阮奕文 - 暨南大学 - 基础医学院

个人简介

2008.10-至今，暨南大学基础医学院解剖学系/粤港澳中枢神经再生研究院，教授 2007.02-2008.10，美国印第安纳州大学医学院解剖学与细胞生物学系，副研究员 2000.07-2002.07，美国印第安纳州大学医学院解剖学与细胞生物学，博士后研究 1996.09-2000.05，中山医科大学解剖学与神经生物学专业，获医学博士学位 1991.07-1993.01，香港中文大学医学院解剖学系，访问学者 1984.09-1987.07，中山医科大学解剖学与神经生物学专业，获医学硕士学位 1982.12-2004.08，中山大学医学院人体解剖学教研室，助教，讲师，副教授，教授 1978.03-1982.12，中山医科大学临床医学专业，获医学学士学位

研究领域

从事脑缺血、脑发育、脑衰老与老年性痴呆、神经干细胞及脊髓损伤等研究

近期论文

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1.Shi Z, Zhu L, Li T, Tang X, Xiang Y, Han X, Xia L, Zeng L, Nie J, Huang Y, Tsang C, Wang Y, Lei Z, Xu Z, So K*, Ruan Y*.Neuroprotective mechanisms of Lycium barbarum polysaccharides against ischemic insults by regulating NR2B and NR2A containing NMDA receptor signaling pathways.Front Cell Neurosci, 2017,11:288. 2. Xiong Z, Lu W, Zhu L, Zeng L, Shi C, Jing Z, Xiang Y, Li W, Tsang CK,Ruan Y*, Huang L*. Dl-3-n-Butylphthalide treatment enhances hemodynamics and ameliorates memory deficits in rats with chronic cerebral hypoperfusion. Front Aging Neurosci, 2017,9:238. 3. Zhu H, Zhang Y, Shi Z, Lu D, Li T, Ding Y, Ruan Y*, Xu A*. The neuroprotection of liraglutide against ischaemia-induced apoptosis through the activation of the PI3K/AKT and MAPK pathways. Sci Rep, 2016, 6:26859. 4. Xia L, Lei Z, Shi Z, Guo D, Su H, Ruan Y*, Xu ZC*. Enhanced autophagy signaling in diabetic rats with ischemia-induced seizures. Brain Res, 2016, 1643:18-26. 5. Han X, Shi Z, Xia L, Zhu L, Zeng L, Nie J, Xu Z, Ruan Y*. Changes in synaptic plasticity and expression of glutamate receptor subunits in the CA1 and CA3 areas of the hippocampus after transient global ischemia. Neuroscience,2016,327: 64–78. 6. Deng L#, Ruan Y#, Chen C, Frye C, Xiong W, Jin X, Jones K, Sengelaub D, Xu X.Characterization of dendritic morphology and neurotransmitter phenotype of thoracic descending propriospinal neurons after complete spinal cord transection and GDNF treatment. Experimental Neurology, 2016,277:103–114. 7. Jing Z, Shi C, Zhu L, Xiang Y, Chen P, Xiong Z, Li W, Ruan Y*, Huang L*. Chronic cerebral hypoperfusion induces vascular plasticity and hemodynamics but also neuronal degeneration and cognitive impairment. J Cereb Blood Flow Metab, 2016,35:1249–1259. 8. Zhang S, Lai X, Li W, Jing Z, Xiong Z, Xu A,Ruan Y*, Huang L* . VASP phosphorylation and genetic polymorphism for clopidogrel resistance in Chinese patients with non-cardioembolic ischemic stroke. Thromb Res, 2014, 134(6):1272-1277. 9. Dong D, Zhang Y, Yang W, Wang-Qin R, Xu A*, Ruan Y*.Hyperphosphorylation of tau protein in the ipsilateral thalamus after focal cortical infarction in rats. Brain Res,2014,1543:280-289. 10. Ruan Y, So K, Pritz M.Calcium binding protein expression in the optic tectum of Alligator during early development. Dev Neurobiol, 2013,73(12):899-910. 11. Zhao Y, Yu B, Xiang Y, Han X, Xu Y, So K, Xu A*, Ruan Y*. Changes in the retinal morphology, electroretinogram and visual behavior after transient global ischemia in adult rats. PLoS One, 2013,8(6):e65555. 12. Ruan Y, Han X, Shi Z, Lei Z, Xu Z. Remodeling of synapses in the CA1 area of the hippocampus after transient global ischemia. Neuroscience, 2012,218:268-277. 13. Ruan Y, Lei Z, Fan Y, Zou B, Xu Z. Diversity and fluctuation of spine morphology in CA1 pyramidal neurons after transient global ischemia. J Neurosci Res, 2009,87(1):61-8. 14. Ruan Y, Zou B, Fan Y, Li Y, Lin N, Zhang Y, Xu Z. Morphological heterogeneity of CA1 pyramidal neurons in response to ischemia. J Neurosci Res,2007,85(1): 193-204. 15. Ruan Y, Zou B, Fan Y, Li Y, Lin N, Zeng Y, Gao T, Yao Z, Xu Z.Dendritic plasticity of CA1 pyramidal neurons after transient global ischemia. Neurosci, 2006, 140(1): 191-201. 16. Ruan Y, Ling G, Zhang J, Xu Z.Apoptosis in the adult striatum after transient forebrain ischemia and the effects of ischemic severity. Brain Res, 2003,982(2): 228-40. 17. Ruan Y, Li W, Lam D, Yew D.The c-fos immunoreactivities in the developing and adult rat cerebella. Cell Mol Biol Res, 1995,41(2):111-115.