杨光富 - 华中师范大学

个人简介

1992年毕业于华中师范大学化学系，获理学学士学位；1997年毕业于南开大学元素有机化学国家重点实验室农药学专业，获理学博士学位。2002~2014年任华中师范大学化学学院院长。2014~2017年任华中师范大学校长助理。2004～2005年赴美国University of Kentucky药学院做高级访问学者。2012年赴加拿大McMaster University化学与化学生物学系做高级访问学者。现任华中师范大学教授、博士生导师、校学术委员会副主任、智能生物传感技术与健康国际联合研究中心主任、农药与化学生物学教育部重点实验室主任。

研究领域

长期从事绿色农药及药物分子设计研究，建立了基于活性小分子与作用靶标相互作用研究的生物合理设计创新研究体系，发展了药效团链接碎片虚拟筛选、计算突变扫描等分子设计新方法，成功创制出喹草酮、吡唑喹草酯、氟苯醚酰胺和醚唑磺胺酯等多个农药候选新品种以及抗肿瘤活性候选化合物。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Diaryl Ether: A Privileged Scaffold for Drug and Agrochemical Discovery. Tao Chen, Hao Xiong, Jing-Fang Yang, Xiao-Lei Zhu, Ren-Yu Qu,* and Guang-Fu Yang*2020-08-11 An Activity-based Fluorogenic Probe Enables Cellular and In Vivo Profiling of Carboxylesterase Isozymes. Shi-Yu Liu（共一）, Ren-Yu Qu（共一）, Rong-Rong Li, Yao-Chao Yan, Yao Sun, Wen-Chao Yang,*,† and Guang-Fu Yang*,†‡ 2020-06-09 Discovery of Novel Pyrazole−Quinazoline-2,4-dione Hybrids as 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors. He, B.; Wu, F. X.; Yu, L. K.; Wu, L.; Chen, Q.; Hao, G. F.; Yang, W. C.; Lin, H. Y.;* Yang, G. F.*2020-05-06 Auto in silico ligand directing evolution (AILDE) to facilitate the rapid and efficient discovery of drug lead. Wu, F. X.; Zuo, L. S.; Wang, F.; Huang, W.;* Hao, G. F.;* Yang, G. F.*2020-04-29 In Vivo Imaging of Human Neutrophil Elastase for Pulmonary Diseases based on Fluorescence Resonance Energy Transfer Using CdSe/ZnS Quantum Dots. Yan, A. M.; Liu, S. Y.; Fang, Y. Y.; Dong, Q. J.; Li, R. R.; Sun, Y.; Yang, W. C.;* Yang, G. F.*2020-04-28 Graph attention convolutional neural network accurately predicts chemical poisoning of honey bees. Wang, F.; Yang, J. F.; Wang, M. Y.; Jia, C. Y.; Shi, X. X.; Hao, G. F.;* Yang, G. F.*2020-04-03 Graph attention convolutional neural network model for chemical poisoning of honey bees’ prediction. Fan Wang, Jing-Fang Yang, Meng-Yao Wang, Chen-Yang Jia, Xing-Xing Shi, Ge-Fei Hao, Guang-Fu Yang 2020-04-03 Cross-resistance, biochemical mechanism and fitness costs of laboratory-selected resistance to pyridalyl in diamondback moth, Plutella xylostella. Wang, R.; Qu, C.; Wang, Z. Y.;* Yang, G. F.*2020-02-12 Genome-wide phylogenetic and structural analysis reveals the molecular evolution of the ABA receptor gene family. Yang, J. F.; Chen, M. X.; Zhang, J. H.; Hao, G. F.,* Yang, G. F.*2020-02-07 A drug-likeness toolbox facilitates ADMET study in drug discovery. Jia, C. Y.; Li, J. Y.; Hao, G. F.;* Yang, G. F.2020-01-15 Molecular pathogenesis of tumorigenesis caused by succinate dehydrogenase defect. Moosavi, B.;* Zhu, X. L.; Yang, W. C.; Yang, G. F.*2020-01-15 Fragment-based Discovery of Flexible Inhibitor Targeting Wild-type Acetohydroxyacid Synthase and P197L Mutant. Qu, R. Y.; Yang, J. F.; Chen, Q.; Niu, C. W.; Xi, Z.; Yang, W. C.; Yang, G. F.*2020-01-14 Development of a Web-Based Laboratory Class to Reduce the Challenges in Teaching Fragment-Based Drug Design. Shi, X. X.; Li, J. Y.; Chen, Q.; Hao, G. F.;* Yang, G. F.*2020-01-09 The anti-cancer compound Schweinfurthin A targets Osh2 and disrupts lipid metabolism in yeast model. Moosavi, B.;* Gao, M. Q.; Zhu, X. L.; Yang, G. F.*2020-01-03 An overview of spirooxindole as a promising scaffold for novel drug discovery. Zhou, L. M.; Qu, R. Y.; Yang, G. F.*2020-01-02 Synthesis and Biological Evaluation of New MET Inhibitors with 1,6-Naphthyridinone Scaffold. Wang, M. S.; Zuo, L. S.; Yang, F. P.; Wang, W. J.; Huang, W.;* Yang, G. F.*2020-01-01 LARMD: integration of bioinformatic resources to profile ligand-driven protein dynamics with a case on the activation of estrogen receptor. Yang, J. F.; Wang, F.; Chen, Y. Z.; Hao, G. F.,* Yang, G. F.*2019-12-03 Pyrazole-Isoindoline-1,3-dione Hybrid: A Promising Scaffold for 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors. He, B.; Dong, J.; Lin, H. Y.; Wang, M. Y.; Li, X. K.; Zheng, B. F.; Chen, Q.; Hao, G. F.; Yang, W. C.;* Yang, G. F.*2019-09-17