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个人简介

男,1980年10月出生。湖北枣阳人 1999年9月至2003年6月:华中师范大学化学学院学习,获理学学士学位 2003年9月至2009年10月:华中师范大学化学学院有机化学专业研究生学习,获理学博士学位 2005年9月至2009年10月:作为联合培养博士生在美国肯塔基大学药学院学习和研究 2009年12月至2010年12月:美国肯塔基大学药学院博士后研究 2009年12月至2012年6月:华中师范大学化学学院,讲师 2009年12月至2017年6月:华中师范大学化学学院,副教授 2017年7月2023年3月:华中师范大学化学学院,教授 2023年3月至今:贵州大学精细化工研究开发中心,教授

研究领域

1. 农药化学生物学 2. 生物分析化学 3. 基于靶标结构的新型药物分子的合理设计

近期论文

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Fu, Y.X.; Guo, W.Y.; Wang, N.; Dai, Y.J.; Zhang, Z.Y; Sun, X.L.; Yang, W.C.*; Yang, G.F. Diagnosis of Bacterial Plant Diseases via a Nitroreductase-Activated Fluorescent Sensor. Anal. Chem. 2022, 94, 17692−17699. Fu, Y.X.; Zhang, Z.Y; Guo, W.Y.; Dai, Y.J.; Wang, Z.Y.; Yang, W.C.*; Yang, G.F.* In Vivo Fluorescent Screening for HPPD-Targeted Herbicide Discovery. Pest Management Science. 2022, 78, 4947–4955. (Front cover) Fu, Y.X.; Liu, S.Y; Guo, W.Y.; Liu, G.Z.; Dong, J.; Nan, J.X.; Lin, H.Y.; Mei, L.C.; Yang, W.C.*; Yang, G.F.* In vivo diagnostics of abiotic plant stress responses via in situ real-time fluorescence imaging. Plant Physiology. 2022, 190, 196−201. Guo, W.Y.; Li, R.R.; Liu, S.Y; Fu, Y.X.; Liu, G.Z.; Yang, W.C.*; Yang, G.F. Pyroglutamate Aminopeptidase I Promotes Hepatocellular Carcinoma via IL-6/STAT3 Activation as Revealed by a Specific Biosensor. Anal. Chem. 2021, 93, 13311−13318. Lin, H.Y.; Chen X.; Dong, J.; Ye, Y.; Xiao, H.; Zhan, C.G.; Yang, W.C.*; Yang, G.F.* Rational Redesign of Enzyme via the Combination of Quantum Mechanics/Molecular Mechanics, Molecular Dynamics, and Structural Biology Study. J. Am. Chem. Soc. 2021, 143, 15674−15687 X. Wang, H. Lin, J. Liu et al., The structure of 4-hydroxylphenylpyruvate dioxygenase complexed with 4-hydroxylphenylpyruvic acid reveals an unexpected inhibition mechanism, Chin. Chem. Lett., 2021, 32, 1920−1924 Rajapaksha, A.A.; Fu, Y.X.; Guo, W.Y.; Liu, S.Y; Li, Z.W.; Xiong C.Q.; Yang, W.C.*; Yang, G.F. Review on the recent progress in the development of fluorescent probes targeting enzymes. Methods and Applications in Fluorescence. 2021, 9, 032001. Guo, W.Y.; Fu, Y.X.; Liu, S.Y; Mei, L.C.; Sun, Y.; Yin, J.; Yang, W.C.*; Yang, G.F.* Multienzyme-Targeted Fluorescent Probe as a Biosensing Platform for Broad Detection of Pesticide Residues. Anal. Chem. 2021, 93, 7079−7085. 9)Qu, R.Y.; Yang, J.F.; Chen, Q.; Niu, C.W.; Xi, Z; Yang, W.C.*; Yang, G.F.* Fragment-based discovery of flexible inhibitor targeting wild-type acetohydroxyacid synthase and P197L mutant. Pest. Manag. Sci. 2020, 76, 3403–3412. 封面文章 Liu, S.Y.; Qu, R.Y.; Li, R.R; Yang, Y.C.; Sun, Y.; Yang, W.C.*; Yang, G.F.* An Activity-Based Fluorogenic Probe Enables Cellular and in Vivo Profiling of Carboxylesterase Isozymes. Anal. Chem. 2020, 92, 9205-9213. Liu, S.Y.; Yan, A.M.; Guo, W. Y.; Fang, Y.Y.; Dong, Q.J.; Li, R.R; Ni, S.N.; Sun, Y.; Yang, W.C.*; Yang, G.F.* Human Neutrophil Elastase Activated Fluorescent Probe for Pulmonary Diseases Based on Fluorescence Resonance Energy Transfer Using CdSe/ZnS Quantum Dots. ACS Nano. 2020, 14, 4244-4254. Liu, S.Y.; Xiong, H.; Li, R.R; Yang, W.C.*; Yang, G.F.* Activity-based Near-Infrared Fluorogenic Probe Enables In Vitro and In Vivo Profiling of Neutrophil Elastase. Anal. Chem. 2019, 91, 3877-3884. 封面文章 He, B.; Dong, J.; Lin, H.Y.; Wang, M.Y.; Li, X.K.; Zheng, B.F.; Chen, Q.; Hao, G.F.; Yang, W.C.*; Yang, G.F.* Pyrazole−Isoindoline-1,3-dione Hybrid: A Promising Scaffold for 4‑Hydroxyphenylpyruvate Dioxygenase Inhibitors. J. Agric. Food Chem. 2019, 67, 10844-10852. Lin, H.Y.; Chen X.; Chen, J.N.; Wang, D.W.; Wu, F.X.; Lin, S.J.; Zhan, C.G.; Wu, J.W.; Yang, W.C.*; Yang, G.F.* Crystal Structure of 4-Hydroxyphenylpyruvate Dioxygenase in Complex with Substrate Reveals A New Starting Point for Inhibitor Discovery. Research. 2019, DOI:10.34133/2019/2602414. (国产高影响期刊) Lin, H.Y.; Yang, J.F.; Wang, D.W.; Hao, G.F.; Dang, J.Q.; Wang, Y.X.; Yang, W.C.*; Wu, J.W.; Zhan, C.G.; Yang, G.F.* Molecular insights into the mechanism of 4-hydroxyphenylpyruvate dioxygenase inhibition: enzyme kinetics, X-ray crystallography and computational simulations. The FEBS J. 2019, 286, 975-990. Ndikuryayo, F.; Wu, F.X.; Kang, W.M.; Yang, W. C.;* Yang, G. F.* Hydrophobicity-oriented drug design (HODD) of new human 4-hydroxyphenylpyruvate dioxygenase inhibitors. Eur. J. Med. Chem. 2019, 166, 22-31.

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