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个人简介

2018.04-至今,暨南大学基础医学院,药理学系,教授 2014.09-2017.12,中山大学,博士后 2009.09-2014.06,中山大学中山医学院,药理学,博士 2005.09-2009.07,山东大学药学院,药学,学士

研究领域

1、溶瘤病毒疗法 2、肿瘤免疫疗法

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Zhang H, Li K, Lin Y, Xing F, Xiao X, Cai J, Zhu W, Liang J, Tan Y, Fu L, Wang F, Yin W, Lu B, Qiu P, Su X, Gong S, Bai X, Hu J, Yan G. Targeting vcp enhances anticancer activity of oncolytic virus m1 in hepatocellular carcinoma. Science Translational Medicine. 2017;9. (IF: 17.136,IF均为五年平均影响因子) Highlighted in Science translational medicine. Comment in Nature reviews| gastroenterology&hepatology. 2. Xiao X, Liang J, Huang C, Li K, Xing F, Zhu W, Lin Z, Xu W, Wu G, Zhang J, Lin X, Tan Y, Cai J, Hu J, Chen X, Huang Y, Qin Z, Qiu P, Su X, Chen L, Lin Y, Zhang H* (co-corresponding author), Yan G. DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage. Nature Communications. 2018;9:4342. (IF:13.691) 3. Lin Y, Zhang H# (co-first author), Liang J, Li K, Zhu W, Fu L, Wang F, Zheng X, Shi H, Wu S, Xiao X, Chen L, Tang L, Yan M, Yang X, Tan Y, Qiu P, Huang Y, Yin W, Su X, Hu H, Hu J, Yan G. Identification and characterization of alphavirus m1 as a selective oncolytic virus targeting zap-defective human cancers. Proc Natl Acad Sci U S A. 2014;111:E4504-4512. (IF:10.414) 4. Li K, Zhang H #(co-first author), Qiu J, Lin Y, Liang J, Xiao X, Fu L, Wang F, Cai J, Tan Y, Zhu W, Yin W, Lu B, Xing F, Tang L, Yan M, Mai J, Li Y, Chen W, Qiu P, Su X, Gao G, Tai PW, Hu J, Yan G. Activation of cyclic adenosine monophosphate pathway increases the sensitivity of cancer cells to the oncolytic virus m1. Mol Ther. 2016;24:156-165. (IF: 6.913) 5. Zhang H, Lin Y, Li K, Liang J, Xiao X, Cai J, Tan Y, Xing F, Mai J, Li Y, Chen W, Sheng L, Gu J, Zhu W, Yin W, Qiu P, Su X, Lu B, Tian X, Liu J, Lu W, Dou Y, Huang Y, Hu B, Kang Z, Gao G, Mao Z, Cheng SY, Lu L, Bai XT, Gong S, Yan G, Hu J. Naturally existing oncolytic virus m1 is nonpathogenic for the nonhuman primates after multiple rounds of repeated intravenous injections. Hum Gene Ther. 2016;27:700-711. (IF: 3.658) 6. Zhang H, Zhu W, Su X, Wu S, Lin Y, Li J, Wang Y, Chen J, Zhou Y, Qiu P, Yan G, Zhao S, Hu J, Zhang J. Triptolide inhibits proliferation and invasion of malignant glioma cells. J Neurooncol. 2012;109:53-62. (IF: 3.046) 7. Li K, Hu C, Xing F, Gao M, Liang J, Xiao X, Cai J, Tan Y, Hu J, Zhu W, Yin W, Li Y, Chen W, Lu B, Mai J, Qiu P, Su X, Yan G, Zhang H* (co-corresponding author), and Lin Y. Deficiency of the ire1α-autophagy axis enhances the antitumor effects of the oncolytic virus m1. J Virol, 2017. ( 4.272) 8. Tan Y, Lin Y, Li K, Xiao X, Liang J, Cai J, Guo L, Li C, Zhu W, Xing F, Mai J, Gu J, Tan X, Yin W, Lu B, Qiu P, Su X, Gao M, Hu J, He S, Lu L, Gong S, Yan G, Zhang H* (corresponding author). Selective antagonism of bcl-xl potentiates m1 oncolysis by enhancing mitochondrial apoptosis. Hum Gene Ther. 2017. (IF: 3.658) 9. Cai J, Lin Y, Zhang H, Liang J, Tan Y, Cavenee WK, Yan G. Selective replication of oncolytic virus m1 results in a bystander killing effect that is potentiated by smac mimetics. Proc Natl Acad Sci U S A. 2017;114:6812-6817. (IF: 10.414) 10. Xing F, Luan Y, Cai J, Wu S, Mai J, Gu J, Zhang H, Li K, Lin Y, Xiao X, Liang J, Li Y, Chen W, Tan Y, Sheng L, Lu B, Lu W, Gao M, Qiu P, Su X, Yin W, Hu J, Chen Z, Sai K, Wang J, Chen F, Chen Y, Zhu S, Liu D, Cheng S, Xie Z, Zhu W, Yan G. The anti-warburg effect elicited by the camp-pgc1alpha pathway drives differentiation of glioblastoma cells into astrocytes. Cell Rep. 2017;18:468-481. (IF: 8.728) 11. Li K, Liang J, Lin Y, Zhang H, Xiao X, Tan Y, Cai J, Zhu W, Xing F, Hu J, Yan G. A classical pka inhibitor increases the oncolytic effect of m1 virus via activation of exchange protein directly activated by camp 1. Oncotarget. 2016;7:48443-48455. (IF: 5.312) 12. Ying L, Cheng H, Xiong XW, Yuan L, Peng ZH, Wen ZW, Ka LJ, Xiao X, Jing C, Qian TY, Liang GZ, Mei YG, Bo ZW, Liang P. Interferon alpha antagonizes the anti-hepatoma activity of the oncolytic virus m1 by stimulating anti-viral immunity. Oncotarget. 2017;8:24694-24705. (IF: 5.312) 13. Shu M, Zhou Y, Zhu W, Zhang H, Wu S, Chen J, Yan G. Microrna 335 is required for differentiation of malignant glioma cells induced by activation of camp/protein kinase a pathway. Mol Pharmacol. 2012;81:292-298. (IF: 3.879) 14. Chen J, Ouyang Y, Cao L, Zhu W, Zhou Y, Zhang H, Yang X, Mao L, Lin S, Lin J, Hu J, Yan G. Diazepam inhibits proliferation of human glioblastoma cells through triggering a g0/g1 cell cycle arrest. J Neurosurg Anesthesiol. 2013;25:285-291. (IF: 2.91) 15. Wang Y, Tang L, Yin W, Chen J, Leng T, Zheng X, Zhu W, Zhang H, Qiu P, Yang X, Yan G, Hu H. Simultaneous determination of seven neuroactive steroids associated with depression in rat plasma and brain by high performance liquid chromatography-tandem mass spectrometry. Anal Sci. 2016;32:981-988. (IF: 1.229) 16. Xiao X, Chen L, Ouyang Y, Zhu W, Qiu P, Su X, Dou Y, Tang L, Yan M, Zhang H, Yang X, Xu D, Yan G. Pregnenolone, a cholesterol metabolite, induces glioma cell apoptosis via activating extrinsic and intrinsic apoptotic pathways. Oncol Lett. 2014;8:645-650. (IF: 1.495)

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