个人简介

2011- NIH Pathway to Independence Award 2003 Jack Miller Award for Excellence in Teaching, Columbia University 2001-2004 Alfred Bader Fellow

研究领域

Organic Chemistry

The field of glycobiology is gaining in importance as new discoveries continue to reveal the fundamental contributions of glycans (also called carbohydrates, saccharides, or, simply, sugars) in biology. Cell-surface and extracellular matrix glycoconjugates govern myriad biological processes intimately linked to healthy development as well as the onset and progression of many diseases. Glycans are typically organized on polypeptide scaffolds in patterns that encode protein-binding motifs. The patterns span tens to hundreds of nanometers and it is the nanoscale encoding of information by glycans (and their exclusion from the direct purview of the Genome) that makes them elusive to interrogation by traditional genetic and biochemical methods. Our group combines synthetic chemistry approaches with concepts of nanoscience to generate glycomaterials that match the dimensions and sophistication of native glycoconjugates and can be used to intercept, analyze, and dynamically perturb signaling pathways controlled by these biomolecules. The two classes of glycoconjugates under investigation in our lab are proteoglycans and mucins. Proteoglycans are known regulators of growth factor signaling during development. We are interested in creating functional surrogates of proteoglycans and using them to guide embryonic stem cell differentiation into specific tissue lineages with an eye toward regenerative medicine applications. Mucins are linear heavily glycosylated proteins forming a protective mucous layer on epithelial surfaces lining many of our organs. Outside of their protective function, mucins mediate cellular signaling and communication by engaging surface receptors via their glycan ligands. Our lab uses a novel screening platform comprising microarrayed libraries of structurally well-defined synthetic mucin mimetics to systematically profile the role of specific glycan structures and their nanoscale presentation in the context of maintenance of proper mucous barrier function and in modulating pathogen adhesion to epithelial surfaces.

近期论文

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Huang ML, Smith RA, Trieger GW, Godula K, "Glycocalyx remodeling with proteoglycan mimetics promotes neural specification in embryonic stem cells.", J Am Chem Soc, 2014, Vol. 136, Issue 30, 10565-8 [View Abstract] Paszek MJ, DuFort CC, Rossier O, Bainer R, Mouw JK, Godula K, Hudak JE, Lakins JN, Wijekoon AC, Cassereau L, Rubashkin MG, Magbanua MJ, Thorn KS, Davidson MW, Rugo HS, Park JW, Hammer DA, Giannone G, Bertozzi CR, Weaver VM, "The cancer glycocalyx mechanically primes integrin-mediated growth and survival.", Nature, 2014, Vol. 511, Issue 7509, 319-25 [View Abstract] Smith EL, Giddens JP, Iavarone AT, Godula K, Wang LX, Bertozzi CR, "Chemoenzymatic Fc glycosylation via engineered aldehyde tags.", Bioconjug Chem, 2014, Vol. 25, Issue 4, 788-95 [View Abstract] Mauris J, Mantelli F, Woodward AM, Cao Z, Bertozzi CR, Panjwani N, Godula K, Argüeso P, "Modulation of Ocular Surface Glycocalyx Barrier Function by a Galectin-3 N-terminal Deletion Mutant and Membrane-Anchored Synthetic Glycopolymers.", PLoS One, 2013, Vol. 8, Issue 8, e72304 [View Abstract] Godula K, Bertozzi CR, "Density variant glycan microarray for evaluating cross-linking of mucin-like glycoconjugates by lectins.", J Am Chem Soc, 2012, Vol. 134, Issue 38, 15732-42 [View Abstract] Godula K, Bertozzi CR, "Synthesis of glycopolymers for microarray applications via ligation of reducing sugars to a poly(acryloyl hydrazide) scaffold.", J Am Chem Soc, 2010, Vol. 132, Issue 29, 9963-5 [View Abstract] Godula K, Rabuka D, Nam KT, Bertozzi CR, "Synthesis and microcontact printing of dual end-functionalized mucin-like glycopolymers for microarray applications.", Angew Chem Int Ed Engl, 2009, Vol. 48, Issue 27, 4973-6 [View Abstract] Godula K, Umbel ML, Rabuka D, Botyanszki Z, Bertozzi CR, Parthasarathy R, "Control of the molecular orientation of membrane-anchored biomimetic glycopolymers.", J Am Chem Soc, 2009, Vol. 131, Issue 29, 10263-8 [View Abstract] Godula K, Sames D, "C-H bond functionalization in complex organic synthesis.", Science, 2006, Vol. 312, Issue 5770, 67-72 [View Abstract]