个人简介

1996-1998 EMBO Long-Term Fellow 1996 Otto-Hahn Medal of the Max-Planck Society, Germany

研究领域

Organic Chemistry

We are exploring the structure, function and molecular recognition of ribonucleic acid (RNA). RNA molecules participate as key players in many biological processes and adopt complex architectures that are required for function. The development of ligands that bind specifically to RNA targets opens exciting new ways to expand the existing repertoire of protein-directed therapeutics. Our research employs diverse techniques, including molecular biology, biochemistry, X-ray crystallography as well as synthetic organic chemistry.

近期论文

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Boerneke MA, Dibrov SM, Gu J, Wyles DL, Hermann T, "Functional conservation despite structural divergence in ligand-responsive RNA switches.", Proc Natl Acad Sci U S A, 2014, Vol. 111, Issue 45, 15952-7 [View Abstract] Brunn ND, Dibrov SM, Kao MB, Ghassemian M, Hermann T, "Analysis of mRNA recognition by human thymidylate synthase.", Biosci Rep, 2014, Vol. in press, [View Abstract] Dibrov SM, Parsons J, Carnevali M, Zhou S, Rynearson KD, Ding K, Garcia Sega E, Brunn ND, Boerneke MA, Castaldi MP, Hermann T, "Hepatitis C virus translation inhibitors targeting the internal ribosomal entry site.", J Med Chem, 2014, Vol. 57, Issue 5, 1694-707 [View Abstract] Ding K, Wang A, Boerneke MA, Dibrov SM, Hermann T, "Aryl-substituted aminobenzimidazoles targeting the hepatitis C virus internal ribosome entry site.", Bioorg Med Chem Lett, 2014, Vol. 24, Issue 14, 3113-7 [View Abstract] Rynearson KD, Charrette B, Gabriel C, Moreno J, Boerneke MA, Dibrov SM, Hermann T, "2-Aminobenzoxazole ligands of the hepatitis C virus internal ribosome entry site.", Bioorg Med Chem Lett, 2014, Vol. 24, Issue 15, 3521-5 [View Abstract] Shasha C, Henley RY, Stoloff DH, Rynearson KD, Hermann T, Wanunu M, "Nanopore-based conformational analysis of a viral RNA drug target.", ACS Nano, 2014, Vol. 8, Issue 6, 6425-30 [View Abstract] Chou FC, Sripakdeevong P, Dibrov SM, Hermann T, Das R, "Correcting pervasive errors in RNA crystallography through enumerative structure prediction.", Nat Methods, 2013, Vol. 10, Issue 1, 74-6 [View Abstract] Rynearson KD, Dutta S, Tran K, Dibrov SM, Hermann T "Synthesis of oxazole analogs of streptolidine lactam", Eur J Org Chem, 2013, 7337-7342 Zhou S, Rynearson KD, Ding K, Brunn ND, Hermann T, "Screening for inhibitors of the hepatitis C virus internal ribosome entry site RNA.", Bioorg Med Chem, 2013, Vol. 21, Issue 20, 6139-6144 [View Abstract] Brunn ND, Garcia Sega E, Kao MB, Hermann T, "Targeting a regulatory element in human thymidylate synthase mRNA.", Chembiochem, 2012, Vol. 13, Issue 18, 2738-44 [View Abstract] Dibrov SM, Ding K, Brunn ND, Parker MA, Bergdahl BM, Wyles DL, Hermann T, "Structure of a hepatitis C virus RNA domain in complex with a translation inhibitor reveals a binding mode reminiscent of riboswitches.", Proc Natl Acad Sci U S A, 2012, Vol. 109, Issue 14, 5223-8 [View Abstract] Dibrov S, McLean J, Hermann T, "Structure of an RNA dimer of a regulatory element from human thymidylate synthase mRNA.", Acta Crystallogr D Biol Crystallogr, 2011, Vol. 67, Issue Pt 2, 97-104 [View Abstract] Dibrov SM, McLean J, Parsons J, Hermann T, "Self-assembling RNA square.", Proc Natl Acad Sci U S A, 2011, Vol. 108, Issue 16, 6405-8 [View Abstract] Carnevali M, Parsons J, Wyles DL, Hermann T, "A modular approach to synthetic RNA binders of the hepatitis C virus internal ribosome entry site.", Chembiochem, 2010, Vol. 11, Issue 10, 1364-7 [View Abstract] Dibrov SM, Parsons J, Hermann T, "A model for the study of ligand binding to the ribosomal RNA helix h44.", Nucleic Acids Res, 2010, Vol. 38, Issue 13, 4458-65 [View Abstract] Dutta S, Higginson CJ, Ho BT, Rynearson KD, Dibrov SM, Hermann T, "1,3-Diazepanes of natural product-like complexity from cyanamide-induced rearrangement of epoxy-delta-lactams.", Org Lett, 2010, Vol. 12, Issue 2, 360-3 [View Abstract] Parsons J, Castaldi MP, Dutta S, Dibrov SM, Wyles DL, Hermann T, "Conformational inhibition of the hepatitis C virus internal ribosome entry site RNA.", Nat Chem Biol, 2009, Vol. 5, Issue 11, 823-5 [View Abstract] Dibrov SM, Johnston-Cox H, Weng YH, Hermann T, "Functional architecture of HCV IRES domain II stabilized by divalent metal ions in the crystal and in solution.", Angew Chem Int Ed Engl, 2007, Vol. 46, Issue 1-2, 226-9 [View Abstract]