个人简介
楚天学者，国家海外高层次人才引进计划青年项目获得者，国家农业转基因生物安全委员会委员.2004 年博士毕业于中科院北京动物所。先后在美国温安洛研究所，芝加哥洛约拉大学医学院，洛杉矶国家医学中心从事胆汁酸核受体，肝脏再生与干细胞、代谢、炎症和药物开发等动物模型研究
教育经历
2001.09 - 2004.07， 中科院动物所，生理学，博士生
工作经历
2014.6-现在，华中农业大学教授、博士生导师
近期论文
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1.Chen W*, Zhang L*, Zhang K, Zhou B, Kuo M, Hu S, Chen L, Tang M, Chen Y, Yang L, Ann K D, Yen Y. (2014) Reciprocal regulation of autophagy and dNTP pools in human cancer cells. Autophagy 10:1272-1284(* Equal contribution)
2.Zhang L, Yang L, Liu X, Chen W, Chang L, Chen L, Loera S, Chu P, Huang W, Liu Y, Yen Y. (2013) MiR-657 promotes tumorigenesis in hepatocellular carcinoma by targeting transducin-like enhancer protein 1 through NF-κB pathways . Hepatology 57:1990-1995.
3.Zhang L, Wang Y, Chen W, Wang X, Lou G, Liu N, Lin M, Forman B, and Huang W. (2012) Promotion of liver regeneration/repair by Farnesoid X Receptor in both liver and intestine in mice. Hepatoloy 56: 2336–2343
4.Zhang L, Li T, Yu D, Barry F, Huang W. (2012) FXR protects lung from LPS induced acute injury. Mol Endocrinol. 26: 27-36
5.Zhang L*, Huang X*, Meng Z, Dong B, Shiah S, Moore DD, Huang W. (2009) Significance and mechanism of CYP7a1 gene regulation during the acute phase of liver regeneration. Mol Endocrinol. 23:137-145. (* Equal Contribution)
6.Zhang L, Kang L, Bond W, Zhang N. (2009) Interaction between syntaxin 8 and HECTd3, a HECT domain ligase. Cell Mol Neurobiol. 29(1):115-121.
7.Chen W, Wang Y, Zhang L, Shiah S, Wang M, Yang F, Yu D, Forman B, Huang W. (2010) Farnesoid X receptor alleviates age-related proliferation defects in regenerating mouse livers by activating Foxm1b transcription. Hepatology. 51(3):953-962
8.Liu N, Meng Z, Lou G, Zhou W, Wang X, Zhang Y, Zhang L, Liu X, Yen Y, Lai L, Forman BM, Xu Z, Xu R, Huang W. (2012) Hepatocarcinogenesis in FXR-/- mice mimics human HCC progression that operates through HNF1α regulation of FXR expression. Mol Endocrinol. 26:775-85.
9.Chen WD, Wang YD, Meng Z, Zhang L, Huang W. (2011) Nuclear bile acid receptor FXR in the hepatic regeneration. Biochim Biophys Acta. 1812(8): 888-892
10.Meng Z, Liu N, Fu X, Wang X, Wang YD, Chen WD, Zhang L, Forman BM, Huang W. (2011) Insufficient bile acid signaling impairs liver repair in CYP27(-/-) mice. J Hepatol. 55(4):885-895.
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