个人简介

2000 Hellman Faculty Fellow 1997 American Cancer Society Postdoctoral Fellow 1994-1998 Postdoctoral Associate, University of California, Santa Cruz, 1987-1989 Department of Biotechnology Merit Scholarship 1986-1987 Recipient of Loyola College Gold Medal 1985-1986 Recipient of Loyola College Gold Medal 1984-1985 Recipient of Loyola College Gold Medal

研究领域

Biochemistry

We study how cells make proteins, which is a fundamental process for life. Ribosomes are the machines responsible for protein synthesis in all cells. Ribosomes accurately "read" the genetic information in mRNAs to assemble all the proteins required by the cell. Ribosomes are large macromolecular complexes made up of RNA and protein. The process of protein synthesis is very complex and highly regulated in eukaryotic cells. Currently we are focusing on three research areas: First, we are studying how the different steps in bacterial protein synthesis are catalyzed by the ribosome and several translational factors. This will provide insights for developing new antibiotics to treat drug-resistrant bacterial infections. Second, we are studying the mechanism of translational control by the Fragile X Mental Retardation Protein (FMRP). Fragile X Syndrome is the most common form of mental retardation. We are interested in understanding how FMRP regulates the synthesis of numerous proteins in the nervous system. Third, we are studying the mechanism used by the influenza virus to enhance the translation of viral mRNAs. Previous studies have shown that influenza virus infection blocks the transport and translation of host mRNAs, whereas viral mRNAs are translated efficiently. We are interested in understanding the protein-protein and protein-RNA interactions that are important for this process. These studies may provide insights for developing new anti-viral agents to treat flu.

近期论文

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Khade PK, Joseph S, "Messenger RNA interactions in the decoding center control the rate of translocation.", Nat Struct Mol Biol, 2011, Vol. 18, Issue 11, 1300-2 [View Abstract] Hetrick B, Khade PK, Lee K, Stephen J, Thomas A, Joseph S, "Polyamines accelerate codon recognition by transfer RNAs on the ribosome.", Biochemistry, 2010, Vol. 49, Issue 33, 7179-89 [View Abstract] Hetrick B, Lee K, Joseph S, "Kinetics of stop codon recognition by release factor 1.", Biochemistry, 2009, Vol. 48, Issue 47, 11178-84 [View Abstract] Shi X, Chiu K, Ghosh S, Joseph S, "Bases in 16S rRNA important for subunit association, tRNA binding, and translocation.", Biochemistry, 2009, Vol. 48, Issue 29, 6772-82 [View Abstract] Garcia-Ortega L, Stephen J, Joseph S, "Precise alignment of peptidyl tRNA by the decoding center is essential for EF-G-dependent translocation.", Mol Cell, 2008, Vol. 32, Issue 2, 292-9 [View Abstract] Ali IK, Lancaster L, Feinberg J, Joseph S, Noller HF, "Deletion of a conserved, central ribosomal intersubunit RNA bridge.", Mol Cell, 2006, Vol. 23, Issue 6, 865-74 [View Abstract] Studer SM, Joseph S, "Unfolding of mRNA secondary structure by the bacterial translation initiation complex.", Mol Cell, 2006, Vol. 22, Issue 1, 105-15 [View Abstract] Studer SM, Feinberg JS, Joseph S, "Rapid kinetic analysis of EF-G-dependent mRNA translocation in the ribosome.", J Mol Biol, 2003, Vol. 327, Issue 2, 369-81 [View Abstract] Phelps SS, Jerinic O, Joseph S, "Universally conserved interactions between the ribosome and the anticodon stem-loop of A site tRNA important for translocation.", Mol Cell, 2002, Vol. 10, Issue 4, 799-807 [View Abstract] Feinberg JS, Joseph S, "Identification of molecular interactions between P-site tRNA and the ribosome essential for translocation.", Proc Natl Acad Sci U S A, 2001, Vol. 98, Issue 20, 11120-5 [View Abstract]