秘晓林 - 大连医科大学 - 肿瘤干细胞研究院

个人简介

秘晓林，博士，教授，博士生导师，基础医学院副院长，生物科学系主任。中国科学院引进国外杰出人才“百人计划”研究员，辽宁省“攀登学者”。主要研究基因组稳定性的维护与疾病的关系，特别是与肿瘤发生发展和临床治疗的关系，包括肿瘤抑制因子在细胞周期调节、凋亡的功能和作用机制，DNA损伤应答蛋白在细胞中的定位与转录调控，miRNA的功能与调节，肿瘤干细胞分化等。作为通讯作者，在Oncogene,Biomaterials,JournalofCellScience,HumanMolecularGenetics,Nanotoxicology等国际高水平刊物上发表多篇研究论文。

研究领域

1.基因组稳定性维护与肿瘤发生发展和治疗的关系； 2.DNA损伤应答关键蛋白在细胞中的定位与损伤后的转录调控； 3.microRNA调控DNA损伤应答的机制及与肿瘤的关系； 4.DNA损伤应答与干细胞分化。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.Cong,W.,Wang,P.,Qu,Y.,Tang,J.,Bai,R.,Zhao,Y.,Chen,C.,Bi,X.*EvalutationoftheinfluenceofFullerenolonagingandstressresistanceusingCaenorhabditiselegans.Biomaterials.2015.42:78-86.IF8.3 2.YuanQ.,HanJ.,CongW.,GeY.,MaD.,DaiZ.,LiY.,BiX.*Docetaxel-loadedsolidlipidnanoparticlessuppressbreastcancercellsgrowthwithimprovedcellapoptosisandgeneexpressionprofileandreducedmyelosuppressiontoxicity.IntJNanomed.2014.9(1):4829-4846.IF4.2 3.XieQ.,PengS.,TaoL.,RuanH.,YangY.,LiTM.,AdamsU.,MengS.,BiX.,DongMQ.,YuanZ.E2FTranscriptionFactor1RegulatesCellularandOrganismalSenescencebyInhibitingForkheadBoxOTranscriptionFactors.JBiolChem.2014289(49):34205-34213.IF4.6 4.Chen,H.,Wang,B.,Feng,W.,Du,W.,Ouyang,H.,Chai,Z.,Bi,X.*OralMagnetiteNanoparticlesDisturbtheDevelopmentofDrosophilaMelanogasterfromOogenesistoAdultEmergence.Nanotoxicology.2014Jun25:1-11.[Epubaheadofprint]doi:10.3109/17435390.2014.929189.IF7.8 5.Fang,G.,Zhang,D.,Yin,H.,Zheng,L.,Bi,X.*,Yuan,L.*CentleinmaintainscentrosomecohesionbybridginganinteractionbetweenC-Nap1andCep68.JCellSci.2014.127(Pt8):1631-1639.IF5.9 6.Wang,Y.,Wang,Z.,Joshi,BH.,Puri,R.,Stultz,B.,Yuan,Q.,Bai,Y.,Zhou,P.,Yuan,Z.,Hursh,DA.,Bi,X.*ThetumorsuppressorCalibanregulatesDNAdamageinducedapoptosisthroughp53-dependentand–independentactivity.Oncogene.2013.32(33):3857-3866.IF8.6 7.Liu,W.,Jiang,F.,Bi,X.*,Zhang,Q.*DrosophilaFMRPparticipatesinDNAdamageresponsebyregulatingG2/Mcellcyclecheckpointandapoptosis.HumanMolecularGenetics.2012.21(21):4655-4668.IF7.7 8.Kong,L.,YuanY.,Zhu,H.,Li,Y.,Guo,Q.,Zhao,Y.,Wang,Q.,Bi,X.*,Gao,X.*ThesuppressionofprostateLNCaPcancercellsgrowthbySeleniumnanoparticlesthroughAkt/Mdm2/ARcontrolledapoptosis.Biomaterials.2011.32(27)：6515-6522.IF7.6 9.Wang,P.,Bai,Y.,Song,B.,Wang,Y.,Liu,D.,Lai,Y.,Bi,X.*,Yuan,Z.*PP1A-mediateddephosphorylationpositivelyregulatesYAP2activity.PLoSONE.2011.6(9):e24288.IF4.3 10.Gao,G.,Bi,X.,Chen,J.,Srikanta,D.,Rong,YS.Mre11-Rad50-NbscomplexisrequiredtocaptelomeresduringDrosophilaembryogenesis.Proc.Nat.Acad.Sci.USA.2009.106(26):10728–10733.(Equalcontribution).IF9.8 11.Bi,X.,Jones,T.,Abbasi,F.,Lee,H.,Stultz,B.,Hursh,D.,Mortin,M.DrosophilaCaliban,anuclearexportmediator,canfunctionasatumorsuppressorinhumanlungcancercells.Oncogene.2005.24:8229-8239.IF6.9 12.Bi,X.,Srikanta,D.,Fanti,L.,Pimpinelli,S.,Badugu,R.,Kellum,R.,Rong,Y.S.DrosophilaATMandATRcheckpointkinasescontrolpartiallyredundantpathwaysfortelomeremaintenance.Proc.Nat.Acad.Sci.USA.2005.102(42):15167-15172.IF9.8 13.Bi,X.,Gong,M.,Srikanta,D.,Rong,Y.S.DrophilaATMandMre11areessentialfortheG2/Mcheckpointinducedbylow-doseirradiation.Genetics.2005.171:845-847.IF4.3 14.Bi,X.,Wei,S.D.,Rong,Y.S.Telomereprotectionwithoutatelomerase:theroleofATMandMre11inDrosophilatelomeremaintenance.CurrBiol.2004.14:1348-1353.IF11.9 15.Bi,X.,Kajava,A.,Demidenko,Z.,Jones,T.,Mortin,M.ThecarboxylterminusofProsperoregulatesitssubcellularlocalization.MolCellBiol.2003.23(3):1014-1024.IF8.9

学术兼职

•GeneticsSocietyofAmerica(GSA),Member •AmericanAssociationforCancerResearch(AACR),Member •AmericanJournalofHumanGenetics,SeniorEditorialBoardMember •JournalofBiochemistryandMolecularBiologyResearch,EditorialBoardMember •PrecisionMedicine,AssociateEditor •《中国生化药物杂志》编委 •中国环境诱变剂学会理事