研究领域
1. 单分子超高灵敏度荧光显微镜的发展
2. 与癌症高度相关的端粒和端粒酶的深入研究
3. 开发新一代分子医疗诊断技术
近期论文
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Single molecule fluorescence under conditions of fast flow. Haitao Li et al Analytical Chemistry 2011; 84(1):179-85
Single-Molecule analysis of human Telomerase monomer, Haitao Li et al, Nature Chemical Biology 4 287-289 2008.
Two-color fluorescence analysis of individual virions determines the distribution of copy number of proteins in herpes simplex virus particles Haitao Li et al Biophysical Journal 93 1329 –1337, 2007.
Evidence for Resonance Optical Trapping of Individual Fluorophore-Labeled Antibodies Using Single Molecule Fluorescence Spectroscopy, Haitao Li et al J. Am. Chem. Soc., 128 (17), 5711 -5717, 2006.
Analysis of Human Telomerase Activity and Function by Two Color Single Molecule Coincidence Fluorescence Spectroscopy, Haitao Li et al J Am Chem Soc. Apr 19;128(15):4992-5000. 2006.
Characterization of a single molecule DNA switch in free solution, Haitao Li et al. J Am Chem Soc. 128, 11423-32. 2006.
Macroscopic 2D Networks Self-Assembled from Nanometer-Sized Protein/DNA Complexes, Haitao Li et al. Nano Lett., 6 (3), 365 -370, 2006.
Electrostatic orientation of enzymes on surfaces for ligand screening probed by force spectroscopy Haitao Li et al Langmuir. 2006 Jan 31;22(3):887-92.
Probing Single Molecule Intramolecular Dynamics in Solution by Two-Color Filtered Ratiometric Fluorescence Correlation Spectroscopy, Haitao Li et al Proc. Natl. Acad. Sci. USA 101, 14425-14430, 2004.
luorescence Studies of Single Biomolecules, Haitao Li et al, Biochem. Soc. Trans. 32(5):753-756, 2004.
Molecule by molecule direct and quantitative counting of antibody-protein complexes in solution, Haitao Li et al. Anal Chem. 2004 Aug 1;76(15):4446-51.
Studies on the Structure and Dynamics of the Human Telomeric G-Quadruplex by Single Molecule FRET, Haitao Li et al Proc. Natl. Acad. Sci. USA 100,14629-14634 (2003).
Ultrasensitive Coincidence Fluorescence Detection of Single DNA Molecules. Haitao Li et al. Anal. Chem.; 75(7); 1664-1670 (2003).
Identification of a new RNA•RNA interaction site for human telomerase RNA (hTR): structural implications for hTR accumulation and a dyskeratosis congenital point mutation. Haitao Li et al. Nucleic Acids Res. 31, 6509-6515 (2003).
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