郝健磊 - 暨南大学 - 生物医学转化研究院

个人简介

2003 - 2012，南开大学，生命科学学院，本科、硕博连读 2012 - 2013，美国西北大学，医学院，博士后 2013 - 2016，暨南大学，生物医学转化研究院，博士后 2014 - 2016，美国耶鲁大学，医学院，访问博士后 2017 -至今，暨南大学，生物医学转化研究院，副研究员

研究领域

gamma deltaT细胞是独特的T细胞亚群，具有天然免疫细胞的多种特征。前期的工作表明，gamma deltaT细胞在肿瘤免疫应答早期来到肿瘤部位，行使直接对肿瘤的杀伤或局部免疫功能的调节。本研究组主要研究小鼠gamma delta T细胞的发育、分化以及在肿瘤微环境中的调节作用规律，为gamma deltaT细胞参与的疾病提供诊断、干预的理论基础。研究方向：雷帕霉素加强gamma deltaT细胞抗肿瘤功能的分子机制 gamma deltaT细胞代谢对其NKG2D的表达调控机制 gamma deltaT细胞与肠道菌群的相互调控机制 gamma deltaT细胞的胸腺发育信号探索 gamma deltaT细胞的昼夜节律及机制探索

近期论文

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He, W.*,Hao, J.*, Dong, S., Gao, Y., Tao, J., Chi, H., Flavell, R., O'Brien, R.L., Born, W.K., Craft, J., Han, J., Wang, P., Zhao, L., Wu, J. & Yin, Z. Naturally activated Vgamma4 gamma delta T cells play a protective role in tumor immunity through expression of eomesodermin.J Immunol, 2010, 185: 126-133. Hao, J., Wu, X., Xia, S., Li, Z., Wen, T., Zhao, N., Wu, Z., Wang, P., Zhao, L. & Yin, Z. Current progress in gamma delta T-cell biology.Cell Mol Immunol, 2010, 7: 409-413. Hao, J., Dong, S., Xia, S., He, W., Jia, H., Zhang, S., Wei, J., O'Brien, R.L., Born, W.K., Wu, Z., Wang, P., Han, J., Hong, Z., Zhao, L. & Yin, Z. Regulatory role of Vgamma1 gamma delta T cells in tumor immunity through IL-4 production.J Immunol, 2011, 187: 4979-4986. Zhao, N.*,Hao, J.*, Ni, Y.*, Luo, W., Liang, R., Cao, G., Zhao, Y., Wang, P., Zhao, L., Tian, Z., Flavell, R., Hong, Z., Han, J., Yao, Z., Wu, Z. & Yin, Z. Vgamma4 gamma delta T cell-derived IL-17A negatively regulates NKT cell function in Con A-induced fulminant hepatitis.J Immunol, 2011, 187: 5007-5014. Cao, G., Wang, Q., Li, G., Meng, Z., Liu, H., Tong, J., Huang, W., Liu, Z., Jia, Y., Wei, J., Chi, H., Yang, H., Zhao, L., Wu, Z.,Hao, J.#, & Yin, Z#. mTOR inhibition potentiates cytotoxicity of Vgamma4 gamma delta T cells via up-regulating NKG2D and TNF-alpha.J Leukoc Biol. 2016, 100:1181-1189. Tao, J., Kamanaka, M.,Hao, J., Hao, Z., Jiang, X., Craft, J., Flavell, R., Wu, Z., Hong, Z., Zhao, L. & Yin, Z. IL-10 signaling in CD4+ T cells is critical for the pathogenesis of collagen-induced arthritis.Arthritis Res Ther, 2011, 13: R212. Wen, T., Li, Y., Wu, M., Sun, X., Bao, X., Lin, Y.,Hao, J., Han, L., Cao, G., Wang, Z., Liu, Y., Wu, Z., Hong, Z., Wang, P., Zhao, L., Li, Z., Wang, Q., Yin, Z. Therapeutic effects of a novel tylophorine analog, NK-007, on collagen-induced arthritis through suppressing tumor necrosis factor α production and Th17 cell differentiation.Arthritis Rheum. 2012, 64: 2896-906. Zhang, S., Liang, R., Luo, W., Liu, C., Wu, X., Gao, Y.,Hao, J., Cao, G., Chen, X., Wei, J., Xia, S., Li, Z., Wen, T., Wu, Y., Zhou, X., Wang, P., Zhao, L., Wu, Z., Xiong, S., Gao, X., Gao, X., Chen, Y., Ge, Q., Tian, Z., Yin, Z.. High susceptibility to liver injury in IL-27 p28 conditional knockout mice involves intrinsic interferon-gamma dysregulation of CD4+ T cells.Hepatology. 2013, 57: 1620-31. Wei, J., Xia, S., Sun, H., Zhang, S., Wang, J., Zhao, H., Wu, X., Chen, X.,Hao, J., Zhou, X., Zhu, Z., Gao, X., Gao, J.X., Wang, P., Wu, Z., Zhao, L., Yin, Z. Critical Role of Dendritic Cell-Derived IL-27 in Antitumor Immunity through Regulating the Recruitment and Activation of NK and NKT Cells.J Immunol. 2013, 191: 500-8. Zhao, Y., Zhao, H., Sun, Y.,Hao, J., Qi, X., Zhou, X., Wu, Z., Wang, P., Kaech, S.M., Weaver, C.T., Flavell, R.A., Zhao, L., Yao, Z., Yin, Z. IL-4 induces a suppressive IL-10-producing CD8+ T cell population via a Cdkn2a-dependent mechanism.J Leukoc Biol. 2013, 94: 1103-12. Zhu, E., Wang, X., Zheng, B., Wang, Q.,Hao, J., Chen, S., Zhao, Q., Zhao, L., Wu, Z., Yin, Z. miR-20b suppresses Th17 differentiation and the pathogenesis of experimental autoimmune encephalomyelitis by targeting ROR gamma t and STAT3.J Immunol. 2014, 192: 5599-5609. Li, Y., Wu, Y., Zhang, C., Li, P., Cui, W.,Hao, J., Ma, X., Yin, Z., Du, J. gamma delta T Cell-derived interleukin-17A via an interleukin-1 beta-dependent mechanism mediates cardiac injury and fibrosis in hypertension.Hypertension. 2014, 64: 305-314.