研究领域
主要研究领域是化学生物学和药物化学。目前的兴趣集中于天然活性小分子化合物与生物体内某些具有重要生理功能的蛋白的相互作用机制研究。
近期论文
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S-Nitrosylation of Drp1 mediates A?-Related mitochondrial fission and neuronal injury.Science (Accepted)
S-Nitrosylation of peroxiredoxin 2 (Prx2) promotes oxidative stress-induced neuronal cell death in Parkinson’s disease.Proc. Natl. Acad. Sci. U. S. A., 2007, 104 (47): 18742-18747
Inhibition of thioredoxin and thioredoxin reductase by 4-hydroxy-2-nonenal in vitro and in vivo.J. Am. Chem. Soc., 2006, 128(6):1879-1885
Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity.Cancer Res., 2006, 66(8):4410-4418
Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity.J. Biol. Chem., 2005, 280(26):25284-25290
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