张永安 - 华中农业大学

个人简介

教育经历 1991.09-1998.07，陕西师范大学，理学学士/硕士 1998.09-2001.07，中国科学院水生生物研究所，理学博士主要职历 2001.07-2004.02，中国科学院水生生物研究所，助理研究员/副研究员 2002.01-2003.10，阿伯丁大学（英国），访问学者/博士后 2004.03-2005.02，新墨西哥大学（美国），博士后 2005.03-2011.02，宾夕法尼亚大学（美国），博士后/研究助理 2011.03-2018.05，中国科学院水生生物研究所，研究员 2018.06-现在，华中农业大学水产学院，教授（二级岗）

研究领域

主要从基因、蛋白和细胞水平探索鱼类免疫系统的防御机制，并将其用于鱼类病害预防药物的研发以及与高等脊椎动物免疫系统的比较研究中。主要科研方向包括：（1）鱼类免疫反应的应用基础研究，从免疫学基础理论研究入手揭示鱼类免疫反应的分子生物学与细胞生物学机理；（2）鱼类主要病害的免疫预防研究，针对经济鱼类主要疫病研发新型高效的疫苗、佐剂以及免疫增强剂；（3）发育与比较免疫学的进化理论研究，结合发育生物学与比较生物学的方法研究脊椎动物免疫系统的个体发育与系统演化

近期论文

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1．Li S, Lu L F, Liu S B, Zhang C, Li Z C, Zhou X Y & Zhang Y A*. Spring viraemia of carp virus modulates p53 expression using two distinct mechanisms. PLoS Pathogens. 2019, 15(3):e1007695. (通讯作者) 2．Li S, Lu L F, Li Z C, Zhang C, Zhou X Y, Zhou Y & Zhang Y A*. Zebrafish MVP recruits and degrades TBK1 to suppress IFN production. Journal of Immunology 2019, 202 (2): 559-566. (通讯作者) 3．Lu L F, Li S, Wang Z X, Liu S B, Chen D D & Zhang Y A*. Zebrafish NDRG1a Negatively Regulates Interferon Induction by Promoting the Degradation of IRF7. Journal of Immunology 2019, 202 (1): 119-130. (通讯作者) 4．Lu X B, Wang Z X, Liu S B, Zhang X Y, Lu L F, Chen D D, Nie P & Zhang Y A*. Interferon regulatory factors 1 and 2 play different roles in MHC II expression mediated by CIITA in grass carp, Ctenopharyngodon idella. Frontiers in Immunology 2019, (in press). (通讯作者) 5．Su Y L, Wang B, Hu M D, Cui Z W, Wan J, Bai H, Yang Q, Cui Y F, Xiong L, Wan C H, Zhang Y A* & Geng H*. Site-specific N-glycan Characterization of Grass carp Serum IgM. Frontiers in Immunology 2018, 9: 2645. (共同通讯作者) 6．Zhang X J, Wang P, Zhang N, Chen D D, Nie P, Li J L & Zhang Y A*. B cell functions can be modulated by antimicrobial peptides in rainbow trout Oncorhynchus mykiss: novel insights into the innate nature of b cells in fish. Frontiers in Immunology 2017, 8: 388. (通讯作者) 7．Lu L F, Li S, Wang Z X, Du S Q, Chen D D, Nie P& Zhang Y A*. Grass Carp Reovirus VP41 Targets Fish MITA to Abrogate the IFN Response. Journal of Virology 2017, 91: e00390-17. (通讯作者) 8．Li S, Lu L F, Wang Z X, Lu X B, Chen D D, Nie P & Zhang Y A*. The P Protein of Spring Viremia of Carp Virus Negatively Regulates Fish IFN Response by Inhibiting the Kinase Activity of TANK-binding kinase 1. Journal of Virology 2016, 90 (23): 10728-10737. (通讯作者) 9．Lu L F, Li S, Lu X B, Scott E L, Zhang N, Zhang X J, Chen D D, Nie P & Zhang Y A*. Spring viremia of carp virus N protein suppresses fish IFNφ1 production by targeting the mitochondrial antiviral signaling protein. Journal of Immunology 2016, 196 (9): 3744-3753. (通讯作者) 10．Zhang X J, Zhang X Y, Zhang N, Guo X, Peng K S, Wu H, Lu L F, Wu N, Chen D D, Li S, Nie P & Zhang Y A*. Distinctive structural hallmarks and biological activities of the multiple cathelicidin antimicrobial peptides in a primitive teleost fish. Journal of Immunology 2015, 194 (10): 4974-4987. (通讯作者) 11．Li S, Lu L F, Feng H, Wu N, Chen D D, Zhang Y B, Gui J F, Nie P & Zhang Y A*. IFN regulatory factor 10 is a negative regulator of the IFN responses in fish. Journal of Immunology 2014, 193 (3): 1100-1109. (通讯作者) 12．Zhang Y A#, Salinas I#, Li J, Parra D, Bjork S J, Xu Z, LaPatra S E, Bartholomew J L& Sunyer J O. IgT, a primitive immunoglobulin class specialized in mucosal immunity. Nature Immunology 2010, 11 (9): 827-835. (并列第一作者) 13．Zhang Y A#, Hikima J-I#, Li J, LaPatra S E, Luo Y P & Sunyer J O. Conservation of structural and functional features in a primordial CD80/86 molecule from rainbow trout (Oncorhynchus mykiss), a primitive teleost fish. Journal of Immunology 2009, 183: 83-96. (并列第一作者) 14．Chang C-I#, Zhang Y A#, Zou J, Nie P & Secombes C J. Two cathelicidin genes are present in both rainbow trout (Oncorhynchus mykiss) and Atlantic salmon (Salmo salar). Antimicrobial Agents and Chemotherapy 2006, 50: 185-195. (并列第一作者) 15．Li J, Barreda D R#, Zhang Y A#, Boshra H, Gelman A E, LaPatra S, Tort L & Sunyer J O. B lymphocytes from early vertebrates have potent phagocytic and microbicidal abilities. Nature Immunology 2006, 7: 1116-1124. (并列第二作者)