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个人简介

2018.09 暨南大学,教授 2012.07-2018.08(美)爱默瑞大学,讲师/助理教授 2008.07-2012.06(美)爱默瑞大学,博士后,研究员 2004.02.-2008.06中国科学技术大学,博士 1995.09-2003.07安徽中医药大学,本科/硕士

研究领域

肿瘤代谢重编程的分子病理机制及应对策略研究

近期论文

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1.Xia, S., Lin, R., Jin L, Zhao, L., Kang HB, Pan, Y., Liu, S., Qian, G., Qian,Z., Konstantakou,E., Zhang, B., Dong, J.T., Chung, R., Abdel-Wahab, O., Merghoub, T., Zhou,L., . Kudchadkar, R.R., Lawson, D., Lonial, S., Khoury, H.J., Khuri, F.R., Lee, B.H., Boise, L.H., Arbiser, J., Pollack, B.P., Fan, J. *, Lei, Q.Y. *and Chen, J. * (2016) Prevention of dietary fat-fueled ketogenesis attenuates BRAF V600E-positive melanoma Cell Metabolism (2017) Feb 7;25(2):358-373. doi: 10.1016/j.cmet.2016.12.010. Epub 2017 Jan 12) * 共同通讯作者(IF=20.1) 2.Lin, R.-T., Elf, S., Shan, C., Kang, H.-B., Shan, C., Kang, H.-B., Zhou, L., Hitosugi, T., Zhang, L., Zhang, S., Seo, J.H, Xie, J., Tucker, M., Gu, T.-L., Sudderth, J.A., Jiang,L., DeBerardinis R.J., Wu, S., Li, Y., Mao, H., Chen, Z.G., Hurwitz,S.J., Lonial, S., Arellano, M., Khoury, H.J., Khuri, F.R., Lee, B.H., Lei, Q.-Y., Brat, D.J., Ye, K., Boggon, T.J., He, C., Kang, S. *, Fan, J. *, and Chen, J*. (2015) 6-phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumor growth by inhibiting LKB1-AMPK signaling Nature Cell Biology 2015, doi:10.1038/ncb3255 共同通讯作者(IF=22.0) 3.Shan, C., Kang, H.-B., Elf, S., Xie, J., Gu, T.-L., Aguiar Mike, Scott Lonning, Hitosugi, T., Chung T-W, Martha Arellano , Khoury, H.J., Khuri, F.R., Shin, D.M., Boggon, T. and Fan, J. (2014) Tyr-94 Phosphorylation Inhibits Pyruvate Dehydrogenase Phosphatase 1 and Promotes Tumor Growth. J. Biol. Chem. 2014, 289:21413-21422通讯作者(IF=4.125) 4.Shan, C., Elf, S., Ji, Q., Kang, H.-B., Zhou, L., Hitosugi, T., Zhang, L., Seo, J.H., Xie, J., Tucker, M., Gu, T.-L., Sudderth, J.A., DeBerardinis R.J., Wu, S., Li, Y., Mao, H., Chen, P., Lonial, S., Arellano, M., Khoury, H.J., Khuri, F.R., Lee, B.H., Brat, D.J., Ye, K., Boggon, T.J., He, C., Kang, S., Fan, J. *, and Chen, J*. (2014) Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth. Molecular Cell (10.1016/j.molcel.2014.06.020.) *共同通讯作者(IF=14.714) 5.Fan, J.*, Lin, R., Xia, S., Chen, D., Elf, S., Liu, S., Pan, Y., Xu, H., Shan, C., Zhou,L., Lei,Q., Li,Y., Mao, H., Lee, B.H., Gaddh, M., Arellano, M.L., Khoury, H.J., Khuri, F.R., Gaddh, M., Doetsch, P.W., Lonial, S., Boggon, T.J., Curran, W.J. and Chen, J*. (2016) Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor growth. Molecular Cell 2016 Dec 1;64(5):859-874. doi: 10.1016/j.molcel.2016.10.014. Epub 2016 Nov 17.) * 第一作者和共同通讯作者(IF=14.714) 6.Fan, J. *, Shan, C. *, Kang, H.-B. *, Elf, S., Xie, J., Tucker, M., Gu, T.-L., Aguiar, M., Lonning, S., Chen, H., Mohannadi, M., Britton, L.-M. P., Garcia, B.A., Aleckovic, M., Kang, Y., Kaluz, S., Devi, N., Van Meir, E., Hitosugi, T., Seo, J.H., Lonial, S., Gaddh, M., Arellano, M., Khoury, H.J., Khuri, F.R., Boggon, T.J., Kang, S., and Chen, J. (2013) Tyr-phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate pyruvate dehydrogenase complex. Molecular Cell Jan 30 2014 online publication; 10.1016/j.molcel.2013.12.026 *: 第一作者(IF=14.714) 7.Kang, H.-B. *, Fan, J. *, Lin, R.-T.*, Elf, S., Ji, Q., Seo, J.H., Arbiser, J., Cohen, C Brat, D, Miziorko, H.M., Abdel-Wahab, O., Merghoub, T., Fröhling, S., Scholl, C., Tamayo, P., Barbie, D.A., Lonial, S., Khoury, H.J., Khuri, F.R., Lee, B.H., He, C., Kang, S., and Chen, J. (2014) Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling. Molecular Cell doi:10.1016/j.molcel.2015.05.037 共同第一作者(IF=14.714) Preview: Addicted to AA (Acetoacetate): A Point of Convergence between metabolism and BRAF Signaling 2015 Aug 6;59(3):333-4. doi: 10.1016/j.molcel.2015.07.024. * Co-first author 8.Fan, J. *, Shan, C., Kang, H.-B., Elf, S., Hitosugi, T., Xie, J., Tucker, M., Gu, T.-L., Khoury, H.J., Khuri, F.R., Lee, B.H., Boggon, T.J., and Chen, J. * (2014) Tyr-301 phosphorylation inhibits pyruvate dehydrogenase by blocking substrate binding, and promotes the Warburg effect. J. Biol. Chem. (published online August 7, 2014 doi:10.1074/jbc.M114.593970) *第一作者和共同通讯作者 (IF=4.125) 9.Hitosugi, T. *, Fan, J. *, Chung, T.W. *, Lythgoe, K., Wang, X., Xie, J., Ge, Q., Gu, T.-L., Polakiewicz, R.D., Roesel, J.L., Chen, Z., Boggon, T.J., Lonial, S., Fu, H., Khuri, F.R., Kang, S., and Chen, J. (2011) Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism. Molecular Cell 2011 Dec 23;44(6):864-77. *共同第一作者(IF=14.714) 10.Fan, J.*, Hitosugi, T. *, Chung, T.W., Lythgoe, K., Wang, X., Xie, J., Ge, Q., Gu, T.-L., Polakiewicz, R.D., Roesel, J.L., Chen, Z., Boggon, T.J., Lonial, S., Khuri, F.R., Kang, S., and Chen, J. (2011) Tyrosine Phosphorylation of Lactate Dehydrogenase A Is Important for NADH/NAD+ Redox Homeostasis in Cancer Cells. Mol. Cell. Biol. 2011 Dec;31(24):4938-50. Epub 2011 Oct 3. (Selected as a Spotlight Article by Editors) 第一作者(IF=4.398) 11.Fan, J. *, Ren, H-G, * Fei, E-K, Jia, N-L, Ying, Z., Jiang, P., Wu, M. Wang, G-H DJ-1(K130R), the sumoylation-deficient mutant fails to decrease Bax. (2008) FEBS Letters Apr2;582(7):1151-6. *第一作者 (IF=3.623) 12.Fan, J., Ren, H.-G., Jia, N.-L., Fei, E.-K., Zhou, T., Jiang, P., Wu, M. Wang, G.-H, DJ-1 decreases Bax expression through repressing p53 transcriptional activity. J. Biol. Chem (2008) Feb 15; 283(7):4022-30 第一作者(IF=4.125)

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