肖明 - 南京医科大学

个人简介

肖明,博士,1972年11月出生，现任南京医科大学江苏省神经退行性疾病重点实验室研究员，博士生导师；1995年本科毕业于南京医科大学临床医学系；2001硕士研究生毕业于南京医科大学人体解剖学与组织胚胎学专业，获硕士学位；2005年博士研究生毕业于南京医科大学药理学专业，获博士学位。近5年来，主持国家自然基金面上项目2项，以通讯作者身份发表SCI论文20余篇。主持或参加科研项目及人才计划项目： 1．国家自然科学基金面上项目，水通道蛋白-4在阿尔茨海默病进程中的作用及机制(81271210)，起止日期：2013/01-2016/12，主持。 2．国家自然科学基金面上项目，水通道蛋白-4对星形胶质细胞功能的调节及其与阿尔茨海默病的相关性研究(30971020)，起止日期：2010/01-2012/12，主持。 3．国家自然科学基金重点项目，甲状旁腺素相关肽核定位序列和C末端在抗衰老中的作用机制研究(30830103)，起止日期：2009/01-2012/12，参与人（2/9）。 4．江苏省普通高校“青蓝工程”中青年学术带头人基金项目，起止日期：2012/12-2015/12。

研究领域

神经退行性疾病

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

近5年来发表通讯作者论文： 1.XuZQ,HuangH,ChenYL,GaoYY,XuJ,MarshallC,CaiZY,XiaoM*.Differentexpressionpatternsofamyloid-βproteinprecursorsecretasesinhumanandmousehippocampalneurons:Apotentialcontributiontospeciesdifferencesinneuronalsusceptibilitytoamyloid-βpathogenesis.JAlzheimersDis.2016Jan20.[Epubaheadofprint]PubMedPMID:26836155. 2.ChenYL,WangLM,ChenY,GaoJY,MarshallC,CaiZY,HuG,XiaoM*.Changesinastrocytefunctionalmarkersandβ-amyloidmetabolism-relatedproteinsintheearlystagesofhypercholesterolemia.Neuroscience.2016Mar1;316:178-91. 3.XuZ,XiaoN,ChenY,HuangH,MarshallC,GaoJ,CaiZ,WuT,HuG,XiaoM*.Deletionofaquaporin-4inAPP/PS1miceexacerbatesbrainAβaccumulationandmemorydeficits.MolNeurodegener.2015Nov2;10:58. 4.HuangH,WangL,CaoM,MarshallC,GaoJ,XiaoN,HuG,XiaoM*.IsolationHousingExacerbatesAlzheimer'sDisease-LikePathophysiologyinAgedAPP/PS1Mice.IntJNeuropsychopharmacol.2015Jan7;18(7):pyu116. 5.YuanC,GaoJ,GuoJ,BaiL,MarshallC,CaiZ,WangL,XiaoM*.Dimethylsulfoxidedamagesmitochondrialintegrityandmembranepotentialinculturedastrocytes.PLoSOne.2014Sep19;9(9):e107447. 6.HaoL,HuangH,GaoJ,MarshallC,ChenY,XiaoM*.Theinfluenceofgender,ageandtreatmenttimeonbrainoxidativestressandmemoryimpairmentinducedbyD-galactoseinmice.NeurosciLett.2014Jun13;571:45-9. 7.XiaoM*,HuG.Involvementofaquaporin4inastrocytefunctionandneuropsychiatricdisorders.CNSNeurosciTher.2014May;20(5):385-90. 8.WuQ,ZhangYJ,GaoJY,LiXM,KongH,ZhangYP,XiaoM*,ShieldsCB,HuG.Aquaporin-4mitigatesretrogradedegenerationofrubrospinalneuronsbyfacilitatingedemaclearanceandglialscarformationafterspinalcordinjuryinmice.MolNeurobiol.2014Jun;49(3):1327-37. 9.XuZQ,ZhangLQ,WangQ,MarshallC,XiaoN,GaoJY,WuT,DingJ,HuG,XiaoM*.Aerobicexercisecombinedwithantioxidativetreatmentdoesnotcounteractmoderate-ormid-stageAlzheimer-likepathophysiologyofAPP/PS1mice.CNSNeurosciTher.2013Oct;19(10):795-803. 10.GuM,ShenL,BaiL,GaoJ,MarshallC,WuT,DingJ,MiaoD#,XiaoM#.HeterozygousknockoutoftheBmi-1genecausesanearlyonsetofphenotypesassociatedwithbrainaging.Age(Dordr).2014Feb;36(1):129-39. 11.LiuXL,LuYS,GaoJY,MarshallC,XiaoM*,MiaoDS,KaraplisA,GoltzmanD,DingJ.Calciumsensingreceptorabsencedelayspostnatalbraindevelopmentviadirectandindirectmechanisms.MolNeurobiol.2013Dec;48(3):590-600. 12.LiX,GaoJ,DingJ,HuG,XiaoM*.Aquaporin-4expressioncontributestodecreasesinbrainwatercontentduringmousepostnataldevelopment.BrainResBull.2013May;94:49-55. 13.WeiS,XuZ,GaoJ,DingJ,XiaoM*.PrenatalethanolexposuredoesnotcauseneurologicalalterationsinadultCD1mice.Neuroreport.2013Mar6;24(4):196-201. 14.GaoJ,TanM,GuM,MarshallC,DingJ,HuG,XiaoM*.Cellularlocalizationofaquaporin-1inthehumanandmousetrigeminalsystems.PLoSOne.2012;7(9):e46379. 15.LiL,XiaoN,YangX,GaoJ,DingJ,WangT,HuG,XiaoM*.Ahighcholesteroldietameliorateshippocampus-relatedcognitiveandpathologicaldeficitsinovariectomizedmice.BehavBrainRes.2012Apr21;230(1):251-8. 16.YangW,WuQ,YuanC,GaoJ,XiaoM*,GuM,DingJ,HuG.Aquaporin-4mediatesastrocyteresponsetoβ-amyloid.MolCellNeurosci.2012Apr;49(4):406-14. 17.CaoG,GuM,ZhuM,GaoJ,YinY,MarshallC,XiaoM*,DingJ,MiaoD.Bmi-1absencecausesprematurebraindegeneration.PLoSOne.2012;7(2):e32015. 18.LiuL,LuY,KongH,LiL,MarshallC,XiaoM*,DingJ,GaoJ,HuG.Aquaporin-4deficiencyexacerbatesbrainoxidativedamageandmemorydeficitsinducedbylong-termovarianhormonedeprivationandD-galactoseinjection.IntJNeuropsychopharmacol.2012Feb;15(1):55-68. 19.WuW,LiM,LiuL,GaoJ,KongH,DingJ,HuG,XiaoM*.Astrocyteactivationbutnotneuronalimpairmentoccursinthehippocampusofmiceafter2weeksofd-galactoseexposure.LifeSci.2011Sep12;89(11-12):355-63. 20.LiL,DingJ,MarshallC,GaoJ,HuG,XiaoM*.PretrainingaffectsMorriswatermazeperformancewithdifferentpatternsbetweencontrolandovariectomizedplusD-galactose-injectedmice.BehavBrainRes.2011Feb2;217(1):244-7.

学术兼职

南京医科大学科学技术处副处长南京医科大学基础医学院青年（教师）联谊会主席江苏解剖学会秘书长担任NeurobiologyofDisease,Neuroscience,EuropeJournalofNeuroscience,RejuvenationResearch等近30种SCI期刊审稿专家 AgingandNeurodegeneration、InternationalJournalofClinicalandExperimentalNeurology、InternationalJournalofBehavioralResearch&Psychology、TherapeuticTargetsforNeurologicalDiseases和AustinJournalofAnatomy编委荷兰NIH重点项目评审专家