个人简介
王学健,男,36岁,博士,副教授。毕业于山东大学药学院获医学博士学位,2012年到潍坊医学院药理学教研室工作。先后主持国家自然科学基金青年基金、山东省优秀中青年科学家科研奖励基金、山东省高等学校科技计划项目、山东省医药卫生科技发展计划项目、潍坊医学院前沿探索重点研究基金,并参与科技部火炬计划、国家自然科学基金等课题。获得山东省高等学校科学技术奖二等奖、潍坊市自然科学奖二等奖、第四届山东药理学会-福瑞达青年药理学工作者二等奖,以第一作者或通讯作者,累计发表SCI收录论文10篇。
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ChunhuiDou,ChunyanFang*,YanZhao,XiaoyanFu,YufeiZhang,DongqiZhu,HuinaWu,HuijieLiu,JianZhang,WenfangXu,ZhijunLiu,HongyanWang,DaqiLi*andXuejianWang*,BC-02eradicateslivercancerstemcellsbyupregulatingtheROS-dependentDNAdamage,InternationalJournalofOncology,2017.IF3.0
YuqiJiang,XiaoyangLi,JinningHou,YongxueHuang,YupingJia,MingmingZou,JianZhang,XuejianWang*(co-correspondingauthor),WenfangXu*,YingjieZhang*,DiscoveryofBC-01,anovelmutualprodrug(hybriddrug)ofubenimexandfluorouracilasanticanceragent,EurJMedChem,2016,121:649-657.IF3.9
XuejianWang,LihongShi,YilinDeng,MeihuaQu,ShumeiMao,LiyanXu,WenfangXu,ChunyanFang,InhibitionofLeucineAminopeptidase3SuppressesInvasionofOvarianCancerCellsthroughDown-regulationofFascinandMMP-2/9,EURJPHARMACOL,2015,768:116-122.IF2.7
ZhipengSun,JianZhang,LihongShi,XiurongZhang,YuDuan,WenfangXu,GongDai,XuejianWang*,AminopeptidaseNinhibitor4ccsynergizesantitumoreffectsof5-fluorouracilonhumanlivercancercellsthroughROS-dependentCD13inhibition,BIOMEDPHARMACOTHER,2015,76:65-72.IF2.3
Xue-JianWang,YuDuan,Zong-TaoLi,Jin-HongFeng,Xiang-PoPan,Xiu-RongZhang,Li-HongShi,TaoZhang,PreparationandAntitumorActivityofaTamibarotene-FuroxanDerivative,AsianPacJCancerPrev,2014,15(15):6343-6347.IF2.5
XuejianWang,XiurongZhang,LeiZhang,QinghuaLi,LinWang,LihongShi,ChunyanFang,Anewcellcountingmethodtoevaluateanti-tumorcompoundactivity,AsianPacJCancerPrev,2014,15(8):3397-3401.IF2.5
孙志朋,王学健(并列第一),房春燕,戴功,徐文方,氨肽酶N:肝癌干细胞的治疗靶点,国际药学研究杂志,2014,41(5):522-527.
De-XuanCui,Xue‑JianWang(co-firstauthor),Xiu‑RongZhang,Ting‑KunZhao,Xiu‑XiangGuo,Shun‑MeiLiu,BingWang,Wen‑QuanMaandZhi‑QinGao,Preliminarydetectionoftheanti‑tumouractivityofindoline‑2,3‑dionederivativeDH‑12atargetingaminopeptidaseN,MOLMEDREP,2014,10(5):2681-2688.IF1.5
XuejianWang,FanboJing,HuaweiZhu,HaoFang,JianZhang,WenfangXu,ActivityScreeningandStructure-ActivityRelationshipoftheHitCompoundsTargetingAPN/CD13.Fundam.Clin.Pharmacol.2011,25(2):217–228.IF2.1
XuejianWang,LeiZhang,KanghuiYang,CaiZhang,JianZhang,HaoFang,WenfangXu,TheEffectofDifferentSpeciesAminopeptidaseNStructureontheActivityDeterminationofAPNInhibitor.Biol.Pharm.Bull.2010,33(10):1658-65.IF1.6
Xue-JianWang,JianChen,Zheng-BingLv,Zuo-MingNie,DanWang,Hong-DanShen,Xue-DongWang,Xiang-FuWu,Yao-ZhouZhang,ExpressionandFunctionalAnalysisoftheCellularRetinoicAcidBindingProteinfromSilkwormPupae(Bombyxmori).JCellBiochem.2007,102(4):970-9.IF3.6