赵伟栋 - 新乡医学院 - 医学检验学院

个人简介

男，1983.06-，2014年毕业于法国艾克斯-马赛大学免疫学专业获博士学位，2010.03-2014.01在欧洲马赛免疫学中心完成了博士课题。

研究领域

围绕食源性沙门氏菌与宿主相互作用来开展，通过运用现代分子生物学、细胞生物学、生物化学等技术及小鼠遗传学手段来研究沙门氏菌多种毒力因子的分子致病机制。主要包括沙门氏菌毒素-抗毒素模型、抗宿主氧化应激毒力因子及沙门氏菌毒力效应蛋白。熟悉沙门氏菌感染的各种特征特性，在动物模型感染方面积累了良好基础。

近期论文

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Moest T#, Zhao W#, Zhao Y, Schüssler JM, Yan W, Gorvel JP, Méresse S*. Contribution of bacterial effectors and host proteins to the composition and function of Salmonella-induced tubules. Cell Microbiol. 2018 Dec;20(12):e12951. doi: 10.1111/cmi.12951. Zhao W#, Moest T, Zhao Y, Guilhon AA, Buffat C, Gorvel JP, Méresse S*. The Salmonella effector protein SifA plays a dual role in virulence. Sci Rep. 2015 Aug 13;5:12979. doi: 10.1038/srep12979. Zhao W#, Méresse S*. A method to introduce an internal tag sequence into a Salmonella chromosomal gene. Methods Mol Biol. 2015;1225:81-92. doi: 10.1007/978-1-4939-1625-2_5. Martirosyan A#, Von Bargen K, Arce Gorvel V, Zhao W, Hanniffy S, Bonnardel J, Méresse S, Gorvel JP*. In Vivo Identification and Characterization of CD4+ Cytotoxic T Cells Induced by Virulent Brucellaabortus Infection. PLoS One. 2013 Dec 19;8(12):e82508. doi: 10.1371/journal.pone.0082508. De la Cruz MA#, Zhao W, Farenc C, Gimenez G, Raoult D, Cambillau C, Gorvel JP, Méresse S*. A Toxin-AntitoxinModule of SalmonellaPromotesVirulence in Mice. PLoS Pathog. 2013;9(12):e1003827. doi: 10.1371/journal.ppat.1003827. Ordoñez-Rueda D#, Jönsson F, Mancardi DA, Zhao W, Malzac A, Liang Y, Bertosio E, Grenot P, Blanquet V, Sabrautzki S, de Angelis MH, Méresse S, Duprez E, Bruhns P, Malissen B, Malissen M*. A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia. Eur J Immunol. 2012 Sep;42(9):2395-408. doi: 10.1002/eji.201242589. Aussel L#, Zhao W, Hébrard M, Guilhon AA, Viala JP, Henri S, Chasson L, Gorvel JP, Barras F*, Méresse S*. Salmonella detoxifying enzymes are sufficient to cope with the host oxidative burst. Mol Microbiol. 2011 May;80(3):628-40. doi: 10.1111/j.1365-2958.2011.07611.x. Schroeder N#, Henry T, de Chastellier C, Zhao W, Guilhon AA, Gorvel JP, Méresse S*. The virulence protein SopD2 regulates membrane dynamics of Salmonella-containing vacuoles. PLoS Pathog. 2010 Jul 15;6(7):e1001002. doi: 10.1371/journal.ppat.1001002.