个人简介
王雪融，女，1974年2月出生，博士。
主持课题：
1.国家自然科学基金“Glibenclamide通过靶向SUR1-p70S6K调控细胞代谢酶表达抑制非小细胞肺癌作用机制的研究（81473241）（2015-2018）”。
2.国家自然科学基金“IRS-1在头颈部鳞状上皮癌转移中作用和机制的研究（81172004）（2012-2015）”。
3.国家自然科学基金“eIF4E在erlotinib耐药性中作用和机制的研究（81102458），（2012-2014）”。
近期论文
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近期发表论文：
1.ShengjieWu,LiYang,DandanWu,ZhongyuanGao,PingLi,WenbinHuang,XuerongWang.AEG-1inducesgastriccancermetastasisbyupregulationofeIF4Eexpression.JournalofCellularandMolecularMedicine.2017Jun29.Doi:10.1111/jcmm.13258.[Epubaheadofprint]
2.DandanWu,JieCheng,GengSun,ShengjieWu,MinLi,ZhongyuanGao,SulanZhai,PingLi,DongmingSu,XuerongWang.p70S6KpromotesIL-6-inducedepithelial-mesenchymaltransitionandmetastasisofheadandnecksquamouscellcarcinoma.Oncotarget.2016June14;7(24):36539-36550.
3.XiChen,LingjunZhu,ZhuoMa,GengSun,MinLi,SulanZhai,PingLi,XuerongWang.OncogenicmiR-9isatargetoferlotinibinNSCLCs.ScientificReports.2015Nov;5:17031.
4.MeijuanZou,ChenHu,QidongYou,AixiaZhang,XuerongWang（共同通讯作者）,QinglongGuo.OroxylinAinducesautophagyinhumanmalignantgliomacellsviathemTOR-STAT3-Notchsignalingpathway.MolecularCarcinogenesis.2015Nov;54(11):1363-1375.
5.YikunLi,XuerongWang（共同第一作者）,PingYue,HuiTao,SureshS.Ramalingam,TaofeekK.Owonikoko,XingmingDeng,YaWang,HaianFu,FadloR.Khuri,Shi-YongSun.Proteinphosphatase2AandDNA-dependentproteinkinaseareinvolvedinmediatingrapamycin-inducedAktphosphorylation.ThejournalofBiologicalChemistry.2013May10;288(19):13215-24.
6.WenbinHuang,LiYang,SongLiang,DongxiaoLiu,XiChen,ZhuoMa,SulanZhai,PingLi,XuerongWang.AEG-1isatargetofperifosineandisover-expressedingastricdysplasiaandcancer.DigestiveDiseasesandSciences.2013Oct;58(10):2873-80.
7.ZhuoMa,LingjunZhu,XuanLuo,SulanZhai,PingLi,XuerongWang.PerifosineenhancesmTORC1-targetedcancertherapybyactivationofGSK3βinNSCLCcells.CancerBiologyandTherapy.2012Sep;13(11):1009-1017.(IF=2.636)
8.XuerongWang,Shi-YongSun.EnhancingmTOR-targetedcancertherapy.ExpertOpiniononTherapeuticTargets.2009October20;13(10):1193-1203.
9.XuerongWang,NatalynHawk,PingYue,JohnKauh,SureshS.Ramalingam,HaianFu,FadloR.Khuri,andShi-YongSun.OvercomingmTORinhibition-inducedparadoxicalactivationofsurvivalsignalingpathwaysenhancesmTORinhibitors’anticancerefficacy.CancerBiologyandTherapy.2008December;7(12):1952-1958.
10.XuerongWang,PingYue,YoungaeKim,HaianFu,FadloR.Khuri,Shi-YongSun.EnhancingmTOR-targetedcancertherapybypreventingmTOR/raptorinhibition-initiated,mTOR/rictor-independentAktactivation.CancerResearch.2008September15;68(18):7409-7418.
11.XuerongWang,PingYue,Chi-BunChan,KeqiangYe,TakeshiUeda,RieWatanabe-Fukunaga,RikiroFukunaga,HaianFu,FadloR.Khuri,andShi-YongSun.Inhibitionofmammaliantargetofrapamycininducesphosphatidylinositol3kinase-dependentandMnk-mediatedeIF4Ephosphorylation.MolecularandCellularBiology.2007November;27(21):7405-7413.
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