麻彤辉 - 大连医科大学 - 国际教育学院

个人简介

麻彤辉职务: 教授专业: 病理生理学 Education/Working Experience EDUCATION 1/1991-4/1994: Ph.D. in Molecular Biology and Immunology, Norman Bethune University of Medical Sciences (NBUMS), China . 9/1984-8/1987: M.S. in Immunology, Department of Microbiology & Immunology, NBUMS, Changchun, P.R. China. 9/1979-8/1984: M.D. in School of Medicine, NBUMS, Changchun, P.R. China. PROFESSIONAL EXPERIENCES 7/2013-present: Professor and Dean – College of Basic Medical Sciences, Dalian Medical University, Dalian, P.R. China. 7/2009-6/2013: Professor and Director – Central Research Laboratory, Bethune Second Hospital, Jilin University, Changchun, P.R. China. 2/2003-7/2009: Professor and Director – Membrane Channel Research Laboratory, Northeast Normal University, Changchun, P.R. China. 2/2001-2/2003: Assistant Professor of Medicine – Department of Medicine, UCSF Medical Center, San Francisco, CA, USA. 1/1996-1/2001: Assistant Research Molecular Biologist - Cardiovascular Research Institute (CVRI), UCSF Medical Center, San Francisco, CA, USA. 1/1991-1/1996: Postdoctoral Research Fellow - CVRI, UCSF Medical Center, San Francisco, CA, USA. Research Projects/Grants CURRENT FUNDINGS Title: Role of Calcium-activated chloride channel in the pathogenesis of rotaviral diarrhea, Natural Science Fund (31471099), P.R. China. Amount: RMB860,000 Period: 1/2015 to 12/2018 P.I.: Tonghui Ma Title: Ovarian local factors in the defect of ovlation, National Basic Research Program of China (973 project, No.2009CB521908), P.R. China. Amount: RMB2,100,000 Period: 1/2012 to 12/2016 P.I.: Tonghui Ma Title: Discovery of Natural Product CaCC inhibitors, Natural Science Fund (81173109), P.R. China. Amount: RMB650,000 Period: 1/2012 to 12/2015 P.I.: Tonghui Ma

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Aquaporin Field： 1. Lan YL, Zhao J, Ma T*, Li S*. The Potential Roles of Aquaporin 4 in Alzheimer's Disease. Mol Neurobiol. 2015 Oct 3. [Epub ahead of print] 2. Lan YL, Fang DY, Zhao J,Ma T*, Li S*. A research update on the potential roles of aquaporin 4 in neuroinflammation. Acta Neurol Belg. 2015 Aug 11. [Epub ahead of print] 3. Sha XY, Liu HS*,Ma TH. Osmotic water permeability diversification in primary trophoblast cultures from aquaporin 1-deficient pregnant mice. J Obstet Gynaecol Res. 2015 Sep;41(9):1399-405. 4. Li L*, Weng Z, Yao C, Song Y,Ma T*. Aquaporin-1 Deficiency Protects Against Myocardial Infarction by Reducing Both Edema and Apoptosis in Mice. Sci Rep. 2015 Sep 8;5:13807. 5. Zhang Y, Chen Q, Zhang H, Wang Q, Li R, Jin Y, Wang H,Ma T*, Qiao J*, Duan E*. Aquaporin-dependent excessive intrauterine fluid accumulation is a major contributor in hyper-estrogen induced aberrant embryo implantation. Cell Res. 2015 Jan; 25(1):139-42.. 6. Li M, Su W, Wang J, Pisani F, Frigeri A,Ma T*. Detection of anti-aquaporin-4 autoantibodies in the sera of Chinese neuromyelitis optica patients. Neural Regen Res. 2013 Mar 15;8(8):708-13. 7. Su W, Guan X, Zhang D, Sun M, Yang L, Yi F, Hao F, Feng X,Ma T*. Occurrence of multi-oocyte follicles in aquaporin 8-deficient mice. Reprod Biol Endocrinol. 2013 Sep 10;11:88. 8. Fei Y, Khan M, Gao H, Hao F, Sun M, Zhong L, Lu C, Feng X,Ma T*. Increased differentiation capacity of bone marrow-derived mesenchymal stem cells in aquaporin-5 deficiency. Stem Cells Dev. 2012 Sep 1; 21(13):2495-507. 9. Ma T*, Gao H, Fang X, Yang H. Water channel proteins in the peripheral nervous system in health and disease. Mol Asp Med. 2012 Oct; 33(5-6):605-11. 10. Zhu N, He C, Feng X, Ma Q, Guo L, Wang W, Yang H andMa T*. Defective macrophage function in aquaporin-3 deficiency. Faseb J. 2011 Dec; 25(12):4233-9. 11. Ma TH*, Gao HW, Fang XD, Yang H. Expression and function of aquaporins in peripheral nervous system. Acta Pharmacol Sin. 2011 Jun; 32(6):711-5. 12. Sha XY, Xiong ZF, Liu HS, Zheng Z,Ma TH*. Pregnant phenotype in aquaporin 8-deficient mice. Acta Pharmacol Sin. 2011 Jun; 32(6):840-4. 13. Chen Q, Peng H, Lei L, Zhang Y, Kuang H, Cao Y, Shi QX,Ma T, Duan E. Aquaporin3 is a sperm water channel essential for postcopulatory sperm osmoadaptation and migration. Cell Res. 2011 Jun; 21(6):922-33. 14. Su W, Qiao Y, Yi F, Guan X, Zhang D, Zhang S, Hao F, Xiao Y, Zhang H, Guo L, Yang L, Feng X,Ma T*. Increased female fertility in aquaporin 8-deficient mice. IUBMB Life. 2010 Nov; 62(11):852-7. 15. Guan XG, Su WH, Yi F, Zhang D, Hao F, Zhang HG, Liu YJ, Feng XC,Ma TH*. NPA motifs play a key role in plasma membrane targeting of aquaporin-4. IUBMB Life. 2010 Feb 23; 62(3): 222-226. 16. Zhang YW, Bi LT, Hou SP, Zhao XL, Song YL,Ma TH*. Reduced Lung Water Transport Rate Associated With Down-Regulation of AQP1 and AQP5 In Aged Mice. Clin Exp Pharmacol Physiol. 2009 Jul; 36(7):734-8. 17. Li L, Zhang H,Ma T*, Verkman AS. Very high aquaporin-1 facilitated water permeability in mouse gallbladder. Am J Physiol Gastrointest Liver Physiol. 2009 Apr;2 96(4):G816-22. 18. Feng X, Papadopoulos MC, Liu J, Li L, Zhang D, Zhang H, Verkman AS,Ma T*. Sporadic obstructive hydrocephalus in Aqp4 null mice. J Neurosci Res. 2009 Apr; 87(5):1150-5. 19. Liang HT, Feng XC,Ma TH*. Water channel activity of plasma membrane affects chondrocyte migration and adhesion. Clin Exp Pharmacol Physiol. 2008 Jan; 35(1):7-10. 20. Wang F, Feng XC, Li YM, Yang H,Ma TH*. Aquaporins as potential drug targets. Acta Pharmacol Sin. 2006 Apr; 27(4):395-401. 21. Jin SY, Liu YL, Xu LN, Jiang Y, Wang Y, Yang BX, Yang H,Ma TH*. Cloning and characterization of porcine aquaporin 1 water channel expressed extensively in gastrointestinal system. World J Gastroenterol. 2006 Feb 21; 12(7):1092-7. 22. Gao H, He C, Fang X, Hou X, Feng X, Yang H, Zhao X,Ma T*. Localization of aquaporin-1 water channel in glial cells of the human peripheral nervous system. Glia. 2006 May; 53(7):783-7. 23. Liu J, Shi LL, Yang H,Ma TH*. Water channels on the move: a new focus on mechanisms of cell migration and related biological processes. Prog Biochem Biophys. 2005, 32:583-586. 24. Feng XC,Ma TH*. Physiological importance of aquaporin water channels accessed by phenotype studies of aquaporin knockout mice. Prog Biochem Biophys. 2005, 32:291-297. 25. Binder DK, Oshio K,Ma T, Verkman AS, Manley GT. Increased seizure threshold in mice lacking aquaporin-4 water channels. Neuroreport. 2004 Feb 9; 15(2):259-62. 26. Hara M,Ma T, Verkman AS. Selectively reduced glycerol in skin of aquaporin-3-deficient mice may account for impaired skin hydration, elasticity, and barrier recovery. J Biol Chem. 2002 Nov 29; 277(48):46616-21. 27. Ma T*, Hara M, Sougrat R, Verbavatz JM, Verkman AS. Impaired stratum corneum hydration in mice lacking epidermal water channel aquaporin-3. J Biol Chem. 2002 May 10; 277(19):17147-53. 28. Kim YH, Earm JH,Ma T, Verkman AS, Knepper MA, Madsen KM, Kim J. Aquaporin-4 expression in adult and developing mouse and rat kidney. J Am Soc Nephrol. 2001 Sep; 12(9):1795-804. 29. Ma T*, Jayaraman S, Wang KS, Song Y, Yang B, Li J, Bastidas JA, Verkman AS. Defective dietary fat processing in transgenic mice lacking aquaporin-1 water channels. Am J Physiol Cell Physiol. 2001 Jan; 280(1):C126-34. 30. Song Y, Yang B, Matthay MA,Ma T, Verkman AS. Role of aquaporin water channels in pleural fluid dynamics. Am J Physiol Cell Physiol. 2000 Dec; 279(6):C1744-50. 31. Yang B,Ma T, Verkman AS. Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3. J Biol Chem. 2001 Jan 5; 276(1):624-8. 32. Wang KS,Ma T, Filiz F, Verkman AS, Bastidas JA. Colon water transport in transgenic mice lacking aquaporin-4 water channels. Am J Physiol Gastrointest Liver Physiol. 2000 Aug; 279(2):G463-70. 33. Wang KS, Komar AR,Ma T, Filiz F, McLeroy J, Hoda K, Verkman AS, Bastidas JA. Gastric acid secretion in aquaporin-4 knockout mice. Am J Physiol Gastrointest Liver Physiol. 2000 Aug; 279(2):G448-53. 34. Moore M,Ma T, Yang B, Verkman AS. Tear secretion by lacrimal glands in transgenic mice lacking water channels AQP1, AQP3, AQP4 and AQP5. Exp Eye Res. 2000 May; 70(5):557-62. 35. Song Y, Fukuda N, Bai C,Ma T, Matthay MA, Verkman AS. Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in oedema formation following acute lung injury: studies in transgenic aquaporin null mice. J Physiol. 2000 Jun 15;525 Pt 3:771-9. 36. Yang B, Verbavatz JM, Song Y, Vetrivel L, Manley G, Kao WM,Ma T,Verkman AS. Skeletal muscle function and water permeability in aquaporin-4 deficient mice. Am J Physiol Cell Physiol. 2000 Jun; 278(6):C1108-15. 37. Verkman AS, Yang B, Song Y, Manley GT,Ma T. Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice. Exp Physiol. 2000 Mar; 85 Spec No:233S-241S. 38. Ma T, Song Y, Yang B, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS. Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels. Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):4386-91. 39. Yang B,Ma T, Dong JY, Verkman AS. Partial correction of the urinary concentrating defect in aquaporin-1 null mice by adenovirus-mediated gene delivery. Hum Gene Ther. 2000 Mar 1;11(4):567-75. 40. van Hoek AN,Ma T,Yang B, Verkman AS, Brown D. Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidney. Am J Physiol Renal Physiol. 2000 Feb; 278(2):F310-6. 41. Manley GT, Fujimura M,Ma T, Noshita N, Filiz F, Bollen AW, Chan P, Verkman AS. Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat Med. 2000 Feb; 6(2):159-63. 42. Yang B, Fukuda N, van Hoek A, Matthay MA,Ma T, Verkman AS. Carbon dioxide permeability of aquaporin-1 measured in erythrocytes and lung of aquaporin-1 null mice and in reconstituted proteoliposomes. J Biol Chem. 2000 Jan 28; 275(4):2686-92. 43. Pallone TL, Edwards A,Ma T, Silldorff EP, Verkman AS. Requirement of aquaporin-1 for NaCl-driven water transport across descending vasa recta. J Clin Invest. 2000 Jan; 105(2):215-22. 44. Ma T, Fukuda N, Song Y, Matthay MA, Verkman AS. Lung fluid transport in aquaporin-5 knockout mice. J Clin Invest. 2000 Jan; 105(1):93-100. 45. Song Y,Ma T, Matthay MA, Verkman AS. Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method. J Gen Physiol. 2000 Jan;115(1):17-27. 46. Ma T, Song Y, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS. Defective secretion of saliva in transgenic mice lacking aquaporin-5 water channels. J Biol Chem. 1999 Jul 16; 274(29):20071-4. 47. Ma T, Verkman AS. Aquaporin water channels in gastrointestinal physiology. J Physiol. 1999 Jun 1; 517 ( Pt 2):317-26. 48. Yang B,Ma T, Xu Z, Verkman AS. cDNA and genomic cloning of mouse aquaporin-2: functional analysis of an orthologous mutant causing nephrogenic diabetes insipidus. Genomics. 1999 Apr 1;57(1):79-83. 49. Bai C, Fukuda N, Song Y,Ma T, Matthay MA, Verkman AS. Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice. J Clin Invest. 1999 Feb;103(4):555-61. 50. Chou CL, Knepper MA, Hoek AN, Brown D, Yang B,Ma T, Verkman AS. Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice. J Clin Invest. 1999 Feb; 103(4):491-6. 51. Yang B, Folkesson HG, Yang J, Matthay MA,Ma T, Verkman AS. Reduced osmotic water permeability of the peritoneal barrier in aquaporin-1 knockout mice. Am J Physiol. 1999 Jan; 276(1 Pt 1):C76-81. 52. Schnermann J, Chou CL,Ma T, Traynor T, Knepper MA, Verkman AS. Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null mice. Proc Natl Acad Sci U S A. 1998 Aug 4; 95(16):9660-4. 53. Ma T, Yang B, Matthay MA, Verkman AS. Evidence against a role of mouse, rat, and two cloned human t1alpha isoforms as a water channel or a regulator of aquaporin-type water channels. Am J Respir Cell Mol Biol. 1998 Jul; 19(1):143-9. 54. Ma T, Yang B, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS. Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels. J Biol Chem. 1998 Feb 20; 273(8):4296-9. 55. Chou CL,Ma T,Yang B, Knepper MA, Verkman AS. Fourfold reduction of water permeability in inner medullary collecting duct of aquaporin-4 knockout mice. Am J Physiol. 1998 Feb; 274(2 Pt 1):C549-54. 56. Verbavatz JM,Ma T, Gobin R, Verkman AS. Absence of orthogonal arrays in kidney, brain and muscle from transgenic knockout mice lacking water channel aquaporin-4. J Cell Sci. 1997 Nov;110 ( Pt 22):2855-60. 57. Ma T, Yang B, Verkman AS. Cloning of a novel water and urea-permeable aquaporin from mouse expressed strongly in colon, placenta, liver, and heart. Biochem Biophys Res Commun. 1997 Nov 17; 240(2):324-8. 58. Ma T, Yang B, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS. Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4. J Clin Invest. 1997 Sep 1; 100(5):957-62. 59. Ma T,Yang B, Umenishi F, Verkman AS. Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13. Genomics. 1997 Aug 1; 43(3):387-9. 60. Ma T, Yang B, Verkman AS. cDNA cloning of a functional water channel from toad urinary bladder epithelium. Am J Physiol. 1996 Nov; 271(5 Pt 1):C1699-704. 61. Ma T, Yang B, Kuo WL, Verkman AS. cDNA cloning and gene structure of a novel water channel expressed exclusively in human kidney: evidence for a gene cluster of aquaporins at chromosome locus 12q13. Genomics. 1996 Aug 1;35(3):543-50. 62. Ma T, Yang B, Verkman AS. Gene structure, cDNA cloning, and expression of a mouse mercurial-insensitive water channel. Genomics. 1996 May 1; 33(3):382-8. 63. Verkman AS, van Hoek AN,Ma T,Frigeri A, Skach WR, Mitra A, Tamarappoo BK, Farinas J. Water transport across mammalian cell membranes. Am J Physiol. 1996 Jan; 270(1 Pt 1):C12-30. 64. Verkman AS, Shi LB, Frigeri A, Hasegawa H, Farinas J, Mitra A, Skach W, Brown D, Van Hoek AN,Ma T. Structure and function of kidney water channels. Kidney Int. 1995 Oct; 48(4):1069-81. 65. Katsura T, Verbavatz JM, Farinas J,Ma T,Ausiello DA, Verkman AS, Brown D. Constitutive and regulated membrane expression of aquaporin 1 and aquaporin 2 water channels in stably transfected LLC-PK1 epithelial cells. Proc Natl Acad Sci U S A. 1995 Aug 1; 92(16):7212-6. 66. Shi LB, Skach WR,Ma T, Verkman AS. Distinct biogenesis mechanisms for the water channels MIWC and CHIP28 at the endoplasmic reticulum. Biochemistry. 1995 Jul 4; 34(26):8250-6. 67. Verbavatz JM, Van Hoek AN,Ma T, Sabolic I, Valenti G, Ellisman MH, Ausiello DA, Verkman AS, Brown D. A 28 kDa sarcolemmal antigen in kidney principal cell basolateral membranes: relationship to orthogonal arrays and MIP26. J Cell Sci. 1994 Apr;107 ( Pt 4):1083-94. 68. Hasegawa H,Ma T, Skach W, Matthay MA, Verkman AS. Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues. J Biol Chem. 1994 Feb 25; 269(8):5497-500. 69. Ma T, Hasegawa H, Skach WR, Frigeri A, Verkman AS. Expression, functional analysis, and in situ hybridization of a cloned rat kidney collecting duct water channel. Am J Physiol. 1994 Jan; 266(1 Pt 1):C189-97. 70. Ma T, Frigeri A, Skach W, Verkman AS. Cloning of a novel rat kidney cDNA homologous to CHIP28 and WCH-CD water channels. Biochem Biophys Res Commun. 1993 Dec 15; 197(2):654-9. 71. Verbavatz JM, Brown D, Sabolić I, Valenti G, Ausiello DA, Van Hoek AN,Ma T, Verkman AS. Tetrameric assembly of CHIP28 water channels in liposomes and cell membranes: a freeze-fracture study. J Cell Biol. 1993 Nov; 123(3):605-18. 72. Ma T, Frigeri A, Tsai ST, Verbavatz JM, Verkman AS. Localization and functional analysis of CHIP28k water channels in stably transfected Chinese hamster ovary cells. J Biol Chem. 1993 Oct 25; 268(30):22756-64. Chloride channel field： 73. Onur Cil, Puay-Wah Phuan, Sujin Lee, Joseph Tan, Peter M. Haggie, Marc H. Levin, Liang Sun, Jay R. Thiagarajah,Tonghui Ma*, and Alan S. Verkman*. CFTR activator increases intestinal fluid secretion and normalizes stool output in a mouse model of constipation. Cell Mol Gastroenterol Hepatol. 2016, DOI: http://dx.doi.org/10.1016/j.jcmgh.2015.12.010. 74. Sui Y, Sun M, Wu F, Yang L, Di W, Zhang G, Zhong L, Ma Z, Zheng J, Fang X,Ma T*. Inhibition of TMEM16A expression suppresses growth and invasion in human colorectal cancer cells. PLoS One. 2014 Dec 26;9(12):e115443. 75. Sun M, Sui Y, Li L, Su W, Hao F, Zhu Q, Di W, Gao H,Ma T*. Anoctamin 1 calcium-activated chloride channel downregulates estrogen production in mouse ovarian granulosa cells. Endocrinology. 2014 Aug;155(8):2787-96. 76. Yang H, Xu LN, Sui YJ, Liu X, He CY, Fang RY, Liu J, Hao F,Ma TH*. Stimulation of Airway and Intestinal Mucosal Secretion by Natural Coumarin CFTR Activators. Front Pharmacol. 2011; 2:52. 77. Yang H, Xu LN, He CY, Liu X, Fang RY,Ma TH. CFTR chloride channel as a molecular target of anthraquinone compounds in herbal laxatives. Acta Pharmacol Sin. 2011 Jun; 32(6):834-9. 78. Liang H, Yang L,Ma T, Zhao Y. Functional Expression of Cystic Fibrosis Transmembrane Conductance Regulator in Mouse Chondrocytes. Clin Exp Pharmacol Physiol. 2009 Oct; 37(4): 506-508. 79. Liu Y, Wang Y, Jiang Y, Zhu N, Liang H, Xu L, Feng X, Yang H,Ma T*. Mild processing defect of porcine DeltaF508-CFTR suggests that DeltaF508 pigs may not develop cystic fibrosis disease. Biochem Biophys Res Commun. 2008 Aug 15; 373(1):113-8. 80. Springsteel MF, Galietta LJ,Ma T, By K, Berger GO, Yang H, Dicus CW, Choung W, Quan C, Shelat AA, Guy RK, Verkman AS, Kurth MJ, Nantz MH. Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain. Bioorg Med Chem. 2003 Sep 1; 11(18):4113-20. 81. Sammelson RE,Ma T, Galietta LJ, Verkman AS, Kurth MJ. 3-(2-Benzyloxyphenyl)isoxazoles and isoxazolines: synthesis and evaluation as CFTR activators. Bioorg Med Chem Lett. 2003 Aug 4; 13(15):2509-12. Drug discovery field： Antitumor： 82. Khan M, Maryam A, Zhang H, Mehmood T, Ma T*. Killing cancer with platycodin D through multiple mechanisms. J Cell Mol Med. 2016 Mar;20(3):389-402. 83. Khan M, Maryam A, Qazi JI,Ma T*. Targeting Apoptosis and Multiple Signaling Pathways with Icariside II in Cancer Cells. Int J Biol Sci. 2015 Jul 16;11(9):1100-12. 84. Di W, Khan M, Rasul A, Sun M, Sui Y, Zhong L, Yang L, Zhu Q, Feng L,Ma T*. Isoalantolactone inhibits constitutive NF-κB activation and induces reactive oxygen species-mediated apoptosis in osteosarcoma U2OS cells through mitochondrial dysfunction. Oncol Rep. 2014 Oct;32(4):1585-93 85. Rasul A, Khan M, Yu B, Ali M, Bo YJ, Yang H,Ma T*. Isoalantolactone, a sesquiterpene lactone, induces apoptosis in SGC-7901 cells via mitochondrial and phosphatidylinositol 3-kinase/Akt signaling pathways. Arch Pharm Res. 2013 Oct;36(10):1262-9. 86. Khan M, Li T, Ahmad Khan MK, Rasul A, Nawaz F, Sun M, Zheng Y,Ma T*. Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction. Biomed Res Int. 2013; 2013:719858. 87. Zhou Y, Bi Y, Yang C, Yang J, Jiang Y, Meng F, Yu B, Khan M,Ma T, Yang H. Magnolol induces apoptosis in MCF-7 human breast cancer cells through G2/M phase arrest and caspase-independent pathway. Pharmazie. 2013 Sep;68(9):755-62. 88. Rasul A, Ding C, Li X, Khan M, Yi F, Ali M,Ma T*. Dracorhodin perchlorate inhibits PI3K/Akt and NF-κB activation, up-regulates the expression of p53, and enhances apoptosis. Apoptosis. 2012 Oct; 17(10):1104-19. 89. Khan M, Yi F, Rasul A, Li T, Wang N, Gao H, Gao R,Ma T*. Alantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation, and mitochondrial dysfunction. IUBMB Life. 2012 Sep; 64(9):783-94. 90. Khan M, Zheng B, Yi F, Rasul A, Gu Z, Li T, Gao H, Qazi JI, Yang H,Ma T*. Pseudolaric Acid B Induces Caspase-Dependent and Caspase-Independent Apoptosis in U87 Glioblastoma Cells. Evid Based Complement Alternat Med. 2012; 2012:957568. 91. Khan M, Ding C, Rasul A, Yi F, Li T, Gao H, Gao R, Zhong L, Zhang K, Fang X,Ma T*. Isoalantolactone Induces Reactive Oxygen Species Mediated Apoptosis in Pancreatic Carcinoma PANC-1 Cells. Int. J. Biol. Sci. 2012; 8(4):533-547. 92. Khan M, Yu B, Rasul A, Al Shawi A, Yi F, Yang H,Ma T*. Jaceosidin Induces Apoptosis in U87 Glioblastoma Cells through G2/M Phase Arrest. Evid Based Complement Alternat Med. 2012; 2012:703034. 93. Rasul A, Yu B, Khan M, Zhang K, Iqbal F,Ma T*, Yang H. Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways. Int J Oncol. 2012 Apr; 40(4):1153-61. 94. Rasul A, Yu B, Zhong L, Khan M, Yang H,Ma T*. Cytotoxic effect of evodiamine in SGC-7901 human gastric adenocarcinoma cells via simultaneous induction of apoptosis and autophagy. Oncol Rep. 2012 May; 27(5):1481-7. 95. Rasul A, Yu B, Yang LF, Ali M, Khan M, Ma T, Yang H. Induction of mitochondria-mediated apoptosis in human gastric adenocarcinoma SGC-7901 cells by kuraridin and Nor-kurarinone isolated from Sophora flavescens. Asian Pac J Cancer Prev. 2011;12(10):2499-504. 96. Rasul A, Khan M, Yu B,Ma T, Yang H. Xanthoxyletin, a coumarin induces S phase arrest and apoptosis in human gastric adenocarcinoma SGC-7901 cells. Asian Pac J Cancer Prev. 2011;12(5):1219-23. 97. Khan M, Rasul A, Yi F, Zhong L,Ma T. Jaceosidin induces p53-dependent G2/M phase arrest in U87 glioblastoma cells. Asian Pac J Cancer Prev. 2011;12(12):3235-8. Antiviral： 98. Miao Yu, Ye Wang, Li Tian, Yanyan Wang, Xizhu Wang, Weiguo Liang, Jiyu Yang, Dahai Yu,Tonghui Ma* and Xuexun Fang. Safflomin A inhibits neuraminidase activity and influenza virus replication. RSC Adv., 2015,5, 94053-94066. 99. Xu L, Su W, Jin J, Chen J, Li X, Zhang X, Sun M, Sun S, Fan P, An D, Zhang H, Zhang X, Kong W,Ma T*, Jiang C*. Identification of Luteolin as Enterovirus 71 and Coxsackievirus A16 Inhibitors through Reporter Viruses and Cell Viability-Based Screening. Viruses. 2014 Jul 17;6(7):2778-95. 100. Ko EA, Jin BJ, Namkung W,Ma T, Thiagarajah JR, Verkman AS. Chloride channel inhibition by a red wine extract and a synthetic small molecule prevents rotaviral secretory diarrhoea in neonatal mice. Gut. 2014 Jul;63(7):1120-9. Chloride channeldrug discovery： 101. Jiang Y, Yu B, Fang F, Cao H,Ma T, Yang H*. Modulation of chloride channel functions by the plant lignan compounds kobusin and eudesmin. Front Plant Sci. 2015 Nov 25;6:1041. 102. Yu B, Jiang Y, Liu Y,Ma T*, Yang H*. Chloride channel inhibition by ethanol extract from Bistortae rhizoma prevents secretory diarrhea. Bangladesh J Pharmacol 2015; 10: 00-00. 103. Yang H*,Ma T. F508del-cystic fibrosis transmembrane regulator correctors for treatment of cystic fibrosis: a patent review. Expert Opin Ther Pat. 2015 Sep;25(9):991-1002. 104. Chen L, Yu B, Zhang Y, Gao X, Zhu L,Ma T, Yang H. Bioactivity-Guided Fractionation of an Antidiarrheal Chinese Herb Rhodiola kirilowii (Regel) Maxim Reveals (-)-Epicatechin-3-Gallate and (-)-Epigallocatechin-3-Gallate as Inhibitors of Cystic Fibrosis Transmembrane Conductance Regulator. PLoS One. 2015 Mar 6;10(3):e0119122. 105. Zhang Y, Yu B, SuiY, Gao X, Yang H*,Ma T*. Identification of Resveratrol Oligomers as Inhibitors of Cystic Fibrosis Transmembrane Conductance Regulator by High-throughput Screening of Natural Products from Chinese Medicinal Plants. PLoS One. 2014 Apr 8;9(4):e94302. 106. Jiang Y, Yu B, Wang X, Sui Y, Zhang Y, Yang S, Yang H*,Ma T. Stimulation effect of wide type CFTR chloride channel by the naturally occurring flavonoid tangeretin. Fitoterapia. 2014 Dec;99:284-91. 107. Yu B, Zhang Y, Sui Y, Yang S, Luan J, Wang X,Ma T, Yang H*. Potentiation of mutant CFTR Cl- channel currents by the naturally occurring stilbene compound resveratrol. Pharmazie. 2013 Nov;68(11):877-81. 108. Yang S, Yu BO, Sui Y, Zhang Y, Wang X, Hou S,Ma T, Yang H*. CFTR chloride channel is a molecular target of the natural cancer preventive agent resveratrol. Pharmazie. 2013 Sep;68(9):772-6. 109. Xu LN, Na WL, Liu X, Hou SG, Lin S, Yang H,Ma TH*. Identification of natural coumarin compounds that rescue defective DeltaF508-CFTR chloride channel gating. Clin Exp Pharmacol Physiol. 2008 Aug; 35(8):878-83. 110. Yang H, Shelat AA, Guy RK, Gopinath VS,Ma T, Du K, Lukacs GL, Taddei A, Folli C, Pedemonte N, Galietta LJ, Verkman AS. Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating. J Biol Chem. 2003 Sep 12; 278(37):35079-85. 111. Caci E, Folli C, Zegarra-Moran O,Ma T,Springsteel MF, Sammelson RE, Nantz MH, Kurth MJ, Verkman AS, Galietta LJ. CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds. Am J Physiol Lung Cell Mol Physiol. 2003 Jul; 285(1):L180-8. 112. Ma T, Thiagarajah JR, Yang H, Sonawane ND, Folli C, Galietta LJ, Verkman AS. Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. J Clin Invest. 2002 Dec; 110(11):1651-8. 113. Ma T, Vetrivel L, Yang H, Pedemonte N, Zegarra-Moran O, Galietta LJ, Verkman AS. High-affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening. J Biol Chem. 2002 Oct 4; 277(40):37235-41. Anti-coagulation： 114. Xiao YH, Yang LF, Feng XC, Yang H,Ma TH*. Tanshinones Increase Fibrinolysis through Inhibition of Plasminogen Activator Inhibitor-1. CNS Neurosci Ther. 2012 May; 18(5):436-8. Neurodegenerative disease： 115. Li GY, Li T, Fan B, Zheng YC,Ma TH*. The D(1) dopamine receptor agonist, SKF83959, attenuates hydrogen peroxide-induced injury in RGC-5 cells involving the extracellular signal-regulated kinase/p38 pathways. Mol Vis. 2012;18:2882-95. 116. Li GY, Fan B,Ma TH. Visible light may directly induce nuclear DNA damage triggering the death pathway in RGC-5 cells. Mol Vis. 2011; 17:3279-89.