个人简介

2013 The George W. and Carol A. Lattimer Campus Professor 2011 Editor-In-Chief Organic Chemistry Insights 2006 Teddy Traylor Scholar in Organic Chemistry 2006 Editor-in-Chief "Perspectives in Medicinal Chemistry" 1996 Hellman Faculty Fellowship

研究领域

Organic Chemistry

Outlined below are three major areas of current interest: RNA-Small Molecule Interactions Little is known about the interactions between small organic molecules and RNA biomolecules despite the central role RNA plays in numerous biological processes. The long term goal of our program is to understand RNA-ligand interactions and to develop small molecules that specifically interfere with the formation of essential RNARNA and RNAprotein complexes. This involves analyzing the structural and functional features of multiple families of RNA binding molecules by applying synthetic chemistry, biochemical assays, and biophysical tools. Revealing the "language" employed by proteins and small molecules to recognize RNA is applied for the design and synthesis of novel antibacterial and antiviral agents. New Luminescent Molecules We explore the fabrication of new emissive probes based on both organic and metal-containing chromophores. The ultimate goals of this program are: (a) to understand the relationship between structure and emission properties, (b) to develop fluorescent analogs of biologically important building blocks (e.g., nucleosides), and (c) to assemble biophysical assays for monitoring nucleic acid recognition. Cellular Delivery Facilitating the uptake of molecules into living cells is of substantial interest for basic research and drug delivery applications. We explore delivery systems based on guanidinoglycosides, a family of synthetic transporters that can carry large, bioactive molecules across cell membranes. We investigate the mechanism of uptake and explore its potential for cell-selective drug delivery.

近期论文

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M. Inoue, W. Tong, J. D. Esko, and Y. Tor "Aggregation-mediated macromolecular uptake by a molecular transporter", ACS Chem. Biol., 2013, Vol. 8, 1383–1388 A. C. Rios and Y. Tor "Refining the genetic alphabet: A late period selection pressure?", Astrobiology, 2012, Vol. 12, 884–891 R. J. Fair, M. E. Hensler, W. Thienphrapa, Q. N. Dam, V. Nizet, and Y. Tor "Selectively Guanidinylated Aminoglycosides as Antibiotics", ChemMedChem, 2012, Vol. 7, 1237–1244 D. Shin, R. W. Sinkeldam and Y. Tor "Emissive RNA Alphabet", J. Am. Chem. Soc., 2011, Vol. 133, 14912–14915 L. McCoy, Y. Xie and Y. Tor "Antibiotics that target protein synthesis", WIREs RNA, 2011, Vol. 2, 209–232 R. W. Sinkeldam, N. J. Greco and Y. Tor "Fluorescent Analogs of Biomolecular Building Blocks: Design, Properties and Applications", Chem. Rev., 2010, Vol. 110, 2579–2619 S. Sarrazin, B. Wilson, W. S. Sly, Y. Tor and J. D. Esko "Guanidinylated Neomycin Mediates Heparan Sulfate-Dependent Transport of Active Enzymes to Lysosomes", Molecular Therapy, 2010, Vol. 18, 1268–1274 Y. Xie, T. Maxson, and Y. Tor "Fluorescent ribonucleoside as a FRET acceptor for tryptophan in native proteins", J. Am. Chem. Soc., 2010, Vol. 132, 11896–11897 M. Schuksz, M. M. Fuster, J. R. Brown, B. E. Crawford, D. P. Ditto, R. Lawrence, C. A. Glass, L. Wang, Y. Tor, and J. D. Esko "Surfen, a small molecule antagonist of heparan sulfate", Proc. Natl. Acad. Sci. U.S.A, 2008, Vol. 105, 13075–13080 S. G. Srivatsan, N. J. Greco, and Y. Tor "A highly emissive fluorescent nucleoside that signals the activity of toxic ribosome-inactivating proteins", Angew. Chem. Int. Ed., 2008, Vol. 47, 6661–6665 L. Elson-Schwab, O. B. Garner, M. Schuksz, B. E. Crawford, J. D. Esko and Y. Tor "Guanidinylated Neomycin Delivers Large, Bioactive Cargo into Cells through a Heparan Sulfate-dependent Pathway", J. Biol. Chem., 2007, Vol. 282, 13585-13591 S. G. Srivatsan, and Y. Tor "Fluorescent Pyrimidine Ribonucleotide: Synthesis, Enzymatic Incorporation, and Utilization", J. Am. Chem. Soc., 2007, Vol. 129, 2044-2053 V. Tam, D. Kwong and Y. Tor "Fluorescent HIV-1 Dimerization Initiation Site (DIS): Design, properties and use for ligand discovery", J. Am. Chem. Soc., 2007, Vol. 129, 3257-3266 K. F. Blount, F. Zhao, T. Hermann and Y. Tor "Conformational Constraint as a Means for Understanding RNA-Aminoglycoside Specificity", J. Am. Chem. Soc., 2005, Vol. 127, 9818-9829 N. Greco and Y. Tor "Simple Fluorescent Pyrimidine Analogs Detect the Presence of DNA Abasic Sites", J. Am. Chem. Soc., 2005, Vol. 127, 10784-10785