研究领域

研究方向：分子细胞生物学及在神经退行性病的发病机制中的作用

主要研究领域包括单胺类神经递质传递分子药理机制及巴金森氏病的发病机理中的运用，后又将细胞膜运输的概念融入神经递质传递和神经特异性亚细胞器如突触囊泡等的形成和功能研究中

近期论文

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代表性的论文： 1.Liu,Y.,Peter,D.,Roghani,A.,Schuldiner,S.,Prive,G.G.,Eisenberg,D.,Brecha,N.andEdwards,R.H.(1992)AcDNAthatsuppressesMPP+toxicityencodesavesicularaminetransporter.Cell70:539-551.2.ChenCX,HuangSY,ZhangLandLiuYJ.(2005)SynaptophysinenhancestheneuroprotectionofVMAT2inMPP+-inducedtoxicityinMN9Dcells.NeurobiolDis.19(3):419-26. 3.ColganL,LiuH,HuangSY,andLiuYJ.(2007)Dileucinemotifissufficientforinternalizationandsynapticvesicletargetingofvesicularacetylcholinetransporter.Traffic8(5):512-22. 4.Bai,X.,Ma,D.,Shen,X.Y.,QimingWang,Q.,Liu,YJ.andJiang,Y.(2007)RhebactivatesmTORbyantagonizingitsinherentinhibitor,FKBP38.Science318(5852):977-80. 5.Koharudin,LMI.,Furey,W.,Liu,H.,Liu,YJ.andGronenborn,AM.(2009)Thephoxdomainofsortingnexin5lacksphosphatidylinositol3-phosphate(PtdIns(3)P)specificityandpreferentiallybindstophosphatidylinositol4,5-bisphosphate(PtdIns(4,5)P2).J.Biol.Chem.284,23697-70.ZhouH.,HuangC.,Tong,J.,Hong,WC.,LiuYJ*.andXia,XG.(2011)TemporalexpressionofmutantLRRK2inadultratsimpairsdopaminereuptake.Int.J.Biol.Sci.7(6):753-61.*Correspondingauthor 6.Zou,H.,Lai,Y.,Zhao,Y.,Yan,G.,Ma,D.,Cardenes,N.,Shiva,S.,Liu,Y.,Bai,X.andJiang,Y.(2013)Regulationofmammaliantargetofrapamycincomplex1byBcl-2andBcl-XLproteins.JBiolChem288:28824-30 7Gallo,L.,Liao,Y.,Ruiz,WG.,Li,M.,Liu,YJ.,Jiang,Y.,Fukuda,M.,Apodaca,G.andYin,XM.(2014)TBC1D9BfunctionsasaGTPase-activatingproteinforRab11ainpolarizedMDCKcells.Mol.Biol.Cell.25(23):3779-97. 8.Plowey,ED.,Johnson,JW.,Eisenberg,DA.,Valentino,NM.,Liu,YJ.andChu,CT.(2014)MutantLRRK2enhancesglutamatergicsynapseactivityandevokesexcitotoxicdendritedegeneration.BBA1842:1596-603. 9.Zhao,X.,Zhong,M.,Yuan,W.,Yan,G.,Tong,M.,Guo,S.,Zhu,Y.,Jiang,Y.,Liu,YJ.,andYuJiang(2015)TumorSuppressorFolliculinRegulatesmTORC1throughPrimaryCilia.EMBOJ.submitted.