周军 - 华中科技大学 - 化学与化工学院

研究领域

本课题组综合运用细胞和动物模型（包括基因敲除动物与转基因动物模型）及体外化学体系，从整体动物、组织、细胞和分子等多个层次上致力于理解以下问题：(1) 硒与活性氧/氮在糖尿病发生发展中的作用及其机制；(2) 糖脂代谢紊乱的分子机制及药物干预；(3) 硒蛋白的生物学功能及其与重大疾病的关系。

近期论文

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Zhou J, Yan J, Bai Z, Li K, Huang K. Hypoglycemic activity and potential mechanism of a polysaccharide from the loach in streptozotocin-induced diabetic mice. Carbohydrate Polymers, 2015, 121: 199-206. Zhou J, Xu G, Yan J, Li K, Bai Z, Cheng W, Huang K. Rehmannia glutinosa (Gaertn.) DC. polysaccharide ameliorates hyperglycemia, hyperlipemia and vascular inflammation in streptozotocin-induced diabetic mice. Journal of Ethnopharmacology 2015, 164: 229-238. Wang Q, Xie Z, Zhang W, Zhou J, Wu Y, Zhang M, Zhu H, Zou MH. Myeloperoxidase deletion prevents high-fat diet-induced obesity and insulin resistance. Diabetes. 2014, 63: 4172-4185. Zhou J, Wang Q, Ding Y, Zou MH. Hypochlorous acid via peroxynitrite activates protein kinase C and insulin resistance in adipocytes. Journal of Molecular Endocrinology. 2015, 54(1): 25-37. Jia Y, Zhou J, Liu H, Huang K. Effect of methionine sulfoxide reductase B1 (SelR) gene silencing on peroxynitrite-induced F-actin disruption in human lens epithelial cells. Biochem Biophys Res Commun. 2014, 443: 876-881. Zhou J, Huang K, Lei X G. Selenium and diabetes—Evidence from animal studies. Free Radical Biology and Medicine. 2013, 65: 1548-1556. (Highlighted Article) 周军，白兆帅，徐辉碧，黄开勋。硒蛋白与糖尿病——硒的两面性。化学进展. 2013, 25: 488-494. Li Y, Jia Y, Zhou J, Huang K. Effect of methionine sulfoxide reductase B1 silencing on high-glucose-induced apoptosis of human lens epithelial cells. Life Sci. 2013, 92:193-201. Jun Zhou, Kaixun Huang. Peroxynitrite mediates muscle insulin resistance in mice via nitration of IRβ/IRS-1 and Akt. Toxicology and Applied Pharmacology. 2009, 241(1): 101-110. Jun Zhou, Xingmu He, Kaixun Huang. Bidirectional regulation of insulin receptor autophosphorylation and kinase activity by peroxynitrite. Archives of Biochemistry and Biophysics. 2009, 488(1): 1-8. Jun Zhou, Haidong Li, Jinhong Zeng, Kaixun Huang. Effects of peroxynitrite-induced protein tyrosine nitration on insulin-stimulated tyrosine phosphorylation in HepG2 cells. Molecular and Cellular Biochemistry. 2009, 331(1-2): 49-57. Jun Zhou, Dingxian Han. Safety evaluation of protein of silkworm (Antheraea pernyi) pupae. Food and Chemical Toxicology. 2006, 44(7): 1123-1130. Jun Zhou, Dingxian Han. Proximate, amino acid and mineral composition of pupae of the silkworm Antheraea pernyi in China. Journal of Food Composition and Analysis. 2006, 19(8): 850-853. Jinhong Zeng, Jun Zhou, Kaixun Huang. Effect of selenium on pancreatic proinflammatory cytokines in streptozotocin-induced diabetic mice. Journal of Nutritional Biochemistry. 2009, 20(7): 530-536. Shaoqing Du, Jun Zhou, Yi Jia, Kaixun Huang. SelK is a novel ER stress-regulated protein and protects HepG2 cells from ER stress agent-induced apoptosis. Archives of Biochemistry and Biophysics.2010, 502(2): 137-43. Jinhong Zeng, Shaoqing Du, Jun Zhou, Kaixun Huang. Role of SelS in lipopolysaccharide-induced inflammatory response in hepatoma HepG2 cells. Archives of Biochemistry and Biophysics. 2008, 478(1): 1-6.