁代谢与胆汁淤积中的病生理功能与机制研究,2018.4-2022.3,主持 国家自然科学基金面上项目:Metformin与T0901317联用防治动脉粥样硬化的机理研究,2018.1-2021.12,主持 步长制药集团:龙生蛭胶囊对阿尔兹海默症的作用与机制研究,2018.5-2019.5,主持 步长制药集团:龙生蛭胶囊治疗缺血性脑卒中的作用与机制研究,2017.5-2018.5,主持 步长制药集团:脑心通胶囊类阿司匹林作用机制研究,2016.7-2017.10,主持

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自2012年发表的论文(*:通讯作者) 1.LiangY,HanH,LiuL,DuanY,YangX,MaC,ZhuY,HanJ,LiX*,ChenY*.CD36playsacriticalroleinproliferation,migrationandtamoxifen-inhibitedgrowthofER-positivebreastcancercells.Oncogenesis2018;7:98 2.MaJ,ZhaoD,WangX,MaC,FengK,ZhangS,ChenY,ZhuY,GaoX,ZhaoB,WangY,QianK,LiX,DuanY,HanJ*,YangX*.LongShengZhicapsulereducesestablishedatheroscleroticlesionsinapoEdeficientmicebyamelioratinghepaticlipidmetabolismandinhibitinginflammation.JournalofCardiovascularPharmacology2018Dec10.doi:10.1097/FJC.0000000000000642 3.LiuY,WeiZ,ZhangY,MaX,ChenY,YuM,MaC,LiX,CaoY,LiuJ,HanJ,YangX*,DuanY*.ActivationofliverXreceptorplaysacentralroleinantiviralactionsof25-hydroxycholesterol.JournalofLipidResearch2018;59:2287-2296(封面论文) 4.HanH,YangS,LiangY,ZengP,LiuL,YangX,DuanY,HanJ,ChenY*.TeniposideregulatesthephenotypeswitchingofvascularsmoothmusclecellsinamiR-21-dependentmanner.BiochemicalandBiophysicalResearchCommunications2018;506:1040-1046 5.VariyaBC,BakraniaAK,ChenY,HanJ,PatelSS.Suppressionofabdominalfatandanti-hyperlipidemicpotentialofEmblicaofficinalis:UpregulationofPPARsandidentificationofactivemoiety.Biomedicine&Pharmacotherapy2018;108:1274-1281 6.LiuL,ZengP,YangX,DuanY,ZhangW,MaC,ZhangX,YangS,LiX,YangJ,LiangY,HanH,ZhuY,HanJ*,ChenY*.Inhibitionofvascularcalcification—Anewanti-atherogenicmechanismofDNAtopoisomeraseIIinhibitors.Arteriosclerosis,ThrombosisandVascularBiology2018;38:2382-239 7.LiQ,ChenY,ZhaoD,WeiZ,ZhangS,ChenY,WangY,QianK,ZhaoB,ZhuY,GaoX,DongP,LiX,DuanY,HanJ*,YangX*.NaoXinTongCapsuleInhibitsCarrageenan-InducedThrombosisinMice.JournalofCardiovascularPharmacology2018;72:49-59 8.YangS,LiuM,ChenY,MaC,LiuL,ZhaoB,WangY,LiX,ZhuY,GaoX,KongD,DuanY,HanJ*,YangX*.NaoXinTongCapsulesinhibitthedevelopmentofdiabeticnephropathyindb/dbmice.ScientificReports2018;8:9158 9.MaC,ZhangW,LiuY,LiuL,YangX,FengK,ZhangX,YangS,SunL,YuM,YangJ,LiX,MiaoQR,ZhuY,HanJ*,ChenY*,DuanY*.FunctionalinterplaybetweenLXRandAMPKαreducesinhibitsatherosclerosisticlesionsinapoEknockoutmice-deficientmice--Anewanti-atherogenicstrategy.BritishJournalofPharmacology2018;175:1486-1503 10.OwoichoOrgahJ,WangM,YangX,WangZ,WangD,ZhangQ,FanG,HanJ,QinG,GaoX,ZhuY.DanhongInjectionprotectsagainsthypertension-inducedrenalinjuryviadown-regulationofmyoglobinexpressioninspontaneouslyhypertensiverats.KidneyandBloodPressureResearch2018;43:12-24 11.LiuY,WeiZ,MaX,YangX,ChenY,SunL,YuM,MaC,GuJ,MiaoRQ,HajjarDP,HanJ*,DuanY*.25-Hydroxycholesterolinducesitsownproductionbyactivatingcholesterol25-hydroxylaseexpressioninanLXRdependentmechanism.JournalofLipidResearch2018;59:439-451 12.ZhangW,YangX,ChenY,HuW,LiuL,ZhangX,LiuM,SunL,LiuY,YuM,LiX,LiL,ZhuY,MiaoQR*,HanJ*,DuanY*.ActivationofhepaticNogo-Breceptorexpression--Anewanti-liversteatosismechanismofstatins.BBA-MolecularCellBiologyofLipid2018;1863:177-190 13.ChenX,FengY,ShenX,PanG,FanG,GaoX,HanJ,ZhuY.Anti-sepsisprotectionofXuebijinginjectionismediatedbydifferentialregulationofpro-andanti-inflammatoryTh17andTregulatorycellsinamurinemodelofpolymicrobialsepsis.JournalofEthnopharmacology2018;211:358-365 14.LyuM,YanC,LiuH,ChenX,WangY,HanJ,FanG,ZhuY.NetworkpharmacologyexplorationrevealsendothelialinflammationasacommontargetforcoronaryarterydiseaseandstroketreatmentbyDanhonginjection.ScientificReports2017;7:15427 15.YangX,OrgahJ,WangD,FanG,JingyangH,HanJ,QinG,GaoX,ZhuY.Danhonginjectionreducesvascularremodelingandup-regulatestheKallikrein-kininsysteminspontaneouslyhypertensiverats.ScientificReports2017;7:4308 16.SunL,YangX,LiQ,ZengP,LiuY,LiuL,ChenY,YuM,MaC,LiX,LiY,ZhangR,ZhuY,MiaoQ,HanJ*,DuanY*.Activationofadiponectinreceptorregulatesproproteinconvertasesubtilisin/kexintype9expressionandinhibitslesionsinapoEdeficientmice.Arteriosclerosis,ThrombosisandVascularBiology2017;37:1290-1300 17.YuM,LiuY,DuanY,ChenY,HanJ,SunL,YangX.InhibitionofglutathioneproductionbyL-S,R-buthioninesulfoximineactivateshepaticascorbatesynthesis--auniqueanti-oxidativestressmechanisminmice.BiochemicalandBiophysicalResearchCommunications2017;484:56-63 18.YangX,LiY,SunL,LiuY,MaC,ChenY,TanH,LiQ,LiX,WangY,DuanY,ZhaoB*,HanJ*.NaoXinTongenhancesatorvastatin-reducedatherosclerosiswhileantagonizingatorvastatin-inducedhepaticinflammation.JournalofCardiovascularPharmacology2017;69:55-64 19.HeS,ZhaoT,GuoH,MengY,QinG,GoukassianDA,HanJ,GaoX,ZhuY.CoordinatedactivationofVEGF/VEGFR-2andPPARdpathwaysbyamulti-componentChinesemedicineDHIacceleratedrecoveryfromperipheralarterialdiseaseintype2diabeticmice.PLoSOne2016;11:e0167305 20.ZhangK,CaiHX,GaoS,YangGL,DengHT,XuGC,HanJ,ZhangQZ,LiLY.TNFSF15suppressesVEGFproductioninendothelialcellsbystimulatingmiR-29bexpressionviaactivationofJNK-GATA3signals.Oncotarget2016;7:69436-69449 21.HuW,ZhangW,ChenY,RanaU,TengR,DuanY,LiuZ,ZhaoB,FoecklerJ,WeilerH,KallingerRE,ThomasMJ,ZhangK,HanJ*,MiaoQR*.Nogo-BreceptordeficiencyincreasesLXRanucleartranslocationandhepaticlipogenesis.Hepatology2016;64:1559-1576 22.YuM,JiangM,ChenY,ZhangS,ZhangW,YangX,LiX,LiY,DuanS,HanJ*,DuanY*.2016.InhibitionofmacrophageCD36expressionandcellularoxLDLaccumulationbytamoxifen--APPARgdependentmechanism.TheJournalofBiologicalChemistry2016;291:16977-89(封面论文) 23.YangX,ZhangW,ChenY,LiY,SunL,LiuY,LiuM,YuM,LiX,HanJ*,YajunDuan*.2016ActivationofPPARgandCD36expression--thedualpathophysiologicalroleofprogesterone.TheJournalofBiologicalChemistry2016;291:15108-18 24.ZhangL,ChenY,YangX,YangJ,CaoX,LiX,LiLY,MiaoQR,HajjarDP,DuanY*,HanJ*.2016.MEK1/2inhibitorsactivatemacrophageABCG1expressionandreversecholesteroltransport--ananti-atherogenicfunctionofERK1/2inhibition.BBA-MolecularandCellBiologyofLipid2016;1861:1180-1191 25.WangQ,SunL,YangX,MaX,LiQ,ChenY,LiuY,ZhangD,LiX,XiangR,WeiY,HanJ*,DuanY*.2016.ActivationofliverXreceptorinhibitsthedevelopmentofpulmonarycarcinomasinducedby3-methylcholanthreneandbutylatedhydroxytoluene.ScientificReports2016;6:27295 26.YangM,OrgahJ,ZhuJ,FanG,HanJ,WangX,ZhangB,ZhuY.DanhongInjectionattenuatescardiacinjuryinducedbyischemicandreperfusedneuronalcellsthroughregulatingargininevasopressinexpressionandsecretion.BrainResearch2016;1642:516-23 27.ZhangY,ShenL,StupackDG,BaiN,XunJ,RenG,HanJ,LiL,LuoY,XiangR,TanX.JMJD3promotessurvivalofdiffuselargeB-celllymphomasubtypesviadistinctmechanisms.Oncotarget2016;7:29387-9928.LiX,CaoX,ZhangX,KangY,ZhangW,YuM,MaC,HanJ,DuanY,ChenY.MEK1/2inhibitorsinduceinterleukin-5expressioninmousemacrophagesandlymphocytes.BiochemicalandBiophysicalResearchCommunications2016;473:939-46 29.LiuM,ZhangW,LiX,HanJ,ChenY,DuanY.ImpactofageandsexonthedevelopmentofatherosclerosisandexpressionoftherelatedgenesinapoEdeficientmice.BiochemicalandBiophysicalResearchCommunications2016;469;456-462 30.YangX,SunL,LiY,MaC,YangJ,ZhangW,ZhaoB,JiaL,DuanY,HanJ,LiX*,ChenY*.NaoXinTonginhibitstheadvancedatherosclerosisandenhancestheplaquestabilityinapoEdeficientmice.JournalofCardiovascularPharmacology2016;67:203-11 31.YangX,YaoH,ChenY,SunL,MaX,DuanS,LiX,XiangR,HanJ*,DuanY*.InhibitionofglutathioneproductioninducesmacrophageCD36expressionandenhancescellularoxLDLuptake.TheJournalofBiologicalChemistry2015;290:21788-21799 32.LiuM,PanQ,ChenY,YangX,ZhaoB,JiaL,ZhuY,ZhangB,GaoX,LiX,HanJ*,DuanY*.AdministrationofDanhongInjectiontodiabeticdb/dbmiceinhibitsthedevelopmentofdiabeticretinopathyandnephropathy.ScientificReports2015;5,11219 33.LiuM,ChenY,ZhangL,WangQ,MaX,LiX,XiangR,ZhuY,QinS,YuY,JiangX,DuanY,HanJ*.RegulationofhepaticcholesterylestertransferproteinexpressionandreversecholesteroltransportbyinhibitionofDNAtopoisomeraseII.TheJournalofBiologicalChemistry2015;290:14418–14429 34.ZhangW,WangX,HuW,LiuL,LiX,HanJ,ChenY*,DuanY*.Co-treatmentofpitavastatinanddexamethasoneexacerbatesthehighfatdiet-inducedatherosclerosisinapoE-/-mice.JournalofCardiovascularPharmacology2015;66:189-95 35.MaX,LiuY,WangQ,ChenY,LiuM,LiX,XiangR,WeiY,DuanY*,HanJ*.TamoxifeninducesthedevelopmentofherniainmicebyactivatingMMP-2andMMP-13expression.BBA-MolecularBasisofDiseases2015;1852:1038-104836.ChenY,DuanY,YangX,SunL,LiuM,WangQ,MaX,ZhangW,LiX,HuW,MiaoQR,XiangR,HajjarDP,HanJ*.InhibitionofERK1/2andactivationofLXRsynergisticallyreduceatheroscleroticlesionsinapoEdeficientmice.Arteriosclerosis,ThrombosisandVascularBiology2015;35:948-959 37.LiuM,PanQ,ChenY,YangX,ZhaoB,JiaL,ZhuY,HanJ,LiX*,DuanY*.NaoXinTonginhibitsthedevelopmentofdiabeticretinopathyindb/dbmice.Evidence-BasedComplementaryandAlternativeMedicineVolume2015;ArticleID242517,8pages,http://dx.doi.org/10.1155/2015/242517 38.MaX,WangQ,LiuY,ChenY,ZhangL,JiangM,LiX,XiangR,MiaoRQ,DuanY*,HanJ*.InhibitionoftumorgrowthbyU0126isassociatedwithinductionofinterferon-gproduction.InternationalJournalofCancer2015;136:771-783(封面论文) 39.WangQ,MaX,ChenY,ZhangL,JiangM,LiX,XiangR,MiaoR,HajjarDP,DuanY*,HanJ*.Identificationofinterferon-gasanewmoleculartargetofliverXreceptor.BiochemicalJournal2014;459:345-354(专评论文:BiochemicalJournal.2014;459:e1-e3) 40.ChenY,LiuM,ZhaoT,ZhaoB,JiaL,ZhuY,ZhangB,GaoX,LiG,LiX,XiangR,HanJ,DuanY*.DanhongInjectioninhibitsthedevelopmentofatherosclerosisinbothApoe-/-andLdlr-/-mice.JournalofCardiovascularPharmacology2014;63:441-452 41.LiuM,ChenY,YangX,ZhangL,ZhaoT,ZhaoB,JiaL,ZhuY,GaoX,ZhangB,LiX,HanJ,DuanY*.DanhonginjectioninhibitsthedevelopmentofprimaryabdominalaorticaneurysmsinapoEknockoutmice.ChineseScienceBulletin2014;59:1366-1373 42.YuanJ,ZhangD,WangL,LiuM,MaoJ,YinY,YeX,LiuN,HanJ,GaoY,ChengT,KeefeDL,LiuL.Noevidenceforneo-oogenesismaylinktoovariansenescenceinadultmonkey.StemCells2013;31:2538-2550 43.JiangM,ZhangL,MaX,HuW,ChenY,YuM,WangQ,LiX,YinZ,ZhuY,GaoX,HajjarDP,DuanY*,HanJ*.TamoxifeninhibitsmacrophageFABP4expressionthroughthecombinedeffectsofGRandPPARgpathways.BiochemicalJournal2013;454:467-477 44.QiaoL,WuQ,LuX,ZhouY,Fernández-AlvarezA,YeL,ZhangX,HanJ,CasadoM,LiuQ.SREBP-1aactivationbyHBxandtheeffectonhepatitisBvirusenhancerII/corepromoter.BiochemicalBiophysicalResearchCommunication2013;432:643-649ZhangL,JiangM,ShuiY,ChenY,WangQ,HuW,MaX,LiX,LiuX,CaoX,LiuM,DuanY*,HanJ*.DNAtopoisomeraseIIinhibitorsinducemacrophageABCA1expressionandcholesterolefflux---anLXR-dependentmechanism.BBA-MolecularandCellBiologyofLipids2013;1831:1134-1145 46.MengX,ZhangY,JiaZ,HuoX,HeX,TianG,WuM,WangZ,ZhouX,XiongS,GaoX,WuZ,HanJ,ZhaoL,WangP,HongZ,WangQ,YinZ.AnoveltylophorineanalogW-8up-regulatesforkheadboxP3expressionandamelioratesmurinecolitis.JournalofLeukocyteBiology2013;93:83-93 47.ChenY,DuanY*,KangY,YangX,LiG,YinZ,HuW,DongP,LiX,HajjarDP,HanJ*.ActivationofliverXreceptorinducesmacrophageinterleukin-5expression.TheJournalofBiologicalChemistry2012;287:43340-43350 48.DuanY,ChenY,HuW,LiX,ZhouX,YinZ,KongD,HajjarDP,LiuL,LiuQ,HanJ*.PPARgactivationbyligandsanddephosphorylationinducesPCSK9andLDLRexpression.TheJournalofBiologicalChemistry2012;287:23667-23677 49.HuW,ZhouX,JiangN,DuanY,ChenY,LiX,YinZ,HeG,YaoZ,ZhuY,HajjarDP,HanJ*.Statinssynergizedexamethasone-inducedadipocytefattyacidbindingproteinexpressioninmacrophages.Atherosclerosis2012;222:434-443 50.ZhengW,WangZ,SongL,ZhaoQ,ZhangJ,LiD,WangS,HanJ,ZhengXL,YangZ,KongD.EndothelializationandpatencyofRGD-functionalizedvasculargraftsinarabbitcarotidarterymodel.Biomaterials2012;33:2880-2891

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