王少峡 - 天津中医药大学 - 中西医结合学院

个人简介

男，博士，研究员，硕士生导师。 2004年至今在天津中医药大学工作。2005年7月至2006年9月在日本铃鹿医疗科学技术大学东洋医学研究所任客座研究员。2014年1月至2015年1月在美国匹兹堡大学神经科学系任博士后。天津市“131”创新型人才，天津市中西医结合学会神经科委员会委员。国家自然科学基金评审专家，《Ethnopharmacology》《Clinical and Experimental Phamacology and Physiology》《Pharmaceutical Biology》等杂志审稿人。主要承担本科生《微生物学与免疫学》、《医学遗传学》、《分子生物学》等教学任务。发表SCI论文二十多篇，其中第一作者或通讯作者10篇。获得发明专利1项。主持结题国家重大新药创制项目子课题、国家自然科学基金等国家及省部级课题多项。获中华中医药学会科学技术一等奖1项，天津市科学技术进步奖三等奖1项，天津市科学技术进步奖二等奖1项。

研究领域

中药神经保护，在小胶质细胞、中药抗脑缺血研究方面有多年的积累，对一些中药重大品种如血栓通注射液、注射用丹参多酚酸、丹红注射液等进行了深入的药效学、作用机制研究。

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

[1]Zuo-Yan Sun, Fu-Jiang Wang, Hong Guo, Lu Chen, Li-Juan Chai, Rui-Lin Li, Li-Min Hu, Hong Wang, Shao-Xia Wang*（通讯作者）. Shuxuetong injection protects cerebral microvascular endothelial cells against oxygen-glucose deprivation reperfusion. Neural Regeneration Research, 2019, 14(5):783-793. [2]Begum G, Song S, Wang S, et al. Selective knockout of astrocytic Na1/H1 exchanger isoform 1 reduces astrogliosis, BBB damage, infarction, and improves neurological function after ischemic stroke. Glia. 2017;00:000–000. 1346 https://doi.org/10.1002/glia.23232 [3]Shaoxia Wang, Fujiang Wang, Hongyun Yang, Ruilin Li, Hong Guo, Limin Hu⁎. Diosgenin glucoside provides neuroprotection by regulating microglial M1 polarization. International Immunopharmacology. Volume 50, September 2017, Pages 22–29. 2.956 [4]Fujiang Wang, Qiansong He, Jinxin Wang, Qing Yuan, Hong Guo, Lijuan Chai, Shaoxia Wang*（共同通讯作者）, Limin Hu*, Yue Zhang. Neuroprotective effect of salvianolate lyophilized injection against cerebral ischemia in type 1 diabetic rats. BMC Complementary and Alternative Medicine (2017) 17:258. 2.288 [5]Haoran Jing, Shaoxia Wang, Min Wang, Wenliang Fu, Chao Zhang, Donggang Xu. Isobavachalcone Attenuates MPTP-Induced Parkinson’s Disease in Mice by Inhibition of Microglial Activation through NF-κB Pathway. PLOS ONE DOI:10.1371/journal.pone.0169560 January 6, 2017. [6]Xumei Wang, Shaoxia Wang*（通讯作者）, Jinxin Wang, Hong Guo, Zhaopeng Dong, Lijuan Chai, Limin Hu, Yue Zhang, Hong Wang, and Lu Chen. Neuroprotective Effect of Xueshuantong for Injection (Lyophilized) in Transient and Permanent Rat Cerebral Ischemia Model Evidence-Based Complementary and Alternative Medicine. 2015, http://dx.doi.org/10.1155/2015/134685 1.74 [7]Gulnaz Begum, Hui Yuan, Kristopher T. Kahle, Liaoliao Li, Shaoxia Wang, Yejie Shi, Boris E. Shmukler, Sung-Sen Yang, Shih-Hua Lin, Seth L. Alper, Dandan Sun. Inhibition of WNK3 Kinase Signaling Reduces Brain Damage and Accelerates Neurological Recovery After Stroke. Stroke, 2015, DOI: 10.1161/STROKEAHA.115.008939. [8]Shaoxia Wang, Haoran Jing, Hongyun Yang, Zhidong Liu, Hong Guo, Lijuan Chai, Limin Hu. Tanshinone I selectively suppresses pro-inflammatory genes expression in activated microglia and prevents nigrostriatal dopaminergic neurodegeneration in a mouse model of Parkinson’s disease. Journal of Ethnopharmacology, 2015, 164(22): 247–255. 2.981 [9]Qiansong He, Shaoxia Wang, Xiaolei Liu, Hong Guo, Hongyun Yang, Li Zhang, Pengwei Zhuang, Yanjun Zhang, Zhengliang Ye, Limin Hu. Salvianolate lyophilized injection promotes post-stroke functional recovery via the activation of VEGF and BDNF-TrkB-CREB signaling pathway in T1DM-MCAO rats. Int J Clin Exp Med, 2015, 8(1):108-122. [10]Shaoxia Wang, Hong Guo, Xumei Wang, Lijuan Chai, Limin Hu, Tao Zhao, Buchang Zhao, Xiaoxu Tan, Feifei Jia. Pretreatment with Danhong injection protects the brain against ischemia-reperfusion injury. Neural Regeneration Research, 2014, 9(15): 1453-1459. [11]Hong Guo, Mei-jiao Li, Qing-qing Liu, Li-li Guo, Meng-meng Ma, Shao-xia Wang, Bin Yu, Li-Min Hu. Danhong Injection Attenuates Ischemia/Reperfusion-Induced Brain Damage Which is Associating with Nrf2 Levels In Vivo and In Vitro. Neurochemical Research, 2014, 39:1817–1824. [12]Xumei Wang, Shaoxia Wang* (通讯作者), Limin Hu. Neuroprotective Effect of Panax Notoginseng Saponins and Its Main Components. World of Journal Neuroscience. 2014, 4, 12-17. [13]Lijuan Chai, Hong Guo, Hui Li, Shaoxia Wang, Yu-lin Wang, Fang Shi, Li-min Hu,Yang Liu, Dickson Adah. Scutellarin and caffeic acid ester fraction, active components of Dengzhanxixin injection, upregulate neurotrophins synthesis and release in hypoxia/reoxygenation rat astrocytes. J Ethnopharmacol. 2013 Oct 28;150(1):100-7. [14]Shaoxia Wang, Hong Wang, Haoran Jing, Shixiang Wang, Liyuan Kang, Xiumei Gao, Limin Hu, Xiaohui Zheng. Anti-Inflammatory Effects of Isopropyl 3-(3, 4-Dihydroxyphenyl)-2-Hydroxypropanoate, a Novel Metabolite from Danshen, on Activated Microglia. Chinese Journal of Physiology, 2012, 55(6): 428-434. [15]Shaoxia Wang, Hong Guo, Limin Hu, Ya-nan LIU, Yue-fei WANG, Li-yuan KANG, and Xiu-mei GAO. Caffeic acid ester fraction from Erigeron breviscapus can inhibit microglial activation and provide neuroprotection. Chin J integr Med, 2012,18(6):437-444. [16]Shaoxia Wang, Hong Wang, Hong Guo, Liyuan Kang, Xiumei Gao, Limin Hu. Neuroprotection of Scutellarin is mediated by inhibition of microglial inflammatory activation. Neuroscience, 2011, 185：150-160. [17]Shao-Xia Wang, Li-Min Hu, Xiu-Mei Gao , Hong Guo, Guan-Wei Fan. Anti-inflammatory Activity of Salvianolic Acid B in Microglia Contributes to its Neuroprotective Effect. Neurochemical Research, 2010, 35:1029–1037.