康宁 - 天津中医药大学 - 中西医结合学院

个人简介

本科毕业于北京师范大学生物系生物学专业，硕士毕业于中国医科大学遗传学专业，博士毕业于沈阳药科大学微生物与生化药学专业。2000年9月至2014年10月，沈阳药科大学生命科学与生物制药学院助教、讲师、副教授，2014年11月至今，天津中医药大学中西医结合学院副教授、教授、博士生导师。

研究领域

长期致力于中西医结合抗肿瘤及抗代谢性疾病基础研究，在中医药及其活性成分抗肿瘤、降糖、降脂作用筛查及作用机制研究方面积累了丰富的经验，取得一定的成绩。

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Cao SJ, Huang YY, Zhang Q, Lu FJ, Donkor PO, Zhu Y, Qiu F, Kang N*. Molecular mechanisms of apoptosis and autophagy elicited by combined treatment with oridonin and cetuximab in laryngeal squamous cell carcinoma. Apoptosis. 2019, 24(1-2):33-45（SCI收载） 2. Huang YY, Cao SJ, Zhang Q, Zhang HY, Fan YQ, Qiu F, Kang N*. Biological and pharmacological effects of hexahydrocurcumin, a metabolite of curcumin. Arch Biochem Biophys. 2018, 646:31-37（SCI收载） 3. Cao SJ, Xu PX, Yan JK, Liu H, Liu L, Cheng LN, Qiu F, Kang N*. Berberrubine and its analog, hydroxypropyl-berberrubine, regulate LDLR and PCSK9 expression via the ERK signal pathway to exert cholesterol-lowering effects in human hepatoma HepG2 cells. J Cell Biochem. 2018, 120(2): 1340~1349（SCI收载） 4. Cao SJ, Yu SY, Cheng LN, Yan JK, Zhu Y, Deng YR, Qiu F, Kang N*. 9-O-benzoyl-substituted berberine exerts a triglyceride-lowering effect through AMPK signaling pathway in human hepatoma HepG2 cells. Environ Toxicol Pharmacol. 2018, 64:11-17（SCI收载） 5. Fan YQ, Mao YW, Cao SJ, Xia GY, Zhang Q, Zhang HY, Qiu F, Kang N*. S5, a Withanolide Isolated from Physalis Pubescens L., Induces G2/M Cell Cycle Arrest via the EGFR/P38 Pathway in Human Melanoma A375 Cells. Molecules. 2018, 23(12): 3175 （SCI收载） 6. Wang T, Jiang HM, Cao SJ, Chen Q, Cui MY, Wang ZJ, Li DD, Zhou J, Wang T, Qiu F, Kang N*. Baicalin and its metabolites suppresses gluconeogenesis through activation of AMPK or AKT in insulin resistant HepG-2 cells. Eur J Med Chem. 2017, 141:92-100 （SCI收载） 7. Zhang Q, Zhang ZN, Liu H, Cao SJ, Lv YH, Cao HR, Peng YF, Qiu F, Gao XM, Kang N*. Role of caspase-9 in anti-tumor activities by active compounds from natural products. Asian J Trad Med. 2017, 12(2):67-86 8. Kang N, Jian JF, Cao SJ, Zhang Q, Mao YW, Huang YY, Peng YF, Qiu F, Gao XM. Physalin A induces G2/M phase cell cycle arrest in human non-small cell lung cancer cells: involvement of the p38 MAPK/ROS pathway. Mol Cell Biochem. 2016; 415(1-2):145-55 （SCI收载） 9. Cao SJ, Xia MJ, Mao YW, Zhang Q, Donkor PO, Qiu F, Kang N*. Combined oridonin with cetuximab treatment shows synergistic anticancer effects on laryngeal squamous cell carcinoma: involvement of inhibition of EGFR and activation of reactive oxygen species-mediated JNK pathway. Int J Oncol. 2016, 49(5):2075-2087. （SCI收载） 10. Kang N, Cao SJ, Zhou Y,He H, Tashiro S, Onodera S, Qiu F, Ikejima T. Inhibition of caspase-9 by oridonin, a diterpenoid isolated from Rabdosia rubescens, augments apoptosis in human laryngeal cancer cell. Int J Oncol. 2015; 47(6): 2045-2056（SCI收载） 11. Kang N, Wang MM, Wang YH, Zhang ZN, Cao HR, Lv YH, Yang Y, Fan PH, Qiu F, Gao XM. Tetrahydrocurcumin induces G2/M cell cycle arrest and apoptosis involving p38 MAPK activation in human breast cancer cells. Food Chem Toxicol. 2014; 67: 193- 200（SCI收载） 12. Zhou Y, Cao S, Wang Y, Xu P, Yan J, Bin W, Qiu F, Kang N*. Berberine metabolites could induce low density lipoprotein receptor up-regulation to exert lipid-lowering effects in human hepatoma cells. Fitoterapia. 2014;92:230-237（SCI收载） 13. Cao SJ, Zhou Y, Xu PX, Wang Y, Yan JK, Bin W, Qiu F, Kang N*. Berberine metabolites exhibit triglyceride-lowering effects via activation of AMP-activated protein kinase in Hep G2 cells. J Ethnopharmacol. 2013;149(2):576-582 （SCI收载） 14. Yu L, Wang X, Wei X, Chen L, Wang M, Cao S, Kang N*, Qiu F. Triterpenoid saponins from Xanthoceras sorbifolia Bunge and their inhibitory activity on human cancer cell lines. Bioorg Med Chem Lett. 2012;22(16):5232-5238（SCI收载） 15. Kang N, Zhang JH, Qiu F, Tashiro S, Onodera S, Ikejima T. Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways. Cancer Lett. 2010; 294(2): 147-158（SCI收载） 16. Kang N, Zhang JH, Qiu F, Chen S, Tashiro S, Onodera S, Ikejima T. Induction of G (2)/M Phase Arrest and Apoptosis by Oridonin in Human Laryngeal Carcinoma Cells. J Nat Prod. 2010; 73(6): 1058-1063（SCI收载） 17. Kang N, Li F, Fu W, Zhang J, Sun K.A combined strategy of conventional cytogenetics, fluorescent in situ hybridization and microsatellite polymerase chain reaction to analyze the deletion of chromosome 6 in Laryngeal Squamous cell Carcinoma. Oncol Rep. 2007; 18(6): 1379-1385（SCI收载） 18. 刘璐，程丽娜，曹世杰，邱峰，康宁*. 肿瘤坏死因子-α诱导脂肪细胞胰岛素抵抗模型的建立及评价指标. 天津中医药. 2018; 35(11): 848-853