周学敏 - 南京医科大学

个人简介

周学敏，国家自然科学基金评审专家，江苏省新药评审专家。作为课题负责人获得国家各类新药证书和生产批件20余项。曾获得江苏省科技进步三等奖(1/6);南京市第二届城镇妇女科技创造发明成果二等奖(1/1);南京市科技进步三等奖(1/5)；江苏省教育教学与研究成果三等奖(1/5)。主持国家自然科学基金项目5项；参加国家科技部“重大新药创制”专项化药1.1类新药研究2项。在Angew.Chem.，AnalyticalChemistry，BiosensBioelectron.，ACSAppl.Mater.Interfaces等发表SCI论文50余篇，累计最新IF235，总被引1215篇次，通讯作者论文最高IF大于12，IF大于5的26篇，其中2篇进入ESI学科前2%。为AnalyticalChemistry、BiosensBioelectron.、ACSAppl.Mater.Interfaces、Anal.Chim.Acta等期刊审稿人。获得授权中国发明专利22项。近年在研与完成课题情况： [1]国家自然科学基金项目“基于DNA-银纳米簇新型分子信标的荧光传感系统及医学应用”(81773681,2018.1-2021.12)；课题负责人 [2]国家自然科学基金项目“基于磁性分子印记聚合物的磁控电化学传感膜及临床标志物分析”(81572081,2016.1-2019.12)；课题负责人 [3]国家自然科学基金项目“基于还原氧化石墨烯和金属纳米粒层层自组装的分子印记电化学传感体系及临床应用”(81273480,2013.1-2016.12)；课题负责人 [4]国家自然科学基金项目“功能纳米硅胶表面高效率分子印记可控自组装体系构建及应用研究”(21175070,2012.1-2015.12)；课题负责人 [5]国家自然科学基金项目“基于纳米硅胶表面分子印迹的固相微萃取技术用于雌激素残留分析的研究”(20875048,2009.1-2011.12)；课题负责人

研究领域

研究方向： 1.复杂体系中高灵敏和高选择性微痕量物质信息捕获新技术与新纳米元件研究及应用 2.纳米可控自组装分子靶向化学与生物传感体系构建及应用 3.药物质量控制及药代动力学研究

近期论文

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近年以通讯作者发表的主要SCI论文： [1]WanyingZhu,ChaoyiGu,JohanDunevall,LinRen,XueminZhou*,AndrewG.Ewing*.CombinedAmperometryandElectrochemicalCytometryRevealDifferentialEffectsofCocaineandMethylphenidateonExocytosisandtheFractionofChemicalRelease.Angew.Chem.Int.Ed.58:4238–4242,2019. [2]BingzhiLi,YueChen,JingWang,QiaoyunLu,WanyingZhu,JiepingLuo,JunliHong,XueminZhou*.DetectingtranscriptionfactorswithallostericDNA-Silvernanoclusterswitches.AnalyticaChimicaActa,1048:168-177,2019. [3]ChunhongZhu,WanyingZhu,LeiXu,XueminZhou*.Alabel-freeelectrochemicalaptasensorbasedonmagneticbiocompositeswithPb2þ-dependentDNAzymeforthedetectionofthrombin.AnalyticaChimicaActa,1047:21-27,2019. [4]XiaoxuLi,BingzhiLi,JunliHong*,XueminZhou*.Highlyselectivedeterminationofacidphosphataseinbiologicalsamplesusingabiomimeticrecognition-basedSERSsensor.Sensors&Actuators:B.Chemical,276:421–428,2018. [5]JiepingLuo.XinShen.BingzhiLi.XiaoyunLi.XueminZhou*.SignalamplificationbystranddisplacementinacarbondotbasedfluorometricassayforATP.MicrochimicaActa,185:392,2018. [6]BingzhiLi,YueChen,JingWang,QiaoyunLu,WanyingZhu,LeiXu,XinShen,JiepingLuo,ChunhongZhu,XiaoxuLi,JunliHong,XueminZhou*.DNA-silvernanoclusters/polypyrrolenanoparticles:Alabel-freeandenzyme-freeplatformformultiplexedtranscriptionfactorsdetection.Sensors&Actuators:B.Chemical,274:481–490,2018. [7]ZhuWanying;ShenXin;ZhuChunhong;LiBingzhi;HongJunli*;ZhouXuemin*,Turn-onfluorescentassaybasedonpurificationsystemviamagneticseparationforhighlysensitiveprobingofadenosine,SensorsandActuatorsB:Chemical,259:855–861,2018. [8]LiBingzhi;XuLei;ChenYue;ZhuWanying;ShenXin;ZhuChunhong;LuoJieping;LiXiaoxu;HongJunli;ZhouXuemin*,SensitiveandLabel-FreeFluorescentDetectionofTranscriptionFactorsBasedonDNA-AgNanoclustersMolecularBeaconsandExonucleaseIII-AssistedSignalAmplification,AnalyticalChemistry,89:7316-7323,2017. [9]XuLei;ShenXin;LiBingzhi;ZhuChunhong;ZhouXuemin*.G-quadruplexbasedExoIII-assistedsignalamplificationaptasensorforthecolorimetricdetectionofadenosine,AnalyticaChimicaActa,980:58-64,2017. [10]ShenXin;XuLei;ZhuWanying;LiBingzhi;HongJunli*;ZhouXuemin*,Aturn-onfluorescenceaptasensorbasedoncarbondotsforsensitivedetectionofadenosine,NewJournalofChemistry,41:9230,2017. [11]JiangGuoyi;ZhuWanying;ShenXin;XuLei;LiXiaoxu;WangRui;LiuChunyu;ZhouXuemin*,Colorimetricandvisualdeterminationofadenosinetriphosphateusingaboronicacidastherecognitionelement,andbasedonthedeaggregationofgoldnanoparticles,MicrochimicaActa,184:4305-4312,2017. [12]LuoJieping;ChenNing;YangZaiyue;HanJiyong;ZhuWanying;HongJunli*;ZhouXuemin*,DeterminationofactiveingredientsinChinesemedicineDanningTabletsusingdispersionsolidphaseextractionbymolecularimprintingnanomaterialscoupledwithHPLC-DAD,AnalyticalMethods,9:2585,2017. [13]ZhuWanying;XuLei;ZhuChunhong;LiBengzhi;XiaoHong;JiangHuijun;ZhouXuemin*.Magneticallycontrolledelectrochemicalsensingmembranebasedonmultifunctionalmolecularlyimprintedpolymersfordetectionofinsulin,ElectrochimicaActa,218:91-100,2016. [14]CaiQizhi;YangZaiyue;ChenNing;ZhouXuemin*;HongJunli*,SelectivecaptureandrapididentificationofPanaxnotoginsengmetabolitesinratfaecesbytheintegrationofmagneticmolecularlyimprintedpolymersandhigh-performanceliquidchromatographycoupledwithorbitrapmassspectrometry,JournalofChromatographyA,1455:65-73,2016. [15]HanQing;ShenXin;ZhuWanying;ZhuChunhong;ZhouXuemin*;JiangHuijun*,MagneticsensingfilmbasedonFe3O4@Au-GSHmolecularlyimprintedpolymersfortheelectrochemicaldetectionofestradiol,BiosensBioelectron,79:180-186,2016. [16]LiBingzhi;WangXi;ShenXin;ZhuWanying;XuLei;ZhouXuemin*.Aggregation-inducedemissionfromgoldnanoclustersforuseasaluminescence-enhancednanosensortodetecttraceamountsofsilverions,JournalofColloidandInterfaceScience,467:90–96,2016 [17]ZaiyueYang,QizhiCai,NingChen,ZhouXuemin*andJunliHong*,SelectiveseparationandidentificationofmetabolitegroupsofPolygonumcuspidatumextractinratplasmausingdispersionsolid-phaseextractionbymagneticmolecularlyimprintedpolymerscoupledwithLC/Q-TOF-MS,RSCAdv,6:12193–12204,2016. [18]XiaoxuLi,XiaoliangMei,LeiXu,XinShen,WanyingZhu,JunliHong,ZhouXuemin*,Developmentandapplicationofnovelclonazepammolecularlyimprintedcoatingsforstirbarsorptiveextraction,JournalofColloidandInterfaceScience,468:183–191,2016. [19]XiWang,XinShen,BingzhiLi,GuoyiJiang,ZhouXuemin*andHuijunJiang*,One-stepfacilesynthesisofnovelb-aminoalcoholfunctionalizedcarbondotsforthefabricationofaselectivecopperionsensinginterfacebasedonthebiuretreaction,RSCAdv,6:18326–18332,2016 [20]ZhuWanying;JiangGuoyi;XuLei;LiBingzhi;CaiQizhi;JiangHuijun;ZhouXuemin*.Facileandcontrollableone-stepfabricationofmolecularlyimprintedpolymermembranebymagneticfielddirectedself-assemblyforelectrochemicalsensingofglutathione,Anal.Chim.Acta,886:37-47,2015. [21]WangXi;ChenNing;HanQing;YangZaiyue;WuJinhua;XueCheng;HongJunli;ZhouXuemin*;JiangHuijun,Selectiveseparationanddeterminationofthesyntheticcolorantsinbeveragesbymagneticsolid-phasedispersionextractionbasedonaFe3O4/reducedgrapheneoxidenanocompositefollowedbyhigh-performanceliquidchromatographywithdiodearraydetection,JSep.Sci,38(12):2167-2173,2015. [22]WuJinhua;YangZaiyue;ChenNing;ZhuWanying;HongJunli;HuangChanggao;ZhouXuemin*,Vanillin-molecularlytargetedextractionofstirbarbasedonmagneticfieldinducedself-assemblyofmultifunctionalFe3O4@Polyanilinenanoparticlesfordetectionofvanilla-flavorenhancersininfantmilkpowders,JColloidInterf.Sci,442:22-29,2015. [23]WenTingting;ZhuWanying;XueCheng;WuJinhua;HanQing;WangXi;ZhouXuemin*;JiangHuijun*,Novelelectrochemicalsensingplatformbasedonmagneticfield-inducedself-assemblyofFe3O4@Polyanilinenanoparticlesforclinicaldetectionofcreatinine,BiosensBioelectron,56:180-185,2014. [24]XueCheng;WangXi;ZhuWanying;HanQing;ZhuChunhong;HongJunli;ZhouXuemin*;JiangHuijun,Electrochemicalserotoninsensinginterfacebasedondouble-layeredmembraneofreducedgrapheneoxide/polyanilinenanocompositesandmolecularlyimprintedpolymersembeddedwithgoldnanoparticles,Sensor.Actuat.B,196:57-63,2014. [25]HanQing;WangXi;YangZaiyue;ZhuWanying;ZhouXuemin*;JiangHuijun*,Fe3O4@rGOdopedmolecularlyimprintedpolymermembranebasedonmagneticfielddirectedself-assemblyforthedeterminationofamaranth,Talanta,123:101-108,2014. [26]XueCheng;HanQing;WangYang;WuJinhua;WenTingting;WangRuoyu;HongJunli;ZhouXuemin*;JiangHuijun*,Amperometricdetectionofdopamineinhumanserumbyelectrochemicalsensorbasedongoldnanoparticlesdopedmolecularlyimprintedpolymers,BiosensBioelectron,49:199-203,2013. [27]LiYun;WenTingting;XueCheng;HanQing;WangYang;HongJunli;ZhouXuemin*;JiangHuijun*,RGOLBLmodifiedbiomimeticelectrochemicalsensorfordetectionofSildenafilinherbalsexualhealthproducts,BiosensBioelectron,42:287-292,2013. [28]WangRuoyu;WangYang;XueCheng;WenTingting;WuJinhua;HongJunli;ZhouXuemin*,Selectiveseparationandenrichmentofglibenclamideinhealthfoodsusingsurfacemolecularlyimprintedpolymerspreparedviadendriticgraftingofmagneticnanoparticles,JSep.Sci,36(6):1015-1021,2013. [29]WangYang;WuJinhua;XueCheng;WangRuoyu;WenTingting;HongJunli;HuQin;LiFei;ZhouXuemin*,Dumbbell-shapedstirbarcoatedwithdendrimer-basedMIPsforselectiveextractionandanalysisofvardenafilanditsanaloguesildenafilinhealthfoods,Anal.Methods,5(17):4494-4500,2013. [30]WuXiaoli;LiuJie;WuJinhua;WangYang;XueCheng;WangRuoyu;HongJunli;ZhouXuemin*,Molecularimprinting-basedmicro-stirbarsorptiveextractionforspeciﬁcanalysisofGlibenclamideinherbaldietarysupplements,JSep.Sci,35(24):3593-3599,2012. [31]WangShu;WangRuoyu;WuXiaoli;WangYang;XueCheng;WuJinhua;HongJunli;LiuJie;ZhouXuemin*.Magneticmolecularlyimprintednanoparticlesbasedondendritic-graftingmodiﬁcationfordeterminationofestrogensinplasmasamples,JChromatogr.B,905:105-112,2012. [32]WuXiaoli;WuJinhua;WangShu;WangRuoyu;LiYun;WenTingting;ZhongDandan;HongJunli;HuQin;ZhouXuemin*,AnanalyticalmethodforestrogensinmilkpowderbypseudotemplateimprintedpolymercoatedﬁbercoupledwithHPLC,Anal.Methods,4:3300-3306,2012. [33]WenTingting;XueCheng;LiYun;WangYang;WangRuoyu;HongJunli;ZhouXuemin*;JiangHuijun*,Reducedgrapheneoxide-platinumnanoparticlescompositesbasedimprintingsensorforsensitivelyelectrochemicalanalysisof17β-estradiol,JElectroanal.Chem,682:121-127,2012. [34]YuanLihua;MaJing;DingMeijuan;WangShu;WuXiaoli;LiYun;MaKunfang;ZhouXuemin*;LiFei*,Preparationofestriol–molecularlyimprintedsilicananoparticlesfordeterminingoestrogensinmilktablets,FoodChem,131(3):1063-1068,2012. [35]YuanLihua;ZhangJun;ZhouPing;ChenJiaxing;WangRuoyu;WenTingting;LiYun;ZhouXuemin*;JiangHuijun*,Electrochemicalsensorbasedonmolecularlyimprintedmembranesatplatinumnanoparticles-modifiedelectrodefordeterminationof17β-estradiol,BiosensBioelectron.,29(11):29-33,2011. [36]WangShu;LiYun;WuXiaoli;DingMeijuan;XuJinhui;WangRuoyu;HuangWenyu;ZhouPing;MaKunfang;ZhouXuemin*;DuShuhu*,Self-assemblymolecularlyimprintedpolymersof17β-estradiolonthesurfaceofmagneticnanoparticlesforselectiveseparationanddetectionofestrogenichormonesinfeeds,JChromatogr.B,879(25):2595-2600,2011. [37]LiYun;DingMeijuan;WangShu;WangRuoyu;WuXiaoli;WenTingting;YuanLihua;DaiPeng;LinYuhui;ZhouXuemin*.PreparationofImprintedPolymersatSurfaceofMagneticNanoparticlesfortheSelectiveExtractionofTadalafilfromMedicines,ACSAppl.Mater.Interfaces,3(9):3308-3315,2011. [38]DingMeijuan;WuXiaoli;YuanLihua;WangShu;LiYun;WangRuoyu;WenTingting;DuShuhu;ZhouXuemin*,Synthesisofcore–shellmagneticmolecularlyimprintedpolymersanddetectionofsildenafilandvardenafilinherbaldietarysupplements,JHazard.Mater,191(1–3):177-183,2011. [39]WangShu;LiYun;WuXiaoli;DingMeijuan;YuanLihua;WangRuoyu;WenTingting;ZhangJun;ChenLina;ZhouXuemin*;LiFei*,ConstructionofuniformlysizedpseudotemplateimprintedpolymerscoupledwithHPLC-UVfortheselectiveextractionanddeterminationoftraceestrogensinchickentissuesamples.,JHazard.Mater,186(2-3):1513-1519,2011. [40]MaJing;YuanLihua;DingMeijuan;WangShu;RenFeng;ZhangJun;DuShuhu;LiFei;ZhouXuemin*,Thestudyofcore–shellmolecularlyimprintedpolymersof17β-estradiolonthesurfaceofsilicananoparticles,BiosensBioelectron,26(5):2791-2795,2011. [41]MaJing;YuanLihua;DingMeijuan;ZhangJun;ZhangQing;XuQunwei;ZhouXuemin*,DeterminationofitopridehydrochlorideinhumanplasmabyRP-HPLCwithfluorescencedetectionanditsuseinbioequivalencestudy,Pharmacol.Res,59(3):189-193,2009.