王澈 - 辽宁师范大学 - 化学化工学院

研究领域

1 “新型膜活性多肽抗生素药物的研发”获2013年辽宁省科学技术发明三等奖（2013F-3-08-02，第二完成人）

近期论文

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Wang C, Cai ZX, You ZL, Guo HS, Shang DJ, Wang XL, Zhang L, Ma LJ, Tan J, Le WD, Li S. Free radical scavenging activity and neuroprotective potentials of D138, one Cu(II)/Zn(II) schiff-Base complex derived from N,N'-bis (2-Hydroxynaphthylmethylidene) -1,3- propanediamine. Neurochemical Research. 2014; 39(9): 1834-1844. （SCI收录, IF2.551） Che Wang, Min Li, Darrell Sawmiller, Yaxin Fan,Yinghua Ma, Jun Tan, Yiwei Ren, Song Li*. Chronic mild stress-induced changes of risk assessment behaviors in mice are prevented by chronic treatment with ﬂuoxetine but not diazepam. Pharmacology, Biochemistry and Behavior. 2014, 116: 116–128. （SCI收录, IF2.82） Che Wang, Li-Li Tian, Song Li, Hui-Bing Li, Yang Zhou, He Wang, Qing-Zhu Yang, Li-Jie Ma, De-Jing Shang*. Rapid cytotoxicity of antimicrobial peptide tempoprin-1CEa in breast cancer cells through membrane destruction and intracellular calcium mechanism. PLoS ONE, 2013, 8(4): e60462.（SCI收录, IF3.534） Che Wang, Zhou Y, Li S, Li H, Tian L, Wang H, De-Jing Shang*. Anticancer mechanisms of temporin-1CEa, an amphipathic α-helical antimicrobial peptide, in Bcap-37 human breast cancer cells. Life Sciences, 2013, 92(20-21):1004-1014. (SCI 收录, IF 2.296) Qingzhu Yang, Che Wang*, De-Jing Shang*. Design of potent, non-toxic anticancer peptides based on the structure of the antimicrobial peptide, temporin-1CEa. Archives of Pharmacal Research, 2013, 36(11):1302-1310. (SCI 收录, IF 1.751) Che Wang, Hui-Bing Li, Song Li, Li-Li Tian, De-Jing Shang*. Antitumor effects and cell selectivity of temporin-1CEa, an antimicrobial peptide from the skin secretions of the Chinese brown frog (Rana chensinensis). Biochimie, 2012, 94: 434-441. （SCI收录, IF 3.123） Che Wang, Song Li*, De-Jing Shang, Xiao-ling Wang, Zhong-lu You, Hui-bing Li. Antihyperglycemic and neuroprotective effects of one novel Cu–Zn SOD mimetic. Bioorganic & Medicinal Chemistry Letters. 2011; 21(14): 4320-4324（SCI收录, IF 2.331） Che Wang*, Song Li, Min-wei Wang. Evodiamine-induced human melanoma A375-S2 cell death was mediated by PI3K/Akt/caspase and Fas-L/NF-κB signaling pathways and augmented by ubiquitin–proteasome inhibition. Toxicology in Vitro. 2010; 24(3): 898-904（SCI收录, IF 3.207） Xiaonan Bi, Che Wang, Weibing Dong, Wei Zhu, Dejing Shang*. Antimicrobial properties and interaction of two Trp-substituted cationic antimicrobial peptides with a lipid bilayer. Journal of Antibiotics. 2014; 67(5): 361-368.（SCI收录, IF2.041） Dejing Shang*, Yue Sun, Che Wang, Shi Wei, Lijie Ma, Li Sun. Membrane interaction and antibacterial properties of chensinin-1, an antimicrobial peptide with atypical structural features from the skin of Rana chensinensis. Appl Microbiol Biotechnol. 2012; 96(6): 1551-1560.（SCI收录，IF3.811） Dejing Shang*, Yue Sun, Che Wang, Shi Wei, Lijie Ma, et al. Rational design of anti-microbial peptides with enhanced activity and low cytotoxicity based on the structure of the arginine/histidine-rich peptide, chensinin-1. Journal of Applied Microbiology. 2012; 113(3): 677-685.（SCI收录，IF2.386） Shang DJ*, Li Y, Wang C, Wang XM, Yu Z, Fu X. A novel polysaccharide from Se-enriched Ganoderma lucidum induces apoptosis of human breast cancer cells. Oncology Reports. 2011; 25(1): 267-272（SCI收录，IF2.191） Li S*, Wang W, Wang C, Tang YY. Possible involvement of NO/NOS signaling in hippocampal amyloid-β production induced by transient focal cerebral ischemia in aged rats. Neuroscience Letters. 2010; 470(2): 106-110（SCI收录, IF2.055, Wang XL, You ZL*, Wang C. Syntheses, Characterization and Crystal Structures of Two Isostructural Hydrazone Compounds N’- (3-Bromo-5-chloro-2-hydroxybenzylidene) -4-chlorobenzohydrazide Methanol Solvate and N’-(3,5-Dichloro-2-hydroxybenzylidene) -4-chlorobenzohydrazide Methanol Solvate. Journal of Chemical Crystallography. 2011; 41(5): 621-624（SCI收录，IF0.479） Han J, Xing Y*, Wang C, Hou P, Bai F, Zeng X, Zhang X, Ge M. Two complexes (Cu, Zn) with 1,10-phenanthroline and a tridentate amino-Schiff-base: Crystal structures, spectra, thermogravimetric analyses and superoxide dismutase activity. Journal of Coordination Chemistry. 2009; 62(5): 745-756 （SCI收录，IF2.224） You ZL*, Hou P, Wang C. Syntheses and crystal structures of two copper(II) complexes derived from 2-bromo-4-chloro-6-[(2-morpholin-4-ylethylimino)methyl]phenol. Journal of Coordination Chemistry. 2009; 62(4): 593-599（SCI收录，IF2.224）