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个人简介

2018-至今暨南大学,教授 2008-2018,汕头大学医学院,教授,附属肿瘤医院/肿瘤研究中心 2004-2008,美国UT MD Anderson 癌症中心,讲师,分子肿瘤学系/遗传系 1999-2004,美国贝勒医学院,博士后研究员,分子细胞学系 1994-1999,日本岛根医科大学,博士,发育生物学/细胞生物学 1988-1994,中国医科大学附属盛京医院,住院医/主治医/讲师,内科内分泌科 1984-1987,中国医科大学,硕士,内科内分泌学 1979-1984,中国医科大学,本科,临床医学

研究领域

炎症和肿瘤干细胞、外泌体液态活检和个体化肿瘤治疗

近期论文

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Ning Z, Gan J, Chen C, Zhang D, Zhang H*: Molecular functions and significance of the MTA family in hormone-independent cancer. Cancer Metastasis Rev 2014, 33(4):901-919.(invited review) Zheng L, Wang L, Gan J, Zhang H*: RNA activation: promise as a new weapon against cancer. Cancer lett 2014, 355(1):18-24. (invited review) Ma L, Yao Z, Deng W, Zhang D, Zhang H*: The Many Faces of MTA3 Protein in Normal Development and Cancers. Current protein & peptide science 2016,7(11):1452-64(invited review) Du L, Ning Z, Liu F, Zhang H*: metastasis-associated protein 3 modulates epithelia-to-mesenchymal transition and metastasis. Chinese Journal of Cancer 2017,36(1):28.(invited review) Yang Z, Zhang H, Kumar R*: Regulation of E-cadherin. Breast Cancer Online 8 (3). (Cambridge Univeristy Press, www.camridge.org). (invited review)(共同第一作者) Gan J, Ke X, Jiang J, Dong H, Yao Z, Lin Y, Lin W, Wu X, Yan S, Zhuang Y, Chu WK, Cai R, Zhang X, Cheung HS, Block NL, Pang CP, Schally AV, Zhang H*:Growth hormone-releasing hormone receptor antagonists inhibit human gastric cancer through downregulation of PAK1-STAT3/NF-κB signaling. Proc Natl Acad Sci US A. 2016,113(51) Dong H, Ma L, Gan J, Lin W, Chen C, Yao Z, Du L, Zheng L, Ke C, Huang X, Song H, Kumar R, Yeung SC, Zhang H*. PTPRO represses ERBB2-driven breast oncogenesis by dephosphorylation and endosomal internalization of ERBB2. Oncogene. 2017; 36(3):410-422. Dong H, Xu J, Li W, Gan J, Lin W, Ke J, Jiang J, Du L, Chen Y, Zhong X, Zhang D, Yeung SC, Li X, Zhang H*. Reciprocal androgen receptor/interleukin-6 crosstalk drives oesophageal carcinoma progression and contributes to patient prognosis. J Pathol 2017; 241: 448–462. Feng Y, Ke C, Tang Q, Dong H, Zheng X, Lin W, Ke J, Huang J, Yeung SC, Zhang H*: Metformin promotes autophagy and apoptosis in esophageal squamous cell carcinoma by downregulating Stat3 signaling. Cell Death Dis 2014, 5:e1088. Li Z, Zou X, Xie L, Chen H, Chen Y, Yeung SC,Zhang H*: Personalizing risk stratification by addition of PAK1 expression to TNM staging: improving the accuracy of clinical decision for gastroesophageal junction adenocarcinoma. Int J Cancer 2015, 136(7):1636-1645. Zhang H*, Lin W, Kannan K, Luo L, Li J, Chao PW, Wang Y, Chen YP, Gu J, Yen L*: Aberrant chimeric RNA GOLM1-MAK10 encoding a secreted fusion protein as a molecular signature for human esophageal squamous cell carcinoma. Oncotarget 2013, 4(11) Tang Q, Li G, Wei X, Zhang J, Chiu JF, Hasenmayer D, Zhang D, Zhang H*: Resveratrol-induced apoptosis is enhanced by inhibition of autophagy in esophageal squamous cell carcinoma. Cancer Lett 2013, 336(2):325-337. You YJ, Chen YP, Zheng XX, Meltzer SJ, Zhang H*: Aberrant methylation of the PTPRO gene in peripheral blood as a potential biomarker in esophageal squamous cell carcinoma patients. Cancer Lett 2012, 315(2):138-144. Zhang H, Singh RR, Talukder AH, Kumar R*: Metastatic tumor antigen 3 is a direct corepressor of the Wnt4 pathway. Genes Dev 2006, 20(21):2943-2948. Zhang H, Kuang SQ, Liao L, Zhou S, Xu J*: Haploid inactivation of the amplified-in-breast cancer 3 coactivator reduces the inhibitory effect of peroxisome proliferator-activated receptor gamma and retinoid X receptor on cell proliferation and accelerates polyoma middle-T antigen-induced mammary tumorigenesis in mice. Cancer Res 2004, 64(19):7169-7177. Zhang H, Stephens LC, Kumar R*: Metastasis tumor antigen family proteins during breast cancer progression and metastasis in a reliable mouse model for human breast cancer. Clin Cancer Res 2006, 12(5):1479-1486. Zhou C*, Wu YL, Chen G, Liu X, Zhu Y, Lu S, Feng J, He J, Han B, Wang J, Jiang G, Hu C, Zhang H, Cheng G, Song X, Lu Y, Pan H, Zheng W, Yin AY. BEYOND: A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Phase III Study of First-Line Carboplatin/Paclitaxel Plus Bevacizumab or Placebo in Chinese Patients With Advanced or Recurrent Nonsquamous Non-Small-Cell Lung Cancer.J Clin Oncol. 2015,pii: JCO.2014.59.4424. Kumar R*, Zhang H, Holm C, Vadlamudi RK, Landberg G, Rayala SK: Extranuclear coactivator signaling confers insensitivity to tamoxifen. Clin Cancer Res 2009, 15(12):4123-4130. Wang RA, Zhang H, Balasenthil S, Medina D, Kumar R*: PAK1 hyperactivation is sufficient for mammary gland tumor formation. Oncogene 2006, 25(20):2931-2936. Peng M, Zhang H, Jaafar L, Risinger JI, Huang S, Mivechi NF, Ko L*: Human ovarian cancer stroma contains luteinized theca cells harboring tumor suppressor gene GT198 mutations. J Biol Chem 2013, 288(46):33387-33397. Goo YH, Na SY, Zhang H, Xu J, Hong S, Cheong J, Lee SK, Lee JW*: Interactions between activating signal cointegrator-2 and the tumor suppressor retinoblastoma in androgen receptor transactivation. J Biol Chem 2004, 279(8):7131-7135. Kuang SQ, Liao L, Zhang H, Pereira FA, Yuan Y, DeMayo FJ, Ko L, Xu J*: Deletion of the cancer-amplified coactivator AIB3 results in defective placentation and embryonic lethality. J Biol Chem 2002, 277(47):45356-45360.

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