史壮志 - 南京大学 - 配位化学国家重点实验室

个人简介

Dr. Zhuangzhi Shi was born in Jiangsu-Rugao. He received his B.S. and M.S. degree in chemistry and organic chemistry from Yangzhou University in 2005 and 2008. Then he moved to Peking University and completed his Ph.D. degree in medicine and organic chemistry with Prof. Ning Jiao. In 2011, he joined the group of Prof. Frank Glorius at Westfalische Wilhelms-Universitat Münster, as an Alexander von Humboldt Research Fellow studying rhodium(III)-catalyzed C-H activation reactions. His expertise is in the field of organic synthesis and organometallics. Zhuangzhi has been a full professor at the Nanjing University since the March of 2014. Curriculum Vitae Since 2014.03 Full Professor at Nanjing University 2011-2014 Postdoctoral studies with Prof. Frank Glorius, Westf?lische Wilhelms-Universit?t Münster 2008-2011 PhD in Medicine Chemistry with Prof. Ning Jiao, Peking University 2001-2008 　M.S. in Chemistry & B.S. in Organic Chemistry with Prof. YuYuan, Yangzhou University Awards and Distinctions 2018 Chinese Chemical Society Youth Chemistry Award, China 2018 Distinguished Young Scholar from Jiangsu Provincial Government, China 2017 “Innovation &Entrepreneurship Talents Plan” of Jiangsu Province, China 2016 Thieme Chemistry Journal Awardees 2014 Jiangsu Specially-Appointed Professor, Jiangsu Provincial Government 2014 National Yong Talents Program, Organization Department, CCCPC 2012-2013 Alexander von Humboldt Fellowship, Germany 2011 Outstanding Doctoral Dissertation, Peking University 2011 Scholarship for Outstanding Graduate Students, Peking University 2010 Scholarship Award for Excellent Doctor Student, Ministry of Education of China

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Zexian Li and Zhuangzhi Shi,* Late-Stage Diversification of Phosphines by C–H Activation: A Robust Strategy for Ligand Design and Preparation, Acc. Chem. Res. DOI:10.1021/acs.accounts.4c00020. Xueli Lv, Minyan Wang, Yue Zhao and Zhuangzhi Shi,* P(III)-Directed Asymmetric C–H Arylation toward Planar Chiral Ferrocenes by Palladium Catalysis, J. Am. Chem. Soc. 2024, 146, 3483. Zexian Li, Weipeng Xu, Shuaishuai Song, Minyan Wang,* Yue Zhao and Zhuangzhi Shi,* Enantioselective Rhodium-Catalyzed C–H Arylation Enables Direct Synthesis of Atropisomeric Phosphines, Angew. Chem. Int. Ed. 2024, 63, e202316035. Linlin Ding, Yue Zhao, Hongjian Lu, Zhuangzhi Shi and Minyan Wang,* Nickel-Catalyzed Asymmetric Propargyl-Aryl Cross-Electrophile Coupling, Angew. Chem. Int. Ed. 2024, 63, e202313655. Zexian Li, Minyan Wang, Youqing Yang, Yong Liang, Xiangyang Chen, Yue Zhao, K. N. Houk and Zhuangzhi Shi,* Atroposelective Hydroarylation of Biaryl Phosphines Directed by Phosphorus Centres, Nat. Commun. 2023, 14, 8509. Wang Jiang,§ Xiuxiu Yang,§ Lin Lin, Chaoguo Yan,* Yue Zhao, Minyan Wang and Zhuangzhi Shi,* Merging Visible Light Photocatalysis and P(III)-Directed C–H Activation by a Single Catalyst: Modular Assembly of P-Alkyne Hybrid Ligands, Angew. Chem. Int. Ed. 2023, 62, e202309709. Tianhang Wang,§ Zheng-Jun Wang,§ Minyan Wang,* Lei Wu, Xiaowu Fang, Yong Liang, Jiahang Lv and Zhuangzhi Shi,* Metal-Free Stereoconvergent C–H Borylation of Enamides, Angew. Chem. Int. Ed. 2023, 62, e202313205. Wang Jiang, Jingyi Bai, Jiahang Lv, Yue Zhao, Chaoguo Yan* and Zhuangzhi Shi,* Metal-Free Directed C–H Borylation of Indoles at the Sterically Congested C2 Position, Synlett 2023, 34, 2220. Longlong Xi, Minyan Wang, Yong Liang, Yue Zhao and Zhuangzhi Shi,* Tunably Strained Metallacycles Enable Modular Differentiation of Aza-Arene C–H Bonds, Nat. Commun. 2023, 14, 3986. Chong Lian,§ Longlong Xi,§ Yu Yuan,* Zhuangzhi Shi* and Minyan Wang,* Copper-Catalysed Controllable Hydrodefluorination of Trifluoromethylated Alkenes, Org. Chem. Front. 2023, 10, 3811. Wang Jiang and Zhuangzhi Shi,* Recent Progress in meta-/para-Selective Aromatic C–H Borylation, Chin. J. Org. Chem. 2023, 43, 1691. Jieshuai Xiao,§ Minyan Wang,§ Xuwen Yin, Shuo Yang, Pei Gu, Xueli Lv, Yue Zhao and Zhuangzhi Shi,* Enantioselective Reductive (Hetero)Arylation of Cyclic N-Sulfonyl Imines by Cobalt Catalysis, Angew. Chem. Int. Ed. 2023, 62, e202300743. Ronghui Huang,§ Minyan Wang,§ Hong Deng, Jingkai Xu, Hong Yan,* Yue Zhao and Zhuangzhi Shi,* Stereospecific Nickel-Catalyzed [4+2] Heteroannulation of Alkynes with Aminophosphanes, Sci. Adv. 2023, 9, eade8638. Tianhang Wang,§ Minyan Wang,§ Yandong Wang, Mingjie Li, Yuan Zheng, Qianwei Chen, Yue Zhao and Zhuangzhi Shi,* Ligand Cooperativity Enables Highly Enantioselective C-C σ-Bond Hydroboration of Cyclopropanes, Chem 2023, 9, 130. Lin Lin,§ Xue-jun Zhang,§ Xinyu Xu, Yue Zhao and Zhuangzhi Shi,* Ru3(CO)12-Catalyzed Modular Assembly of Hemilabile Ligands by C–H Activation of Phosphines with Isocyanates, Angew. Chem. Int. Ed. 2023, 62, e202214584. Longlong Xi, Liting Du and Zhuangzhi Shi,* Nickel-Catalyzed Reductive Cross-Coupling of Polyfluoroarenes with Alkyl Electrophiles by Site-Selective C–F Bond Activation,Chin. Chem. Lett. 2022, 33, 4287. Lei Wu, Minyan Wang,* Yong Liang and Zhuangzhi Shi,* Ligand-Controlled Palladium-Catalyzed Regiodivergent Defluorinative Allylation of gem-Difluorocyclopropanes via σ-Bond Activation, Chin. J. Chem. 2022, 40, 2345. Jiefeng Hu, Jiahang Lv and Zhuangzhi Shi,* Emerging Trends in C(sp3)–H Borylation, Trends Chem. 2022, 4, 685. Ziqi Zhu and Zhuangzhi Shi,* Photoassisted Cobalt-Catalyzed Asymmetric Reductive Grignard-Type Addition of Aryl Iodides, Chin. J. Org. Chem. 2022, 42, 1872 (Highlight). Dingyi Wang,§ Mingjie Li,§ Chengdong Shuang, Yong Liang, Yue Zhao, Minyan Wang and Zhuangzhi Shi,* Rhodium-Catalyzed Selective Direct Arylation of Phosphines with Aryl Bromides, Nat. Commun. 2022, 13, 2934. Xiaowei Han, Minyan Wang, Yong Liang, Yue Zhao and Zhuangzhi Shi,* Regio- and Enantioselective Nucleophilic Addition to gem-Difluoroallenes, Nat. Synth. 2022, 1, 227. Ziqi Zhu, Jieshuai Xiao, Mingjie Li and Zhuangzhi Shi,* Nickel-Catalyzed Intermolecular Asymmetric Addition of Aryl Iodides across Aldehydes, Angew. Chem. Int. Ed. 2022, 61, e202201370. Hong Deng,§ Minyan Wang,§ Yong Liang, Xiangyang Chen, Tianhang Wang, Jonathan J. Wong, Yue Zhao, Kendall N. Houk and Zhuangzhi Shi,* Palladium-Catalyzed Stereospecific C–P toward Diverse, Chem 2022, 8, 569. Jiahang Lv and Zhuangzhi Shi,* Directed C–H borylation: From Metal Catalysis to Metal Free,Chinese Science Bulletin. 2022, 67, 3824. Jiahang Lv,§ Xue-Jun Zhang,§ Minyan Wang,* Yue Zhao and Zhuangzhi Shi,* BBr3-Mediated P(III)-Directed C–H Borylation of Phosphines,Chem. Eur. J. 2022, 28, e202104100. Ziqi Zhu, Lin Lin, Jieshuai Xiao and Zhuangzhi Shi,* Nickel-Catalyzed Stereo- and Enantioselective Cross-Coupling of gem-Difluoroalkenes with Carbon Electrophiles by C–F Bond Activation, Angew. Chem. Int. Ed. 2022, 61, e202113209. Huanhuan Luo, Dawei Wang, Minyan Wang* and Zhuangzhi Shi,* Rhodium-Catalyzed, Phosphorus(III)-Directed Hydroarylation of Internal Alkynes: Facile and Efficient Access to New Phosphine Ligands, Synlett 2022, 33, 351. B. Prabagar,§ Youqing Yang,§ and Zhuangzhi Shi,* Site-Selective C–H Functionalization to Access the Arene Backbone of Indoles and Quinolines, Chem. Soc. Rev. 2021, 50, 11249. Cheng Chen,§ Minyan Wang,§ Hongjian Lu,* Binlin Zhao and Zhuangzhi Shi,* Enabling the Use of Alkyl Thianthrenium Salts in Cross-Coupling Reactions by Copper Catalysis, Angew. Chem. Int. Ed. 2021, 60, 21756. Zedong Zhang, Jian Wen, Minyan Wang,* Chao-Guo Yan and Zhuangzhi Shi,* Green Synthesis of α-Deuterated Boronates Using DMTT Reagent, Green Synth. Catal. 2021, 2, 275. Cheng Chen,§ Zheng-Jun Wang,§ Hongjian Lu, Yue Zhao and Zhuangzhi Shi,* Generation of Non-Stabilized Alkyl Radicals from Thianthrenium Salts for C–B and C–C Bond Formation, Nat. Commun. 2021, 12, 4526. Binlin Zhao, Torben Rogge, Lutz Ackermann* and Zhuangzhi Shi,* Metal-Catalysed C–Het (F, O, S, N) and C–C Bond Arylation,Chem. Soc. Rev. 2021, 50, 8903. Jiahang Lv,§ Binlin Zhao,§ Ying Han, Yu Yuan* and Zhuangzhi Shi,* Metal-Free Cascade Boron-Heteroatom Addition and Alkylation with Diazo Compounds, Chin. Chem. Lett. 2021, 32, 691. Longlong Xi and Zhuangzhi Shi,* Enantioselective Nickel-Catalyzed 1,1-Arylboration of Terminal Olefins, Chin. J. Org. Chem. 2021, 41, 1264. (Highlight) Yandong Wang,§ Jingyi Bai,§ Youqing Yang,§ Wenxuan Zhao, Yong Liang,* Di Wang, Yue Zhao and Zhuangzhi Shi,* Rhodium-Catalysed Selective C–C Bond Activation and Borylation of Cyclopropanes, Chem. Sci. 2021, 12, 3599. Jian Wen and Zhuangzhi Shi,* From C4 to C7: Innovative Strategies for Site-Selective Functionalization of Indole C–H Bonds, Acc. Chem. Res. 2021, 54, 1723. ZhengJun Wang, Xiangyang Chen, Lei Wu, Jonathan J. Wong, Yong Liang, Yue Zhao, Kendall N. Houk* and Zhuangzhi Shi,* Metal-Free Directed C–H Borylation of Pyrroles, Angew. Chem. Int. Ed. 2021, 60, 8500. Dingyi Wang, Mingjie Li, Xiangyang Chen, Minyan Wang,* Yong Liang, Yue Zhao, Kendall N. Houk and Zhuangzhi Shi,* Palladium-Catalyzed Silacyclization of (Hetero)Arenes with a Tetrasilane Reagent through Twofold C–H Activation, Angew. Chem. Int. Ed. 2021, 60, 7066. Jiahang Lv,§ Binlin Zhao,§ Ying Hana,* Yu Yuan and Zhuangzhi Shi,* Metal-Free Cascade Boron-Heteroatom Addition and Alkylation with Diazo Compounds, Chin. Chem Lett. 2021, 32, 691. Dingyi Wang,§ Xiangyang Chen,§ Jonathan J. Wong, Liqun Jin, Mingjie Li, Yue Zhao, K. N. Houk and Zhuangzhi Shi,* Phosphorus(III)-Assisted Regioselective C–H Silylation of Heteroarenes, Nat. Commun. 2021, 12, 524. Ben Dong,§ Jiasheng Qian,§ Mingjie Li,§ Zheng-Jun Wang, Minyan Wang, Dingyi Wang, Chengkai Yuan, Ying Han, Yue Zhao and Zhuangzhi Shi,* External Oxidant-Compatible Phosphorus(III)-Directed Site-Selective C–H Carbonylation, Sci. Adv. 2020, 6, eabd1378. Huanhuan Luo,§ Yunfei Zhao,§ Dawei Wang,* Minyan Wang* and Zhuangzhi Shi,* Stereoselective Fluoroarylation of 1,1-Difluoroallenes Enabled by Palladium Catalysis, Green Synth. Catal. 2020, 1, 134. Zexian Li, Minyan Wang and Zhuangzhi Shi,* Radical Addition Enables 1,2-Aryl Migration from Vinyl-Substituted All-Carbon Quaternary Center, Angew. Chem. Int. Ed. 2021, 60, 186. Pan Gao,§ Liuzhou Gao,§ Longlong Xi,§ Zedong Zhang, Shuhua Li* and Zhuangzhi Shi,* Enantioselective Copper-Catalysed Defluorosilylation of Trifluoro-Methylated Alkenes with Silylboronates, Org. Chem. Front. 2020, 7, 2618. Minyan Wang and Zhuangzhi Shi,* Methodologies and Strategies for Selective Borylation of C–Het and C–C Bonds, Chem. Rev. 2020, 120, 7348. Yunfei Zhao, Jingyi Bai, Minyan Wang,* Hongjian Lu* and Zhuangzhi Shi,* Recent Advances in Methylating Agents, Sci Sin Chim. 2020, 50, 526. Jian Wen,§ Ben Dong,§ Jinjun Zhu, Yue Zhao and Zhuangzhi Shi,* Revealing Silylation of C(sp2)/C(sp3)–H Bonds in Arylphosphines by Ruthenium Catalysis, Angew. Chem. Int. Ed. 2020, 59, 10909. Minyan Wang, Yunfei Zhao, Yue Zhao and Zhuangzhi Shi,* Bioinspired Design of A Robust D3-Methylating Agent, Sci. Adv. 2020, 6, eaba0946. Binlin Zhao,* Xiaoyi Wu, Yu Yuan and Zhuangzhi Shi,* Copper-Catalysed Csp3-Csp Cross-Couplings between Cyclobutanone Oxime Esters and Terminal Alkynes Induced by Visible Light, Chem. Commun. 2020, 56, 4676. Yandong Wang, Bailin Tian, Mengning Ding and Zhuangzhi Shi,* Electrochemical Cross‐Dehydrogenative Coupling between Phenols and β‐Dicarbonyl Compounds: Facile Construction of Benzofurans, Chem. Eur. J. 2020, 26, 4297. Yixiao Wu,§ Binlin Zhao,§* Zhuangzhi Shi* and Yu Yuan,* Copper-Catalyzed Fragmentation-Rearrangement Sequence of Cycloketoxime Esters, Tetrahedron 2020, 76, 130873. Jiahang Lv, Binlin Zhao, Yu Yuan, Ying Han and Zhuangzhi Shi,* Boron-Mediated Directed Aromatic C–H Hydroxylation, Nat. Commun. 2020, 11, 1316. Jiahang Lv,§ Xiangyang Chen,§ Xiao-Song Xue, Binlin Zhao, Yong Liang, Minyan Wang, Liqun Jin, Yu Yuan, Ying Han, Yue Zhao, Yi Lu, Jing Zhao, Wei-Yin Sun, Kendall. N. Houk* and Zhuangzhi Shi,* Metal-Free Directed sp2-C–H Borylation, Nature 2019, 575, 336. Pan Gao, Guoqiang Wang, Longlong Xi, Minyan Wang, Shuhua Li* and Zhuangzhi Shi,* Transition-Metal-Free Defluorosilylation of Fluoroalkenes with Silylboronates, Chin. J. Chem. 2019, 37, 1009. Binlin Zhao, Minyan Wang* and Zhuangzhi Shi,* Single-Electron-Transfer-Induced C(sp3)-N Couplings via C-C Bond Cleavage of Cycloketoxime Esters, J. Org. Chem. 2019, 84, 10145. Xiaowei Han, Jiefeng Hu, Cheng Chen, Yu Yuan and Zhuangzhi Shi,* Copper-Catalysed, Diboron-Mediated cis-Dideuterated Semihydrogenation of Alkynes with Heavy Water, Chem. Commun. 2019, 55, 6922. Xiaowei Han, Yu Yuan* and Zhuangzhi Shi,* Rhodium-Catalyzed Selective C-H Trideuteromethylation of Indole at C7 Position Using Acetic-d6 Anhydride, J. Org. Chem. 2019, 84, 12764. Dingyi Wang,§ Ben Dong,§ Yandong Wang, Jiasheng Qian, Jinjun Zhu, Yue Zhao and Zhuangzhi Shi,* Rhodium-Catalysed Direct Hydroarylation of Alkenes and Alkynes with Phosphines through Phosphorous-Assisted C-H Activation, Nat. Commun. 2019, 10, 3539. Dingyi Wang, Yunfei Zhao, Chengkai Yuan, Jian Wen, Yue Zhao and Zhuangzhi Shi,* Rhodium(II)-Catalyzed Dehydrogenative Silylation of Biaryl-Type Monophosphines with Hydrosilanes, Angew. Chem. Int. Ed. 2019, 58, 12529. Binlin Zhao,§ Zexian Li,§ Yixiao Wu, Yandong Wang, Jiasheng Qian, Yu Yuan and Zhuangzhi Shi,* An Olefinic 1,2-Boryl-Migration Enabled by Radical Addition: Construction of gem-Bis(boryl)alkanes, Angew. Chem. Int. Ed. 2019, 58, 9448. Panpan Wang,§ Binlin Zhao,§ Yu Yuan* and Zhuangzhi Shi,* Radical-Induced Ring-Opening and Reconstruction of Cyclobutanone Oxime Esters, Chem. Commun. 2019, 55, 1971. Jian Wen, Dingyi Wang, Jiasheng Qian, Di Wang, Chendan Zhu, Yue Zhao and Zhuangzhi Shi,* Rhodium-Catalyzed PIII-Directed ortho-C-H Borylation of Arylphosphines, Angew. Chem. Int. Ed. 2019, 58, 2078. Xiaodong Qiu,§ Panpan Wang,§ Dingyi Wang, Minyan Wang, Yu Yuan and Zhuangzhi Shi,* PIII-Chelation-Assisted Indole C7-Arylation, Olefination, Methylation, and Acylation with Carboxylic Acids/Anhydrides by Rhodium Catalysis, Angew. Chem. Int. Ed. 2019, 58, 1504.