李志杰 - 暨南大学 - 基础医学院

个人简介

1978.03-1982.12，中山医科大学临床医学专业，获医学学士学位 1982.12-2004.08，中山大学医学院人体解剖学教研室，助教，讲师，副教授，教授 1984.09-1987.07，中山医科大学解剖学与神经生物学专业，获医学硕士学位 1991.07-1993.01，香港中文大学医学院解剖学系，访问学者 1996.09-2000.05，中山医科大学解剖学与神经生物学专业，获医学博士学位 2000.07-2002.07，美国印第安纳州大学医学院解剖学与细胞生物学，博士后研究 2007.02-2008.10，美国印第安纳州大学医学院解剖学与细胞生物学系，副研究员 2008.10-至今，暨南大学基础医学院解剖学系/粤港澳中枢神经再生研究院，教授

研究领域

眼表的免疫学调节机制及其失调引起的免疫学疾病。通过高分辩显微镜、模式动物、细胞和分子生物学技术、生物信息学来解析眼表免疫调节中复杂的基本问题：包括确定免疫细胞在眼表组织中的分布和活动规律，参与眼表疾病发生的重要基因和分子的功能，以及代谢、营养、内分泌和外界环境变化与眼表免疫调节中的交互作用。最终，希望能够解析眼表是如何维持免疫生理学稳态以及失调后疾病的发生机制并寻找行之有效的防治措施。近年来实验室的工作包括：（1）确立某些重要免疫细胞和分子在眼免疫性疾病中的重要作用；（2）解析代谢应激、昼夜节律和肠道微生态对眼表生理免疫稳态的影响；（3）确定数种免疫细胞和分子在眼表发育、创伤修复和炎症触发中的重要机制

近期论文

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1.Shi Z, Zhu L, Li T, Tang X, Xiang Y, Han X, Xia L, Zeng L, Nie J, Huang Y, Tsang C, Wang Y, Lei Z, Xu Z, So K*, Ruan Y*.Neuroprotective mechanisms of Lycium barbarum polysaccharides against ischemic insults by regulating NR2B and NR2A containing NMDA receptor signaling pathways.Front Cell Neurosci, 2017,11:288. 2. Xiong Z, Lu W, Zhu L, Zeng L, Shi C, Jing Z, Xiang Y, Li W, Tsang CK,Ruan Y*, Huang L*. Dl-3-n-Butylphthalide treatment enhances hemodynamics and ameliorates memory deficits in rats with chronic cerebral hypoperfusion. Front Aging Neurosci, 2017,9:238. 3. Zhu H, Zhang Y, Shi Z, Lu D, Li T, Ding Y, Ruan Y*, Xu A*. The neuroprotection of liraglutide against ischaemia-induced apoptosis through the activation of the PI3K/AKT and MAPK pathways. Sci Rep, 2016, 6:26859. 4. Xia L, Lei Z, Shi Z, Guo D, Su H, Ruan Y*, Xu ZC*. Enhanced autophagy signaling in diabetic rats with ischemia-induced seizures. Brain Res, 2016, 1643:18-26. 5. Han X, Shi Z, Xia L, Zhu L, Zeng L, Nie J, Xu Z, Ruan Y*. Changes in synaptic plasticity and expression of glutamate receptor subunits in the CA1 and CA3 areas of the hippocampus after transient global ischemia. Neuroscience,2016,327: 64–78. 6. Deng L#, Ruan Y#, Chen C, Frye C, Xiong W, Jin X, Jones K, Sengelaub D, Xu X.Characterization of dendritic morphology and neurotransmitter phenotype of thoracic descending propriospinal neurons after complete spinal cord transection and GDNF treatment. Experimental Neurology, 2016,277:103–114. 7. Jing Z, Shi C, Zhu L, Xiang Y, Chen P, Xiong Z, Li W, Ruan Y*, Huang L*. Chronic cerebral hypoperfusion induces vascular plasticity and hemodynamics but also neuronal degeneration and cognitive impairment. J Cereb Blood Flow Metab, 2016,35:1249–1259. 8. Zhang S, Lai X, Li W, Jing Z, Xiong Z, Xu A,Ruan Y*, Huang L* . VASP phosphorylation and genetic polymorphism for clopidogrel resistance in Chinese patients with non-cardioembolic ischemic stroke. Thromb Res, 2014, 134(6):1272-1277. 9. Dong D, Zhang Y, Yang W, Wang-Qin R, Xu A*, Ruan Y*.Hyperphosphorylation of tau protein in the ipsilateral thalamus after focal cortical infarction in rats. Brain Res,2014,1543:280-289. 10. Ruan Y, So K, Pritz M.Calcium binding protein expression in the optic tectum of Alligator during early development. Dev Neurobiol, 2013,73(12):899-910. 11. Zhao Y, Yu B, Xiang Y, Han X, Xu Y, So K, Xu A*, Ruan Y*. Changes in the retinal morphology, electroretinogram and visual behavior after transient global ischemia in adult rats. PLoS One, 2013,8(6):e65555. 12. Ruan Y, Han X, Shi Z, Lei Z, Xu Z. Remodeling of synapses in the CA1 area of the hippocampus after transient global ischemia. Neuroscience, 2012,218:268-277. 13. Ruan Y, Lei Z, Fan Y, Zou B, Xu Z. Diversity and fluctuation of spine morphology in CA1 pyramidal neurons after transient global ischemia. J Neurosci Res, 2009,87(1):61-8. 14. Ruan Y, Zou B, Fan Y, Li Y, Lin N, Zhang Y, Xu Z. Morphological heterogeneity of CA1 pyramidal neurons in response to ischemia. J Neurosci Res,2007,85(1): 193-204. 15. Ruan Y, Zou B, Fan Y, Li Y, Lin N, Zeng Y, Gao T, Yao Z, Xu Z.Dendritic plasticity of CA1 pyramidal neurons after transient global ischemia. Neurosci, 2006, 140(1): 191-201. 16. Ruan Y, Ling G, Zhang J, Xu Z.Apoptosis in the adult striatum after transient forebrain ischemia and the effects of ischemic severity. Brain Res, 2003,982(2): 228-40. 17. Ruan Y, Li W, Lam D, Yew D.The c-fos immunoreactivities in the developing and adult rat cerebella. Cell Mol Biol Res, 1995,41(2):111-115.