个人简介
*2018-Present:ExecutiveVice-Director,InstituteofCancerStemCell,DMU
*2012-Present:Professor,InstituteofCancerStemCell,DMU
*2006-2012:Postdoctoralresearchfellow,HarvardMedicalSchool,USA
*2005-2006:GuestScientist,GermanyCancerResearchCenter(DKFZ)
*Ph.D.fromKarolinskaInstitute,Swedenin2004
*2002-2005:Researchtechnician,SouthamptonUniversity,UK
*AssistantprofessorinInstituteofBiophysics,CAS1999
*MSfromChineseAcademyofPreventiveMedicinein1997
*BSfromSichuanUniversity,Chinain1994
研究领域
1.Couplingofdifferentstepsingeneexpression
2.LncRNAsandtheirroleindiseases
3.MechanismonRNAlocalization
近期论文
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HouS,QuD,LiY,ZhuB,LiangD,WeiX,TangW,ZhangQ,HaoJ,GuoW,WangW,ZhaoS,WangQ,AzamS,KhanM,ZhaoH,ZhangL,LeiH*.(2019)XAB2depletioninducesintronretentioninPOLR2Atoimpairglobaltranscriptionandpromotecellularsenescence.NucleicAcidsRes.47(15):8239-8254.(IF:11.147)
AzamS,HouS,ZhuB,WangW,HaoT,BuX,KhanM,LeiH*.(2019)NuclearretentionelementrecruitsU1snRNPcomponentstorestrainsplicedlncRNAsinthenucleus.RNABiol.16(8):1001-1009.(IF:5.477)
ShuaiHou,NaLi,QianZhang,HuiLi,XinyueWei,TianHao,YueLi,SikandarAzam,CaigangLiu,WeiCheng,BilianJin,QuentinLiu,ManLi,andHaixinLei*.(2016)XAB2functionsinmitoticcellcycleprogressionviatranscriptionalregulationofCENPE.CellDeathandDisease7,e2409.(IF:5.959;cited:11)
ShuaiHou,LeiShi,andHaixinLei*.(2016)Biotin-streptavidinaffinitypurificationofRNA-proteincomplexesassembledinvitro.MethodsMolBiol.1421:23-34.
HuiLi,ShuaiHou,TianHao,SikandarAzam,CaigangLiu,LeiShi,andHaixinLei*.(2015)HuRantagonizestheeffectofanintronicpyrimidine-richsequenceinregulatingWT1+/-KTSisoforms.RNABiol.
LeiH,ZhaiB,YinS,GygiS,ReedR.(2013)EvidencethataconsensuselementfoundinnaturallyintronlessmRNAspromotesmRNAexport.NucleicAcidsRes.41(4):2517-25.(IF:11.147;cited:65)
LeiH,DiasAP,ReedR.ExportandstabilityofnaturallyintronlessmRNAsrequirespecificcodingregionsequencesandtheTREXmRNAexportcomplex.ProcNatlAcadSciUSA.108(44):17985-90,2011.(IF:9.58;cited:71)
HaixinLei,KariHemminki,RobertJohansson,AndreaAltieri,KerstinEnquist,RogerHenriksson,PerLennerandAstaFörsti.(2008)PAI-1-6754G/5Gpolymorphismasaprognosticbiomarkerinbreastcancer.BreastCancerResTreat.109(1):165-75.(IF:3.471;cited:39)
HaixinLei,KariHemminki,AndreaAltieri,RobertJohansson,KerstinEnquist,GöranHollmans,PerLennerandAstaFörsti.(2007)Promoterpolymorphismsinmatrixmetalloproteinasesandtheirinhibitors:fewassociationswithbreastcancersusceptibilityandprogression.BreastCancerResTreat.103(1):61-9.(IF:3.471;cited:77)
HaixinLei,IanDayandIgorVorechovsky.(2005)ExonizationofAluYa5inthehumanACEgenerequiresatleasttwopointmutationsandisfacilitatedbyaconservedsplicingenhancer.NucleicAcidsRes.33(12):3897-906.(IF:11.147;cited:33)
HaixinLeiandIgorVorechovsky.(2005)IdentificationofsplicingsilencersandenhancersinsenseAlus:aroleforpseudo-acceptorsinsplicesiterepression.MolCellBiol.25(16):6912-20.(IF:3.735;cited:36)
HaixinLei,IgorVorechovsky.(2003)BACH1517C→Ttransitionimpairsproteintranslocationtonucleus:aroleinbreastcancersusceptibility?IntJCancer.104(3):389-91.(IF:4.982;cited:12)
HaixinLei,DariaPospisilova,AnnicaLindblomandIgorVorechovsky.(2002)Re:DominantnegativeATMmutationsinbreastcancerfamilies.JNatlCancerInst.94(12):951-2.(IF:10.211;cited:10)
HaixinLei,JanZaloudik,IgorVorechovsky.(2002)Lackofassociationofthe-1171(5A)alleleoftheMMP3promoterwithbreastcancer.ClinChem.48(5):798-9.(IF:6.891;cited:29)
LipingLuo*,HaixinLei*,QuanDu,AnnavonWachenfeldt,IngridKockum,HolgerLuthman,IgorVorechovskyandAnnicaLindblom.(2002)NomutationsintheBACH1geneinBRCA1andBRCA2negativebreast-cancerfamilieslinkedto17q22.IntJCancer.98(4):638-9.(IF:4.982;cited:39)
HaixinLei,SaraSjoberg-Margolin,SimaSalahshor,BarbroWerelius,EvaJandakova,KariHemminki,AnnicaLindblomandIgorVorechovsky.(2002)CDH1mutationsarepresentinbothductalandlobularbreastcancer,butpromoterallelicvariantsshownodetectablebreastcancerrisk.IntJCancer.98(2):199-204.(IF:4.982;cited:87)
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